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1. 发明申请

US20070244037A1 Human Chemokine HCC-1 Polypeptides To Improve Stem Cell Transplantation 审中-公开
标题翻译：人趋化因子HCC-1多肽改善干细胞移植
公开(公告)号：US20070244037A1
公开(公告)日：2007-10-18
申请号：US10577053
申请日：2004-10-16
申请人： Rudolf Richter , Reinhard Hen-Schler , Wolf-Georg Forssmann
发明人： Rudolf Richter , Reinhard Hen-Schler , Wolf-Georg Forssmann
IPC分类号： C07K14/52 , A61K38/19 , C07K16/00 , C12N1/00 , C12P21/00
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/523
摘要： The invention discloses the human chemokine HCC-1, N-terminally truncated HCC-1 molecules and glycosylated HCC-1 which improve the homing of stem cells into the -bone marrow during stem cell transplantation. It is also provided a procedure for producing the polypeptides by recombinant techniques or chemical synthesis and for producing antibodies against such polypeptide. Furthermore, it is disclosed the modification of the polypeptide by coupling of amino acid residues and/or chemical groups or deleting amino-acids generating potent derivatives of the polypeptide. Another aspect of the invention provides a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of various associated diseases. The invention concerns also the use of the HCC-1 molecules to increase engraftment of stem cells in the course of the stem cell transplantation performed in stem cell transplantation related diseases.
摘要翻译：本发明公开了人类趋化因子HCC-1，N-末端截短的HCC-1分子和糖基化的HCC-1，其在干细胞移植期间改善了干细胞归巢到骨髓中的归巢。还提供了通过重组技术或化学合成生产多肽并产生针对这种多肽的抗体的方法。此外，公开了通过偶联氨基酸残基和/或化学基团或删除产生多肽的有效衍生物的氨基酸来修饰多肽。本发明的另一方面提供本发明的多肽和合适的药物载体的组合，用于提供治疗有效量的多肽用于治疗各种相关疾病。本发明还涉及在干细胞移植相关疾病中进行的干细胞移植过程中使用HCC-1分子来增加干细胞的移植。

2. 发明授权

US5046926A Control device for a variable displacement hydrostatic machine 失效
标题翻译：可变排量静液压机的控制装置
公开(公告)号：US5046926A
公开(公告)日：1991-09-10
申请号：US559298
申请日：1990-07-30
申请人： Horst Deininger , Gustav Kleineisel , Rudolf Richter
发明人： Horst Deininger , Gustav Kleineisel , Rudolf Richter
IPC分类号： F04B49/08
CPC分类号： F16H61/433 , F04B49/08
摘要： A control device for a variable displacement hydrostatic machine having a stroke-volume regulator which is responsive to an actuating pressure. The control device includes a booster pump. The delivery pressure of the machine is the actuating pressure unless the delivery pressure of the machine is insufficient in which case the actuating pressure is a feed pressure produced by the booster pump. The control device includes a plurality of delivery-pressure lines and a proportioning pressure regulator having an outlet pressure which is proportionally reduced relative to the intake pressure connected between each delivery-pressure line and the stroke-volume regulator.
摘要翻译：一种用于可变排量静液压机器的控制装置，其具有响应于致动压力的行程体积调节器。控制装置包括增压泵。机器的输送压力是致动压力，除非机器的输送压力不足，在这种情况下，致动压力是由增压泵产生的进料压力。控制装置包括多个输送压力管线和比例压力调节器，其具有相对于连接在每个输送压力管线和行程体积调节器之间的进气压力成比例地减小的出口压力。

3. 发明申请

US20080242609A1 Composition for the therapy of diabetes mellitus and adiposity 审中-公开
标题翻译：用于治疗糖尿病和肥胖的组合物
公开(公告)号：US20080242609A1
公开(公告)日：2008-10-02
申请号：US11907623
申请日：2007-10-15
申请人： Wolf Georg Forssmann , Rudolf Richter , Knut Adermann , Markus Meyer
发明人： Wolf Georg Forssmann , Rudolf Richter , Knut Adermann , Markus Meyer
IPC分类号： A61K38/17 , C07K14/47 , A61P3/10
CPC分类号： C07K14/605 , A61K38/00 , A61K38/1709 , A61K45/06 , A61K2300/00
摘要： A composition containing at least two of the following active substances A, B, C, wherein:A=at least one hormone stimulating the production of cAMP;B=at least one substance inhibiting the degradation of a cyclic nucleotide;C=at least one hormone stimulating the production of cGMP.
摘要翻译：含有至少两种以下活性物质A，B，C的组合物，其中：A =至少一种刺激cAMP产生的激素; B =抑制环状核苷酸降解的至少一种物质; C =至少一种刺激cGMP产生的激素。

