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    • 5. 发明授权
    • Dimerized T-cell receptor fragment, its compositions and use
    • 二聚体T细胞受体片段,其组成和用途
    • US07998926B2
    • 2011-08-16
    • US10478194
    • 2002-05-17
    • John Jacob MarchalonisRonald Ross Watson
    • John Jacob MarchalonisRonald Ross Watson
    • A61K38/10
    • C07K14/7051A61K38/00
    • Dimers of a peptide from the T-cell receptor (Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Gln Thr) (SEQ ID NO:1) are disclosed for preventing the progression to AIDS in an animal model. Methods for delaying the progression to AIDS and restoring normal immunological responses in an animal model following infection are shown and comprise administering through various systemic routes dimeric T-cell receptor peptide Vβ CDR1 to restore normal levels of Th1 cytokines interleukin 2 and interferon-γ, which are suppressed following infection, and those of Th2 derived cytokines interleukin 5, interleukin 6, interleukin 10, and immunoglobulin G, which are stimulated following infection.
    • 公开了来自T细胞受体(Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Gln Thr)的肽的二聚体(SEQ ID NO:1),用于在动物模型中防止进展至AIDS。 显示了在感染后的动物模型中延缓AIDS进展和恢复正常免疫应答的方法,包括通过各种全身途径施用二聚体T细胞受体肽V&bgr; CDR1恢复感染后抑制的Th1细胞因子白细胞介素2和干扰素-γ的正常水平,以及感染后刺激的Th2来源细胞因子白细胞介素5,白细胞介素6,白细胞介素10和免疫球蛋白G的正常水平。