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1. 发明授权

US07741110B2 Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches 失效
标题翻译：使用单链，单体，配体依赖多肽开关调节基因表达
公开(公告)号：US07741110B2
公开(公告)日：2010-06-22
申请号：US11280456
申请日：2005-11-15
申请人： Carlos F. Barbas, III , Roger Beerli , Ulrich Schopfer
发明人： Carlos F. Barbas, III , Roger Beerli , Ulrich Schopfer
IPC分类号： C12N15/12 , C12N15/62 , C12N15/63 , C12N5/10 , C07K14/435
CPC分类号： C07K14/72 , C07K14/4702 , C07K14/721 , C07K2319/00 , C12N15/63
摘要： Single chain, monomeric polypeptide gene switches are provided. The gene switches include ligand binding domains and at least one functional domain. Preferred functional domains are DNA binding domains and transcriptional regulating domains. Methods of regulating gene function using the switches are also provided.
摘要翻译：提供单链，单体多肽基因开关。基因切换包括配体结合结构域和至少一个功能结构域。优选的功能结构域是DNA结合结构域和转录调节结构域。还提供了使用开关调节基因功能的方法。

2. 发明授权

US08344111B2 Human monoclonal nicotine specific antibodies 有权
标题翻译：人单克隆尼古丁特异性抗体
公开(公告)号：US08344111B2
公开(公告)日：2013-01-01
申请号：US12745537
申请日：2008-09-11
申请人： Martin Bachmann , Monika Bauer , Roger Beerli , Patrik Maurer
发明人： Martin Bachmann , Monika Bauer , Roger Beerli , Patrik Maurer
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92
摘要： The invention relates to recombinantly produced human monoclonalantibodies which are specifically binding nicotine and to nucleic acids encoding the same. The invention further relates to the use of such antibodies in the treatment of nicotine addiction.
摘要翻译：本发明涉及重组产生的特异性结合尼古丁的人单克隆抗体和编码该烟碱的核酸。本发明还涉及这种抗体在治疗尼古丁成瘾中的用途。

3. 发明授权

US07442784B2 Ligand activated transcriptional regulator proteins 失效
标题翻译：配体活化转录调节蛋白
公开(公告)号：US07442784B2
公开(公告)日：2008-10-28
申请号：US10422934
申请日：2003-04-23
申请人： Carlos F. Barbas, III , Michael Joseph Kadan , Roger Beerli
发明人： Carlos F. Barbas, III , Michael Joseph Kadan , Roger Beerli
IPC分类号： C07H21/04 , C12P21/06 , C12P21/04 , C12N15/00 , C12N5/00 , C12N5/02
CPC分类号： C12N15/63 , A61K48/00 , C07K14/4702 , C07K14/70567 , C07K14/721 , C07K2319/00
摘要： Fusion proteins for use as ligand-dependent transcriptional regulators are provided. The fusion proteins include a nucleotide binding domain operatively linked to a ligand-binding domain. They also can include a transcription regulating domain. The nucleotide binding domain is a zinc-finger peptide that binds to a targeted contiguous nucleotide sequence of from 3 to about 18 nucleotides are provided. The fusion proteins are used for gene therapy. Also provided are polynucleotides encoding the fusion proteins, expression vectors, and transfected cells.
摘要翻译：提供用作配体依赖性转录调节子的融合蛋白。融合蛋白包括可操作地连接到配体结合结构域的核苷酸结合结构域。它们还可以包括转录调节结构域。核苷酸结合结构域是提供与约3至约18个核苷酸的靶向连续核苷酸序列结合的锌指肽。融合蛋白用于基因治疗。还提供了编码融合蛋白，表达载体和转染细胞的多核苷酸。

4. 发明申请

US20110268740A1 FULLY HUMAN INFLUENZA M2 SPECIFIC ANTIBODIES 失效
标题翻译：全人类流感M2特异性抗体
公开(公告)号：US20110268740A1
公开(公告)日：2011-11-03
申请号：US13132658
申请日：2009-11-30
申请人： Martin F. Bachmann , Monika Bauer , Roger Beerli , Nicole Schmitz
发明人： Martin F. Bachmann , Monika Bauer , Roger Beerli , Nicole Schmitz
IPC分类号： A61K39/42 , C07H21/00 , A61P31/16 , C12N1/19 , C12N1/21 , C07K16/10 , C12N5/10
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to human antibodies, preferably to fully human antibodies, which are specifically binding to influenza M2e antigen. The invention further relates to individual light- and/or heavy chains of such antibodies, to nucleic acids encoding said antibodies or their light- and/or heavy chain, and to expression vectors for the expression of said anti-bodies. Furthermore, the invention relates to the use of said antibodies in the treatment and/or prevention of influenza A virus infection, preferably in humans.
摘要翻译：本发明涉及与流感M2e抗原特异性结合的人抗体，优选完全人抗体。本发明还涉及这些抗体的各个轻链和/或重链，编码所述抗体或其轻链和/或重链的核酸，以及用于表达所述抗体的表达载体。此外，本发明涉及所述抗体在治疗和/或预防甲型流感病毒感染中的应用，优选在人类中。

