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1. 发明授权

US07871623B2 Compositions and methods for imaging pain and stress in vivo 有权
标题翻译：用于在体内成像疼痛和压力的组合物和方法
公开(公告)号：US07871623B2
公开(公告)日：2011-01-18
申请号：US11643249
申请日：2006-12-21
申请人： Sandip Biswal , Francis G. Blankenberg
发明人： Sandip Biswal , Francis G. Blankenberg
IPC分类号： A61K39/00 , A61K51/00 , G01N25/14 , G01N24/00
CPC分类号： A61K51/088 , A61K49/1863 , A61K49/1866 , A61K49/1869 , A61K51/087 , Y10T436/24
摘要： Briefly described, embodiments of the present disclosure relate to methods and compositions for imaging pain and/or stress in a subject and methods and compositions for treating associated conditions. In particular, the present disclosure relates to the use of labeled compounds to provide objective diagnosis of pain and/or stress, for imaging regions associated with pain and/or stress, and for treating pain in a subject.
摘要翻译：简要描述，本公开的实施方案涉及用于对受试者的疼痛和/或应激进行成像的方法和组合物以及用于治疗相关病症的方法和组合物。特别地，本公开涉及使用标记化合物来提供疼痛和/或压力的客观诊断，用于与疼痛和/或压力相关的成像区域以及用于治疗受试者的疼痛。

2. 发明申请

US20120010896A1 METHODS AND APPARATUS TO CLASSIFY REPORTS 审中-公开
标题翻译：方法和设备分类报告
公开(公告)号：US20120010896A1
公开(公告)日：2012-01-12
申请号：US12833746
申请日：2010-07-09
申请人： Vijaykalyan Yeluri , Perry Frederick , Sandip Biswal
发明人： Vijaykalyan Yeluri , Perry Frederick , Sandip Biswal
IPC分类号： G06Q10/00 , G06F17/30 , G06Q50/00
CPC分类号： G06Q10/10 , G06Q50/22 , G16H40/20
摘要： Methods and apparatus to classify reports are disclosed herein. An example method includes determining a type of an examination associated with a report; obtaining an identification of a person associated with the report; using the identification to determine whether the person associated with the report is specialized in the type of the examination; when the person associated with the report is specialized in the type of the examination, classifying the report as associated with a specialist; when the person associated with the report is unspecialized in the type of the examination, classifying the report as associated with a non-specialist; and presenting a document consumer with an indication of the classification of the report.
摘要翻译：本文公开了分类报告的方法和装置。示例性方法包括确定与报告相关联的检查的类型; 获得与该报告相关的人员的身份证明; 使用身份证明来确定与报告有关的人是否专门从事考试的类型; 当与报告相关的人专门从事考试的类型时，将报告与专家相关联进行分类; 当与报告相关的人员在审查类型中不专业时，将与非专家相关的报告分类; 并向文档消费者呈现报告分类的指示。

3. 发明授权

US07995818B2 Systems and methods for synchronized image viewing with an image atlas 有权
标题翻译：使用图像图集同步图像查看的系统和方法
公开(公告)号：US07995818B2
公开(公告)日：2011-08-09
申请号：US11924992
申请日：2007-10-26
申请人： Prakash Mahesh , Vijaykalyan Yeluri , Denny Wingchung Lau , Steven P. Roehm , Christopher Allen Beaulieu , Garry Evan Gold , Sandip Biswal , Robert John Herfkens
发明人： Prakash Mahesh , Vijaykalyan Yeluri , Denny Wingchung Lau , Steven P. Roehm , Christopher Allen Beaulieu , Garry Evan Gold , Sandip Biswal , Robert John Herfkens
IPC分类号： G06K9/00 , A61B5/05
CPC分类号： G06T7/38 , G06T7/32 , G06T2207/10081 , G06T2207/30016
摘要： Certain embodiments of the present invention provide methods and systems for synchronizing a view of a patient image with an atlas image. Certain embodiments provide a method for synchronizing a patient image with an atlas image. The method includes retrieving an image atlas including at least one atlas image, registering an atlas image to a patient image and synchronizing a view of the atlas image to a view of the patient image. In certain embodiments, the method further includes registering a plurality of atlas images to a plurality of patient images. In certain embodiments, the step of synchronizing further includes synchronizing at least one of orientation, zoom level, window level and pan of the atlas image to the patient image.
摘要翻译：本发明的某些实施例提供了用于使患者图像的视图与图集图像同步的方法和系统。某些实施例提供了一种使患者图像与图集图像同步的方法。该方法包括检索包括至少一个图集图像的图像图集，将图谱图像注册到患者图像，并将图谱图像的视图同步到患者图像的视图。在某些实施例中，该方法还包括将多个图集图像登记到多个患者图像。在某些实施例中，同步步骤还包括将图谱图像的取向，变焦水平，窗口水平和平移盘中的至少一个同步到患者图像。

