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1. 发明申请

US20070219162A1 Partially-fluorinated ethers, compositions and uses thereof, for long-term tamponade in the eye 审中-公开
标题翻译：部分氟化醚，其组合物和用途，用于眼睛中的长期填塞
公开(公告)号：US20070219162A1
公开(公告)日：2007-09-20
申请号：US11605688
申请日：2006-11-29
申请人： Janet Sparrow , Stanley Chang , Roderic Simpson
发明人： Janet Sparrow , Stanley Chang , Roderic Simpson
IPC分类号： A61K31/075 , A61K31/02 , A61K31/695
CPC分类号： A61K9/0048 , A61K9/08 , A61K31/02 , A61K31/075 , A61K31/08 , A61K31/695 , A61K47/08 , A61K2300/00
摘要： The present invention provides a single high-purity liquid comprising a partially fluorinated ether liquid for use as a long-term tamponade agent. Compositions are directed to liquid tamponade agents consisting essentially of DFPE, or to agents comprising a soluble mixture of a partially fluorinated ether and either a silicone liquid (or oil) or a perfluorocarbon liquid (or any other liquid or oil that is clear, colorless, inert and has a low specific gravity). Partially fluorinated ethers that have a specific gravity between 1.1 and 1.5 are well suited to rectify the deficiencies of silicone and perfluorocarbon liquids when they are used as tamponade agents. The soluble mixtures of the invention can be designed to have a specific gravity so that they do not have buoyancy problems (density greater than water), yet having a specific gravity that is not so high as to damage the posterior retina from mechanical forces (specific gravity less than 1.6). The mixtures can also be designed to have a specific gravity such that the mixture can act as a tamponade on both the superior and inferior retina simultaneously. The present invention provides such soluble mixtures and also partially fluorinated ether liquids alone, for the use and for the method of postoperative tamponade. Thus, partially fluorinated ether liquids, and mixtures thereof, can be left in the eye postoperatively due to their long-term compatibility with the eye, thereby improving the success of retinal reattachment and healing procedures.
摘要翻译：本发明提供一种单一的高纯度液体，其包含用作长期填塞剂的部分氟化醚液体。组合物涉及基本上由DFPE组成的液体填塞剂，或者涉及包含部分氟化醚和有机硅液体（或油）或全氟化碳液体的可溶性混合物（或透明，无色，惰性且比重低）。具有1.1和1.5之间比重的部分氟化醚非常适用于将硅酮和全氟化碳液体用作填塞剂时的缺点。本发明的可溶性混合物可以被设计成具有比重，使得它们不具有浮力问题（密度大于水），但是具有不高的损害后视网膜的比重（特定的重力小于1.6）。混合物也可以设计成具有比重，使得混合物可以同时用作上下视网膜上的填塞物。本发明提供了这种可溶性混合物和单独的部分氟化醚液体，用于术后填塞的方法和方法。因此，由于其与眼睛的长期相容性，部分氟化的醚液体及其混合物可以在术后留在眼睛中，从而改善视网膜再附着和愈合过程的成功。

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