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1. 发明申请

US20190183797A1 BETULIN-CONTAINING WATER-IN-OIL FOAMS AND COMPOSITIONS THEREOF 审中-公开
公开(公告)号：US20190183797A1
公开(公告)日：2019-06-20
申请号：US16318805
申请日：2017-07-18
申请人： Rolf DANIELS , Tobias ZAHN , Amryt Research Limited
发明人： Rolf Daniels , Tobias Zahn
IPC分类号： A61K9/12 , A61K9/107 , A61K36/185 , A61K47/14 , A61K47/44 , A61P17/02
CPC分类号： A61K9/122 , A61K8/046 , A61K8/06 , A61K8/375 , A61K8/922 , A61K8/9789 , A61K9/0014 , A61K9/107 , A61K36/185 , A61K47/06 , A61K47/14 , A61K47/44 , A61P17/02 , A61P31/22 , A61Q19/00
摘要： The present disclosure relates to foams comprising outer birch bard extracts. Stable compositions thereof, as well as methods of producing such foams, and methods of using of such foams are also described herein. The foams of the present disclosure contain triterpenes, which are known to improve wound healing.

2. 发明授权

US09095511B2 Stabilization of oily suspensions comprising hydrophobic silicas 有权
标题翻译：含有疏水二氧化硅的油性悬浮液的稳定化
公开(公告)号：US09095511B2
公开(公告)日：2015-08-04
申请号：US12739873
申请日：2008-11-12
申请人： Iris Heep , Hans-Juergen Hamann , Sabine Koelling , Gert Daube , Klaus-Juergen Steffens , Rolf Daniels
发明人： Iris Heep , Hans-Juergen Hamann , Sabine Koelling , Gert Daube , Klaus-Juergen Steffens , Rolf Daniels
IPC分类号： A61K9/10 , A61K31/44 , A61K31/47 , A61K31/545 , A61K31/7034 , A61K47/10 , A61K47/44 , A61K47/12 , A61K47/26 , A61K45/06 , A61K31/53 , A61K47/02 , A61K47/14
CPC分类号： A61K9/10 , A61K31/44 , A61K31/47 , A61K31/53 , A61K31/545 , A61K31/7034 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/44 , A61K2300/00
摘要： The invention relates to a stabilization of fluid oil-based suspensions comprising a hydrophobic silica, and medicaments based on such suspensions.
摘要翻译：本发明涉及包含疏水性二氧化硅的流体油基悬浮液的稳定化和基于这种悬浮液的药物。

3. 发明申请

US20100316684A1 Surfactant-Free Foam Formulations 审中-公开
标题翻译：无表面活性剂的泡沫配方
公开(公告)号：US20100316684A1
公开(公告)日：2010-12-16
申请号：US12599561
申请日：2008-05-09
申请人： Rolf Daniels
发明人： Rolf Daniels
IPC分类号： A61K8/97 , A61K9/00 , A61K8/02 , A61K9/12 , A61Q17/04 , A61Q19/10 , A61Q19/00 , A61P17/00 , A61K36/736
CPC分类号： A61Q19/00 , A61K8/046 , A61K8/06 , A61K8/062 , A61K8/27 , A61K8/29 , A61K8/731 , A61K9/124 , A61K47/14 , A61K2800/33
摘要： The invention relates to a foam formulation comprising an essentially emulsifier-free emulsion of the oil in water type, comprising an oil phase and a water phase.
摘要翻译：本发明涉及一种泡沫制剂，其包含基本上无乳化剂的水包油型乳液，其包含油相和水相。

4. 发明授权

US09468590B2 Emulsifier-free, polymer-stabilized foam formulations 有权
标题翻译：无乳化剂，聚合物稳定的泡沫配方
公开(公告)号：US09468590B2
公开(公告)日：2016-10-18
申请号：US13514687
申请日：2010-12-10
申请人： Rolf Daniels
发明人： Rolf Daniels
IPC分类号： A61K47/32 , A61K8/81 , A61Q17/04 , C08F226/10 , C08F228/02 , A61K8/04 , A61K8/06 , A61Q19/00 , A61K8/34 , A61K8/36 , A61K8/37
CPC分类号： A61K8/046 , A61K8/062 , A61K8/342 , A61K8/361 , A61K8/37 , A61K8/8147 , A61K8/8158 , A61K8/8182 , A61K2800/33 , A61Q19/00
摘要： The invention relates to a foam formulation comprising a substantially emulsifier-free emulsion of the oil-in-water type, comprising an oil phase and an aqueous phase, the emulsion comprising at least one surface active, ionic polymer with a molecular weight of more than 5000 g/mol, wherein the ionic polymer is a copolymer comprising as monomer units an ionic monomer (M1) and at least one further monomer.
摘要翻译：本发明涉及一种泡沫制剂，其包含基本上不含乳化剂的水包油型乳液，其包含油相和水相，所述乳液包含至少一种分子量大于或等于1的表面活性离子聚合物 5000g / mol，其中离子聚合物是包含作为单体单元的离子单体（M1）和至少一种其它单体的共聚物。