4. 发明申请

US20100284913A1 Methods and compositions for studying, imaging, and treating pain 有权
标题翻译：用于研究，成像和治疗疼痛的方法和组合物
公开(公告)号：US20100284913A1
公开(公告)日：2010-11-11
申请号：US12800053
申请日：2010-05-07
申请人： Justin Du Bois , John Mulcahy , Brian Andresen , David C. Yeomans , Sandip Biswal
发明人： Justin Du Bois , John Mulcahy , Brian Andresen , David C. Yeomans , Sandip Biswal
IPC分类号： A61K51/04 , C07D487/14 , C07K16/00 , C07K14/00 , C07H21/04 , A61K31/519 , A61K47/48 , A61K38/02 , A61P1/00 , A61P13/00 , A61P25/00 , A61P25/08 , A61P29/00 , A61K49/16 , A61K49/14 , A61K49/12 , A61K49/10 , A61K38/43 , A61P17/00 , A61K31/58 , C12N9/96
CPC分类号： C07D487/16 , A61K8/4953 , A61K49/0002 , A61K49/0004 , A61K49/0032 , A61K49/0052 , A61K51/0459 , A61Q19/02 , A61Q19/08 , C07D487/14
摘要： Saxitoxin analogue compounds, compositions, pharmaceutical compositions, methods of synthesis of saxitoxin analogues, methods of imaging, methods of treatment, including methods of treating pain, are provided. Saxitoxin (STX), gonyautoxin (GTX), and zetekitoxin, and variant STX compounds bind to sodium channels and are effective to reduce or block flow of sodium ions through such channels. Such channel block affects nerve and muscle action, and may be effective to reduce or block pain sensations, relax muscles, reduce muscle spasm, and reduce wrinkles. STX analogue binding to sodium channels may also be useful to locate, image, or mark sodium channels, and so be useful in studying sodium channels and sodium channel disorders, and in the diagnosis and treatment of patients suffering from sodium channel disorders. In embodiments, the variant STX compounds include conjugates having increased serum half-life as compared to STX when administered to a subject.In embodiments, the present disclosure provides a method for alleviating pain in a subject in need of treatment, the method comprising administering to the subject an effective amount of a saxitoxin analogue compound, or a pharmaceutically acceptable salt, isomer, tautomer or prodrug thereof, whereby pain in said subject is alleviated.
摘要翻译：提供了类似萨克西汀类似物，组合物，药物组合物，合成硫氧还蛋白类似物的方法，成像方法，治疗方法，包括治疗疼痛的方法。沙眼毒素（STX），戈毒毒素（GTX）和泽西酮毒素，和变体STX化合物结合钠通道，并有效减少或阻断钠离子通过这些通道的流动。这种通道阻滞影响神经和肌肉的作用，并且可以有效地减少或阻止疼痛感觉，放松肌肉，减少肌肉痉挛和减少皱纹。与钠通道的STX类似物结合也可用于定位，成像或标记钠通道，因此可用于研究钠通道和钠通道障碍，以及用于诊断和治疗患有钠通道障碍的患者。在实施方案中，变体STX化合物包括与施用于受试者时相比于STX相比具有增加的血清半衰期的结合物。在实施方案中，本公开提供了一种减轻需要治疗的受试者的疼痛的方法，所述方法包括向受试者施用有效量的沙克西毒素类似物化合物或其药学上可接受的盐，异构体，互变异构体或前药，由此所述受试者的疼痛缓解。

