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1. 发明授权

US06330064B1 Doubly-differential interferometer and method for evanescent wave surface detection 有权
标题翻译：双差分干涉仪和ev逝波表面检测方法
公开(公告)号：US06330064B1
公开(公告)日：2001-12-11
申请号：US09780792
申请日：2001-02-09
申请人： Ronald J. Rieder
发明人： Ronald J. Rieder
IPC分类号： G01B902
CPC分类号： G01N21/45 , G01N21/7703 , G01N2021/7779
摘要： A high speed, highly sensitive optical sensing platform and a method for detecting and/or measuring characteristics of a substance in a measurement sample are disclosed. The platform includes at least one pair of optical paths formed in a waveguide, a light source for injecting optical beams along the optical paths, a light modulator for enabling the excitement of a transverse electric and a transverse magnetic guide modes, and a phase detector for detecting phase differences between the beams propagating along the optical paths. One of the optical paths has a target analyte of unknown concentration with a measurement sample bound to its upper surface, while the second optical path has a reference sample containing a known concentration of the target analyte bound to its upper surface. A guided mode modulator causes an optical beam to propagate through the waveguide sequentially as two polarized modes. The highly sensitive platform is especially useful for directly detecting and/or measuring very small numbers of small molecules, bio-molecules, microorganisms in a liquid or gaseous test sample.
摘要翻译：公开了一种用于检测和/或测量测量样品中物质特性的高速，高灵敏度光学感测平台和方法。平台包括形成在波导中的至少一对光路，用于沿着光路注入光束的光源，用于激励横向电导和横向磁导模的光调制器，以及用于检测沿光路传播的光束之间的相位差。光路中的一个具有未知浓度的目标分析物，测量样品与其上表面结合，而第二光路具有包含与其上表面结合的已知浓度的目标分析物的参考样品。引导模式调制器使光束作为两个偏振模式依次传播通过波导。高度敏感的平台对于在液体或气体测试样品中直接检测和/或测量非常少量的小分子，生物分子，微生物特别有用。

2. 发明申请

US20090197243A1 Method and composition for rapid viability testing of cells 有权
标题翻译：细胞快速生存力测试的方法和组成
公开(公告)号：US20090197243A1
公开(公告)日：2009-08-06
申请号：US11664325
申请日：2007-01-11
申请人： Ronald J. Rieder , Boris A. Zavizion
发明人： Ronald J. Rieder , Boris A. Zavizion
IPC分类号： C12Q1/70 , C12Q1/02 , C12Q1/04
CPC分类号： C12Q1/02
摘要： The present invention relates to a method for rapidly monitoring a stress response of a cell to a stressor and determining the magnitude of the stress response; a method for rapidly detecting the presence or absence of a cell by monitoring a stress response of the cell if said cell is present, or the absence of the stress response if said cell is absent or dead; and a method for determining a predictive outcome for the susceptibility of a cell to a selected concentration of a bio-active agent or environmental factor and a level of stress of the cell at the selected concentration of the bio-active agent. Also disclosed are kits for carrying out the methodology according to an embodiment of the invention.
摘要翻译：本发明涉及一种用于快速监测细胞对应激源的应激反应并确定应激反应的大小的方法; 如果所述细胞存在，则通过监测细胞的应激反应或者如果所述细胞不存在或死亡则不存在应激反应，则快速检测细胞的存在或不存在的方法; 以及用于确定细胞对选定浓度的生物活性剂或环境因子的敏感性和细胞在所选浓度的生物活性剂的应激水平的预测结果的方法。还公开了用于实施根据本发明的实施例的方法的套件。

3. 发明授权

US08364409B2 Method and composition for rapid viability testing of cells 有权
公开(公告)号：US08364409B2
公开(公告)日：2013-01-29
申请号：US11664325
申请日：2007-01-11
申请人： Ronald J. Rieder , Boris A. Zavizion
发明人： Ronald J. Rieder , Boris A. Zavizion
IPC分类号： C12Q1/70 , G01N33/48 , G01N27/02
CPC分类号： C12Q1/02
摘要： The present invention relates to a method for rapidly monitoring a stress response of a cell to a stressor and determining the magnitude of the stress response; a method for rapidly detecting the presence or absence of a cell by monitoring a stress response of the cell if said cell is present, or the absence of the stress response if said cell is absent or dead; and a method for determining a predictive outcome for the susceptibility of a cell to a selected concentration of a bio-active agent or environmental factor and a level of stress of the cell at the selected concentration of the bio-active agent. Also disclosed are kits for carrying out the methodology according to an embodiment of the invention.