5. 发明申请

US20100292089A1 SELECTION OF HUMAN MONOCLONAL ANTIBODIES BY MAMMALIAN CELL DISPLAY 审中-公开
标题翻译：通过MAMMALIAN细胞显示选择人类单克隆抗体
公开(公告)号：US20100292089A1
公开(公告)日：2010-11-18
申请号：US12312372
申请日：2007-10-26
申请人： Martin F. Bachmann , Monika Bauer , Roger Beerli
发明人： Martin F. Bachmann , Monika Bauer , Roger Beerli
IPC分类号： C40B30/04
CPC分类号： C07K16/00 , C07K16/082 , C07K16/10 , C07K2317/21 , C07K2317/55 , C07K2317/622 , C07K2317/92 , C12N15/1037
摘要： The application provides a method of isolating a eukaryotic cell expressing an antibody of desired specificity, preferably a monoclonal single chain antibody (scFv). The application further provides methods which allow to clone the variable regions of said antibody from that isolated eukaryotic cell and to recombinantly produce antibodies comprising said variable regions as fusion protein with a purification tag, eg. as Fc-fusion, as a Fab fragment, or as whole antibodies, such as IgG, IgE, IgD, IgA and IgM. Said methods also allows to recombinantly produce antibodies with desired specificity in a fully species specific form, preferably as fully human antibodies.
摘要翻译：本申请提供了分离表达具有所需特异性的抗体的真核细胞的方法，优选单克隆单链抗体（scFv）。本申请还提供允许克隆来自该分离的真核细胞的所述抗体的可变区的方法，并重组产生包含所述可变区作为融合蛋白的抗体与纯化标签，例如，作为Fc融合体，Fab片段，或作为完整抗体，例如IgG，IgE，IgD，IgA和IgM。所述方法还允许以完全物种特异性形式重组产生具有所需特异性的抗体，优选作为完全人抗体。

6. 发明申请

US20080318839A1 Ligand activated transcriptional regulator proteins 审中-公开
公开(公告)号：US20080318839A1
公开(公告)日：2008-12-25
申请号：US12220328
申请日：2008-07-22
申请人： Carlos F. Barbas, III , Michael Joseph Kadan , Roger Beerli
发明人： Carlos F. Barbas, III , Michael Joseph Kadan , Roger Beerli
IPC分类号： A61K38/00 , C12N5/06 , C12N9/99 , A61P43/00 , A61K31/7088 , C12N15/87
CPC分类号： C12N15/63 , A61K48/00 , C07K14/4702 , C07K14/70567 , C07K14/721 , C07K2319/00
摘要： Fusion proteins for use as ligand-dependent transcriptional regulators are provided. The fusion proteins include a nucleotide binding domain operatively linked to a ligand-binding domain. They also can include a transcription regulating domain. The nucleotide binding domain is a zinc-finger peptide that binds to a targeted contiguous nucleotide sequence of from 3 to about 18 nucleotides are provided. The fusion proteins are used for gene therapy. Also provided are polynucleotides encoding the fusion proteins, expression vectors, and transfected cells.

