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    • 10. 发明授权
    • Method for producing 1-substituted 5-hydroxypyrazoles
    • 1-取代的5-羟基吡唑的制备方法
    • US06472538B1
    • 2002-10-29
    • US09830350
    • 2001-04-25
    • Norbert GötzRoland GötzMichael Rack
    • Norbert GötzRoland GötzMichael Rack
    • C07D23120
    • C07C243/30C07D231/20
    • A process for preparing compounds of the formula I in which R1 is hydrogen, an aliphatic group having 1-8 carbon atoms, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or a cyclic ring system having 3-14 ring atoms, and R2 is hydrogen, an aliphatic group having 1-8 carbon atoms, or R1 and R2 together with the carbon atom to which they are bound form a cyclic or bicyclic ring system having 3-14 ring atoms, comprises the preparation of compounds of the formula II  in which R3 and R4 are readily detachable groups and R1 and R2 are as defined above, as starting materials or intermediates and the cyclization of these under suitable reaction conditions to give compounds of the formula I.
    • 制备式Iin的化合物的方法,其中R 1是氢,具有1-8个碳原子的脂族基团,C 1 -C 6烷氧基羰基,C 1 -C 6烷硫基羰基或具有3-14个环原子的环状体系,R 2是氢 ,具有1-8个碳原子的脂族基团,或R 1和R 2与它们所连接的碳原子一起形成具有3-14个环原子的环状或双环体系,包括制备式II化合物,其中R 3 并且R 4是容易拆分的基团,并且R 1和R 2如上所定义,作为原料或中间体,并在合适的反应条件下环化,得到式I化合物。