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1. 发明申请

US20120021007A1 NITRIC OXIDE FUROXAN DERIVATIVE COMPOUNDS ENDOWED WITH ANTITUMORAL ACTIVITY 有权
标题翻译：具有抗肿瘤活性的氮氧化物呋喃酮衍生化合物
公开(公告)号：US20120021007A1
公开(公告)日：2012-01-26
申请号：US13144389
申请日：2010-01-15
申请人： Antonella Viola , Enzo Bronte , Marco Crosetti , Loretta Lazzarato , Roberta Fruttero , Alberto Gasco
发明人： Antonella Viola , Enzo Bronte , Marco Crosetti , Loretta Lazzarato , Roberta Fruttero , Alberto Gasco
IPC分类号： A61K39/39 , C07D498/04 , C07D413/12 , A61P31/00 , A61K31/4439 , A61P35/00 , A61P37/04 , A61P29/00 , C07D271/08 , A61K31/4245
CPC分类号： C07D271/10 , C07D498/04
摘要： The present invention relates to nitric oxide furoxan derivative compounds which showed to be active in the treatment of tumors. In addition, they may be used as adjuvants in cancer immunotherapy.
摘要翻译：本发明涉及在治疗肿瘤方面具有活性的一氧化氮呋喃糖衍生物化合物。此外，它们可以用作癌症免疫治疗中的佐剂。

2. 发明申请

US20130035360A1 NOVEL WATER SOLUBLE FUROXAN DERIVATIVES HAVING ANTITUMOR ACTIVITY 有权
标题翻译：具有抗肿瘤活性的新型水溶性呋喃酮衍生物
公开(公告)号：US20130035360A1
公开(公告)日：2013-02-07
申请号：US13522026
申请日：2011-02-23
申请人： Enzo Bronte , Marco Crosetti , Loretta Lazzarato , Roberta Fruttero , Alberto Gasco , Antonella Viola
发明人： Enzo Bronte , Marco Crosetti , Loretta Lazzarato , Roberta Fruttero , Alberto Gasco , Antonella Viola
IPC分类号： C07D271/08 , A61P31/00 , A61P29/00 , A61K31/4245 , A61P35/00
CPC分类号： C07D271/08 , A61K31/4245
摘要： Water soluble compounds having a furoxan structure which are capable of inhibiting metabolic pathways involved in the development of the tumours are provided. The use of such compounds as a medicament in the therapy of the tumours and as an adjuvant in the immunotherapy protocols against neoplasms is also described.
摘要翻译：提供了能够抑制涉及肿瘤发展的代谢途径的具有呋喃糖结构的水溶性化合物。还描述了这样的化合物作为药物治疗肿瘤和作为抗肿瘤免疫治疗方案中的佐剂的用途。

