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1. 发明申请

US20160038435A1 TRANSDERMAL FORMULATIONS OF LAQUINIMOD 审中-公开
标题翻译： LAQUINIMOD的透皮配方
公开(公告)号：US20160038435A1
公开(公告)日：2016-02-11
申请号：US14773658
申请日：2014-03-13
申请人： Ralph STEFAN , Hans-Juergen MIKA , Tanja PRIES , Dirk SCHENK , Sabine PROHL
发明人： Ralph STEFAN , Hans-Juergen MIKA , Tanja PRIES , Dirk SCHENK , Sabine PROHL
IPC分类号： A61K9/70 , A61K47/14 , A61K47/12 , A61K31/4704 , A61K47/10
CPC分类号： A61K9/7061 , A61K9/7084 , A61K31/4704 , A61K47/10 , A61K47/12 , A61K47/14
摘要： This invention provides a transdermal patch comprising a) a backing layer; b) a liner; c) optionally, a highly porous membrane; and d) a pharmaceutical composition comprising: (i) optionally, a pressure sensitive adhesive in an amount of up to about 95 wt % of the pharmaceutical composition, (ii) laquinimod in an amount of about 0.1-20 wt % of the pharmaceutical composition, and (iii) optionally, one or more permeation enhancers in a total amount of up to about 70 wt % of the pharmaceutical composition. This invention also provides a method for delivering laquinimod across the skin of the subject and for treating a human subject afflicted with a form of multiple sclerosis comprising administering to the skin of the subject a transdermal patch as described herein. This invention further provides a transdermal patch as described herein for use in treating a human subject afflicted with a form of multiple sclerosis.
摘要翻译：本发明提供一种透皮贴剂，其包含：a）背衬层; b）衬垫; c）任选地，高度多孔的膜; 和d）药物组合物，其包含：（i）任选地，所述药物组合物的至多约95重量％的量的压敏粘合剂，（ii）所述药物组合物的约0.1-20重量％的拉喹莫德，和（iii）任选的一种或多种渗透促进剂，其总量高达药物组合物的约70重量％。本发明还提供了一种递送角质层跨越受试者皮肤并用于治疗患有多发性硬化症形式的人类受试者的方法，包括向受试者的皮肤施用如本文所述的透皮贴片。本发明还提供了本文所述的用于治疗患有多发性硬化症形式的人类受试者的透皮贴剂。

2. 发明申请

US20170071869A1 TRANSMUCOSAL DELIVERY OF LAQUINIMOD BY ORAL PATCHES 审中-公开
标题翻译：通过口头贴子传递LAQUINIMOD
公开(公告)号：US20170071869A1
公开(公告)日：2017-03-16
申请号：US15123208
申请日：2015-03-13
申请人： Ralph Stefan , Hans Juergen Mika , Claudia Lauer , Dirk Schenk , Sabine Prohl
发明人： Ralph Stefan , Hans Juergen Mika , Claudia Lauer , Dirk Schenk , Sabine Prohl
IPC分类号： A61K9/70 , A61K31/4704 , A61K9/00
CPC分类号： A61K9/70 , A61K9/006 , A61K31/4704
摘要： The subject invention provides an oral patch comprising: a) a liner; and b) a film composition thereon, the film composition comprising (i) laquinimod in an amount of about 0.1%-20% by weight of the film composition, and (ii) one or more film forming agents in a total amount of about 40%-90% by weight of the film composition. The subject invention also provides a method for delivering laquinimod across the oral mucosa of a subject, or for treating a human subject afflicted with a form of multiple sclerosis, comprising periodically administering to the human subject an oral patch as described herein. The subject invention also provides an oral patch as described herein for use in treating a human subject afflicted with a form of multiple sclerosis.
摘要翻译：本发明提供口腔贴剂，其包含：a）衬垫; 和b）其上的薄膜组合物，所述薄膜组合物包含（i）按所述薄膜组合物重量计约0.1％-20％重量的拉喹莫德，和（ii）一种或多种总成型量的成膜剂％-90重量％的膜组合物。本发明还提供了一种用于递送穿过受试者的口腔粘膜的laquinimod或用于治疗患有多发性硬化症形式的人类受试者的方法，其包括向所述人类受试者施用本文所述的口腔贴剂。本发明还提供如本文所述的用于治疗患有多发性硬化症形式的人类受试者的口腔贴剂。

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