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1. 发明授权

US07859672B2 Optical element, sensor device, manufacturing method of optical element, detection element, target substance measuring device and detection method 有权
标题翻译：光学元件，传感器装置，光学元件的制造方法，检测元件，靶物质测量装置和检测方法
公开(公告)号：US07859672B2
公开(公告)日：2010-12-28
申请号：US12045335
申请日：2008-03-10
申请人： Tomohiro Yamada , Yoichiro Handa , Satoru Nishiuma , Ryo Kuroda
发明人： Tomohiro Yamada , Yoichiro Handa , Satoru Nishiuma , Ryo Kuroda
IPC分类号： G01N21/00
CPC分类号： B29D11/00365 , B29D11/00807 , G01N21/554
摘要： An optical element of the present invention includes a conductive microstructure having a conductive property, and detects an optical spectrum signal varied by the binding of measured molecules on the surface of the conductive microstructure. The optical element has a distribution in the binding capacity of the measured molecules on the surface of the conductive microstructure in the direction of the electric displacement vector generated inside the conductive microstructure. As a result, it is possible to provide an optical element capable of measuring the density at high accuracy without depending on the binding position of the measured molecules.
摘要翻译：本发明的光学元件包括具有导电特性的导电微结构，并且检测由导电微结构的表面上测量分子的结合而变化的光谱信号。光学元件在导电微结构内部产生的电位移矢量的方向上具有导电微结构表面上测量分子的结合能力分布。结果，可以提供能够高精度地测量密度的光学元件，而不依赖于所测量的分子的结合位置。

2. 发明授权

US07659987B2 Device and method for acquiring information on objective substance to be detected by detecting a change of wavelength characteristics on the optical transmittance 失效
标题翻译：通过检测光透射率上的波长特性的变化来获取关于要检测的物质的信息的装置和方法
公开(公告)号：US07659987B2
公开(公告)日：2010-02-09
申请号：US11659717
申请日：2005-09-14
申请人： Norihiko Utsunomiya , Mitsuro Sugita , Satoru Nishiuma , Takao Yonehara
发明人： Norihiko Utsunomiya , Mitsuro Sugita , Satoru Nishiuma , Takao Yonehara
IPC分类号： G01N21/00
CPC分类号： G01N21/554 , G01N21/648 , G01N2021/258 , G01N2201/0635 , G01N2201/0636
摘要： An information-acquiring device for acquiring information on an objective substance to be detected, which is provided with a sensing element that has a surface capable of fixing the objective substance to be detected thereon, and makes applied light change its wavelength characteristics in response to the fixed state of the objective substance to be detected onto the surface, a light source, and light-receiving means for receiving light emitted from the light source through the sensing element, has the light-receiving means and the light source arranged on the same substrate so that the light which has been emitted from the light source and has been transmitted through the sensing element can be led to the light-receiving means, and has means for varying the wavelength regions of each light incident on each of a plurality of the light-receiving means installed in an optical path from the light source to the light-receiving means.
摘要翻译：一种信息获取装置，用于获取关于待检测的物质的信息，该信息获取装置设置有具有能够固定待检测的物体的表面的感测元件，并且使得施加的光响应于该检测元件的波长特性而改变其要检测的目标物质的固定状态，光源和用于接收通过感测元件从光源发射的光的光接收装置，其中光接收装置和光源布置在同一基板上使得已经从光源发射并已经透射通过感测元件的光可以被引导到光接收装置，并且具有用于改变入射到多个光中的每一个的每个光的波长区域的装置 - 接收装置安装在从光源到光接收装置的光路中。

