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1. 发明申请

US20110177961A1 Method of Diagnosing Active Mycobacterium Tuberculosis with Detecting Chip 审中-公开
标题翻译：用检测芯片诊断活动性结核分枝杆菌的方法
公开(公告)号：US20110177961A1
公开(公告)日：2011-07-21
申请号：US12688120
申请日：2010-01-15
申请人： Shiu-Ru Lin , Ching-Sheng Yeh , Chia-Sui Sun , Jong-Rung Tsai , Ming-Je Yang
发明人： Shiu-Ru Lin , Ching-Sheng Yeh , Chia-Sui Sun , Jong-Rung Tsai , Ming-Je Yang
IPC分类号： C40B30/04
CPC分类号： C12Q1/689 , C12Q1/6837
摘要： The present disclosure diagnoses mycobacterium tuberculosis, not mycobacterium tuberculosis complex only. Specific target genes are selected from regions of difference of mycobacterium tuberculosis. After hybridization with labeling substances, sputum samples are processed through color developments separately for obtaining images to be analyzed automatically. Thus, the present disclosure rapidly diagnoses mycobacterium tuberculosis in the sputum samples with a simple operation and a low cost.
摘要翻译：本公开仅诊断结核分枝杆菌，而不是结核分枝杆菌复合物。特异性靶基因选自结核分枝杆菌差异的区域。与标记物质杂交后，分别通过颜色开发处理痰样品，以获得自动分析的图像。因此，本公开以简单的操作和低成本快速诊断痰样品中的结核分枝杆菌。

2. 发明申请

US20100184623A1 GENE-ARRAY OPERATION CHIP DEVICE 审中-公开
标题翻译：基因阵列操作芯片设备
公开(公告)号：US20100184623A1
公开(公告)日：2010-07-22
申请号：US12357700
申请日：2009-01-22
申请人： Suz-Kai HSIUNG , Shiu-Ru LIN , Hui-Jen CHANG
发明人： Suz-Kai HSIUNG , Shiu-Ru LIN , Hui-Jen CHANG
IPC分类号： C40B40/08
CPC分类号： C40B60/12 , B01F5/0057 , B01F13/0059 , B01J2219/00466 , B01J2219/005 , B01J2219/00531 , B01J2219/00608 , B01L3/5027 , B01L3/502761 , B01L9/527 , B01L2200/027 , B01L2200/0642 , B01L2200/10 , B01L2300/0819 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/165 , B01L2400/043 , B01L2400/049 , B01L2400/0688
摘要： A gene-array operation chip device includes a reaction chamber, and a plurality of inlet holes connected respectively to agitation channels for creating agitation currents within the reaction chamber. Each agitation channel has two ends respectively connected to one of the inlet holes and to the reaction chamber. The agitation channels are inclined with respect to radial directions about an axis of the reaction chamber. Preferably, a flow channel interconnecting two reaction chambers has a hydrophobic wall surface to limit a fluid from flowing naturally between the chambers. In an embodiment, the reaction chamber is a hybridization chamber provided with a membrane-array.
摘要翻译：基因阵列操作芯片装置包括反应室和分别连接到搅拌通道的多个入口孔，用于在反应室内产生搅动电流。每个搅拌通道具有分别连接到一个入口孔和反应室的两端。搅拌通道相对于围绕反应室的轴线的径向倾斜。优选地，互连两个反应室的流动通道具有疏水壁表面，以限制流体在室之间自然流动。在一个实施方案中，反应室是具有膜阵列的杂交室。

3. 发明授权

US07575928B2 Genes for diagnosing colorectal cancer 有权
标题翻译：诊断结肠直肠癌的基因
公开(公告)号：US07575928B2
公开(公告)日：2009-08-18
申请号：US10786148
申请日：2004-02-26
申请人： Shiu-Ru Lin , Jaw-Yuan Wang
发明人： Shiu-Ru Lin , Jaw-Yuan Wang
IPC分类号： G01N33/48 , C12Q1/68 , A61B5/055 , C12N15/867
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： This invention relates to provide the genes for diagnosing colorectal cancer, the gene sequences searching comprise the steps of: (1) deriving epithelium cells from normal intestines, polypus of intestines and colorectal cancer tissue; (2) collecting genes with highly differential gene expression by Suppression Subtractive Hybridization (SSH), and building library; (3) deriving colonies with relatively high signal intensities from cancer tissue; (4) collecting more clinically cancer tissues by Northern Hybridization, real-time Polymerase Chain Reaction (PCR) combined with analysis of bioinformation to affirm variation between differential gene expression; and (5) selecting the most suitable genes from said library, and using the gene sequence as reagent provides the effects of early diagnosis, specificity, highly sensitivity and safety.
摘要翻译：本发明涉及提供用于诊断结肠直肠癌的基因，所述基因序列搜索包括以下步骤：（1）从正常肠道，肠道息肉和结肠直肠癌组织衍生上皮细胞; （2）通过抑制消减杂交（SSH）和建筑图书馆收集具有高度差异基因表达的基因; （3）从癌组织衍生具有较高信号强度的菌落; （4）通过Northern杂交，实时聚合酶链反应（PCR）结合生物信息分析，收集更多的临床癌症组织，证实差异基因表达之间的差异; 和（5）从所述文库中选择最合适的基因，并且使用基因序列作为试剂提供早期诊断，特异性，高灵敏度和安全性的作用。