4. 发明授权

US08318107B2 Apparatus and method for specimen suitability testing 有权
标题翻译：试样适用性试验装置及方法
公开(公告)号：US08318107B2
公开(公告)日：2012-11-27
申请号：US12733519
申请日：2008-08-29
申请人： Ronald J. Rieder , John R. Howatt , Alexander Sloutsky , John Oleksy
发明人： Ronald J. Rieder , John R. Howatt , Alexander Sloutsky , John Oleksy
IPC分类号： G01N33/00
CPC分类号： B01L3/502 , A61B10/0051 , A61B10/0096 , B01L3/5021 , B01L2300/0645 , B01L2400/0409 , B01L2400/0478
摘要： Disclosed herein are a system for collecting a sample and optionally detecting or analyzing an electrical property thereof, the method comprising: means for obtaining a sample in a sample container; means for directing the sample into a sensing chamber in fluid communication with the sample container, the sensing chamber comprising a plurality of sensing chamber electrodes positioned at the sensing chamber and configured to be in contact with the sample when the sample is directed into the sensing chamber; means for applying an electrical signal to the sample with a read-out analyzer via the plurality of sensing chamber electrodes; the plurality of sensing chamber electrodes in operable communication with the read-out analyzer; and means for detecting the effect of the sample on the electrical signal, thereby determining an electrical property of the sample.
摘要翻译：本文公开了一种用于收集样品并任选地检测或分析其电性质的系统，所述方法包括：用于在样品容器中获得样品的装置; 用于将样品引导到与样品容器流体连通的感测室的装置，所述感测室包括位于所述感测室处的多个感测室电极，并且被配置为当所述样品被引导到所述感测室中时与所述样品接触 ; 用于通过所述多个感测室电极用读出分析器向所述样品施加电信号的装置; 所述多个感测室电极与所述读出分析器可操作地通信; 以及用于检测样品对电信号的影响的装置，从而确定样品的电性质。

5. 发明申请

US20110135540A1 APPARATUS AND METHOD FOR SPECIMEN SUITABILITY TESTING 有权
标题翻译：用于样本适用性测试的装置和方法
公开(公告)号：US20110135540A1
公开(公告)日：2011-06-09
申请号：US12733519
申请日：2008-08-29
申请人： Ronald J. Rieder , John R. Howatt , Alexander Sloutsky , John Oleksy
发明人： Ronald J. Rieder , John R. Howatt , Alexander Sloutsky , John Oleksy
IPC分类号： G01N9/30 , G01N27/72 , G01N33/48 , G01R19/00 , G01R27/00
CPC分类号： B01L3/502 , A61B10/0051 , A61B10/0096 , B01L3/5021 , B01L2300/0645 , B01L2400/0409 , B01L2400/0478
摘要： Disclosed herein are a system for collecting a sample and optionally detecting or analyzing an electrical property thereof, the method comprising: means for obtaining a sample in a sample container; means for directing the sample into a sensing chamber in fluid communication with the sample container, the sensing chamber comprising a plurality of sensing chamber electrodes positioned at the sensing chamber and configured to be in contact with the sample when the sample is directed into the sensing chamber; means for applying an electrical signal to the sample with a read-out analyzer via the plurality of sensing chamber electrodes; the plurality of sensing chamber electrodes in operable communication with the read-out analyzer; and means for detecting the effect of the sample on the electrical signal, thereby determining an electrical property of the sample.
摘要翻译：本文公开了一种用于收集样品并任选地检测或分析其电性质的系统，所述方法包括：用于在样品容器中获得样品的装置; 用于将样品引导到与样品容器流体连通的感测室的装置，所述感测室包括位于所述感测室处的多个感测室电极，并且被配置为当所述样品被引导到所述感测室中时与所述样品接触 ; 用于通过所述多个感测室电极用读出分析器向所述样品施加电信号的装置; 所述多个感测室电极与所述读出分析器可操作地通信; 以及用于检测样品对电信号的影响的装置，从而确定样品的电性质。

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