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1. 发明申请

US20060128645A1 Inhibition of proliferation and infiltration of brain tumor cells caused by expression of ampa-type glutamate receptor subunit 审中-公开
标题翻译：抑制由安氏型谷氨酸受体亚单位表达引起的脑肿瘤细胞的增殖和浸润
公开(公告)号：US20060128645A1
公开(公告)日：2006-06-15
申请号：US10524046
申请日：2003-08-08
申请人： Seiji Ozawa , Shogo Ishiuchi
发明人： Seiji Ozawa , Shogo Ishiuchi
IPC分类号： A61K48/00 , C12Q1/68
CPC分类号： A61K48/005 , A01K2267/0331 , A61K48/00 , C07K14/70571 , C12N2799/022 , G01N33/57407
摘要： The present invention is to provide a method of treatment which inhibits proliferation and invasion of brain tumor cells in developing animal brain tumor cells, and a method for measuring proliferation/invasion activity of brain tumor cells, in the brain tumor cells, preferably, in glioblastoma. Proliferation and invasion of brain tumor cells are inhibited by regulating Ca2+ permeability by glutamate receptor subunits in developing animal brain tumor cells. Regulation of Ca2+ permeability by glutamate receptor subunits can be conducted by introducing the GluR2 gene into AMPA-type glutamate receptors in brain tumor cells. Further, the present invention provides a method for measuring proliferation/invasion activity of brain tumor cells by detecting/measuring the expression of glutamate receptor subunits in developing animal brain tumor cells.
摘要翻译：本发明提供一种抑制发育中的动物脑肿瘤细胞中脑肿瘤细胞的增殖和侵袭的治疗方法，以及用于测定脑肿瘤细胞，优选在胶质母细胞瘤中的脑肿瘤细胞的增殖/侵袭活性的方法。通过在发育中的动物脑肿瘤细胞中调节谷氨酸受体亚基的Ca 2+通量而抑制脑肿瘤细胞的增殖和侵袭。通过谷氨酸受体亚基对Ca 2+ 2 +透性的调节可以通过将GluR2基因导入脑肿瘤细胞中的AMPA型谷氨酸受体来进行。此外，本发明提供了通过检测/测量发育中的动物脑肿瘤细胞中谷氨酸受体亚基的表达来测量脑肿瘤细胞的增殖/侵袭活性的方法。

2. 发明授权

US06901230B2 Toner container having lid including lug 失效
标题翻译：具有盖的墨粉容器包括凸耳
公开(公告)号：US06901230B2
公开(公告)日：2005-05-31
申请号：US10782869
申请日：2004-02-23
申请人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
发明人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
IPC分类号： G03G15/08
CPC分类号： G03G15/0868 , G03G15/0855 , G03G15/0865 , G03G15/0872 , G03G2215/0663 , G03G2215/0665 , G03G2215/0668 , G03G2215/0675 , G03G2215/0685 , Y10S220/19 , Y10S222/01
摘要： A toner container has a hollow body having a small diameter mouth portion, a ramp surface at one end and a spiral. A removable lid is positioned at the mouth portion so as to close the mouth portion and a lug is provided at the lid.
摘要翻译：调色剂容器具有中空体，其具有小直径的口部分，一端的斜面和螺旋形。可拆卸的盖子位于嘴部，以便封闭口部，并且在盖子处设置有凸耳。