4. 发明申请

US20080050729A1 Complex cancer cells luminescence detection method 审中-公开
标题翻译：复合癌细胞发光检测方法
公开(公告)号：US20080050729A1
公开(公告)日：2008-02-28
申请号：US11585974
申请日：2006-10-25
申请人： Shiu-Ru Lin , Tian-Lu Cheng
发明人： Shiu-Ru Lin , Tian-Lu Cheng
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837
摘要： A method for detecting cancer cells. A chemical luminescence reaction is used to obtain a result image. The result image is analyzed through a weighting process to a value of each gene. By doing do, a cancer can be precisely diagnosed.
摘要翻译：一种检测癌细胞的方法。使用化学发光反应来获得结果图像。通过加权过程对每个基因的值分析结果图像。通过这样做，可以精确诊断癌症。

5. 发明授权

US08178343B2 Gene cluster diagnosis apparatus 有权
标题翻译：基因簇诊断装置
公开(公告)号：US08178343B2
公开(公告)日：2012-05-15
申请号：US12852652
申请日：2010-08-09
申请人： Shiu-Ru Lin , Hui-Jen Chang , Der-An Tsao
发明人： Shiu-Ru Lin , Hui-Jen Chang , Der-An Tsao
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： C12Q1/6886 , B01J2219/005 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , C12Q2600/158
摘要： A diagnosis apparatus is provided. A gene chip having a target gene cluster is used with the apparatus. The target gene cluster comprises a plurality of target genes related to a cancer. Thus, a fast, accurate, sensitive and cheap WEnCA-Chipball platform is provided for mass analysis and automatic operation while human error and time for diagnosis are both reduced.
摘要翻译：提供诊断装置。与该装置一起使用具有靶基因簇的基因芯片。靶基因簇包含与癌症相关的多个靶基因。因此，提供快速，准确，灵敏和便宜的WEnCA-Chipball平台用于质量分析和自动操作，同时减少了人为错误和诊断时间。

6. 发明申请

US20110281774A1 Gene Cluster Diagnosis Apparatus 有权
标题翻译：基因簇诊断仪
公开(公告)号：US20110281774A1
公开(公告)日：2011-11-17
申请号：US12852652
申请日：2010-08-09
申请人： Shiu-Ru Lin , Hui-Jen Chang , Der-An Tsao
发明人： Shiu-Ru Lin , Hui-Jen Chang , Der-An Tsao
IPC分类号： C40B60/12
CPC分类号： C12Q1/6886 , B01J2219/005 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , C12Q2600/158
摘要： A diagnosis apparatus is provided. A gene chip having a target gene cluster is used with the apparatus. The target gene cluster comprises a plurality of target genes related to a cancer. Thus, a fast, accurate, sensitive and cheap WEnCA-Chipball platform is provided for mass analysis and automatic operation while human error and time for diagnosis are both reduced.
摘要翻译：提供诊断装置。与该装置一起使用具有靶基因簇的基因芯片。靶基因簇包含与癌症相关的多个靶基因。因此，提供快速，准确，灵敏和便宜的WEnCA-Chipball平台用于质量分析和自动操作，同时减少了人为错误和诊断时间。

7. 发明申请

US20050191634A1 Genes for diagnosing colorectal cancer 有权
标题翻译：诊断结肠直肠癌的基因
公开(公告)号：US20050191634A1
公开(公告)日：2005-09-01
申请号：US10786148
申请日：2004-02-26
申请人： Shiu-Ru Lin , Jaw-Yuan Wang
发明人： Shiu-Ru Lin , Jaw-Yuan Wang
IPC分类号： C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： This invention relates to provide the genes for diagnosing colorectal cancer, the gene sequences searching comprise the steps of: (1) deriving epithelium cells from normal intestines, polypus of intestines and colorectal cancer tissue; (2) collecting genes with highly differential gene expression by Suppression Subtractive Hybridization (SSH), and building library; (3) deriving colonies with relatively high signal intensities from cancer tissue; (4) collecting more clinically cancer tissues by Northern Hybridization, real-time Polymerase Chain Reaction (PCR) combined with analysis of bioinformation to affirm variation between differential gene expression; and (5) selecting the most suitable genes from said library, and using the gene sequence as reagent provides the effects of early diagnosis, specificity, highly sensitivity and safety.
摘要翻译：本发明涉及提供用于诊断结肠直肠癌的基因，所述基因序列搜索包括以下步骤：（1）从正常肠道，肠道息肉和结肠直肠癌组织衍生上皮细胞; （2）通过抑制消减杂交（SSH）和建筑图书馆收集具有高度差异基因表达的基因; （3）从癌组织衍生具有较高信号强度的菌落; （4）通过Northern杂交，实时聚合酶链反应（PCR）结合生物信息分析，收集更多的临床癌症组织，证实差异基因表达之间的差异; 和（5）从所述文库中选择最合适的基因，并且使用基因序列作为试剂提供早期诊断，特异性，高灵敏度和安全性的作用。

