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1. 发明授权

US5126448A Pyridine derivatives 失效
标题翻译：吡啶衍生物
公开(公告)号：US5126448A
公开(公告)日：1992-06-30
申请号：US414892
申请日：1989-09-29
申请人： Showa Ueki , Hiromu Kawakubo , Katsuya Okazaki , Tadashi Nagatani
发明人： Showa Ueki , Hiromu Kawakubo , Katsuya Okazaki , Tadashi Nagatani
IPC分类号： C07D491/04 , C07D491/048 , C07D495/04
CPC分类号： C07D491/04 , C07D495/04
摘要： This invention relates to novel pyridine derivatives and 1,2,3,4-tetrahydropyridine derivatives shown by following general formula (I) or (II) and salts thereof which are useful as psychotropic medicaments: ##STR1## wherein A is S or O; R.sub.1 represents an unsubstituted or substituted alkoxy, amino, hydrazino, or 6- or 7-membered heterocyclic group having one or two nitrogen atoms with the proviso that R.sub.1 is not an alkoxy group in formula (I); R.sub.2 and R.sub.3 each represents a hydrogen atom or an unsubstituted or substituted alkyl, aryl, alkenyl, acyl, arylcarbonyl group; and m and n each represents an integer of from 0 to 4.

2. 发明授权

US5059612A Anti-dementia drug 失效
标题翻译：抗真菌药物
公开(公告)号：US5059612A
公开(公告)日：1991-10-22
申请号：US578655
申请日：1990-09-07
申请人： Taiichiro Imanishi , Yasuyuki Ichimaru , Aiko Sawa , Fukio Konno , Helmut Wachtel , Showa Ueki , Michihiro Fujiwara , Tsuneyuki Yamamoto
发明人： Taiichiro Imanishi , Yasuyuki Ichimaru , Aiko Sawa , Fukio Konno , Helmut Wachtel , Showa Ueki , Michihiro Fujiwara , Tsuneyuki Yamamoto
IPC分类号： C07D207/24 , A61K31/40 , A61P25/28
CPC分类号： A61K31/40
摘要： The invention relates to a method of treating dementia, such as cerebro-vascular dementia, for example, multiple infarct dementia and amyloid angiopathic dementia, cerebro-parenchymatous dementia, such as Alzheimer's dementia and Pick's disease, and dementia caused by brain tumor, hydrocephalus, hepatic meningitis, cerebral trauma, or cerebral function disorders, comprising administering rolipram.

3. 发明授权

US5621103A Tetrahydropyridine derivative having substituents on three rings 失效
标题翻译：在三环上具有取代基的四氢吡啶衍生物
公开(公告)号：US5621103A
公开(公告)日：1997-04-15
申请号：US307779
申请日：1994-12-28
申请人： Hiromu Kawakubo , Tadashi Nagatani , Showa Ueki, deceased
发明人： Hiromu Kawakubo , Tadashi Nagatani , Showa Ueki, deceased
IPC分类号： C07D495/04 , A61K31/44 , C07D471/04
CPC分类号： C07D495/04
摘要： A tetrahydropyridine derivative having substituents on three rings represented by the following formula (1): ##STR1## (wherein A represents sulfur atom, sulfoxide group or sulfone group; R.sub.1 represents an amino group substituted with a specific substituent or a specific aliphatic oxy group; R.sub.2 and R.sub.3 each represents hydrogen atom or a hydroxy group; and m and n are each an integer of from 0 to 4; provided that when m and n are 2 or above, R.sub.2 's and R.sub.3 's may be either the same or different from each other respectively, that when A is sulfur atom and R.sub.1 is cyclohexylamino group and R.sub.2 is hydrogen atom, R.sub.3 is hydroxy group, that when A is sulfoxide group and R.sub.1 is cyclohexylamino group or 4-hydroxycyclohexylamino group, R.sub.2 is hydrogen atom and R.sub.3 is hydrogen atom or hydroxy group and that when A is sulfone group and R.sub.1 is cyclohexylamino group, R.sub.2 and R.sub.3 are each hydrogen atom) and an acid addition salt thereof is to be provided, thereby a compound which is useful as a psychotropic drug having anxiolytic and learning-improvement effects is to be provided.
摘要翻译： PCT No.PCT / JP92 / 00460 Sec。 371日期1994年12月28日第 102（e）日期1994年12月28日PCT提交1992年4月10日PCT公布。公开号WO93 / 21189 日期：1993年10月28日由下式（1）表示的三环上具有取代基的四氢吡啶衍生物：其中A表示硫原子，亚砜基或砜基; R1表示被特定取代基取代的氨基或特定的脂族氧基; R2和R3各自表示氢原子或羟基; m和n各自为0〜4的整数;条件是当m和n为2以上时，R2和R3可以相同或分别不同，当A为硫原子且R 1为环己基氨基且R 2为氢原子时，R 3为羟基，当A为亚砜基且R 1为环己基氨基或4-羟基环己基氨基时，R 2为氢原子 R 3为氢原子或羟基，当A为砜基且R 1为环己基氨基时，R 2和R 3各自为氢原子）和其酸加成盐，由此可用作Psyc 提供具有抗焦虑和学习改善效果的热性药物。

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