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1. 发明申请

US20130310338A1 Glucans 有权
标题翻译：葡聚糖
公开(公告)号：US20130310338A1
公开(公告)日：2013-11-21
申请号：US13989580
申请日：2011-11-29
申请人： Rolf Engstad , Thor Nøkland
发明人： Rolf Engstad , Thor Nøkland
IPC分类号： A61K31/716 , A61K9/06
CPC分类号： A61K31/716 , A61K9/06 , A61K9/70 , A61K31/00 , C08B37/0024
摘要： The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol and existing in gel form in aqueous solution at a concentration ≧1% at 25° C. and neutral pH and having a melting temperature (gel to sol) of 30 to 44° C. when the glucan is dissolved in water at a concentration of 2%, methods for the production thereof, medical uses thereof, physical supports having the glucan applied thereto or impregnated thereon and in vitro methods of proliferation of skin cells which comprise contacting a population of skin cells with the glucan.
摘要翻译：本发明涉及基于单链的重均摩尔质量为15,000〜50,000g / mol，聚合物的水溶液中的重均摩尔质量为4〜20×10 5 g / mol的葡聚糖，凝胶形式在25℃和浓度为2％时溶解在水中的溶液温度（凝胶至溶胶）为25℃，中性pH为1％的水溶液，其生产方法，其医疗用途，具有施用于其上或浸渍有葡聚糖的物理载体和皮肤细胞增殖的体外方法，其包括使一群皮肤细胞与葡聚糖接触。

2. 发明申请

US20060079481A1 Method of treating/preventing mucositis 审中-公开
标题翻译：治疗/预防粘膜炎的方法
公开(公告)号：US20060079481A1
公开(公告)日：2006-04-13
申请号：US10962314
申请日：2004-10-08
申请人： Rolf Engstad
发明人： Rolf Engstad
IPC分类号： A61K31/716
CPC分类号： A61K31/716
摘要： A method of treating and/or preventing mucositis which is an inflammation and ulceration of the mucous membranes, typically resulting from a toxic reaction to chemotherapy and/or radiotherapy by the application of water soluble immunomodulatory β-glucan.
摘要翻译：一种治疗和/或预防粘膜炎的方法，其是粘膜的炎症和溃疡，通常是通过施用水溶性免疫调节性β-葡聚糖对化学疗法和/或放射疗法的毒性反应引起的。

3. 发明申请

US20130315979A1 Glucan Gels 有权
标题翻译：葡聚糖凝胶
公开(公告)号：US20130315979A1
公开(公告)日：2013-11-28
申请号：US13989594
申请日：2011-11-29
申请人： Rolf Engstad , Stein-Tore Solem , Dag-Eirik Ramsøy
发明人： Rolf Engstad , Stein-Tore Solem , Dag-Eirik Ramsøy
IPC分类号： A61K9/06 , A61L26/00 , A61L15/00 , A61K31/716
CPC分类号： A61K9/06 , A61K9/0014 , A61K31/716 , A61L15/00 , A61L26/0023 , C08B37/0024 , C08J3/075 , C08J2305/00
摘要： The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol and existing in gel form in aqueous solution at a concentration ≧1% at 25° C. and neutral pH and having a melting temperature (gel to sol) of 35 to 60° C. when the glucan is dissolved in water at a concentration of 2%, methods for the production thereof, medical uses thereof, physical supports having the glucan applied thereto or impregnated thereon and in vitro methods of proliferation of skin cells which comprise contacting a population of skin cells with the glucan.
摘要翻译：本发明涉及基于单链的重均摩尔质量为15,000〜50,000g / mol，聚合物的水溶液中的重均摩尔质量为4〜20×10 5 g / mol的葡聚糖，凝胶形式在25℃和中性pH浓度> 1％的水溶液中，当葡聚糖以2％的浓度溶于水中时，其熔融温度（凝胶至溶胶）为35至60℃。其生产方法，其医疗用途，具有施用于其上或浸渍有葡聚糖的物理载体和皮肤细胞增殖的体外方法，其包括使一群皮肤细胞与葡聚糖接触。

