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1. 发明授权

US06211354B1 Optically active DNA probe having phosphonic diester linkage 有权
标题翻译：具有膦酸二酯键的光学活性DNA探针
公开(公告)号：US06211354B1
公开(公告)日：2001-04-03
申请号：US09305223
申请日：1999-05-05
申请人： Ryuichi Horie , Takahiko Ishiguro
发明人： Ryuichi Horie , Takahiko Ishiguro
IPC分类号： C07H2104
CPC分类号： C07H21/00
摘要： A DNA probe of the following structural formula (1) (wherein P* is an optically active phosphorus atom, each of R1 and R2 is a DNA oligomer having an arbitrary sequence, and R3 is a fluorescent intercalative dye attached via an appropriate linker) which has an optically active configuration about P*.
摘要翻译：以下结构式（1）的DNA探针（其中P *为光学活性磷原子，R1和R2各自为具有任意序列的DNA低聚物，R3为通过适当的连接体连接的荧光插入染料）具有关于P *的光学配置。

2. 发明授权

US5561050A Methods for diagnosis of colon, stomach and pancreatic cancer using antibodies specific for a mucin-type carbohydrate chain 失效
标题翻译：使用特异于粘蛋白型碳水化合物链的抗体诊断结肠癌，胃癌和胰腺癌的方法
公开(公告)号：US5561050A
公开(公告)日：1996-10-01
申请号：US432005
申请日：1995-05-01
申请人： Yong-Suk Chung , Yoshito Yamashita , Michio Sowa , Ryuichi Horie , Takashi Saito , Keiichi Murayama
发明人： Yong-Suk Chung , Yoshito Yamashita , Michio Sowa , Ryuichi Horie , Takashi Saito , Keiichi Murayama
IPC分类号： A61K39/395 , A61K38/00 , A61K45/00 , A61P35/00 , C07K16/30 , G01N33/53 , G01N33/574 , C12N5/20
CPC分类号： C07K16/3046 , C07K16/303 , A61K38/00
摘要： Methods for diagnosis of cancers of digestive organs selected from stomach, colon and pancreatic cancers using antibodies specific for a mucin-type carbohydrate chain of the formula Gal.beta.1--4GlcNAc.beta.1--6GalNAc.alpha.1--1Cer are described.
摘要翻译：使用对公式为Galβ1-4GlcNAcβ1-6GalNAcα1-1Cer的粘蛋白型碳水化合物链特异的抗体来诊断选自胃，结肠和胰腺癌的消化器官的癌症的方法进行了描述。

3. 发明申请

US20090181365A1 NOROVIRUS DETECTION REAGENT 审中-公开
标题翻译：尿毒素检测试剂
公开(公告)号：US20090181365A1
公开(公告)日：2009-07-16
申请号：US12258969
申请日：2008-10-27
申请人： Noriyoshi Masuda , Kiyoshi Yasukawa , Ryuichi Horie
发明人： Noriyoshi Masuda , Kiyoshi Yasukawa , Ryuichi Horie
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6827 , C12Q1/6883
摘要： The present invention provides a combination of oligonucleotides preferable for composing a gene testing reagent capable of detecting all subtypes of norovirus rapidly and with high sensitivity. More specifically, the present invention provides a detection method in which only norovirus is specifically amplified and an oligonucleotide that binds to a specific site of norovirus, by using a primer having a sequence that is homologous or complementary to a base sequence specific for norovirus and is located at a position subject to minimal mutation according to subtype.
摘要翻译：本发明提供了组合可以迅速和高灵敏度地检测诺如病毒的所有亚型的基因检测试剂的寡核苷酸的组合。更具体地说，本发明提供了通过使用具有与诺如病毒特异性的碱基序列同源或互补的序列的引物，并且是特异性扩增诺和病毒的寡核苷酸和与诺罗病毒特异性位点结合的寡核苷酸，位于根据亚型受到最小突变的位置。

4. 发明授权

US07090980B2 Method of detecting acid-fast bacteria using ribosomal RNA as target 有权
标题翻译：使用核糖体RNA作为靶标检测耐酸细菌的方法
公开(公告)号：US07090980B2
公开(公告)日：2006-08-15
申请号：US10737894
申请日：2003-12-18
申请人： Noriyoshi Masuda , Yuichi Isawa , Ryuichi Horie , Kiyoshi Yasukawa
发明人： Noriyoshi Masuda , Yuichi Isawa , Ryuichi Horie , Kiyoshi Yasukawa
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , A61K39/04
CPC分类号： C12Q1/689
摘要： A method of detecting a specific acid-fast bacterium, wherein primers having nucleotide sequences homologous or complementary to the specific regions in the rRNAs of the specific acid-fast bacterium are used to specifically amplify only the rRNAs of the specific acid-fast bacterium.
摘要翻译：检测特异性耐酸细菌的方法，其中使用具有与特异性耐酸细菌的rRNA中的特定区域同源或互补的核苷酸序列的引物仅特异性扩增特异性耐酸细菌的rRNA。