3. 发明申请

US20080225292A1 TARGET SUBSTANCE DETECTING ELEMENT, TARGET SUBSTANCE DETECTION APPARATUS AND TARGET SUBSTANCE DETECTION METHOD 失效
标题翻译：目标物质检测元件，目标物质检测装置和目标物质检测方法
公开(公告)号：US20080225292A1
公开(公告)日：2008-09-18
申请号：US12123167
申请日：2008-05-19
申请人： Satoru Nishiuma , Norihiko Utsunomiya , Takashi Ikeda
发明人： Satoru Nishiuma , Norihiko Utsunomiya , Takashi Ikeda
IPC分类号： G01N21/00 , B01J19/08
CPC分类号： G01N33/54326 , G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： Magnetic particles with a metal coat holding target substance captors are made to react with a target substance contained in a specimen in a solution where the magnetic particles are dispersed in a liquid medium. Subsequently, the dispersion of the magnetic particles is applied to a surface having a periodic structure that is adapted to generate plasmon resonance and a change in the plasmon resonance attributable to the concentration of the target substance held on the magnetic particles fixed magnetically to the surface is optically detected to determine the concentration of the target substance in the specimen.
摘要翻译：使具有保持目标物质俘获物的金属涂层的磁性颗粒与磁性颗粒分散在液体介质中的溶液中的样品中包含的目标物质反应。随后，将磁性颗粒的分散体施加到具有适于产生等离子体共振的周期性结构的表面，并且由于保持在磁性颗粒上的目标物质的浓度与表面固定的等离子体共振的变化是光学检测以确定样品中目标物质的浓度。

4. 发明授权

US08023109B2 Recognition chip for target substance, and detection method and device for the same 有权
标题翻译：目标物质识别芯片及其检测方法及装置
公开(公告)号：US08023109B2
公开(公告)日：2011-09-20
申请号：US12895776
申请日：2010-09-30
申请人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
发明人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
IPC分类号： G01N21/27 , G01N21/64
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译：一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置，当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置基于在照射光时来自多个物体的光输出的总和的属性的变化。

5. 发明授权

US07691648B2 Target substance detecting element, target substance detection apparatus and target substance detection method 失效
标题翻译：目标物质检测元件，目标物质检测装置及目标物质检测方法
公开(公告)号：US07691648B2
公开(公告)日：2010-04-06
申请号：US12123167
申请日：2008-05-19
申请人： Satoru Nishiuma , Norihiko Utsunomiya , Takashi Ikeda
发明人： Satoru Nishiuma , Norihiko Utsunomiya , Takashi Ikeda
IPC分类号： G01N33/553
CPC分类号： G01N33/54326 , G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： Magnetic particles with a metal coat holding target substance captors are made to react with a target substance contained in a specimen in a solution where the magnetic particles are dispersed in a liquid medium. Subsequently, the dispersion of the magnetic particles is applied to a surface having a periodic structure that is adapted to generate plasmon resonance and a change in the plasmon resonance attributable to the concentration of the target substance held on the magnetic particles fixed magnetically to the surface is optically detected to determine the concentration of the target substance in the specimen.
摘要翻译：使具有保持目标物质俘获物的金属涂层的磁性颗粒与磁性颗粒分散在液体介质中的溶液中的样品中包含的目标物质反应。随后，将磁性颗粒的分散体施加到具有适于产生等离子体共振的周期性结构的表面，并且由于保持在磁性颗粒上的目标物质的浓度与表面固定的等离子体共振的变化是光学检测以确定样品中目标物质的浓度。

6. 发明授权

US07387901B2 Target substance detecting element, target substance detection apparatus and target substance detection method 失效
标题翻译：目标物质检测元件，目标物质检测装置及目标物质检测方法
公开(公告)号：US07387901B2
公开(公告)日：2008-06-17
申请号：US11165504
申请日：2005-06-24
申请人： Satoru Nishiuma , Norihiko Utsunomiya , Takashi Ikeda
发明人： Satoru Nishiuma , Norihiko Utsunomiya , Takashi Ikeda
IPC分类号： G01N33/553
CPC分类号： G01N33/54326 , G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： Magnetic particles with a metal coat holding target substance captors are made to react with a target substance contained in a specimen in a solution where the magnetic particles are dispersed in a liquid medium. Subsequently, the dispersion of the magnetic particles is applied to a surface having a periodic structure that is adapted to generate plasmon resonance and a change in the plasmon resonance attributable to the concentration of the target substance held on the magnetic particles fixed magnetically to the surface is optically detected to determine the concentration of the target substance in the specimen.
摘要翻译：使具有保持目标物质俘获物的金属涂层的磁性颗粒与磁性颗粒分散在液体介质中的溶液中的样品中包含的目标物质反应。随后，将磁性颗粒的分散体施加到具有适于产生等离子体共振的周期性结构的表面，并且由于保持在磁性颗粒上的目标物质的浓度与表面固定的等离子体共振的变化是光学检测以确定样品中目标物质的浓度。