3. 发明授权

US4671818A Compositions containing heterocyclic compounds and their use as herbicides 失效
标题翻译：含有杂环化合物的组合物及其作为除草剂的用途
公开(公告)号：US4671818A
公开(公告)日：1987-06-09
申请号：US770482
申请日：1985-08-29
申请人： Rosella Calvino , Roberta Fruttero , Vittorio Messori , Francesco Rodio
发明人： Rosella Calvino , Roberta Fruttero , Vittorio Messori , Francesco Rodio
IPC分类号： A01N43/82 , A01N43/832 , A01N53/12 , C07D271/08 , C07D413/12
CPC分类号： C07D413/12 , A01N43/82 , C07D271/08
摘要： Compositions containing heterocyclic compounds are described which include an amide group, can act as herbicides and be defined by the general formula: ##STR1## in which: R is a linear or branched alkyl group containing from 1 to 6 carbon atoms;the phenyl group;a phenyl group having a substituent, or several substituents which may be identical or different from each other, selected from the halogens and alkyl (C.sub.1 -C.sub.4), oxyalkyl (C.sub.1 -C.sub.4), halogenoalkyl (C.sub.1 -C.sub.4) and nitro groups;R.sub.1 is a linear or branched alkyl group containing from 1 to 12 carbon atoms;a linear or branched alkyl group containing from 1 to 12 carbon atoms substituted with one or more halogen atoms;a cycloalkyl group containing from 3 to 8 carbon atoms;a (methyleneoxy)alkyl (C.sub.1 -C.sub.5) group;a (methyleneoxy)phenyl group;a (methyleneoxy)phenyl group having one or more substituents in the ring which are selected from halogen, (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) halogenoalkyl groups;the phenyl group;the benzyl group;a phenyl or benzyl group having one or more substituents, which may be identical or different from each other, selected from halogen atoms and (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) halogenalkyl, (C.sub.1 -C.sub.4) oxyalkyl and nitro groups;or R.sub.1 is definable by: ##STR2## where R' is a (C.sub.1 -C.sub.2) alkylene group and R" and R"' are linear or branched alkyl groups containing from 1 to 5 carbon atoms; or R" and R"' taken together with the nitrogen atom to which they are connected form a 5 or 6 membered heterocyclic ring possibly containing another heteroatom selected from O, N and S.
摘要翻译：描述了含有杂环化合物的组合物，其包括酰胺基团，可以起除草剂的作用，并由通式（I）定义：其中：R为含有1至6个碳原子的直链或支链烷基; 苯基; 具有取代基的苯基或选自卤素和（C1-C4）烷基（C1-C4），卤代烷基（C1-C4）和硝基中的若干个可相同或不同的取代基; R1是含有1至12个碳原子的直链或支链烷基; 含有1至12个被一个或多个卤原子取代的碳原子的直链或支链烷基; 含有3至8个碳原子的环烷基; （亚甲氧基）烷基（C1-C5）基团; （亚甲氧基）苯基; 在环中具有一个或多个选自卤素，（C 1 -C 4）烷基，（C 1 -C 4）卤代烷基的取代基的（亚甲氧基）苯基; 苯基; 苄基; 具有一个或多个选自卤素原子和（C 1 -C 4）烷基，（C 1 -C 4）卤代烷基，（C 1 -C 4）烷氧基和硝基的取代基可以相同或不同的取代基的苯基或苄基; 其中R'为（C 1 -C 2）亚烷基，R“和R”'为含有1至5个碳原子的直链或支链烷基; 或R“和R”与它们所连接的氮原子一起形成可能含有另外选自O，N和S的杂原子的5或6元杂环。

4. 发明申请

US20100210694A1 NEW NO-DONOR ASPIRIN DERIVATIVES 审中-公开
标题翻译：新的NO-DONOR ASPIRIN衍生物
公开(公告)号：US20100210694A1
公开(公告)日：2010-08-19
申请号：US12679594
申请日：2008-09-03
申请人： Roberta Fruttero , Alberto Gasco , Loretta Lazzarato , Monica Donnola , Barbara Rolando , Stefano Biondi
发明人： Roberta Fruttero , Alberto Gasco , Loretta Lazzarato , Monica Donnola , Barbara Rolando , Stefano Biondi
IPC分类号： A61K31/44 , C07C69/76 , A61K31/216 , C07C69/78 , A61P35/00 , A61P29/00 , A61P9/00 , C07D271/08 , A61K31/4245 , C07D213/79
CPC分类号： C07C203/04 , C07C317/44 , C07C323/62 , C07D213/79 , C07D271/08
摘要： The present invention refers to new NO-donors aspirin derivatives, a process for their preparation and pharmaceutical compositions containing them.
摘要翻译：本发明涉及新的供体阿司匹林衍生物，其制备方法和含有它们的药物组合物。

5. 发明申请

US20080293781A1 Salicylic Acid Derivatives 审中-公开
标题翻译：水杨酸衍生物
公开(公告)号：US20080293781A1
公开(公告)日：2008-11-27
申请号：US12094655
申请日：2006-11-14
申请人： Alberto Gasco , Roberta Fruttero , Loretta Lazzarato , Monica Donnola
发明人： Alberto Gasco , Roberta Fruttero , Loretta Lazzarato , Monica Donnola
IPC分类号： A61K31/4245 , A61P35/00 , A61P29/00 , A61P9/00 , A61P25/00 , C07C69/00 , C07D271/08 , A61K31/216
CPC分类号： C07D271/08 , C07C203/00
摘要： The present invention refers to O-acyl salicylic acid derivatives (I) bearing a NO donor moiety, a process for their preparation and pharmaceutical compositions containing them. (I) wherein: D is ONO2 or (A).
摘要翻译：本发明涉及带有NO供体部分的O-酰基水杨酸衍生物（I），其制备方法和含有它们的药物组合物。（I）其中：D是ONO 2或（A）。