5. 发明申请

US20050112629A1 Detection reagent for thermostable direct hemolysin gene of Vibrio parahaemolyticus 审中-公开
标题翻译：副溶血弧菌热稳定直接溶血素基因检测试剂
公开(公告)号：US20050112629A1
公开(公告)日：2005-05-26
申请号：US10928160
申请日：2004-08-30
申请人： Noriyoshi Masuda , Ryuichi Horie , Kiyoshi Yasukawa
发明人： Noriyoshi Masuda , Ryuichi Horie , Kiyoshi Yasukawa
IPC分类号： C12N15/09 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C12Q1/6865 , Y02A50/451
摘要： A detection reagent for detecting thermostable direct hemolysin (TDH) gene in an amplification process which specifically amplifies TDH RNA, which reagent comprises a first primer having a sequence complementary to a specific sequence of an RNA derived from the TDH gene, and a second primer having a sequence homologous to said specific sequence.
摘要翻译：一种在特异性扩增TDH RNA的扩增过程中检测热稳定性直接溶血素（TDH）基因的检测试剂，该试剂包含具有与衍生自该TDH基因的RNA的特异性序列互补的序列的第一引物，以及具有与所述特异性序列同源的序列。

6. 发明授权

US5991828A System for automatically connecting portable device to network using network environment information including domain name of naming device and community name of network management protocol 失效
标题翻译：使用网络环境信息自动连接便携式设备的系统，包括命名设备的域名和网络管理协议的社区名称
公开(公告)号：US5991828A
公开(公告)日：1999-11-23
申请号：US954994
申请日：1997-10-07
申请人： Ryuichi Horie , Masahito Toriumi
发明人： Ryuichi Horie , Masahito Toriumi
IPC分类号： G06F13/00 , G06F15/16 , G06F15/177 , H04L12/12 , H04L12/24 , H04L12/28 , H04L12/70 , H04L29/12 , G06F13/10 , G06F13/20
CPC分类号： H04L12/24 , H04L29/12216 , H04L29/12311 , H04L29/1232 , H04L41/00 , H04L61/2007 , H04L61/2084 , H04L61/2092 , H04L29/12047 , H04L61/15
摘要： In a method for automatically address information and network environment information in networks mutually connectable to each other under a predetermined protocol network environment, step (a) is to manage, in a setting device connected to one of the networks, address information and network environment information used for each device connected on of the networks to operate under the predetermined protocol network environment. Step (b) sends, from a setting-needed device moved from one of the networks to another network or newly joined to one of the networks, a request message for requesting address information and network environment information to the setting device. Step (c) makes, in the setting device, a correspondence between a device name of the setting-needed device and a network address of the setting-needed device and sending back a reply message to the setting-needed device from the setting device, the reply message in order to send the address information containing the device name and the network address of the setting-needed device and the network environment information. Step (b) stores, in the setting-needed device, the address information and the network environment information sent from the setting device, so that the setting-needed device can operate under the predetermined network environment.
摘要翻译：在用于在预定协议网络环境下自动地相互连接的网络中的信息和网络环境信息的方法中，步骤（a）是在连接到一个网络的设置设备中管理地址信息和网络环境信息用于连接在网络上的每个设备在预定协议网络环境下运行。步骤（b）从设置需要的设备从一个网络移动到另一个网络或新加入到该网络之一的请求消息，向该设置设备发送请求地址信息和网络环境信息的请求消息。步骤（c）在设定装置中，使设置所需设备的设备名称与设置所需设备的网络地址之间的对应关系从设置设备向设置所需设备发送回应消息，回复消息，以便发送包含设备名称和设置所需设备的网络地址的地址信息以及网络环境信息。步骤（b）在所需设备中存储从设置设备发送的地址信息和网络环境信息，使得设置需要的设备可以在预定的网络环境下操作。

7. 发明授权

US07345161B2 Detection reagent for shiga toxin family gene of entero-hemorrhagic Escherichia coli 失效
标题翻译：肠出血性大肠杆菌志贺毒素家族基因检测试剂
公开(公告)号：US07345161B2
公开(公告)日：2008-03-18
申请号：US11048794
申请日：2005-02-03
申请人： Noriyoshi Masuda , Kiyoshi Yasukawa , Ryuichi Horie
发明人： Noriyoshi Masuda , Kiyoshi Yasukawa , Ryuichi Horie
IPC分类号： C07H21/04 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6865
摘要： The present invention provides a combination of oligonucleotides preferable for composing a rapid and specific gene testing reagent for Shiga toxin family gene type 2 (stx) of entero-hemorrhagic Escherichia coli (EHEC). More specifically, the present invention provides a method for detecting stx2 RNA of EHEC by specifically amplifying only stx2 RNA using a primer having a sequence homologous or complementary to a base sequence specific for stx2 gene of EHEC and located at sites free of alterations between genotypes, and an oligonucleotide that binds to a specific site of stx2 RNA.
摘要翻译：本发明提供了用于构成肠出血性大肠杆菌（EHEC）的2型（stx）志贺毒素家族基因的快速特异性基因检测试剂的寡核苷酸组合。更具体地，本发明提供了通过使用具有与EHEC的stx2基因特异性的碱基序列同源或互补的序列的引物特异性扩增stx2 RNA来检测EHEC的stx2RNA的方法，并且位于不具有基因型之间的位点的位点，和与stx2 RNA的特异性位点结合的寡核苷酸。

