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1. 发明授权

US10787607B2 High efficiency fluorescent compound and method for preparing the same 有权
公开(公告)号：US10787607B2
公开(公告)日：2020-09-29
申请号：US14344585
申请日：2012-09-05
申请人： Seong Keun Kim , Seung Bum Park , Il Seung Yang, II , Eun Ha Kim , Jun Hee Kang
发明人： Seong Keun Kim , Seung Bum Park , Il Seung Yang, II , Eun Ha Kim , Jun Hee Kang
IPC分类号： C07C49/00 , C09K11/00 , H01L51/00 , C09K11/06 , C07C49/248 , C07C49/255 , C07H15/203 , A61K49/00 , A61N5/06 , H01L51/50
摘要： The present invention provides a fluorescent resveratrone [(E)-4-(6,8-dihydroxynaphthalen-2-yl)but-3-en-2-one] and its derivatives having Formula 1 and a method for preparing the same by a photochemical reaction of resveratrol and its derivatives which are not fluorescent having Formula 7 or Formula 8. The new fluorescent compounds of the present invention has single-photon absorptive characteristics and/or two-photon absorptive characteristics as well as no or little toxicity according to a cytotoxicity test and can be usefully utilized in the field of organic fluorescent element, display element, spectrometer, two-photon absorptive storing device, laser micro processing apparatus, photo dynamic therapy apparatus and the like.

2. 发明授权

US08482433B2 Method and system for parking assistance and recognizing obstacle 有权
标题翻译：停车辅助方法和系统识别障碍
公开(公告)号：US08482433B2
公开(公告)日：2013-07-09
申请号：US12873619
申请日：2010-09-01
申请人： Seung Bum Park
发明人： Seung Bum Park
IPC分类号： G08G1/01 , B60Q1/00 , G05D1/00 , A01B69/06 , G01S13/00 , B60S9/205
CPC分类号： B62D15/0285 , B60W10/18 , B60W10/20 , B60W30/06
摘要： Disclosed are a system and method for recognizing an obstacle at the time of parking. The inventive system includes: at least one lateral side ultrasonic sensor for sensing lateral distance data between a user's vehicle and an obstacle positioned adjacent to a lateral side of the user's vehicle; a first course calculation unit for calculating lateral position data and a first course on the basis of the lateral distance data; at least one rear side ultrasonic sensor for sensing rear distance data indicating a distance between the user's vehicle and an obstacle positioned behind the rear side of the user's vehicle; a second course calculation unit for extracting rear position data for the obstacle positioned behind the user's vehicle on the basis of the rear distance data, and for extracting and calculating a final target parking position and a final course on the basis of the rear position data; and a control unit which receives information for the first course from the first course calculation unit so as to control the steering wheel of the user's vehicle, thereby moving the user's vehicle forward or backward along the first course, and receives information for the final target parking position and the final course from the second course calculation unit so as to control the steering wheel, thereby moving the user's vehicle is moved along the final course and automatically parked at the final target parking position.
摘要翻译：公开了一种在停车时识别障碍物的系统和方法。本发明的系统包括：至少一个侧面超声波传感器，用于感测用户的车辆与邻近用户车辆的侧面定位的障碍物之间的横向距离数据; 用于基于所述横向距离数据计算横向位置数据和第一路线的第一路线计算单元; 至少一个后侧超声波传感器，用于感测指示用户车辆与位于使用者车辆后侧后方的障碍物之间的距离的后距离数据; 第二过程计算单元，用于根据后距离数据提取位于用户车辆后方的障碍物的后位数据，并且基于后位置数据提取和计算最终目标停车位置和最终路线; 以及控制单元，其从第一路线计算单元接收用于第一路线的信息，以便控制用户车辆的方向盘，从而沿着第一道路向前或向后移动用户车辆，并且接收用于最终目标停车的信息位置和最后路线，以便控制方向盘，从而使用户的车辆移动沿着最后路线移动并自动停在最终目标停车位置。