4. 发明申请

US20070155663A1 Use of chemokine receptor agonists for stem cell transplantation 审中-公开
标题翻译：使用趋化因子受体激动剂进行干细胞移植
公开(公告)号：US20070155663A1
公开(公告)日：2007-07-05
申请号：US10550593
申请日：2004-03-24
申请人： Rudolf Richter , Reinhard Henschler
发明人： Rudolf Richter , Reinhard Henschler
IPC分类号： A61K38/17 , A61N5/00
CPC分类号： A61K31/454 , A61K38/195
摘要： A medicament comprising at least one agonist of receptors selected from the group consisting of the CCR3, CCR6 or CCR8 receptor or combinations thereof and a pharmaceutically acceptable carrier.
摘要翻译：包含至少一种选自CCR3，CCR6或CCR8受体或其组合的受体激动剂的药物和药学上可接受的载体。

5. 发明申请

US20060100145A1 Human chondroosteomodulin (tig2), production, and use for the treatment or diagnosis of bone diseases, cartilage diseases, cartilage diseases, obesity, inflammatory diseases, and skin diseases 审中-公开
标题翻译：人软骨调蛋白（tig2），生产和用于治疗或诊断骨病，软骨疾病，软骨疾病，肥胖症，炎性疾病和皮肤病
公开(公告)号：US20060100145A1
公开(公告)日：2006-05-11
申请号：US10533300
申请日：2003-10-24
申请人： Wolfgang Meder , Martin Wendland , Harald John , Rudolf Richter , Markus Meyer , Wolf-Georg Forssmann
发明人： Wolfgang Meder , Martin Wendland , Harald John , Rudolf Richter , Markus Meyer , Wolf-Georg Forssmann
IPC分类号： A61K38/22 , C40B40/10 , C07K14/575
CPC分类号： C07K14/705 , C07K14/47 , C07K14/51
摘要： The invention relates to the polypeptide COM and its derivatives, and methods for its preparation and recovery in a pure or partially purified form from body fluids and tissues, and its use as a medicament.
摘要翻译：本发明涉及多肽COM及其衍生物及其制备和从体液和组织中纯化或部分纯化形式的回收方法及其作为药物的用途。

6. 发明授权

US6109995A Electrode for a high-pressure discharge lamp, and methods of its manufacture 失效
标题翻译：高压放电灯用电极及其制造方法
公开(公告)号：US6109995A
公开(公告)日：2000-08-29
申请号：US121522
申请日：1998-07-23
申请人： Bernhard Altmann , Rudolf Richter , Klaus Stedele
发明人： Bernhard Altmann , Rudolf Richter , Klaus Stedele
IPC分类号： H01J9/02 , H01J61/073 , H01J9/14
CPC分类号： H01J61/073 , H01J9/02
摘要： The electrode of tungsten material has a cylindrical shaft and a conical tip, in which the conical tip is made essentially by radial deformation, such as hammering or cross-rolling, of the tip portion (9) of the electrode blank (5). This changes the grain structure to be converging. A flat top or plateau (10) can be ground at the very end of the tip.
摘要翻译：钨材料的电极具有圆柱形的轴和锥形尖端，其中锥形尖端主要由电极坯料（5）的尖端部分（9）的径向变形（例如锤击或交叉滚动）制成。这会使晶粒结构变化。平顶或平台（10）可以在尖端的最末端被研磨。

7. 发明授权

US4639195A Power control devices for hydrostatic pumps 失效
标题翻译：静压泵动力控制装置
公开(公告)号：US4639195A
公开(公告)日：1987-01-27
申请号：US687524
申请日：1984-12-28
申请人： Jurgen Norskau , Rudolf Richter
发明人： Jurgen Norskau , Rudolf Richter
IPC分类号： F04B1/32 , F04B1/26
CPC分类号： F04B1/324
摘要： A power control device for an adjustable hydrostatic pump with a lever controlling a control valve piston and a pressure measuring piston loaded with feed pressure acting on said lever to control the pressure feed to a servo piston is provided wherein the pressure measuring piston loaded with feed pressure is mounted in a structural member slidable with the servo piston and slides lengthwise of the lever and the control valve piston is biased by resilient member toward the pressure measuring piston.
摘要翻译：一种用于可调静压泵的动力控制装置，其具有控制控制阀活塞的杆和负载作用在所述杆上的进给压力以控制对伺服活塞的压力进给的压力测量活塞，其中，所述压力测量活塞装载有进给压力安装在可与伺服活塞一起滑动并且沿纵向滑动的结构构件中，并且控制阀活塞被弹性构件朝向压力测量活塞偏压。