3. 发明授权

US06418293B2 Developer replenishing device and developer container for use therewith 失效
标题翻译：显影剂补充装置和显影剂容器用于此
公开(公告)号：US06418293B2
公开(公告)日：2002-07-09
申请号：US09916585
申请日：2001-07-30
申请人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
发明人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
IPC分类号： G03G1508
CPC分类号： G03G15/0868 , G03G15/0855 , G03G15/0865 , G03G15/0872 , G03G2215/0663 , G03G2215/0665 , G03G2215/0668 , G03G2215/0675 , G03G2215/0685 , Y10S220/19 , Y10S222/01
摘要： A developer replenishing device for replenishing a developing device with a developer, and a developer container for use therewith. The developer container, or toner bottle, includes a shoulder portion adjoining a first end of a hollow body. The body is formed with a spiral guide for guiding a developer stored in the developer container. The shoulder portion forms a wall and includes an engaging portion engageable with driver that causes the body to rotate. The engaging portion includes a lug protruding from the shoulder portion which allows a characteristic of toner to be identified. The engaging portion has an outside surface of a guide portion that guides a developer stored in the developer container. Two engaging portions may be angularly spaced from each other by 180 degrees. The developer container also includes a discharge mouth, which adjoins the first end of the body, which is smaller in diameter than the shoulder portion, and which includes an annular collar protruding outwardly, and a positioning portion positioned on a holder for the developer container. The positioning portion includes a lug protruding from an outside surface of the body. The holder for the developer container includes a hitting member which hits against the outside surface when the body is caused to rotate. A plurality of lugs are formed on an outside circumferential surface of the collar of the discharge mouth.
摘要翻译：用于用显影剂补充显影装置的显影剂补充装置和与其一起使用的显影剂容器。显影剂容器或调色剂瓶包括邻接中空体的第一端的肩部。主体形成有用于引导存储在显影剂容器中的显影剂的螺旋引导件。肩部形成壁并且包括与驱动器接合的接合部分，其使得主体旋转。接合部分包括从肩部突出的凸耳，其允许识别调色剂的特性。接合部分具有导向部分的外表面，该引导部分引导存储在显影剂容器中的显影剂。两个接合部分可以彼此成角度地间隔180度。显影剂容器还包括排放口，其邻接于身体的第一端部，其直径小于肩部部分，并且包括向外突出的环形套圈以及位于显影剂容器的保持器上的定位部分。定位部分包括从主体的外表面突出的凸耳。用于显影剂容器的保持器包括当主体旋转时撞击外表面的击打构件。在排出口的轴环的外周面上形成有多个凸耳。

4. 发明授权

US5627631A Developer replenishing device and developer container for use therewith 失效
标题翻译：显影剂补充装置和显影剂容器用于此
公开(公告)号：US5627631A
公开(公告)日：1997-05-06
申请号：US587966
申请日：1996-01-17
申请人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
发明人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
IPC分类号： G03G15/08
CPC分类号： G03G15/0868 , G03G15/0855 , G03G15/0865 , G03G15/0872 , G03G2215/0663 , G03G2215/0665 , G03G2215/0668 , G03G2215/0675 , G03G2215/0685 , Y10S220/19 , Y10S222/01
摘要： A developer replenishing device for replenishing a developing device with a developer, and a developer container for use therewith. The developer container, or toner bottle, has a mouth portion at one end thereof which is smaller in diameter than a hollow cylindrical main body. At the end of the bottle provided with the mouth, a shoulder has the inner periphery thereof partly raised to the edge of the mouth portion to form a raised portion for scooping up a toner. In addition, a part of the inner periphery of the circumferential wall of the bottle which is contiguous with the raised portion is also raised toward the axis of the bottle about which the bottle is rotatable, thereby forming another raised portion. When the bottle is mounted to a bottle holder, which is included in the replenishing device, substantially horizontally with the mouth portion oriented sideways, the bottle is rotated to raise the toner from the bottom of the main body to the mouth portion. As a result, the toner is discharged to the outside via the mouth portion smoothly.
摘要翻译：用于用显影剂补充显影装置的显影剂补充装置和与其一起使用的显影剂容器。显影剂容器或调色剂瓶在其一端具有直径小于中空圆柱形主体的口部。在设置有口部的瓶子的端部，肩部的内周部分地部分地升高到嘴部的边缘，以形成用于舀取调色剂的凸起部分。此外，与凸起部分邻接的瓶的圆周壁的内周的一部分也朝向瓶可旋转的瓶的轴线升高，从而形成另一个凸起部分。当瓶子被安装到包括在补充装置中的瓶保持器时，基本上水平地使口部侧向取向，瓶子被旋转以将调色剂从主体的底部升高到嘴部。结果，调色剂通过口部平滑地排出到外部。

