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    • 5. 发明申请
    • METHOD FOR FUNCTIONALISING A HYDROPHOBIC SUBSTRATE
    • 功能化疏水性基材的方法
    • US20090312192A1
    • 2009-12-17
    • US12097574
    • 2006-12-19
    • Michael A. ReeveSally Anderson
    • Michael A. ReeveSally Anderson
    • C40B30/04C40B40/10C40B50/18
    • C07K17/08C07K7/06C07K7/08
    • The current invention relates to a method of functionalising a substrate comprising immobilising at least one multimeric peptide on the substrate, wherein, the at least one multimeric peptide comprises at least first and second peptide chains, the first peptide chain comprising at least one hydrophobic amino acid residue and at least one functionalising moiety, wherein the at least one hydrophobic amino acid residue and at least one functionalising moiety are positioned in the peptide primary structure so as to result in a hydrophobic face, and a substantially non hydrophobic face comprising the functionalising moiety, and wherein, contacting the peptide with the substrate causes the peptide to be immobilised thereon.
    • 本发明涉及功能化底物的方法,包括固定底物上的至少一种多聚体肽,其中,所述至少一种多聚体肽包含至少第一和第二肽链,所述第一肽链包含至少一个疏水性氨基酸 残基和至少一个官能化部分,其中所述至少一个疏水性氨基酸残基和至少一个官能化部分位于肽一级结构中,以便产生疏水性面,以及包含官能化部分的基本上非疏水性的面, 并且其中,使所述肽与所述底物接触导致所述肽被固定在其上。
    • 6. 发明申请
    • METHOD OF PRODUCING A MULTIMERIC CAPTURE AGENT FOR BINDING A LIGAND
    • 生产用于绑定配对的多功能捕获剂的方法
    • US20090192048A1
    • 2009-07-30
    • US12097791
    • 2006-12-19
    • Michael A ReeveSally Anderson
    • Michael A ReeveSally Anderson
    • C40B30/04C40B50/18C40B40/10
    • G01N33/54386G01N33/6845
    • The current invention relates to a method of fabricating a multimeric capture agent for binding a ligand, the capture agent comprising at least first and second monomers units, the first monomer unit further comprising a first ligand-binding moiety, a first reactive group and an attachment moiety, the second monomer unit further comprising a second ligand-binding moiety, and a second reactive group, wherein the reactive groups may be the same or different for each monomer unit, the method comprising the steps of; a) reacting the first monomer unit with the second monomer unit such that reactive groups present on the monomer units react to form a multimeric capture agent. b) immobilising the first monomer unit on a substrate via the attachment moiety, wherein, step a) can be performed before, simultaneously with, or subsequently to step b).
    • 本发明涉及一种制备用于结合配体的多聚体捕获剂的方法,所述捕获剂包含至少第一和第二单体单元,所述第一单体单元还包含第一配体结合部分,第一反应性基团和附着物 部分,所述第二单体单元还包含第二配体结合部分和第二反应性基团,其中所述反应性基团对于每个单体单元可以相同或不同,所述方法包括以下步骤: a)使第一单体单元与第二单体单元反应,使得存在于单体单元上的反应性基团反应以形成多聚体捕获剂。 b)通过附着部分将第一单体单元固定在基质上,其中步骤a)可以在步骤b)之前,同时或之后进行。