5. 发明申请

US20050276763A1 Emulsion concentrate containing water-soluble and oil-soluble polymers 审中-公开
标题翻译：含有水溶性和油溶性聚合物的乳液浓缩物
公开(公告)号：US20050276763A1
公开(公告)日：2005-12-15
申请号：US11132821
申请日：2005-05-19
申请人： Svenja Pfeifer , Claudia Mundt , Rolf Daniels
发明人： Svenja Pfeifer , Claudia Mundt , Rolf Daniels
IPC分类号： A61K8/06 , A61K8/73 , A61Q1/12 , A61Q17/04 , A61K7/42
CPC分类号： A61K8/062 , A61K8/06 , A61K8/731 , A61K2800/52 , A61Q1/12 , A61Q17/04
摘要： The present invention is the preparation and use of an emulsion concentrate obtainable by drying an oil-in-water emulsion comprising a lipid phase, one or more oil-soluble polymers; an aqueous phase, one or more water-soluble polymers, one or more UV photoprotective filters and optionally further cosmetic or dermatological active ingredients, auxiliaries and additives, to produce a water content of from 0.1 to 20% by weight, based on the total weight of the dried preparation.
摘要翻译：本发明是通过干燥包含脂质相，一种或多种油溶性聚合物的水包油乳液得到的乳液浓缩物的制备和用途; 水相，一种或多种水溶性聚合物，一种或多种UV光保护过滤器和任选的其它化妆品或皮肤病学活性成分，助剂和添加剂，以基于总重量产生0.1至20重量％的水含量的干燥制剂。

6. 发明申请

US20100261688A1 STABILIZATION OF OILY SUSPENSIONS COMPRISING HYDROPHOBIC SILICAS 有权
标题翻译：含有疏水硅的油悬浮液的稳定性
公开(公告)号：US20100261688A1
公开(公告)日：2010-10-14
申请号：US12739873
申请日：2008-11-12
申请人： Iris Heep , Hans-Juergen Hamann , Sabine Koelling , Gert Daube , Klaus-Juergen Steffens , Rolf Daniels
发明人： Iris Heep , Hans-Juergen Hamann , Sabine Koelling , Gert Daube , Klaus-Juergen Steffens , Rolf Daniels
IPC分类号： A61K31/573 , A61K31/496 , A61K31/437 , A61K31/5395 , A61K31/53 , A61P31/00 , A61P33/00
CPC分类号： A61K9/10 , A61K31/44 , A61K31/47 , A61K31/53 , A61K31/545 , A61K31/7034 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/44 , A61K2300/00
摘要： The invention relates to a stabilization of fluid oil-based suspensions comprising a hydrophobic silica, and medicaments based on such suspensions.
摘要翻译：本发明涉及包含疏水性二氧化硅的流体油基悬浮液的稳定化和基于这种悬浮液的药物。

7. 发明申请

US20120244093A1 EMULSIFIER-FREE, POLYMER-STABILIZED FOAM FORMULATIONS 有权
标题翻译：无乳化剂，聚合物稳定的泡沫配方
公开(公告)号：US20120244093A1
公开(公告)日：2012-09-27
申请号：US13514687
申请日：2010-12-10
申请人： Rolf Daniels
发明人： Rolf Daniels
IPC分类号： A61K47/32 , A61Q17/04 , C08F226/10 , A61K8/81 , C08F228/02
CPC分类号： A61K8/046 , A61K8/062 , A61K8/342 , A61K8/361 , A61K8/37 , A61K8/8147 , A61K8/8158 , A61K8/8182 , A61K2800/33 , A61Q19/00
摘要： The invention relates to a foam formulation comprising a substantially emulsifier-free emulsion of the oil-in-water type, comprising an oil phase and an aqueous phase, the emulsion comprising at least one surface active, ionic polymer with a molecular weight of more than 5000 g/mol, wherein the ionic polymer is a copolymer comprising as monomer units an ionic monomer (M1) and at least one further monomer.
摘要翻译：本发明涉及一种泡沫制剂，其包含基本上不含乳化剂的水包油型乳液，其包含油相和水相，所述乳液包含至少一种分子量大于或等于1的表面活性离子聚合物 5000g / mol，其中离子聚合物是包含作为单体单元的离子单体（M1）和至少一种其它单体的共聚物。

