专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07115635B2 Benzylpiperidine compound 有权
标题翻译：苄基哌啶化合物
公开(公告)号：US07115635B2
公开(公告)日：2006-10-03
申请号：US10476149
申请日：2002-04-26
申请人： Masatoshi Kiuchi , Takanobu Kuroita , Hideo Tomozane , Shuuzou Takeda , Yoshihito Tanaka , Hidemitsu Higashi , Shigeki Kuwahara
发明人： Masatoshi Kiuchi , Takanobu Kuroita , Hideo Tomozane , Shuuzou Takeda , Yoshihito Tanaka , Hidemitsu Higashi , Shigeki Kuwahara
IPC分类号： A61K31/445 , C07D419/12
CPC分类号： C07D401/12 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K31/55 , C07D413/12 , C07D417/12 , C07D417/14 , C07D491/10
摘要： The object of the present invention is to provide a compound having a treatment effect based on a chemokine inhibitory activity, which is satisfactory as a pharmaceutical product for oral administration.The present inventors have found that the following benzylpiperidine derivative (the formula (1)) has a chemokine inhibitory activity. Further intensive studies have resulted in successful enhancement of the chemokine inhibitory activity and stability in blood of the present compound, as well as the completion of the present invention. wherein each symbol is as defined in the specification.
摘要翻译：本发明的目的是提供一种具有基于趋化因子抑制活性的治疗效果的化合物，其作为用于口服给药的药物产品是令人满意的。本发明人发现以下苄基哌啶衍生物（式（1））具有趋化因子抑制活性。进一步的深入研究已经导致本发明化合物的趋化因子抑制活性和血液稳定性的成功增强以及本发明的完成。其中每个符号如说明书中所定义。

2. 发明授权

US06528514B1 IgE antibody production inhibitors and autoimmune diseases inhibitors 失效
标题翻译： IgE抗体产生抑制剂和自身免疫疾病抑制剂
公开(公告)号：US06528514B1
公开(公告)日：2003-03-04
申请号：US09646388
申请日：2000-12-20
申请人： Fujio Kobayashi , Shigeki Kuwahara , Naruyasu Komorita , Koji Naito , Teruaki Imada , Tsutomu Yoshikawa
发明人： Fujio Kobayashi , Shigeki Kuwahara , Naruyasu Komorita , Koji Naito , Teruaki Imada , Tsutomu Yoshikawa
IPC分类号： A61K31505
CPC分类号： C07D239/47 , A61K31/506 , A61K31/513 , A61K38/00 , C07K5/06139
摘要： The present invention relates to an IgE antibody production inhibitor and an autoimmune disease suppressant containing a heterocyclic amide compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient wherein R represents a hydrogen atom, alkyl, —CHO, —COOH, etc.; R5, R6 and R7 represent each hydrogen, alkyl, aryl, etc.; M represents a carbon atom or a nitrogen atom; Y represents aryl, etc.; and Z represents hydrogen, alkyl, aryl, etc.
摘要翻译：本发明涉及含有由以下通式（1）表示的杂环酰胺化合物或其药学上可接受的盐作为活性成分的IgE抗体产生抑制剂和自身免疫性疾病抑制剂，其中R表示氢原子，烷基，-CHO， -COOH等; R5，R6和R7表示氢，烷基，芳基等; M表示碳原子或氮原子; Y代表芳基等; Z表示氢，烷基，芳基等。

