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    • 2. 发明授权
    • MEKK1 molecules and uses thereof
    • MEKK1分子及其用途
    • US06818427B1
    • 2004-11-16
    • US09697898
    • 2000-10-27
    • Vito J. PalombellaSha-Mei Liao
    • Vito J. PalombellaSha-Mei Liao
    • C12N912
    • C12N9/1205C07H21/04
    • The invention provides full-length, human isolated nucleic acids molecules, designated MEKK1 nucleic acid molecules, which encode a MEKK family member. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MEKK1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a MEKK1 gene has been introduced or disrupted. The invention still further provides isolated MEKK1 proteins, fusion proteins, antigenic peptides and anti-MEKK1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    • 本发明提供编码MEKK家族成员的全长人分离核酸分子,称为MEKK1核酸分子。 本发明还提供反义核酸分子,含有MEKK1核酸分子的重组表达载体,已经引入了表达载体的宿主细胞,以及其中引入或破坏了MEKK1基因的非人类转基因动物。 本发明还提供了分离的MEKK1蛋白,融合蛋白,抗原肽和抗MEKK1抗体。 还提供了利用本发明组合物的诊断方法。