4. 发明授权

US08501710B2 Methods of skin treatment and use of water-soluble β-(1,3) glucans as active agents for producing therapeutic skin treatment agents 有权
标题翻译：皮肤处理方法和使用水溶性β-（1,3）葡聚糖作为生产治疗性皮肤治疗剂的活性剂
公开(公告)号：US08501710B2
公开(公告)日：2013-08-06
申请号：US10849417
申请日：2004-05-19
申请人： Rolf Engstad , Rolf Seljelid
发明人： Rolf Engstad , Rolf Seljelid
IPC分类号： A61K31/716 , A61K31/715
CPC分类号： A61K31/716 , A61K8/73 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： A method of treating an ulcer comprising applying to the ulcer a preparation comprising a water-soluble β-(1,3) glucan with β-(1,6) linked side-chains, where the side-chains comprise β-(1,3) linkages or up to four consecutive β-(1,6) linkages as active ingredients.
摘要翻译：一种治疗溃疡的方法，包括向所述溃疡施用包含具有β-（1,6）连接的侧链的水溶性β-（1,3）葡聚糖的制剂，其中所述侧链包含β-（1） 3）连接或最多4个连续的β-（1,6）连接作为活性成分。

5. 发明授权

US08252295B2 Enzyme treatment of glucans 失效
标题翻译：葡聚糖的酶处理
公开(公告)号：US08252295B2
公开(公告)日：2012-08-28
申请号：US12978923
申请日：2010-12-27
申请人： Rolf Engstad , Finn Kortner , Borre Robertsen , Gunnar Rorstad
发明人： Rolf Engstad , Finn Kortner , Borre Robertsen , Gunnar Rorstad
IPC分类号： A61K39/00
CPC分类号： A23G3/42 , A61K39/0208 , A61K2039/521 , A61K2039/55511 , C07H1/00 , C08B37/0024 , C12P19/14
摘要： β-(1-6)-Glucanese treatment of glucan from yeast cells, pure or feed grade, especially yeast from the family Saccharomyces and particularly Saccharomyces cerevisiae, provides a novel glucan product suitable for use in enhancing the stimulation of host animal immune systems. Solubilization of such yeast cell glucan is further disclosed to extend the usefulness of yeast cell glucan as an adjuvant.
摘要翻译：（1-6） - 从酵母细胞，纯的或饲料级的葡聚糖葡聚糖处理，特别是酵母菌，特别是酿酒酵母的酵母，提供了适用于增强宿主动物免疫系统刺激的新型葡聚糖产物。进一步公开了这种酵母细胞葡聚糖的增溶以延长作为佐剂的酵母细胞葡聚糖的有效性。

6. 发明申请

US20050009781A1 Methods of skin treatment and use of water-soluble beta-(1,3) glucans as active agents for producing therapeutic skin treatment agents 有权
标题翻译：皮肤处理方法和使用水溶性β-（1,3）葡聚糖作为生产治疗性皮肤治疗剂的活性剂
公开(公告)号：US20050009781A1
公开(公告)日：2005-01-13
申请号：US10849417
申请日：2004-05-19
申请人： Rolf Engstad , Rolf Seljelid
发明人： Rolf Engstad , Rolf Seljelid
IPC分类号： A61K8/73 , A61Q19/00 , A61Q19/08 , A61K31/715
CPC分类号： A61K31/716 , A61K8/73 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： A method of treating an ulcer comprising applying to the ulcer a preparation comprising a water-soluble β-(1,3) glucan with β-(1,6) linked side-chains, where the side-chains comprise β-(1,3) linkages or up to four consecutive β-(1,6) linkages as active ingredients.
摘要翻译：一种治疗溃疡的方法，包括向所述溃疡施用包含具有β-（1,6）连接的侧链的水溶性β-（1,3）葡聚糖的制剂，其中所述侧链包含β-（1） 3）连接或最多4个连续的β-（1,6）连接作为活性成分。

7. 发明授权

US09956245B2 Glucan compositions 有权
公开(公告)号：US09956245B2
公开(公告)日：2018-05-01
申请号：US13989588
申请日：2011-11-29
申请人： Rolf Engstad , Dag-Eirik Ramsøy , Erik Steene
发明人： Rolf Engstad , Dag-Eirik Ramsøy , Erik Steene
IPC分类号： A61K9/00 , A61K31/716 , C08L5/00 , C08J3/075 , A61K9/06
CPC分类号： A61K31/716 , A61K9/0014 , A61K9/06 , C08J3/075 , C08J2305/00 , C08L5/00 , C08L1/286 , C08L1/28 , C08L1/284 , C08L1/32 , C08L89/06 , C08L5/04 , C08L71/02 , C08L29/04
摘要： The present invention relates to a gel composition comprising a glucan and a gelling agent, said composition having a melting point (gel to sol) above 37° C., as well as to the uses of this composition in therapy, in particular in wound healing.