3. 发明申请

US20120156686A1 Multifunctional particles providing cellular uptake and magnetic motor effect 审中-公开
标题翻译：多功能颗粒提供细胞摄取和磁力运动效应
公开(公告)号：US20120156686A1
公开(公告)日：2012-06-21
申请号：US12030863
申请日：2008-02-13
申请人： Jin-Kyu Lee , Myung-Haing Cho , Seung-Bum Park , Tae-Jong Yoon
发明人： Jin-Kyu Lee , Myung-Haing Cho , Seung-Bum Park , Tae-Jong Yoon
IPC分类号： C12Q1/00 , G01N33/50
CPC分类号： G01N33/587 , A61K49/0002 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/183 , A61K49/1848 , A61K49/186 , A61K49/1875 , B82Y5/00
摘要： Preparation of novel multifunctional particles and nanomaterials having a useful combination of magnetic and optical properties and biocompatibility. The internalization efficiencies in various in vitro cell studies have been investigated, and the external magnetic motor effect on the floating cells internalized with magnetic nanoparticles were clearly observed, for the first time. The particle surfaces can be derivatized with, for example, DNA or antibodies. The system is stable, versatile, and well-controlled. Novel gene delivery can be achieved using nanoparticles as a carrier.
摘要翻译：制备具有磁性和光学性质以及生物相容性的有用组合的新型多功能颗粒和纳米材料。已经研究了各种体外细胞研究中的内在化效率，并且首次清楚地观察到磁性纳米颗粒内化的浮动细胞的外部磁电机效应。颗粒表面可以用例如DNA或抗体衍生化。系统稳定，通用性好，控制精良。使用纳米颗粒作为载体可以实现新的基因递送。

4. 发明申请

US20120021933A1 SMALL MOLECULE PRINTING 审中-公开
标题翻译：小分子印刷
公开(公告)号：US20120021933A1
公开(公告)日：2012-01-26
申请号：US13094609
申请日：2011-04-26
申请人： Seung Bum Park , David Barnes-Seeman , Angela N. Koehler , Stuart L. Schreiber
发明人： Seung Bum Park , David Barnes-Seeman , Angela N. Koehler , Stuart L. Schreiber
IPC分类号： C40B30/04 , C40B50/18 , C40B60/08 , C40B40/04
CPC分类号： C40B60/14 , B01J19/0046 , B01J2219/00387 , B01J2219/00454 , B01J2219/00459 , B01J2219/005 , B01J2219/00533 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/0072 , C07B2200/11 , C07C311/49 , C40B30/04 , C40B40/04 , C40B50/14 , G01N33/54353 , Y10S436/809
摘要： The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support, wherein the density of the array of compounds is at least 1000 spots per cm2. In particularly preferred embodiments, these compounds are attached to the solid support through a covalent interaction. In general, these inventive arrays are generated by: (1) providing a solid support, wherein said solid support is functionalized with a selected chemical moiety capable of interacting with a desired chemical compound to form an attachment; (2) providing one or more solutions of one or more types of compounds to be attached to the solid support; and (3) delivering said one or more types of compounds to the solid support, whereby an array is formed and the array of compounds has a density of at least 1000 spots per cm2. In another aspect, the present invention provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest comprising: (1) providing an array of compounds, wherein the array has a density of at least 1000 spots per cm2; (2) contacting the array with one of more types of biological macromolecules of interest; and (3) determining the interaction of specific small molecule-biological macromolecule partners.
摘要翻译：本发明提供了有助于鉴定能够与感兴趣的生物大分子相互作用的化合物的组合物和方法。在一个方面，提供了包含连接到固体支持物上的一种或多种类型化学化合物的阵列的组合物，其中化合物阵列的密度为每cm 2至少1000个点。在特别优选的实施方案中，这些化合物通过共价相互作用连接到固体支持物上。通常，这些本发明的阵列通过以下方式产生：（1）提供固体支持物，其中所述固体支持物用能够与所需化学化合物相互作用以形成附着物的选定化学部分官能化; （2）提供待连接到固体支持物上的一种或多种类型化合物的一种或多种溶液; 和（3）将所述一种或多种类型的化合物递送到固体支持物，由此形成阵列，并且化合物阵列的密度至少为1000个点/ cm2。在另一方面，本发明提供了利用这些阵列鉴定感兴趣的生物大分子的小分子伴侣的方法，包括：（1）提供化合物阵列，其中阵列的密度至少为1000个点/ cm2; （2）使阵列与感兴趣的多种生物大分子之一接触; 和（3）确定特定小分子 - 生物大分子伴侣的相互作用。