7. 发明申请

US20070285666A1 Device and Method for Acquiring Information on Objective Substance to Be Detected By Detecting a Change of Wavelength Characteristics on the Optical Transmittance 失效
标题翻译：通过检测光学透射率波长特性变化来获得要检测的物质信息的装置和方法
公开(公告)号：US20070285666A1
公开(公告)日：2007-12-13
申请号：US11659717
申请日：2005-09-14
申请人： Norihiko Utsunomiya , Mitsuro Sugita , Satoru Nishiuma , Takao Yonehara
发明人： Norihiko Utsunomiya , Mitsuro Sugita , Satoru Nishiuma , Takao Yonehara
IPC分类号： G01N21/00
CPC分类号： G01N21/554 , G01N21/648 , G01N2021/258 , G01N2201/0635 , G01N2201/0636
摘要： An information-acquiring device for acquiring information on an objective substance to be detected, which is provided with a sensing element that has a surface capable of fixing the objective substance to be detected thereon, and makes applied light change its wavelength characteristics in response to the fixed state of the objective substance to be detected onto the surface, a light source, and light-receiving means for receiving light emitted from the light source through the sensing element, has the light-receiving means and the light source arranged on the same substrate so that the light which has been emitted from the light source and has been transmitted through the sensing element can be led to the light-receiving means, and has means for varying the wavelength regions of each light incident on each of a plurality of the light-receiving means installed in an optical path from the light source to the light-receiving means.
摘要翻译：一种信息获取装置，用于获取关于待检测的物质的信息，该信息获取装置设置有具有能够固定待检测的物体的表面的感测元件，并且使得施加的光响应于该检测元件的波长特性而改变其要检测的目标物质的固定状态，光源和用于接收通过感测元件从光源发射的光的光接收装置，其中光接收装置和光源布置在同一基板上使得已经从光源发射并已经透射通过感测元件的光可以被引导到光接收装置，并且具有用于改变入射到多个光中的每一个的每个光的波长区域的装置 - 接收装置安装在从光源到光接收装置的光路中。

8. 发明授权

US08045141B2 Detecting element, detecting device and detecting method 有权
标题翻译：检测元件，检测装置及检测方法
公开(公告)号：US08045141B2
公开(公告)日：2011-10-25
申请号：US12296426
申请日：2007-05-08
申请人： Yoichiro Handa , Satoru Nishiuma
发明人： Yoichiro Handa , Satoru Nishiuma
IPC分类号： G01N33/48 , G01N21/55
CPC分类号： G01N21/554 , B82Y15/00 , G01N33/54386 , G01N33/553 , G01N2021/258
摘要： The present invention provides a detecting element which can stably detect a substance with high sensitivity; a detecting device therefor; and a detecting method therefor. The detecting element and the detecting device according to the present invention have a plurality of planes having a plurality of mutually-separated metallic structures arranged thereon. The detecting method according to the present invention includes making a detecting light irradiate the detecting element so that the light can intersect a plurality of the planes. Thereby, the detecting light is more frequently absorbed in the vicinity of the metallic structure and the detecting device can stably detect a slight change of a spectrum originating from a trace change of a refractive index occurring in the vicinity of the metallic structure, with the high sensitivity.
摘要翻译：本发明提供一种能够以高灵敏度稳定地检测物质的检测元件; 一种检测装置; 及其检测方法。根据本发明的检测元件和检测装置具有多个平面，其上布置有多个相互分离的金属结构。根据本发明的检测方法包括使检测光照射到检测元件，使得光可以与多个平面相交。因此，检测光更多地被吸收在金属结构附近，并且检测装置可以稳定地检测由金属结构附近发生的折射率的痕量变化引起的光谱的轻微变化，高灵敏度。