6. 发明授权

US08946271B2 Water soluble furoxan derivatives having antitumor activity 有权
标题翻译：具有抗肿瘤活性的水溶性呋喃丹衍生物
公开(公告)号：US08946271B2
公开(公告)日：2015-02-03
申请号：US13522026
申请日：2011-02-23
申请人： Antonella Viola , Enzo Bronte , Marco Crosetti , Loretta Lazzarato , Roberta Fruttero , Alberto Gasco
发明人： Antonella Viola , Enzo Bronte , Marco Crosetti , Loretta Lazzarato , Roberta Fruttero , Alberto Gasco
IPC分类号： C07D271/08 , A61K31/4245
CPC分类号： C07D271/08 , A61K31/4245
摘要： Water soluble compounds having a furoxan structure which are capable of inhibiting metabolic pathways involved in the development of the tumours are provided. The use of such compounds as a medicament in the therapy of the tumours and as an adjuvant in the immunotherapy protocols against neoplasms is also described.
摘要翻译：提供了能够抑制涉及肿瘤发展的代谢途径的具有呋喃糖结构的水溶性化合物。还描述了这样的化合物作为药物治疗肿瘤和作为抗肿瘤免疫治疗方案中的佐剂的用途。

7. 发明授权

US08592464B2 Nitric oxide furoxan derivative compounds endowed with antitumoral activity 有权
标题翻译：一氧化呋喃糖衍生物具有抗肿瘤活性
公开(公告)号：US08592464B2
公开(公告)日：2013-11-26
申请号：US13144389
申请日：2010-01-15
申请人： Antonella Viola , Enzo Bronte , Marco Crosetti , Loretta Lazzarato , Roberta Fruttero , Alberto Gasco
发明人： Antonella Viola , Enzo Bronte , Marco Crosetti , Loretta Lazzarato , Roberta Fruttero , Alberto Gasco
IPC分类号： A61K31/41 , C07D413/00
CPC分类号： C07D271/10 , C07D498/04
摘要： The present invention relates to nitric oxide furoxan derivative compounds which showed to be active in the treatment of tumors. In addition, they may be used as adjuvants in cancer immunotherapy.
摘要翻译：本发明涉及在治疗肿瘤方面具有活性的一氧化氮呋喃糖衍生物化合物。此外，它们可以用作癌症免疫治疗中的佐剂。

8. 发明授权

US4502881A Weed-killing furazan compounds 失效
标题翻译：杂草杀虫呋咱化合物
公开(公告)号：US4502881A
公开(公告)日：1985-03-05
申请号：US593772
申请日：1984-03-27
申请人： Renato Francese , Roberta Fruttero , Vittorio Messori , Anna Peluffo
发明人： Renato Francese , Roberta Fruttero , Vittorio Messori , Anna Peluffo
IPC分类号： A01N47/18 , A01N47/22 , C07D271/08 , A01N43/82
CPC分类号： A01N47/18 , C07D271/08
摘要： The description relates to heterocyclic compounds having weed-killing activity and defined by the following general formula: ##STR1## where R is a straight-chain or branched alkyl group with 1 to 6 carbon atoms or the phenyl group, R.sub.1 is a straight-chain or branched alkyl group with 1 to 10 carbon atoms (substituted if required by halide, or phenyl group), an alkenyl group, an alkynyl group, a cycloalkyl group, or the phenyl group.
摘要翻译：该描述涉及具有除草活性并由以下通式定义的杂环化合物：其中R是具有1至6个碳原子的直链或支链烷基或苯基，R 1是具有1至10个碳原子的直链或支链烷基（如果需要，由卤化物或苯基取代），烯基，炔基，环烷基或苯基。

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