5. 发明申请

US20070148092A1 Compositions and methods for imaging pain and stress in vivo 有权
标题翻译：用于在体内成像疼痛和压力的组合物和方法
公开(公告)号：US20070148092A1
公开(公告)日：2007-06-28
申请号：US11643249
申请日：2006-12-21
申请人： Sandip Biswal , Francis Blankenberg
发明人： Sandip Biswal , Francis Blankenberg
IPC分类号： A61K51/00
CPC分类号： A61K51/088 , A61K49/1863 , A61K49/1866 , A61K49/1869 , A61K51/087 , Y10T436/24
摘要： Briefly described, embodiments of the present disclosure relate to methods and compositions for imaging pain and/or stress in a subject and methods and compositions for treating associated conditions. In particular, the present disclosure relates to the use of labeled compounds to provide objective diagnosis of pain and/or stress, for imaging regions associated with pain and/or stress, and for treating pain in a subject.
摘要翻译：简要描述，本公开的实施方案涉及用于对受试者的疼痛和/或应激进行成像的方法和组合物，以及用于治疗相关病症的方法和组合物。特别地，本公开涉及使用标记化合物来提供疼痛和/或压力的客观诊断，用于与疼痛和/或压力相关的成像区域以及用于治疗受试者的疼痛。

6. 发明授权

US08135195B2 Systems and methods for synchronized image viewing with an image atlas 有权
标题翻译：使用图像图集同步图像查看的系统和方法
公开(公告)号：US08135195B2
公开(公告)日：2012-03-13
申请号：US13171217
申请日：2011-06-28
申请人： Prakash Mahesh , Vijaykalyan Yeluri , Denny Wingchung Lau , Steven P. Roehm , Christopher Allen Beaulieu , Garry Evan Gold , Sandip Biswal , Robert John Herfkens
发明人： Prakash Mahesh , Vijaykalyan Yeluri , Denny Wingchung Lau , Steven P. Roehm , Christopher Allen Beaulieu , Garry Evan Gold , Sandip Biswal , Robert John Herfkens
IPC分类号： G06K9/00 , A61B5/05
CPC分类号： G06T7/38 , G06T7/32 , G06T2207/10081 , G06T2207/30016
摘要： Certain embodiments of the present invention provide methods and systems for synchronizing a view of a patient image with an atlas image. Certain embodiments provide a method for synchronizing a patient image with an atlas image. The method includes retrieving an image atlas including at least one atlas image, registering an atlas image to a patient image and synchronizing a view of the atlas image to a view of the patient image. In certain embodiments, the method further includes registering a plurality of atlas images to a plurality of patient images. In certain embodiments, the step of synchronizing further includes synchronizing at least one of orientation, zoom level, window level and pan of the atlas image to the patient image.
摘要翻译：本发明的某些实施例提供了用于使患者图像的视图与图集图像同步的方法和系统。某些实施例提供了一种使患者图像与图集图像同步的方法。该方法包括检索包括至少一个图集图像的图像图集，将图谱图像注册到患者图像，并将图谱图像的视图同步到患者图像的视图。在某些实施例中，该方法还包括将多个图集图像登记到多个患者图像。在某些实施例中，同步步骤还包括将图谱图像的取向，变焦水平，窗口水平和平移盘中的至少一个同步到患者图像。