8. 发明授权

US06586178B1 Nucleic acid probe 有权
标题翻译：核酸探针
公开(公告)号：US06586178B1
公开(公告)日：2003-07-01
申请号：US09519859
申请日：2000-03-06
申请人： Ryuichi Horie , Takahiko Ishiguro , Takumi Tokunaga , Takashi Yamamoto , Juichi Saitoh , Toshitaka Taya
发明人： Ryuichi Horie , Takahiko Ishiguro , Takumi Tokunaga , Takashi Yamamoto , Juichi Saitoh , Toshitaka Taya
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C12Q1/6844 , Y02P20/55 , C12Q2563/173 , C12Q2537/101 , C12Q2525/186
摘要： A nucleic acid probe which is a single-stranded nucleic acid complementary to a specific nucleic acid sequence and is labeled so as to give off a measurable fluorescent signal on hybridization with a nucleic acid containing the specific nucleic acid sequence, wherein the 3′ end of the probe is modified as represented by the following formula (1): wherein R is —COOH, —CONH2, —(CH2)nOH, —CH(OH)—CH2OH, or —CH[(CH2)n—NHR1]—CH2OH, R1 is H, a dye, or an amino protecting group such as Fmoc, and n is an integer of at least 1.
摘要翻译：核酸探针，其是与特定核酸序列互补的单链核酸，并且被标记以便在与含有特定核酸序列的核酸杂交时发出可测量的荧光信号，其中3'末端修饰如下式（1）所示的探针：其中R是-COOH，-CONH 2， - （CH 2）n OH，-CH（OH）-CH 2 OH或-CH [（CH 2）n -NHR 1] -CH 2 OH ，R 1为H，染料或氨基保护基如Fmoc，n为至少1的整数。

9. 发明授权

US07495094B2 Detection reagent for thermostable direct hemolysin-related hemolysin gene of Vibrio parahaemolyticus 失效
标题翻译：副溶血弧菌热稳定性直接溶血素相关溶血素基因检测试剂
公开(公告)号：US07495094B2
公开(公告)日：2009-02-24
申请号：US10928159
申请日：2004-08-30
申请人： Noriyoshi Masuda , Ryuichi Horie , Kiyoshi Yasukawa
发明人： Noriyoshi Masuda , Ryuichi Horie , Kiyoshi Yasukawa
IPC分类号： C07H21/04 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/689 , Y02A50/451
摘要： A detection reagent for detecting thermostable direct hemolysin-related hemolysin (TRH) gene in an amplification process which specifically amplifies TRH1 and TRH2 RNA, which reagent comprises a first primer having a sequence complementary to a specific sequence of an RNA derived from the TRH gene, and a second primer having a sequence homologous to said specific sequence.
摘要翻译：一种用于特异性扩增TRH1和TRH2RNA的扩增过程中检测热稳定性直接溶血素相关溶血素（TRH）基因的检测试剂，该试剂包含具有与衍生自TRH基因的RNA的特异性序列互补的序列的第一引物，和具有与所述特异性序列同源的序列的第二引物。

10. 发明申请

US20060115823A1 Detection reagent for shiga toxin family gene of entero-hemorrhagic escherichia coli 失效
标题翻译：肠出血大肠杆菌志贺毒素家族基因检测试剂
公开(公告)号：US20060115823A1
公开(公告)日：2006-06-01
申请号：US11048794
申请日：2005-02-03
申请人： Noriyoshi Masuda , Kiyoshi Yasukawa , Ryuichi Horie
发明人： Noriyoshi Masuda , Kiyoshi Yasukawa , Ryuichi Horie
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6865
摘要： The present invention provides a combination of oligonucleotides preferable for composing a rapid and specific gene testing reagent for Shiga toxin family gene type 2 (stx) of entero-hemorrhagic Escherichia coli (EHEC). More specifically, the present invention provides a method for detecting stx2 RNA of EHEC by specifically amplifying only stx2 RNA using a primer having a sequence homologous or complementary to a base sequence specific for stx2 gene of EHEC and located at sites free of alterations between genotypes, and an oligonucleotide that binds to a specific site of stx2 RNA.
摘要翻译：本发明提供了用于构成肠出血性大肠杆菌（EHEC）的2型（stx）志贺毒素家族基因的快速特异性基因检测试剂的寡核苷酸组合。更具体地，本发明提供了通过使用具有与EHEC的stx2基因特异性的碱基序列同源或互补的序列的引物特异性扩增stx2 RNA来检测EHEC的stx2RNA的方法，并且位于不具有基因型之间的位点的位点，和与stx2 RNA的特异性位点结合的寡核苷酸。

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