9. 发明授权

US07944564B2 Device and method for acquiring information on objective substance to be detected by detecting a change of wavelength characteristics on the optical transmittance 有权
标题翻译：通过检测光透射率上的波长特性的变化来获取关于要检测的物质的信息的装置和方法
公开(公告)号：US07944564B2
公开(公告)日：2011-05-17
申请号：US12642446
申请日：2009-12-18
申请人： Norihiko Utsunomiya , Mitsuro Sugita , Satoru Nishiuma , Takao Yonehara
发明人： Norihiko Utsunomiya , Mitsuro Sugita , Satoru Nishiuma , Takao Yonehara
IPC分类号： G01N22/00
CPC分类号： G01N21/554 , G01N21/648 , G01N2021/258 , G01N2201/0635 , G01N2201/0636
摘要： An information-acquiring device for acquiring information on an objective substance to be detected, which is provided with a sensing element that has a surface capable of fixing the objective substance to be detected thereon, and makes applied light change its wavelength characteristics in response to the fixed state of the objective substance to be detected onto the surface, a light source, and light-receiving means for receiving light emitted from the light source through the sensing element, has the light-receiving means and the light source arranged on the same substrate so that the light which has been emitted from the light source and has been transmitted through the sensing element can be led to the light-receiving means, and has means for varying the wavelength regions of each light incident on each of a plurality of the light-receiving means installed in an optical path from the light source to the light-receiving means.
摘要翻译：一种信息获取装置，用于获取关于待检测的物质的信息，该信息获取装置设置有具有能够固定待检测的物体的表面的感测元件，并且使得施加的光响应于该检测元件的波长特性而改变其要检测的目标物质的固定状态，光源和用于接收通过感测元件从光源发射的光的光接收装置，其中光接收装置和光源布置在同一基板上使得已经从光源发射并已经透射通过感测元件的光可以被引导到光接收装置，并且具有用于改变入射到多个光中的每一个的每个光的波长区域的装置 - 接收装置安装在从光源到光接收装置的光路中。

10. 发明授权

US07915053B2 Substrate for target substance detecting device, target substance detecting device, target substance detecting apparatus and method using the same, and kit therefor 失效
标题翻译：靶物质检测装置用基板，目标物质检测装置，目标物质检测装置及其使用方法及其用具
公开(公告)号：US07915053B2
公开(公告)日：2011-03-29
申请号：US12088023
申请日：2006-12-20
申请人： Junta Yamamichi , Satoru Nishiuma , Tomohiro Yamada , Masaya Ogino , Ryo Kuroda , Hidenori Shiotsuka
发明人： Junta Yamamichi , Satoru Nishiuma , Tomohiro Yamada , Masaya Ogino , Ryo Kuroda , Hidenori Shiotsuka
IPC分类号： G01N33/551
CPC分类号： G01N21/554 , G01N21/648 , G01N21/658 , Y10S436/805
摘要： A substrate for forming a target substance detecting device includes a supporting member, an underlying layer disposed on a surface of the supporting member, and a metal pattern layer, disposed on a surface of the underlying layer, for being bound to a target substance trapping substance capable of trapping a target substance in a specimen solution at least containing water as a liquid medium to detect the target substance by utilizing plasmon resonance. The underlying layer has a refractive index nb satisfying the following relationship: 0.90 na≦nb≦1.05 na, wherein na represents a refractive index of water.
摘要翻译：用于形成目标物质检测装置的基板包括支撑构件，设置在支撑构件的表面上的下层和设置在下层的表面上的金属图案层，用于与目标物质捕获物质结合能够将至少含有水作为液体介质的样品溶液中的目标物质捕获，以通过利用等离子体共振来检测目标物质。下层具有满足以下关系的折射率nb：0.90 na＆nlE; nb＆nlE; 1.05na，其中na表示水的折射率。

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