7. 发明授权

US09174999B2 Methods and compositions for studying, imaging, and treating pain 有权
标题翻译：用于研究，成像和治疗疼痛的方法和组合物
公开(公告)号：US09174999B2
公开(公告)日：2015-11-03
申请号：US12800053
申请日：2010-05-07
申请人： Justin Du Bois , John Mulcahy , Brian Andresen , David C. Yeomans , Sandip Biswal
发明人： Justin Du Bois , John Mulcahy , Brian Andresen , David C. Yeomans , Sandip Biswal
IPC分类号： C07D487/14
CPC分类号： C07D487/16 , A61K8/4953 , A61K49/0002 , A61K49/0004 , A61K49/0032 , A61K49/0052 , A61K51/0459 , A61Q19/02 , A61Q19/08 , C07D487/14
摘要： Saxitoxin analog compounds, compositions, pharmaceutical compositions, methods of synthesis of saxitoxin analogs, methods of imaging, methods of treatment, including methods of treating pain, are provided. Saxitoxin (STX), gonyautoxin (GTX), and zetekitoxin, and variant STX compounds bind to sodium channels and are effective to reduce or block flow of sodium ions through such channels. Such channel block affects nerve and muscle action, and may be effective to reduce or block pain sensations, relax muscles, reduce muscle spasm, and reduce wrinkles. STX analog binding to sodium channels may also be useful to locate, image, or mark sodium channels, and so be useful in studying sodium channels and sodium channel disorders, and in the diagnosis and treatment of patients suffering from sodium channel disorders. In embodiments, the variant STX compounds include conjugates having increased serum half-life as compared to STX when administered to a subject.In embodiments, the present disclosure provides a method for alleviating pain in a subject in need of treatment, the method comprising administering to the subject an effective amount of a saxitoxin analog compound, or a pharmaceutically acceptable salt, isomer, tautomer or prodrug thereof, whereby pain in said subject is alleviated.
摘要翻译：提供萨克西汀类似物，组合物，药物组合物，合成沙星毒素类似物的方法，成像方法，治疗方法，包括治疗疼痛的方法。沙眼毒素（STX），戈毒毒素（GTX）和泽西酮毒素，和变体STX化合物结合钠通道，并有效减少或阻断钠离子通过这些通道的流动。这种通道阻滞影响神经和肌肉的作用，并且可以有效地减少或阻止疼痛感觉，放松肌肉，减少肌肉痉挛和减少皱纹。与钠通道的STX类似物结合也可用于定位，成像或标记钠通道，因此可用于研究钠通道和钠通道障碍，以及用于诊断和治疗患有钠通道障碍的患者。在实施方案中，变体STX化合物包括与施用于受试者时相比于STX相比具有增加的血清半衰期的结合物。在实施方案中，本公开提供了一种减轻需要治疗的受试者的疼痛的方法，所述方法包括向受试者施用有效量的沙克西毒素类似物化合物或其药学上可接受的盐，异构体，互变异构体或前药，由此所述受试者的疼痛缓解。

8. 发明申请

US20110255760A1 SYSTEMS AND METHODS FOR SYNCHRONIZED IMAGE VIEWING WITH AN IMAGE ATLAS 有权
标题翻译：用于与图像ATLAS同步图像查看的系统和方法
公开(公告)号：US20110255760A1
公开(公告)日：2011-10-20
申请号：US13171217
申请日：2011-06-28
申请人： Prakash Mahesh , Vijaykalyan Yeluri , Denny Wingchung Lau , Steven P. Roehm , Christopher Allen Beaulieu , Garry Evan Gold , Sandip Biswal , Robert John Herfkens
发明人： Prakash Mahesh , Vijaykalyan Yeluri , Denny Wingchung Lau , Steven P. Roehm , Christopher Allen Beaulieu , Garry Evan Gold , Sandip Biswal , Robert John Herfkens
IPC分类号： G06K9/00
CPC分类号： G06T7/38 , G06T7/32 , G06T2207/10081 , G06T2207/30016
摘要： Certain embodiments of the present invention provide methods and systems for synchronizing a view of a patient image with an atlas image. Certain embodiments provide a method for synchronizing a patient image with an atlas image. The method includes retrieving an image atlas including at least one atlas image, registering an atlas image to a patient image and synchronizing a view of the atlas image to a view of the patient image. In certain embodiments, the method further includes registering a plurality of atlas images to a plurality of patient images. In certain embodiments, the step of synchronizing further includes synchronizing at least one of orientation, zoom level, window level and pan of the atlas image to the patient image.
摘要翻译：本发明的某些实施例提供了用于使患者图像的视图与图集图像同步的方法和系统。某些实施例提供了一种使患者图像与图集图像同步的方法。该方法包括检索包括至少一个图集图像的图像图集，将图谱图像注册到患者图像，并将图谱图像的视图同步到患者图像的视图。在某些实施例中，该方法还包括将多个图集图像登记到多个患者图像。在某些实施例中，同步步骤还包括将图谱图像的取向，变焦水平，窗口水平和平移盘中的至少一个同步到患者图像。