5. 发明申请

US20100081130A1 Multifunctional particles providing cellular uptake and magnetic motor effect 审中-公开
标题翻译：多功能颗粒提供细胞摄取和磁力运动效应
公开(公告)号：US20100081130A1
公开(公告)日：2010-04-01
申请号：US12030848
申请日：2008-02-13
申请人： Jin-Kyu Lee , Myung-Haing Cho , Seung-Bum Park , Tae-Jong Yoon
发明人： Jin-Kyu Lee , Myung-Haing Cho , Seung-Bum Park , Tae-Jong Yoon
IPC分类号： C12Q1/68 , C12Q1/02
CPC分类号： G01N33/587 , A61K49/0002 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/183 , A61K49/1848 , A61K49/186 , A61K49/1875 , B82Y5/00
摘要： Preparation of novel multifunctional particles and nanomaterials having a useful combination of magnetic and optical properties and biocompatibility. The internalization efficiencies in various in vitro cell studies have been investigated, and the external magnetic motor effect on the floating cells internalized with magnetic nanoparticles were clearly observed, for the first time. The particle surfaces can be derivatized with, for example, DNA or antibodies. The system is stable, versatile, and well-controlled. Novel gene delivery can be achieved using nanoparticles as a carrier.
摘要翻译：制备具有磁性和光学性质以及生物相容性的有用组合的新型多功能颗粒和纳米材料。已经研究了各种体外细胞研究中的内在化效率，并且首次清楚地观察到磁性纳米颗粒内化的浮动细胞的外部磁电机效应。颗粒表面可以用例如DNA或抗体衍生化。系统稳定，通用性好，控制精良。使用纳米颗粒作为载体可以实现新的基因递送。

6. 发明申请

US20090326015A1 COMPOUNDS WITH EMBEDDED BENZOPYRAN MOTIF FOR CORE STRUCTURES AND PREPARATION METHOD THEREOF 有权
标题翻译：用于核心结构的嵌入式BENZOPYRAN MOTIF的化合物及其制备方法
公开(公告)号：US20090326015A1
公开(公告)日：2009-12-31
申请号：US12481137
申请日：2009-06-09
申请人： Seung Bum Park , Hwan Jong Jang , Sung Kon Ko , EunHa Kim , Sangmi Oh , Jongmin Park
发明人： Seung Bum Park , Hwan Jong Jang , Sung Kon Ko , EunHa Kim , Sangmi Oh , Jongmin Park
IPC分类号： A61K31/41 , A61K31/4433 , A61K31/407 , A61K31/35 , C07D403/04 , C07D491/04 , C07D487/00 , C07D311/00
CPC分类号： C07D491/052 , C07D311/04 , C07D491/107 , C07D491/147 , C07D491/20
摘要： The present invention relates to a compound having benzopyran core, a preparation method of the derivatives by liquid phase synthesis and solid phase synthesis through diversity-oriented synthesis, and an anticancer agent comprising the compound that exhibit excellent cytotoxicity against cancer cells.
摘要翻译：本发明涉及具有苯并吡喃核心的化合物，通过液相合成的衍生物的制备方法和通过多向定向合成的固相合成，以及包含对癌细胞具有优异细胞毒性的化合物的抗癌剂。

7. 发明申请

US20190330524A1 HIGH EFFICIENCY FLUORESCENT COMPOUND AND METHOD FOR PREPARING THE SAME 审中-公开
公开(公告)号：US20190330524A1
公开(公告)日：2019-10-31
申请号：US14344585
申请日：2012-09-05
申请人： Seong Keun Kim , Seung Bum Park , Il Seung Yang , Eun Ha KIM , Jun Hee Kang
发明人： Seong Keun Kim , Seung Bum Park , Il Seung Yang , Eun Ha KIM , Jun Hee Kang
IPC分类号： C09K11/06 , H01L51/50 , H01L51/00 , A61N5/06
摘要： The present invention provides a fluorescent resveratrone [(E)-4-(6,8-dihydroxynaphthalen-2-yl)but-3-en-2-one] and its derivatives having Formula 1 and a method for preparing the same by a photochemical reaction of resveratrol and its derivatives which are not fluorescent having Formula 7 or Formula 8. The new fluorescent compounds of the present invention has single-photon absorptive characteristics and/or two-photon absorptive characteristics as well as no or little toxicity according to a cytotoxicity test and can be usefully utilized in the field of organic fluorescent element, display element, spectrometer, two-photon absorptive storing device, laser micro processing apparatus, photo dynamic therapy apparatus and the like.