7. 发明申请

US20070065408A1 Modified polypeptides for targeting cell-entry of the adenoviruses of subtype b 审中-公开
标题翻译：用于靶向亚型b的腺病毒细胞进入的修饰多肽
公开(公告)号：US20070065408A1
公开(公告)日：2007-03-22
申请号：US10558279
申请日：2004-05-27
申请人： Roger Beerli , Martin Bachmann
发明人： Roger Beerli , Martin Bachmann
IPC分类号： A61K48/00 , C07H21/04 , C12P21/06 , C07K16/30 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00 , C07K16/46 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/43 , C12N15/62
摘要： This invention relates to modified polypeptides comprising two functional components: first, a polypeptide derived from the extracellular region of CD46 as a specific binding site for adenoviruses of the subgroup B, and second, a component capable of binding to a cell surface molecule. Such modified polypeptides are able to direct adenovirus infection specifically to cells having said cell surface molecule on their surface. The invention relates to nucleic acid sequences encoding fusion proteins comprising a) a polypeptide derived from the extracellular domain of CD46 and b) a heterologous polypeptide, methods for the production of the modified polypeptides and suitable recombinant expression vectors and host cells. Pharmaceutical compositions comprising the modified polypeptide of the invention are useful together with recombinant, genetically engineered adenovirus of subtype B for the treatment and prophylaxis of disorders and diseases, like cancer.
摘要翻译：本发明涉及包含两个功能组分的修饰的多肽：首先，衍生自CD46细胞外区域的多肽作为亚组B的腺病毒的特异性结合位点，其次是能够结合细胞表面分子的组分。这种修饰的多肽能够将腺病毒感染特异性地引导到其表面上具有所述细胞表面分子的细胞。本发明涉及编码融合蛋白的核酸序列，其包含a）源自CD46细胞外结构域的多肽和b）异源多肽，产生修饰多肽的方法和合适的重组表达载体和宿主细胞。包含本发明修饰多肽的药物组合物与B型重组基因工程改造的腺病毒一起可用于治疗和预防疾病和疾病如癌症。

8. 发明申请

US20060178502A1 Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches 失效
公开(公告)号：US20060178502A1
公开(公告)日：2006-08-10
申请号：US11280456
申请日：2005-11-15
申请人： Carlos Barbas , Roger Beerli , Ulrich Schopfer
发明人： Carlos Barbas , Roger Beerli , Ulrich Schopfer
IPC分类号： C07K14/72 , C07H21/04 , C12P21/06
CPC分类号： C07K14/72 , C07K14/4702 , C07K14/721 , C07K2319/00 , C12N15/63
摘要： Single chain, monomeric polypeptide gene switches are provided. The gene switches include ligand binding domains and at least one functional domain. Preferred functional domains are DNA binding domains and transcriptional regulating domains. Methods of regulating gene function using the switches are also provided.

9. 发明授权

US07011972B2 Fusion polypeptide comprising two ligand binding domains 失效
标题翻译：融合多肽包含两个配体结合域
公开(公告)号：US07011972B2
公开(公告)日：2006-03-14
申请号：US09908153
申请日：2001-07-18
申请人： Carlos F. Barbas, III , Roger Beerli , Ulrich Schopfer
发明人： Carlos F. Barbas, III , Roger Beerli , Ulrich Schopfer
IPC分类号： C12N5/10 , C12N15/11
CPC分类号： C07K14/72 , C07K14/4702 , C07K14/721 , C07K2319/00 , C12N15/63
摘要： Single chain, monomeric polypeptide gene switches are provided. The gene switches include ligand binding domains and at least one functional domain. Preferred functional domains are DNA binding domains and transcriptional regulating domains. Methods of regulating gene function using the switches are also provided.
摘要翻译：提供单链，单体多肽基因开关。基因切换包括配体结合结构域和至少一个功能结构域。优选的功能结构域是DNA结合结构域和转录调节结构域。还提供了使用开关调节基因功能的方法。

10. 发明授权

US08460670B2 Fully human influenza M2 specific antibodies 失效
标题翻译：全人类流感M2特异性抗体
公开(公告)号：US08460670B2
公开(公告)日：2013-06-11
申请号：US13132658
申请日：2009-11-30
申请人： Martin F. Bachmann , Monika Bauer , Roger Beerli , Nicole Schmitz
发明人： Martin F. Bachmann , Monika Bauer , Roger Beerli , Nicole Schmitz
IPC分类号： A61K39/145 , C12N5/10
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to human antibodies, preferably to fully human antibodies, which are specifically binding to influenza M2e antigen. The invention further relates to individual light- and/or heavy chains of such antibodies, to nucleic acids encoding said antibodies or their light- and/or heavy chain, and to expression vectors for the expression of said anti-bodies. Furthermore, the invention relates to the use of said antibodies in the treatment and/or prevention of influenza A virus infection, preferably in humans.
摘要翻译：本发明涉及与流感M2e抗原特异性结合的人抗体，优选完全人抗体。本发明还涉及这些抗体的各个轻链和/或重链，编码所述抗体或其轻链和/或重链的核酸，以及用于表达所述抗体的表达载体。此外，本发明涉及所述抗体在治疗和/或预防甲型流感病毒感染中的应用，优选在人类中。

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