8. 发明授权

US08309344B2 Automatic system of isolating and incubating circulating tumor cells 有权
标题翻译：自动分离和培养循环肿瘤细胞系统
公开(公告)号：US08309344B2
公开(公告)日：2012-11-13
申请号：US12578522
申请日：2009-10-13
申请人： Hui-Jen Chang , Shiu-Ru Lin , Chun-Hung Lee , Der-And Tsao
发明人： Hui-Jen Chang , Shiu-Ru Lin , Chun-Hung Lee , Der-And Tsao
IPC分类号： C12M3/00 , C12M1/36
CPC分类号： C12M47/04 , C12M41/00 , C12M41/34 , C12M41/46
摘要： The present invention is applied in fields like biological medicine and tissue engineering. A fluid control system in a cell isolation and culture system is used to automatically process sample preparation, circulating tumor cell (CTC) isolation, plate changing and cell culturing. By using the present invention, time and labor are saved; moreover, the present invention has a small size and is easily carried.
摘要翻译：本发明应用于生物医学和组织工程领域。细胞分离培养系统中的流体控制系统用于自动处理样品制备，循环肿瘤细胞（CTC）分离，平板变化和细胞培养。通过使用本发明，省时省力; 此外，本发明具有小尺寸并且容易携带。

9. 发明申请

US20110059519A1 Automatic System of Isolating and Incubating Circulating Tumor Cells 有权
标题翻译：分离和孵育循环肿瘤细胞的自动系统
公开(公告)号：US20110059519A1
公开(公告)日：2011-03-10
申请号：US12578522
申请日：2009-10-13
申请人： Hui-Jen Chang , Shiu-Ru Lin , Chun-Hung Lee , Der-An Tsao
发明人： Hui-Jen Chang , Shiu-Ru Lin , Chun-Hung Lee , Der-An Tsao
IPC分类号： C12M1/36
CPC分类号： C12M47/04 , C12M41/00 , C12M41/34 , C12M41/46
摘要： The present invention is apllied in fields like biological medicine and tissue engineering. A fluid control system in a cell isolation and culture system is used to automatically process sample preparation, circulating tumor cell (CTC) isolation, plate changing and cell culturing. By using the present invention, time and labor are saved; moreover, the present invention has a small size and is easily carried.
摘要翻译：本发明涉及生物医学和组织工程等领域。细胞分离培养系统中的流体控制系统用于自动处理样品制备，循环肿瘤细胞（CTC）分离，平板变化和细胞培养。通过使用本发明，省时省力; 此外，本发明具有小尺寸并且容易携带。

10. 发明申请

US20100130379A1 Weighted Chemiluminescent Chip array Method for Multiple Marker Detection 审中-公开
标题翻译：用于多标记检测的加权化学发光芯片阵列方法
公开(公告)号：US20100130379A1
公开(公告)日：2010-05-27
申请号：US12604393
申请日：2009-10-23
申请人： Shiu-Ru Lin , Chung-Chi Chen
发明人： Shiu-Ru Lin , Chung-Chi Chen
IPC分类号： C40B30/04
CPC分类号： C12Q1/6837 , C12Q2563/131 , C12Q2545/101
摘要： A gene chip for chemiluminescent detection is obtained. The chip uses multiple markers. Weighted scores are given to genes separately according to their influences on forming a cancer. The present invention provides an objective and accurate disease assistant diagnosis with a low cost, a high sensitivity and a good performance. The present invention can be widely applied to personal medical behaviors, like clinical diagnosis, treatment filtration, prognosis review, preventive medicine, etc.
摘要翻译：获得化学发光检测的基因芯片。该芯片使用多个标记。根据其对形成癌症的影响，分别给予基因加权评分。本发明以低成本，高灵敏度和良好的性能提供客观和准确的疾病辅助诊断。本发明可广泛应用于个人医疗行为，如临床诊断，治疗过滤，预后评估，预防医学等。

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