8. 发明申请

US20110104208A1 Enzyme Treatment of Glucans 失效
标题翻译：葡聚糖的酶处理
公开(公告)号：US20110104208A1
公开(公告)日：2011-05-05
申请号：US12978923
申请日：2010-12-27
申请人： Rolf Engstad , Finn Kortner , Borre Robertsen , Gunnar Rorstad
发明人： Rolf Engstad , Finn Kortner , Borre Robertsen , Gunnar Rorstad
IPC分类号： A61K39/00 , A61K31/715 , A61P37/00
CPC分类号： A23G3/42 , A61K39/0208 , A61K2039/521 , A61K2039/55511 , C07H1/00 , C08B37/0024 , C12P19/14
摘要： β-(1-6)-Glucanese treatment of glucan from yeast cells, pure or feed grade, especially yeast from the family Saccharomyces and particularly Saccharomyces cerevisiae, provides a novel glucan product suitable for use in enhancing the stimulation of host animal immune systems. Solubilization of such yeast cell glucan is further disclosed to extend the usefulness of yeast cell glucan as an adjuvant.
摘要翻译：（1-6） - 从酵母细胞，纯的或饲料级的葡聚糖葡聚糖处理，特别是酵母菌，特别是酿酒酵母的酵母，提供了适用于增强宿主动物免疫系统刺激的新型葡聚糖产物。进一步公开了这种酵母细胞葡聚糖的增溶以延长作为佐剂的酵母细胞葡聚糖的有效性。

9. 发明申请

US20050255565A1 Enzyme treatment of glucans 有权
标题翻译：葡聚糖的酶处理
公开(公告)号：US20050255565A1
公开(公告)日：2005-11-17
申请号：US11093427
申请日：2005-03-30
申请人： Rolf Engstad , Finn Koriner , Borre Robertsen , Gunnar Rorstad
发明人： Rolf Engstad , Finn Koriner , Borre Robertsen , Gunnar Rorstad
IPC分类号： A23K1/16 , C08B37/00 , C12P19/14 , C12P19/16 , C12P19/04 , C12N1/18 , C12N9/24
CPC分类号： A23G3/42 , A61K39/0208 , A61K2039/521 , A61K2039/55511 , C07H1/00 , C08B37/0024 , C12P19/14
摘要： β-(1-6)-Glucanase treatment of glucan from yeast cells, pure or feed grade, especially yeast from the family Saccharomyces and particularly Saccharomyces cerevisiae, provides a novel glucan product suitable for use in enhancing the stimulation of host animal immune systems. Solubilization of such yeast cell glucan is further disclosed to extend the usefulness of yeast cell glucan as an adjuvant.
摘要翻译：来自酵母细胞，纯的或饲料级的葡聚糖的β-葡聚糖酶处理，特别是来源于酵母属，特别是酿酒酵母的酵母，提供了适用于增强宿主动物免疫系统刺激的新型葡聚糖产物。进一步公开了这种酵母细胞葡聚糖的增溶以延长作为佐剂的酵母细胞葡聚糖的有效性。

10. 发明授权

US09623043B2 Glucans 有权
公开(公告)号：US09623043B2
公开(公告)日：2017-04-18
申请号：US13989580
申请日：2011-11-29
申请人： Rolf Engstad , Thor Nøkland
发明人： Rolf Engstad , Thor Nøkland
IPC分类号： C08B37/00 , A61K31/716 , A61K31/00 , A61K9/06
CPC分类号： A61K31/716 , A61K9/06 , A61K9/70 , A61K31/00 , C08B37/0024
摘要： The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol and existing in gel form in aqueous solution at a concentration ≧1% at 25° C. and neutral pH and having a melting temperature (gel to sol) of 30 to 44° C. when the glucan is dissolved in water at a concentration of 2%, methods for the production thereof, medical uses thereof, physical supports having the glucan applied thereto or impregnated thereon and in vitro methods of proliferation of skin cells which comprise contacting a population of skin cells with the glucan.

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