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1. 发明授权

US5955729A Surface plasmon resonance-mass spectrometry 失效
标题翻译：表面等离子体共振质谱
公开(公告)号：US5955729A
公开(公告)日：1999-09-21
申请号：US708341
申请日：1996-09-06
申请人： Randall W. Nelson , Jennifer R. Krone , Russell Granzow , Osten Jansson , Stefan Sjolander
发明人： Randall W. Nelson , Jennifer R. Krone , Russell Granzow , Osten Jansson , Stefan Sjolander
IPC分类号： G01N27/62 , G01N21/27 , G01N21/55 , G01N33/543 , B01D59/44 , H01J49/00
CPC分类号： H01J49/0418 , G01N21/553 , H01J49/164
摘要： The invention provides surface plasmon resonance-mass spectroscopy for the rapid, sensitive and accurate investigation of molecular interactions coupled with the identification and quantification of the same. Methods of the invention include capturing an analyte present within a sample by an interactive surface layer on a real-time interaction analysis sensor, analyzing the analyte by surface plasmon resonance while the analyte is captured by the interactive surface layer, and identifying the captured analyte by desorbing/ionizing the analyte from the interactive surface layer while under vacuum within a mass spectrometer. Devices of the invention include a transparent material, a conductive material capable of supporting surface plasmon resonance affixed to the transparent material, an interactive surface affixed to the conductive material, and a means for exposing the interactive surface to the interior of a mass spectrometer without breaking the vacuum therein.
摘要翻译：本发明提供表面等离子体共振 - 质谱法，用于快速，灵敏和准确地研究分子相互作用以及其鉴定和定量。本发明的方法包括通过实时相互作用分析传感器上的交互表面层捕获样品中存在的分析物，通过表面等离子体共振分析分析物，同时通过交互表面层捕获分析物，并通过在质谱仪内真空下从交互表面层解离/电离分析物。本发明的装置包括透明材料，能够支撑固定在透明材料上的表面等离子体共振的导电材料，固定在导电材料上的相互作用表面，以及用于将相互作用表面暴露于质谱仪内部而不断裂的装置其中的真空。

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