5. 发明授权

US06289195B1 Developer replenishing device and developer container for use therewith 有权
标题翻译：显影剂补充装置和显影剂容器用于此
公开(公告)号：US06289195B1
公开(公告)日：2001-09-11
申请号：US09549510
申请日：2000-04-14
申请人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
发明人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
IPC分类号： G03G1508
CPC分类号： G03G15/0868 , G03G15/0855 , G03G15/0865 , G03G15/0872 , G03G2215/0663 , G03G2215/0665 , G03G2215/0668 , G03G2215/0675 , G03G2215/0685 , Y10S220/19 , Y10S222/01
摘要： A developer replenishing device for replenishing a developing device with a developer, and a developer container for use therewith. The developer container, or toner bottle, has a mouth portion at one end thereof which is smaller in diameter than a hollow cylindrical main body. At the end of the bottle provided with the mouth portion, a shoulder has the inner periphery thereof partly raised to the edge of the mouth portion to form a raised portion for scooping up a toner. In addition, a part of the inner periphery of the circumferental wall of the bottle, which is contiguous with the raised portion, is also raised toward the axis of the bottle, about which the bottle is rotatable, thereby forming another raised portion. When the bottle is mounted on a bottle holder, which is included in the replienishing device, substantially horizontally with the mouth portion oriented sideways, the bottle is rotated to raise the toner from the bottom of the main body to the mouth portion. As a result, the toner is discharged to the outside via the mouth portion smoothly.
摘要翻译：用于用显影剂补充显影装置的显影剂补充装置和与其一起使用的显影剂容器。显影剂容器或调色剂瓶在其一端具有直径小于中空圆柱形主体的口部。在设置有口部的瓶的端部，肩部的内周部分地向嘴部的边缘升高，以形成用于舀起调色剂的凸起部分。此外，与凸起部分相邻的瓶子的外周壁的内周的一部分也朝向瓶子的轴线升高，瓶子可旋转，从而形成另一个凸起部分。当瓶子被安装在包括在复制装置中的瓶保持器上时，基本上水平地将口部侧向取向，使瓶子旋转以将调色剂从主体的底部升高到嘴部。结果，调色剂通过口部平滑地排出到外部。

6. 发明授权

US5878262A Program development support system 失效
标题翻译：程序开发支持系统
公开(公告)号：US5878262A
公开(公告)日：1999-03-02
申请号：US790297
申请日：1997-01-31
申请人： Tsutomu Shoumura , Hiroshi Suganuma , Tsutomu Funada , Seiji Ozawa , Takeshi Nii , Takashi Kido , Naofumi Mitsuhashi , Toshikazu Hirano
发明人： Tsutomu Shoumura , Hiroshi Suganuma , Tsutomu Funada , Seiji Ozawa , Takeshi Nii , Takashi Kido , Naofumi Mitsuhashi , Toshikazu Hirano
IPC分类号： G06F9/06 , G06F9/44 , G06F13/00
CPC分类号： G06F8/20 , G06Q10/0631 , Y10S707/99931 , Y10S707/99945 , Y10S707/99953
摘要： Disclosed is a program development support system so adapted as to integrally manage a variety of information necessary for the development of a program by creating necessary links between information such as source programs to be employed for the development of the program, program parts, tools, specifications, handling persons and so on, by managing such information as resource information and by retaining attribute information of the links. The program development support system has a store means for storing program development information on the development of a program; a create means for creating attribute information on an attribute of the program development information and link information between each of the program development information; a management means for managing the program development information, the attribute information created by the create means and the link information created thereby each as one resource for the development of the program by providing the resource with a unique number; and a system-structuring element creating means for creating a system-structuring element from the resource by using the link information.
摘要翻译：公开了一种程序开发支持系统，该系统适用于通过在诸如用于开发程序，程序部件，工具，规格的源程序之类的信息之间建立必要的链接，整体地管理开发程序所需的各种信息，处理人员等，通过管理资源信息等信息，并保留链接的属性信息。程序开发支持系统具有用于存储关于程序开发的程序开发信息的存储装置; 创建用于创建关于所述程序开发信息的属性和每个所述程序开发信息之间的链接信息的属性信息的装置; 管理装置，用于通过向资源提供唯一的号码来管理程序开发信息，由创建装置创建的属性信息和由此创建的链接信息作为开发程序的一个资源; 以及用于通过使用所述链接信息从所述资源创建系统结构化元素的系统结构元素创建装置。