8. 发明授权

US08772463B2 Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof 有权
标题翻译：荧光染料标记的葡萄糖生物探针，其合成方法和用途
公开(公告)号：US08772463B2
公开(公告)日：2014-07-08
申请号：US12876520
申请日：2010-09-07
申请人： Seung Bum Park , Hyang Yeon Lee , Jong Min Park
发明人： Seung Bum Park , Hyang Yeon Lee , Jong Min Park
IPC分类号： C07H17/02
CPC分类号： C07H15/26
摘要： Disclosed are a novel fluorescent glucose analogue, a method for the synthesis thereof and the use thereof. The novel fluorescent glucose analogue is labeled with fluorescent dye by O-1-glycosylation and via various linkers. The fluorescent glucose analogue can be applied to molecular bioimaging and a method for screening curative or preventive drugs for glucose metabolism-related diseases.
摘要翻译：公开了一种新型荧光葡萄糖类似物，其合成方法及其应用。新型荧光葡萄糖类似物通过O-1-糖基化和通过各种接头用荧光染料标记。荧光葡萄糖类似物可用于分子生物成像和用于筛选用于葡萄糖代谢相关疾病的治疗或预防药物的方法。

9. 发明授权

US08703813B2 Compound with spiro chiral carbon backbone, preparation method thereof, and pharmaceutical composition containing the same 有权
标题翻译：具有螺环手性碳骨架的化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US08703813B2
公开(公告)日：2014-04-22
申请号：US13126979
申请日：2009-10-30
申请人： Heon-Joong Kang , Jung-Rae Rho , Jeong-Ho Hong , Seung-Bum Park , Chan-Soo Shin , Jae-Hwan Lee , Jun-Young Hong , Eun-O Kim , Jeong-Ah Kim , Sang-Mi Oh
发明人： Heon-Joong Kang , Jung-Rae Rho , Jeong-Ho Hong , Seung-Bum Park , Chan-Soo Shin , Jae-Hwan Lee , Jun-Young Hong , Eun-O Kim , Jeong-Ah Kim , Sang-Mi Oh
IPC分类号： C07D307/94 , A61K31/35
CPC分类号： C07D493/10
摘要： Provided is a compound having a spiro chiral carbon backbone, a stereoisomer thereof, an enantiomer thereof, an in vivo hydrolysable precursor thereof, or a pharmaceutically acceptable salt thereof. The compound having the spiro chiral carbon backbone has excellent osteoblast differentiation activity, mast cell inhibitory activity, and fatty acid synthesis inhibitory activity in the liver. Therefore, the compound can be expected to play an innovative role in treatment of osteoporosis, fatty liver, and obesity.
摘要翻译：本发明提供具有螺状手性碳骨架的化合物，其立体异构体，其对映异构体，其体内可水解的前体或其药学上可接受的盐。具有螺状手性碳骨架的化合物在肝脏中具有优异的成骨细胞分化活性，肥大细胞抑制活性和脂肪酸合成抑制活性。因此，该化合物可以预期在骨质疏松症，脂肪肝和肥胖症的治疗中发挥创新作用。

10. 发明授权

US07932213B2 Small molecule printing 有权
标题翻译：小分子印刷
公开(公告)号：US07932213B2
公开(公告)日：2011-04-26
申请号：US10370885
申请日：2003-02-20
申请人： Seung Bum Park , David Barnes-Seeman , Angela N. Koehler , Stuart L. Schreiber
发明人： Seung Bum Park , David Barnes-Seeman , Angela N. Koehler , Stuart L. Schreiber
IPC分类号： C40B40/04 , C40B30/04 , C40B50/08 , C40B60/04 , G01N33/566 , G01N33/543 , G01N33/53
CPC分类号： C40B60/14 , B01J19/0046 , B01J2219/00387 , B01J2219/00454 , B01J2219/00459 , B01J2219/005 , B01J2219/00533 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/0072 , C07B2200/11 , C07C311/49 , C40B30/04 , C40B40/04 , C40B50/14 , G01N33/54353 , Y10S436/809
摘要： The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. A composition is provided that comprises an array of chemical compounds attached to a solid support, wherein the density of the array of compounds is at least 1000 spots per cm2. The inventive arrays are generated by: providing a solid support functionalized with a selected chemical moiety capable of interacting with a chemical compound to form an attachment and delivering compounds to the solid support having a density of at least 1000 spots per cm2. The present invention also provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest.
摘要翻译：本发明提供了有助于鉴定能够与感兴趣的生物大分子相互作用的化合物的组合物和方法。提供了包含连接到固体支持物上的化学化合物阵列的组合物，其中化合物阵列的密度为每cm 2至少1000个点。本发明的阵列通过以下方式产生：提供用选择的能够与化学化合物相互作用的选择的化学部分官能化的固体支持物，以形成连接并将化合物输送到具有至少1000个点/ cm 2的密度的固体支持物。本发明还提供了利用这些阵列鉴定感兴趣的生物大分子的小分子配偶体的方法。

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