8. 发明授权

US07887782B2 Radiotherapeutic formulations containing 224RA and a method for their production 有权
标题翻译：含224RA的放射治疗剂及其制备方法
公开(公告)号：US07887782B2
公开(公告)日：2011-02-15
申请号：US10362049
申请日：2001-08-07
申请人： Uwe Schwarz , Rolf Daniels
发明人： Uwe Schwarz , Rolf Daniels
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/02 , A61K51/121
摘要： The invention relates to novel radiotherapeutic formulations containing 224Ra and methods for their production. The invention discloses, in particular, radiotherapeutic formulations comprising at least one salt of the isotope 224Ra, which are characterized in that the content of other radionuclides, in particular, the respective content of certain longeval radionuclides does not exceed a specific numerical value in mBq/g. The invention also relates to a method for producing radiotherapeutic formulations of this type, which is characterized by the following steps: after at least one centrifugation of an aqueous suspension of the compound 228Th(OH)4 and optionally after the resuspension of the raw sediment obtained in said centrifugation, the precipitated 228Th(OH)4 sediment is separated. The supernatant solution of a 224Ra salt that has been obtained is subsequently subjected to sterile filtration and is then made up to the required dose. Finally, said solution is sterilized and bottled in ampoules in a manner known per se.
摘要翻译：本发明涉及含有224Ra的新型放射治疗剂及其制备方法。本发明特别公开了包含至少一种同位素224Ra盐的放射治疗制剂，其特征在于其它放射性核素的含量，特别是某些长寿放射性核素的含量不超过特定的数值，以mBq / G。本发明还涉及这种类型的放射治疗剂的制备方法，其特征在于以下步骤：在化合物228Th（OH）4的水性悬浮液至少一次离心后，任选地在所得到的沉淀物再悬浮后在离心过程中，析出的沉淀物228Th（OH）4分离。随后将已经获得的224Ra盐的上清液进行无菌过滤，然后使其达到所需剂量。最后，所述溶液以本身已知的方式灭菌并装入安瓿瓶中。

9. 发明申请

US20050266055A1 Low-viscosity cosmetic or dermatological preparations 审中-公开
标题翻译：低粘度化妆品或皮肤病学制剂
公开(公告)号：US20050266055A1
公开(公告)日：2005-12-01
申请号：US11064214
申请日：2005-02-23
申请人： Sabine Stiller , Jens Schulz , Rolf Daniels , Ingo Hahn , Stephanie Fecht , Birgit Groteluschen
发明人： Sabine Stiller , Jens Schulz , Rolf Daniels , Ingo Hahn , Stephanie Fecht , Birgit Groteluschen
IPC分类号： A61K8/06 , A61K8/25 , A61K8/27 , A61K8/29 , A61Q17/04 , A61K9/70 , A61K7/06 , A61K7/11 , A61K7/42
CPC分类号： A61K8/0208 , A61K8/25 , A61K8/27 , A61K8/29 , A61K2800/33 , A61K2800/413 , A61Q17/04
摘要： A low-viscosity Pickering water-in-oil emulsion having a viscosity of less than 3000 mPa·s, comprising (1) an oil phase, (2) a water phase, (3) at least one type of microfine, inorganic metal oxide particles a) having an average particle size of less than 200 nm, b) exhibiting both hydrophilic and also lipophilic properties, c) dispersible both in lipophilic and also in hydrophilic liquids and d) optionally surface-coated, (4) 0.01 to 5% by weight of at least one polymeric nonionic and/or cationic thickener and (5) at most 0.5% by weight of one or more emulsifiers.
摘要翻译：粘度小于3000mPa.s的低粘度Pickering油包水乳液，其包含（1）油相，（2）水相，（3）至少一种类型的微细无机金属氧化物 a）具有小于200nm的平均粒度，b）具有亲水性和亲油性，c）均可分散于亲油性和亲水性液体中，d）任选表面包衣，（4）0.01至5％的至少一种聚合物非离子和/或阳离子增稠剂，和（5）至多0.5重量％的一种或多种乳化剂。

10. 发明授权

US06471971B1 Cellulose-ether-stabilized oil-in-water emulsions as a vehicle for homeopathic and herbal active ingredients 失效
标题翻译：纤维素 - 醚稳定的水包油乳剂作为顺势疗法和草药活性成分的载体
公开(公告)号：US06471971B1
公开(公告)日：2002-10-29
申请号：US09695938
申请日：2000-10-25
申请人： Christian Wollenweber , Rainer Oschmann , Marianne Heger , Rolf Daniels
发明人： Christian Wollenweber , Rainer Oschmann , Marianne Heger , Rolf Daniels
IPC分类号： A61K700
CPC分类号： A61K47/38 , A61K9/0014 , A61K47/10 , A61K47/14 , A61K47/44
摘要： An oil-in-water emulsion preparation comprises oil, water, alcohol, at least one of an homeopathic active ingredient and an herbal active ingredient, and a cellulose ether. A method of preparing an emulsion and a use of the emulsion are also provided.
摘要翻译：水包油乳液制剂包括油，水，醇，顺势疗法活性成分和草药活性成分中的至少一种和纤维素醚。还提供了制备乳液的方法和乳液的使用。

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