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2. 发明申请

US20040053857A1 Glycoalkaloid compositions and various uses thereof 审中-公开
标题翻译：糖类生物碱组合物及其各种用途
公开(公告)号：US20040053857A1
公开(公告)日：2004-03-18
申请号：US10607890
申请日：2003-06-27
申请人： SOLBEC PHARMACEUTICALS LIMITED
发明人： Stephen John Carter , Elizabeth Williams
IPC分类号： A61K031/7052 , A61K031/58
CPC分类号： A61K31/58 , A61K31/704 , A61K31/7052
摘要： A composition comprising at least two glycoalkaloids of formula I: 1 wherein: either one or both of the dotted lines represents a double bond, and the other a single bond, or both represent single bonds; A: represents a radical selected from the following radicals of general formulae (II) to (V): 2 each of R1 is a radical separately selected from the group consisting of hydrogen, amino, oxo and OR4; each of R2 is a radical separately selected from the group consisting of hydrogen, amino and OR4; each of R3 is a radical separately selected from the group consisting of hydrogen, carbohydrate and a carbohydrate derivative; nullXnull is a radical selected from the group comprising nullCH2null, nullOnull and nullNH2null; and wherein the compound includes at least one R4 group that is a carbohydrate or a derivative thereof selected from the group comprising glyceric aldehyde, glycerose, erythrose, threose, ribose, arabinose, xylose, lyxose, altrose, allose, gulose, mannose, glucose, idose, galactose, talose, rhamnose, dihydroxyactone, erythrulose, ribulose, xylulose, psicose, fructose, sorbose, tagatose, and other hexoses, heptoses, octoses, nanoses, decoses, deoxysugars with branched chains, (e.g. apiose, hamamelose, streptose, cordycepose, mycarose and cladinose), compounds wherein the aldehyde, ketone or hydroxyl groups have been substituted (e.g. N-acetyl, acetyl, methyl, replacement of CH2OH), sugar alcohols, sugar acids, benzimidazoles, the enol salts of the carbohydrates, saccharinic acids, sugar phosphates; wherein the ratio of said glycoalkaloids is between 6:1 and 1:6 and on the proviso that when the glycoalkaloids are solamargine and solasonine and they are present in a 1:1 ratio the solamargine and solasonine are isolated.
摘要翻译：一种组合物，其包含至少两种式I的生物碱：其中：虚线中的一个或两个表示双键，而另一个单键或两者均表示单键; A：表示选自以下通式（II）至（V）的基团的基团：R 1各自独立地选自氢，氨基，氧代和OR 4; R 2中的每一个是分别选自氢，氨基和OR 4的基团。 R 3中的每一个是分别选自氢，碳水化合物和碳水化合物衍生物的基团; “X”是选自-CH 2 - ， - O-和-NH 2 - 的基团; 并且其中所述化合物包括至少一个R 4基团，其为选自甘油醛，甘油糖，赤藓糖，苏糖，核糖，阿拉伯糖，木糖，莱克糖，阿卓糖，阿洛糖，古洛糖，甘露糖的碳水化合物或其衍生物，葡萄糖，偶氮，半乳糖，罗糖，鼠李糖，二羟基内酯，赤藓酮糖，核酮糖，木酮糖，灵芝蛋白，果糖，山梨糖，塔格糖和其他己糖，肝素，辛酸，纳米，脱衣剂，具有支链的脱氧糖（例如阿糖，链烷烃，冬虫夏草，麦考罗糖和分裂蛋白），其中醛，酮或羟基已经被取代的化合物（例如N-乙酰基，乙酰基，甲基，CH 2 OH的取代基），糖醇，糖酸，苯并咪唑，碳水化合物的烯醇盐，糖精，糖磷酸盐; 其中所述糖生物碱的比例在6:1至1:6之间，并且条件是当糖生物碱为solamargine和solasonine并且它们以1:1的比例存在时，分离出solamargine和solasonine。

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