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    • 1. 发明授权
    • Method for producing imatinib base
    • 生产伊马替尼碱的方法
    • US08563720B2
    • 2013-10-22
    • US13483750
    • 2012-05-30
    • Hearan SuhSang Kyu NamJong Sun LeeSeung Ki Kim
    • Hearan SuhSang Kyu NamJong Sun LeeSeung Ki Kim
    • C07D417/10
    • C07D401/06C07D241/04C07D401/04
    • The present invention relates to a novel method for preparing an imatinib base, and more particularly to a method for preparing an imatinib base, which comprises reacting 4-(4-methyl-piperazinomethyl)-benzoic acid with a 2,2′-dibenzothiazolyl disulfide derivative in the presence of a phosphine derivative to prepare a novel thioester compound and preparing an imatinib base using the thioester compound as a reaction intermediate. In addition, the invention provides a novel thioester compound, which is used in the preparation of imatinib base, and a preparation method thereof. Ultimately, the invention provides a method of preparing the imatinib base in an economic manner and in high yield and purity and is expected to be used in the commercial production of large amounts of the imatinib base.
    • 本发明涉及一种制备伊马替尼碱的新方法,更具体地涉及一种制备伊马替尼碱的方法,该方法包括使4-(4-甲基 - 哌嗪基甲基) - 苯甲酸与2,2'-二苯并噻唑基二硫醚 在膦膦衍生物的存在下制备新的硫酯化合物,并使用硫酯化合物作为反应中间体制备伊马替尼碱。 另外,本发明提供了用于制备伊马替尼碱的新的硫酯化合物及其制备方法。 最终,本发明提供了一种以经济的方式,高产率和纯度制备伊马替尼碱的方法,并且预期用于商业生产大量的伊马替尼碱。
    • 4. 发明授权
    • Air cleaner
    • 空气净化器
    • US08551234B2
    • 2013-10-08
    • US12672543
    • 2008-08-07
    • Seung Ki KimJun Hyung Bae
    • Seung Ki KimJun Hyung Bae
    • B01D46/46
    • F24F3/16F24F2001/0096F24F2013/207G05G1/087G05G1/105H01H3/08H01H19/025H01H2003/085H01H2219/06H01H2221/07
    • An air cleaner having a manipulator is disclosed. The manipulator (200) includes a rotary manipulation unit (300), which is provided so as to be movable between a first position, at which the rotary manipulation unit is retracted into the air cleaner, and a second position, to which the rotary manipulation unit is extracted from the air cleaner to enable a user to manipulate the rotary manipulation unit. The manipulator further includes a lift unit (400), which is installed in the air cleaner to move the rotary manipulation unit between the first position and the second position. In the present invention, the manipulator can control several functions of the air cleaner obviating the need for having several control buttons, thus being more convenient for a user. Furthermore, the present invention can prevent water from permeating a PCB mounted in the rotary manipulation unit, thus preventing malfunction of the encoder unit.
    • 公开了一种具有操纵器的空气净化器。 操纵器(200)包括旋转操作单元(300),该旋转操作单元(300)设置成可在旋转操作单元缩回到空气滤清器中的第一位置和第二位置之间移动,旋转操作 单元从空气滤清器中抽出,以使用户能够操纵旋转操纵单元。 操纵器还包括提升单元(400),其安装在空气净化器中以在第一位置和第二位置之间移动旋转操作单元。 在本发明中,机械手可以控制空气滤清器的若干功能,从而避免需要具有多个控制按钮,从而对用户更方便。 此外,本发明可以防止水渗透到安装在旋转操作单元中的PCB,从而防止编码器单元的故障。