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1. 发明申请

US20110070166A1 REDUCED DYE PROBES FOR THE DETECTION OF RADICAL OXYGEN SPECIES 有权
标题翻译：用于检测放射性氧物种的减少的染色体探针
公开(公告)号：US20110070166A1
公开(公告)日：2011-03-24
申请号：US12892379
申请日：2010-09-28
申请人： Niren Murthy , W. Robert Taylor , Kousik Kundu , Sarah F. Knight , Sungmun Lee
发明人： Niren Murthy , W. Robert Taylor , Kousik Kundu , Sarah F. Knight , Sungmun Lee
IPC分类号： A61K49/00 , C07D403/06 , C12Q1/02 , G01N33/50 , B65D69/00
CPC分类号： A61K49/0021 , C09B11/24 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/086 , G01N33/5091
摘要： Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes capable of detecting one or more reactive oxygen species are described herein. The reduced dyes exhibit little or no fluorescence due to the disrupted π conjugation. However, upon reaction with ROS, the reduced dyes are oxidized, regenerating the extended π conjugation and causing a substantial increase in fluorescence intensity. In many case, the oxidized dye is generally membrane impermeable. However, upon reduction, many of the reduced dyes are membrane permeable. Thus, reduced dyes can accumulate in cells and/or tissue to amplify the signal. Once inside the cell or tissue, the reduced dye is reoxidized upon reaction with ROS, and the oxidized dye again becomes membrane impermeable, trapping the dye within the cell. The reduced dyes can be used to image ROS, such as hydroxide radical and superoxide, in serum, cell cultures, tissue explants, and in vivo.
摘要翻译：本文描述了能够检测一种或多种活性氧的还原染料，例如氢氰酸，氘代菁和/或其它氘代染料。由于被破坏的pgr，还原的染料表现出很少或没有荧光; 共轭。然而，当与ROS反应时，还原的染料被氧化，再生延长的＆lt; 共轭并导致荧光强度的显着增加。在许多情况下，氧化染料通常是不透膜的。然而，在还原时，许多还原染料是可透膜的。因此，还原染料可以积聚在细胞和/或组织中以放大信号。一旦在细胞或组织内部，还原的染料在与ROS反应时被再氧化，并且氧化的染料再次变成不透膜的，将染料捕获在细胞内。还原染料可用于在血清，细胞培养物，组织外植体和体内成像ROS，例如氢氧根和超氧化物。

2. 发明授权

US08628753B2 Reduced dye probes for the detection of radical oxygen species 有权
标题翻译：用于检测自由基氧的减少的染料探针
公开(公告)号：US08628753B2
公开(公告)日：2014-01-14
申请号：US12892379
申请日：2010-09-28
申请人： Niren Murthy , W. Robert Taylor , Kousik Kundu , Sarah F. Knight , Sungmun Lee
发明人： Niren Murthy , W. Robert Taylor , Kousik Kundu , Sarah F. Knight , Sungmun Lee
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00
CPC分类号： A61K49/0021 , C09B11/24 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/086 , G01N33/5091
摘要： Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes capable of detecting one or more reactive oxygen species are described herein. The reduced dyes exhibit little or no fluorescence due to the disrupted π conjugation. However, upon reaction with ROS, the reduced dyes are oxidized, regenerating the extended π conjugation and causing a substantial increase in fluorescence intensity. In many case, the oxidized dye is generally membrane impermeable. However, upon reduction, many of the reduced dyes are membrane permeable. Thus, reduced dyes can accumulate in cells and/or tissue to amplify the signal. Once inside the cell or tissue, the reduced dye is reoxidized upon reaction with ROS, and the oxidized dye again becomes membrane impermeable, trapping the dye within the cell. The reduced dyes can be used to image ROS, such as hydroxide radical and superoxide, in serum, cell cultures, tissue explants, and in vivo.
摘要翻译：本文描述了能够检测一种或多种活性氧的还原染料，例如氢氰酸，氘代菁和/或其它氘代染料。还原的染料表现出很少的或没有荧光，由于破坏的π共轭。然而，当与ROS反应时，还原的染料被氧化，再生延长的π共轭并引起荧光强度的显着增加。在许多情况下，氧化染料通常是不透膜的。然而，在还原时，许多还原染料是可透膜的。因此，还原染料可以积聚在细胞和/或组织中以放大信号。一旦在细胞或组织内部，还原的染料在与ROS反应时被再氧化，并且氧化的染料再次变成不透膜的，将染料捕获在细胞内。还原染料可用于在血清，细胞培养物，组织外植体和体内成像ROS，例如氢氧根和超氧化物。

3. 发明申请

US20120302575A1 Methods for Preventing Oxidative Stress Injury of a Tissue by a Folate-Tempol Conjugate. 有权
标题翻译：通过叶酸 - 坦莫酚缀合物预防组织氧化应激损伤的方法。
公开(公告)号：US20120302575A1
公开(公告)日：2012-11-29
申请号：US13497398
申请日：2010-09-21
申请人： W. Robert Taylor , Sarah F. Knight , Niren Murthy , Kousik Kundu
发明人： W. Robert Taylor , Sarah F. Knight , Niren Murthy , Kousik Kundu
IPC分类号： A61K31/519 , A61P13/12 , C12N5/071 , A61P9/10 , C07D475/04 , A01N1/02
CPC分类号： A61K31/4985 , A61K47/551
摘要： The present disclosure is generally related to methods of preventing oxidative stress injury induced by renal is-chemia-reperfusion by a Folate-TEMPOL conjugate.
摘要翻译：本公开通常涉及通过叶酸-TEMPOL缀合物预防由肾脏化学 - 再灌注引起的氧化应激损伤的方法。

4. 发明授权

US08815860B2 Methods for preventing oxidative stress injury of a tissue by a Folate-TEMPOL conjugate 有权
标题翻译：用于通过叶酸-TEMPOL缀合物预防组织的氧化应激损伤的方法
公开(公告)号：US08815860B2
公开(公告)日：2014-08-26
申请号：US13497398
申请日：2010-09-21
申请人： W. Robert Taylor , Sarah F. Knight , Niren Murthy , Kousik Kundu
发明人： W. Robert Taylor , Sarah F. Knight , Niren Murthy , Kousik Kundu
IPC分类号： C07D401/10 , C07D475/08 , A61K31/519 , A61K31/445
CPC分类号： A61K31/4985 , A61K47/551
摘要： The present disclosure is generally related to methods of preventing oxidative stress injury induced by renal ischemia-reperfusion by a Folate-TEMPOL conjugate.
摘要翻译：本公开通常涉及通过叶酸-TEMPOL缀合物预防肾缺血再灌注诱导的氧化应激损伤的方法。

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