7. 发明授权

US5822663A Developer replenishing device and developer container for use therewith 失效
公开(公告)号：US5822663A
公开(公告)日：1998-10-13
申请号：US751617
申请日：1996-11-18
申请人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
发明人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
IPC分类号： G03G15/08
CPC分类号： G03G15/0868 , G03G15/0855 , G03G15/0865 , G03G15/0872 , G03G2215/0663 , G03G2215/0665 , G03G2215/0668 , G03G2215/0675 , G03G2215/0685 , Y10S220/19 , Y10S222/01
摘要： A developer replenishing device for replenishing a developing device with a developer, and a developer container for use therewith. The developer container, or toner bottle, has a mouth portion at one end thereof which is smaller in diameter than a hollow cylindrical main body. At the end of the bottle provided with the mouth, a shoulder has the inner periphery thereof partly raised to the edge of the mouth portion to form a raised portion for scooping up a toner. In addition, a part of the inner periphery of the circumferential wall of the bottle which is contiguous with the raised portion is also raised toward the axis of the bottle about which the bottle is rotatable, thereby forming another raised portion. When the bottle is mounted to a bottle holder, which is included in the replenishing device, substantially horizontally with the mouth portion oriented sideways, the bottle is rotated to raise the toner from the bottom of the main body to the mouth portion. As a result, the toner is discharged to the outside via the mouth portion smoothly.

8. 发明授权

US5455662A Developer replenishing device and developer container for use therewith 失效
公开(公告)号：US5455662A
公开(公告)日：1995-10-03
申请号：US174698
申请日：1993-12-28
申请人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
发明人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
IPC分类号： G03G15/08 , G03G15/06
CPC分类号： G03G15/0868 , G03G15/0855 , G03G15/0865 , G03G15/0872 , G03G2215/0663 , G03G2215/0665 , G03G2215/0668 , G03G2215/0675 , G03G2215/0685 , Y10S220/19 , Y10S222/01
摘要： A developer replenishing device for replenishing a developing device with a developer, and a developer container for use therewith. The developer container, or toner bottle, has a mouth portion at one end thereof which is smaller in diameter than a hollow cylindrical main body. At the end of the bottle provided with the mouth, a shoulder has the inner periphery thereof partly raised to the edge of the mouth portion to form a raised portion for scooping up a toner. In addition, a part of the inner periphery of the circumferential wall of the bottle which is contiguous with the raised portion is also raised toward the axis of the bottle about which the bottle is rotatable, thereby forming another raised portion. When the bottle is mounted to a bottle holder, which is included in the replenishing device, substantially horizontally with the mouth portion oriented sideways, the bottle is rotated to raise the toner from the bottom of the main body to the mouth portion. As a result, the toner is discharged to the outside via the mouth portion smoothly.