9. 发明申请

US20080189137A1 Systems and Methods For Retrieving Relevant Prior Medical Examination Reports Based on Report Content 审中-公开
标题翻译：基于报告内容检索相关事前体格检查报告的系统和方法
公开(公告)号：US20080189137A1
公开(公告)日：2008-08-07
申请号：US11670242
申请日：2007-02-01
申请人： Tom Gentles , Eric Feingold , Lawrence Chow , Sandip Biswal , Raghav Raman , Vijaykalyan Yeluri , Denny Lau
发明人： Tom Gentles , Eric Feingold , Lawrence Chow , Sandip Biswal , Raghav Raman , Vijaykalyan Yeluri , Denny Lau
IPC分类号： G06Q50/00
CPC分类号： G06Q10/10 , G06Q50/24
摘要： Certain embodiments of the present invention provide a system for the identification and retrieval of relevant archived medical information. The system includes a user interface component and a processing component. The user interface component is adapted to determine a key, which includes one or more key values. The key values may represent one or more anatomical feature of a patient. The processing component is adapted to aggregate data based at least in part on the key values. The system may also include a searchable database containing relevant archived medical information. The system may also include a display device and a storage device adapted to, respectively, display and store data retrieved from the database.
摘要翻译：本发明的某些实施例提供了用于识别和检索相关归档医疗信息的系统。该系统包括用户界面组件和处理组件。用户界面组件适于确定包括一个或多个键值的键。关键值可以表示患者的一个或多个解剖特征。处理组件适于至少部分地基于键值聚合数据。该系统还可以包括包含相关归档医疗信息的可搜索数据库。该系统还可以包括适于分别显示和存储从数据库检索的数据的显示设备和存储设备。

10. 发明申请

US20080118125A1 Systems and Methods for Synchronized Image Viewing With an Image Atlas 有权
标题翻译：用于图像的同步图像查看的系统和方法图集
公开(公告)号：US20080118125A1
公开(公告)日：2008-05-22
申请号：US11924992
申请日：2007-10-26
申请人： Prakash Mahesh , Vijaykalyan Yeluri , Denny Wingchung Lau , Steven P. Roehm , Christopher Allen Beaulieu , Garry Evan Gold , Sandip Biswal , Robert John Herfkens
发明人： Prakash Mahesh , Vijaykalyan Yeluri , Denny Wingchung Lau , Steven P. Roehm , Christopher Allen Beaulieu , Garry Evan Gold , Sandip Biswal , Robert John Herfkens
IPC分类号： G06K9/00
CPC分类号： G06T7/38 , G06T7/32 , G06T2207/10081 , G06T2207/30016
摘要： Certain embodiments of the present invention provide methods and systems for synchronizing a view of a patient image with an atlas image. Certain embodiments provide a method for synchronizing a patient image with an atlas image. The method includes retrieving an image atlas including at least one atlas image, registering an atlas image to a patient image and synchronizing a view of the atlas image to a view of the patient image. In certain embodiments, the method further includes registering a plurality of atlas images to a plurality of patient images. In certain embodiments, the step of synchronizing further includes synchronizing at least one of orientation, zoom level, window level and pan of the atlas image to the patient image.
摘要翻译：本发明的某些实施例提供了用于使患者图像的视图与图集图像同步的方法和系统。某些实施例提供了一种使患者图像与图集图像同步的方法。该方法包括检索包括至少一个图集图像的图像图集，将图谱图像注册到患者图像，并将图谱图像的视图同步到患者图像的视图。在某些实施例中，该方法还包括将多个图集图像登记到多个患者图像。在某些实施例中，同步步骤还包括将图谱图像的取向，变焦水平，窗口水平和平移盘中的至少一个同步到患者图像。

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