8. 发明申请

US20140024585A1 Composition for the therapy of diabetes mellitus and adiposity 审中-公开
标题翻译：用于治疗糖尿病和肥胖的组合物
公开(公告)号：US20140024585A1
公开(公告)日：2014-01-23
申请号：US13084040
申请日：2011-04-11
申请人： Wolf Georg Forssmann , Rudolf Richter , Knut Adermann , Markus Meyer
发明人： Wolf Georg Forssmann , Rudolf Richter , Knut Adermann , Markus Meyer
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , A61K38/1709 , A61K45/06 , A61K2300/00
摘要： A composition containing at least two of the following active substances A, B, C, wherein: A=at least one hormone stimulating the production of cAMP; B=at least one substance inhibiting the degradation of a cyclic nucleotide; C=at least one hormone stimulating the production of cGMP.
摘要翻译：含有至少两种以下活性物质A，B，C的组合物，其中：A =至少一种刺激cAMP产生的激素; B =抑制环状核苷酸降解的至少一种物质; C =至少一种刺激cGMP产生的激素。

9. 发明申请

US20050130891A1 Composition for the therapy of diabetes mellitus and adiposity 审中-公开
标题翻译：用于治疗糖尿病和肥胖的组合物
公开(公告)号：US20050130891A1
公开(公告)日：2005-06-16
申请号：US10844598
申请日：2004-05-13
申请人： Wolf Forssmann , Rudolf Richter , Knut Adermann , Markus Meyer
发明人： Wolf Forssmann , Rudolf Richter , Knut Adermann , Markus Meyer
IPC分类号： A61K45/00 , A61K31/381 , A61K31/4015 , A61K31/4166 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/519 , A61K31/54 , A61K38/00 , A61K38/22 , A61K38/23 , A61K38/26 , A61P3/04 , A61P3/06 , A61P3/10 , C07K14/605 , A61K31/522 , A61K31/675
CPC分类号： C07K14/605 , A61K38/00 , A61K38/1709 , A61K45/06 , A61K2300/00
摘要： A composition containing at least two of the following active substances A, B, C, wherein: A=at least one hormone stimulating the production of cAMP; B=at least one substance inhibiting the degradation of a cyclic nucleotide; C=at least one hormone stimulating the production of cGMP.
摘要翻译：含有至少两种以下活性物质A，B，C的组合物，其中：A =至少一种刺激cAMP产生的激素; B =抑制环状核苷酸降解的至少一种物质; C =至少一种刺激cGMP产生的激素。

10. 发明授权

US4388946A Valves 失效
标题翻译：阀门
公开(公告)号：US4388946A
公开(公告)日：1983-06-21
申请号：US255388
申请日：1981-04-20
申请人： Rudolf Richter , Walter Kropp
发明人： Rudolf Richter , Walter Kropp
IPC分类号： F15B13/04 , F15B11/04 , F15B13/02
CPC分类号： F15B13/04 , Y10T137/86702 , Y10T137/87169 , Y10T137/87241
摘要： A valve is provided, particularly as a part of a block control device, made up of an elongate housing having a longitudinal bore with spaced work chambers, inlet chambers and exhaust chambers intersecting the bore and an elongate cylindrical spool slidable in said bore, having a second bore in each end of said spool, a brake piston movable in each second bore, a pair of restrictor passage means one in said spool and one in said brake piston connecting the interior of said spool with both ends of each bore in the spool on opposite ends of the piston, a pair of spaced transverse passages at each end of the spool communicating with each bore in the spool and spaced to connect a work chamber and pressure fluid chamber at one end of the spool and a work chamber and exhaust chamber at the other end of the spool in a work position, an annular groove in the brake piston capable of connecting said spaced passages within the bore in the spool whereby in said work position pressure fluid flows from a pressure fluid chamber through said transverse passages to a work chamber at one end of the spool, and the pressure fluid from a pressure fluid chamber through said restricting passages to act on the brake piston to move it to position the groove between the passages at the other end of the spool to regulate flow of fluid between the work chamber and exhaust chamber in accordance with the relative pressure in the pressure fluid chamber.
摘要翻译：特别是作为块控制装置的一部分提供了一个阀门，它由具有间隔开的工作室的纵向孔的细长壳体，与孔相交的进气室和排气室以及可在所述孔中滑动的细长柱塞阀芯组成，所述阀芯每端的第二孔，可在每个第二孔中移动的制动活塞，一对限制器通道装置，一个在所述阀芯中，一个在所述制动器活塞中，一个在所述阀芯的内部连接所述阀芯的内部，活塞的相对端，一对间隔开的横向通道，位于阀芯的每个端部处，与阀芯中的每个孔连通并间隔开，以连接阀芯一端的工作室和压力流体室，以及工作室和排气室阀芯的另一端处于工作位置，制动活塞中的环形槽能够连接阀芯内孔内的所述间隔通道，由此在所述工作位置压力流体流动其中压力流体室通过所述横向通道连接到阀芯一端处的工作室，以及来自压力流体室的压力流体通过所述限制通道作用在制动器活塞上以使其移动以将槽定位在通道之间阀芯的另一端根据压力流体室中的相对压力来调节工作室和排气室之间的流体流动。

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