9. 发明授权

US06751431B2 Developer replenishing device and developer container for use therewith 失效
标题翻译：显影剂补充装置和显影剂容器用于此
公开(公告)号：US06751431B2
公开(公告)日：2004-06-15
申请号：US10173981
申请日：2002-06-19
申请人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
发明人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
IPC分类号： G03G1508
CPC分类号： G03G15/0868 , G03G15/0855 , G03G15/0865 , G03G15/0872 , G03G2215/0663 , G03G2215/0665 , G03G2215/0668 , G03G2215/0675 , G03G2215/0685 , Y10S220/19 , Y10S222/01
摘要： A developer replenishing device for replenishing a developing device with a developer, and a developer container for use therewith. The developer container, or toner bottle, includes a shoulder portion adjoining a first end of a hollow body. The body is formed with a spiral guide for guiding a developer stored in the developer container. The shoulder portion forms a wall and includes an engaging portion engageable with driver that causes the body to rotate. The engaging portion includes a lug protruding from the shoulder portion which allows a characteristic of toner to be identified. The engaging portion has an outside surface of a guide portion that guides a developer stored in the developer container. Two engaging portions may be angularly spaced from each other by 180 degrees. The developer container also includes a discharge mouth, which adjoins the first end of the body, which is smaller in diameter than the shoulder portion, and which includes an annular collar protruding outwardly, and a positioning portion positioned on a holder for the developer container. The positioning portion includes a lug protruding from an outside surface of the body. The holder for the developer container includes a hitting member which hits against the outside surface when the body is caused to rotate. A plurality of lugs are formed on an outside circumferential surface of the collar of the discharge mouth.
摘要翻译：用于用显影剂补充显影装置的显影剂补充装置和与其一起使用的显影剂容器。显影剂容器或调色剂瓶包括邻接中空体的第一端的肩部。主体形成有用于引导存储在显影剂容器中的显影剂的螺旋引导件。肩部形成壁并且包括与驱动器接合的接合部分，其使得主体旋转。接合部分包括从肩部突出的凸耳，其允许识别调色剂的特性。接合部分具有导向部分的外表面，该引导部分引导存储在显影剂容器中的显影剂。两个接合部分可以彼此成角度地间隔180度。显影剂容器还包括排放口，其邻接于身体的第一端部，其直径小于肩部部分，并且包括向外突出的环形套圈以及位于显影剂容器的保持器上的定位部分。定位部分包括从主体的外表面突出的凸耳。用于显影剂容器的保持器包括当主体旋转时撞击外表面的击打构件。在排出口的轴环的外周面上形成有多个凸耳。

10. 发明授权

US6075963A Developer replenishing device and developer container for use therewith 有权
公开(公告)号：US6075963A
公开(公告)日：2000-06-13
申请号：US306048
申请日：1999-05-06
申请人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
发明人： Hideo Ichikawa , Takeshi Saito , Sunao Ikeda , Nobuhiro Makita , Seiji Ozawa , Shigeru Yoshiki , Takaaki Yanagisawa
IPC分类号： G03G15/08
CPC分类号： G03G15/0868 , G03G15/0855 , G03G15/0865 , G03G15/0872 , G03G2215/0663 , G03G2215/0665 , G03G2215/0668 , G03G2215/0675 , G03G2215/0685 , Y10S220/19 , Y10S222/01
摘要： A developer replenishing device for replenishing a developing device with a developer, and a developer container for use therewith. The developer container, or toner bottle, has a mouth portion at one end thereof which is smaller in diameter than a hollow cylindrical main body. At the end of the bottle provided with the mouth, a shoulder has the inner periphery thereof partly raised to the edge of the mouth portion to form a raised portion for scooping up a toner. In addition, a part of the inner periphery of the circumferential wall of the bottle which is contiguous with the raised portion is also raised toward the axis of the bottle about which the bottle is rotatable, thereby forming another raised portion. When the bottle is mounted to a bottle holder, which is included in the replenishing device, substantially horizontally with the mouth portion oriented sideways, the bottle is rotated to raise the toner from the bottom of the main body to the mouth portion. As a result, the toner is discharged to the outside via the mouth portion smoothly.

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