3. 发明授权

US5308840A Substituted or unsubstituted benzhydryl heteroalkyl-substituted aminophenol compounds and pharmaceutical compositions thereof 失效
标题翻译：取代或未取代的二苯甲基杂烷基取代的氨基苯酚化合物及其药物组合物
公开(公告)号：US5308840A
公开(公告)日：1994-05-03
申请号：US863752
申请日：1992-04-06
申请人： Naoki Sugiyama , Fumihiko Akaboshi , Haruko Yakumaru , Tomokazu Gotoh , Masanori Sugiura , Shigeki Kuwahara , Masahiko Kajii , Yoshiko Tanaka , Takao Kondoh , Chikara Fukaya
发明人： Naoki Sugiyama , Fumihiko Akaboshi , Haruko Yakumaru , Tomokazu Gotoh , Masanori Sugiura , Shigeki Kuwahara , Masahiko Kajii , Yoshiko Tanaka , Takao Kondoh , Chikara Fukaya
IPC分类号： A61K31/135 , A61K31/445 , A61K31/495 , A61K31/695 , A61P29/00 , A61P37/08 , C07C215/76 , C07C215/80 , C07C217/76 , C07C217/82 , C07D211/14 , C07D211/22 , C07D211/46 , C07D213/64 , C07D213/74 , C07D241/18 , C07D279/24 , C07D295/12 , C07D295/13 , C07D295/135 , A61K31/435 , A61K31/55
CPC分类号： C07D213/64 , C07C215/80 , C07C217/76 , C07D211/22 , C07D211/46 , C07D213/74 , C07D279/24 , C07D295/13 , C07D295/135 , Y02P20/55
摘要： Aminophenol derivatives of the following formula (I) ##STR1## wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A is hydrogen atom or lower alkyl, t is an integer of 1 to 5, l and m are respectively an integer of 2 to 4, E and W are nitrogen atoms, F is a direct bond or oxygen atom, P and Q are each hydrogen atom, halogen atom, lower alkyl or lower alkoxy, and R.sup.8 is hydrogen atom, hydroxy or a hydroxy-protecting group, and their pharmcologically acceptable salts. Since the aminophenol derivatives (I) of the present invention have excellent antioxidative action and antiinflammatory and antiallergic action in mammalian animals including human, they are extremely useful as pharmaceuticals such as an antiinflammatory or an antiallergic.
摘要翻译：下式（I）的氨基苯酚衍生物其中X是氢原子，低级烷基或酚羟基的保护基，Y是氢原子或低级烷基，Z是氢原子，低级烷基，卤素原子或三氟甲基，A是氢原子或低级烷基，t是1〜5的整数，l和m分别是2〜4的整数，E和W是氮原子，F是直接键或氧原子，P和Q 各自为氢原子，卤素原子，低级烷基或低级烷氧基，R8为氢原子，羟基或羟基保护基，以及它们的药学上可接受的盐。由于本发明的氨基苯酚衍生物（I）在包括人的哺乳动物动物中具有优异的抗氧化作用和抗炎和抗过敏作用，所以它们作为药物如抗炎药或抗过敏药物是非常有用的。

4. 发明授权

US5750545A Triazole derivative and pharmaceutical use thereof 失效
标题翻译：三唑衍生物及其药物用途
公开(公告)号：US5750545A
公开(公告)日：1998-05-12
申请号：US586787
申请日：1996-01-23
申请人： Fumihiko Akahoshi , Takehiro Okada , Shinji Takeda , Youichiro Naito , Chikara Fukaya , Shigeki Kuwahara , Masahiko Kajii , Hiroko Nishimura , Masanori Sugiura
发明人： Fumihiko Akahoshi , Takehiro Okada , Shinji Takeda , Youichiro Naito , Chikara Fukaya , Shigeki Kuwahara , Masahiko Kajii , Hiroko Nishimura , Masanori Sugiura
IPC分类号： C07D249/14 , C07D487/04 , A61K31/41 , A61K31/53
CPC分类号： C07D487/04 , C07D249/14
摘要： An agent for the prophylaxis and treatment of immune-related diseases, in particular, immunosuppressant, an agent for the prophylaxis and treatment of allergic diseases, an agent for the prophylaxis and treatment of eosinophil-related diseases and an eosinophilia inhibitor, comprising, as an active ingredient, a series of triazole derivatives of the following formula (I) ##STR1## or the following formula (III) ##STR2## wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. A novel monocyclic or bicyclic triazole derivative. The agent for the prophylaxis and treatment of immune-related diseases, in particular, immunosuppressant, the agent for the prophylaxis and treatment of allergic diseases, the agent for the prophylaxis and treatment of eosinophil-related diseases, the eosinophilia inhibitor and the novel triazole derivative of the present invention all, have superior eosinophilia-inhibitory action and lymphocyte activation-inhibitory action. They are low toxic and persistent in action. They are particularly effective in the treatment of accumulation and activation of eosinophil and lymphocytes, inflammatory respiratory tract diseases, eosinophil-related diseases such as eosinophilia, and immune-related diseases.
摘要翻译： PCT No.PCT / JP94 / 01215 Sec。 371日期1996年1月23日 102（e）日期1996年1月23日PCT提交1994年7月22日PCT公布。公开号WO95 / 03286 日期1995年2月2日预防和治疗免疫相关疾病的药剂，特别是免疫抑制剂，预防和治疗过敏性疾病的药物，预防和治疗嗜酸性粒细胞相关疾病的药剂和嗜酸性粒细胞增多抑制剂（I）或下式（III）的化合物（III），其中每个符号如说明书中所定义，或其药学上可接受的盐。新型单环或双环三唑衍生物。用于预防和治疗免疫相关疾病的药物，特别是免疫抑制剂，用于预防和治疗过敏性疾病的药物，用于预防和治疗嗜酸性粒细胞相关疾病的药物，嗜酸性粒细胞增多抑制剂和新型三唑衍生物所有这些都具有优良的嗜酸性粒细胞增多抑制作用和淋巴细胞活化抑制作用。它们是低毒性和持续性的。它们在治疗嗜酸性粒细胞和淋巴细胞的积累和活化，炎性呼吸道疾病，嗜酸性粒细胞相关疾病如嗜酸性粒细胞增多和免疫相关疾病方面特别有效。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式