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    • 5. 发明授权
    • Solid pharmaceutical composition
    • 固体药物组成
    • US5190760A
    • 1993-03-02
    • US887393
    • 1992-05-21
    • Rodney C. Baker
    • Rodney C. Baker
    • A61K9/00
    • A61K9/0068
    • A solid pharmaceutical composition for release of a biologically active substance into a desired aqueous environment, containing a core and an outer layer, said core comprising between 17 and 93% by weight of the biologically active substance, between 0.01 and 7% by weight of a water swellable polymer material and between 0 and 83% of one or more accessory ingredients, relative to the total weight of the core; and the outer layer comprising between 25 and 75% by weight of the biologically active substance, between 25 and 75% by weight of a material for enabling rapid dispersion of the outer layer into the aqueous environment and 0 to 50% by weight of one or more accessory ingredients, relative to the total weight of the outer layer. The composition is preferably formulated as a bolus for veterinary use.
    • 一种用于将生物活性物质释放到含有核心和外层的所需水性环境中的固体药物组合物,所述核心包含17至93重量%的生物活性物质,0.01至7重量% 水溶胀性聚合物材料和相对于芯的总重量的0至83%的一种或多种辅助成分; 并且外层包含25至75重量%的生物活性物质,25至75重量%的用于使外层快速分散到水性环境中的材料和0至50重量%的一种或多种 更多的辅助成分,相对于外层的总重量。 该组合物优选配制成用于兽医用途的药丸。