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1. 发明授权

US09149569B2 Treatment of diseases or disorders using placental stem cells 有权
标题翻译：使用胎盘干细胞治疗疾病或病症
公开(公告)号：US09149569B2
公开(公告)日：2015-10-06
申请号：US13108871
申请日：2011-05-16
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： C12N5/071 , A61M1/02 , C12N5/073 , C12N5/0775 , A61K35/12 , A61K48/00
CPC分类号： C12N5/0605 , A01N1/021 , A61K35/12 , A61K35/50 , A61K48/00 , A61K2035/124 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12M29/10 , C12M47/04 , C12N5/0603 , C12N5/0647 , C12N5/0668 , C12N2509/00 , C12N2510/02 , C12N2533/90
摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
摘要翻译：本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

2. 发明申请

US20150239949A1 GENETICALLY MODIFIED MICROORGANISMS 审中-公开
标题翻译：遗传修饰微生物
公开(公告)号：US20150239949A1
公开(公告)日：2015-08-27
申请号：US14557415
申请日：2014-12-01
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： C07K14/495 , A23L1/305
CPC分类号： A61K38/1703 , A23L33/14 , A23L33/17 , A23L33/195 , A23V2002/00 , A23V2200/316 , C07K14/4703 , C07K14/495 , C12C2200/05 , A23V2250/546
摘要： Embodiments of the present invention are generally related to genetically modified microorganisms. More specifically, embodiments of the present invention relate to genetically modified microorganisms having the avian follistatin genome engineered therein to create a microorganism strain having the enhanced properties of follistatin. In accordance with one embodiment of the present invention, a method of treating an individual with a muscle degenerative disease comprises administering an effective amount of avian follistatin, wherein the avian follistatin is derived from a genetically modified microorganism.
摘要翻译：本发明的实施方案通常涉及转基因微生物。更具体地，本发明的实施方案涉及在其中改造的禽类卵泡抑素基因组的遗传修饰的微生物，以产生具有增强的卵泡抑素特性的微生物菌株。根据本发明的一个实施方案，治疗患有肌肉退行性疾病的个体的方法包括施用有效量的禽卵泡抑素，其中禽卵泡抑素衍生自遗传修饰的微生物。

3. 发明授权

US08926964B2 Methods of generating natural killer cells 有权
标题翻译：产生天然杀伤细胞的方法
公开(公告)号：US08926964B2
公开(公告)日：2015-01-06
申请号：US13182250
申请日：2011-07-13
申请人： Robert J. Hariri , Mohammad A. Heidaran , Stephen Jasko , Lin Kang , Eric Law , Ajai Pal , Bhavani Stout , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
发明人： Robert J. Hariri , Mohammad A. Heidaran , Stephen Jasko , Lin Kang , Eric Law , Ajai Pal , Bhavani Stout , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
IPC分类号： A01N63/00 , C12N5/00 , C12N5/0783 , A61K35/12
CPC分类号： C12N5/0646 , A61K35/17 , A61K2035/124 , C12N2500/05 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2501/125 , C12N2501/145 , C12N2501/2302 , C12N2501/2303 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2501/59 , C12N2501/91 , C12N2501/998 , C12N2506/11
摘要： Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the NK cells produced by the method to an individual having the cancer or viral infection.
摘要翻译：本文提供了使用两步膨胀和分化方法生产天然杀伤细胞的方法。本文还提供了抑制肿瘤细胞增殖，治疗患有癌症或病毒感染的个体的方法，包括将通过该方法产生的NK细胞施用于具有癌症或病毒感染的个体。

4. 发明授权

US08889411B2 Modulation of stem and progenitor cell differentiation, assays, and uses thereof 有权
标题翻译：茎和祖细胞分化的调节，测定及其用途
公开(公告)号：US08889411B2
公开(公告)日：2014-11-18
申请号：US12396397
申请日：2009-03-02
申请人： Robert J. Hariri , David I. Stirling , Laure A. Moutouh-De Parseval , Kyle W. H. Chan
发明人： Robert J. Hariri , David I. Stirling , Laure A. Moutouh-De Parseval , Kyle W. H. Chan
IPC分类号： C12N5/00 , C12N5/0789 , C12N5/0784 , C12N5/0787 , A61K35/12
CPC分类号： A61K31/454 , A61K2035/124 , C12N5/0639 , C12N5/0642 , C12N5/0647 , C12N2501/125 , C12N2501/14 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2501/385 , C12N2501/70 , C12N2506/02
摘要： The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
摘要翻译：本发明涉及调节哺乳动物干细胞和祖细胞分化的方法。本发明的方法可用于调节和控制特定细胞和组织谱系中哺乳动物，特别是人干细胞的分化和成熟。本发明的方法涉及某些小有机分子在特定细胞和组织谱系中调节干细胞或祖细胞群的分化的用途，特别是涉及来源于产后胎盘的胚胎样干细胞的分化或用于将早期祖细胞分化成粒细胞谱系。最后，本发明涉及这种分化的干细胞或祖细胞在移植和其他医学治疗中的用途。

5. 发明授权

US08580563B2 Placental stem cells 有权
标题翻译：胎盘干细胞
公开(公告)号：US08580563B2
公开(公告)日：2013-11-12
申请号：US12259259
申请日：2008-10-27
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： C12N5/071 , A01N63/00
CPC分类号： C12N5/0605 , A01N1/021 , A61K35/12 , A61K35/50 , A61K48/00 , A61K2035/124 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12M29/10 , C12M47/04 , C12N5/0603 , C12N5/0647 , C12N5/0668 , C12N2509/00 , C12N2510/02 , C12N2533/90
摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
摘要翻译：本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

6. 发明授权

US08562972B2 Methods and compositions for treatment of bone defects with placental cell populations 有权
标题翻译：用于治疗胎盘细胞群体骨缺损的方法和组合物
公开(公告)号：US08562972B2
公开(公告)日：2013-10-22
申请号：US11877475
申请日：2007-10-23
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Kristen S. Labazzo , Marian Pereira , Sascha Dawn Abramson
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Kristen S. Labazzo , Marian Pereira , Sascha Dawn Abramson
IPC分类号： C12N5/00 , A61K35/50
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/3834 , A61L27/3847 , C12N5/0605 , C12N5/0654 , C12N5/0668 , C12N2500/38 , C12N2500/42 , C12N2501/39 , C12N2506/025 , C12N2506/03 , C12N2533/18 , C12N2533/54
摘要： Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.
摘要翻译：本文提供了使用粘附性胎盘干细胞和胎盘干细胞群的方法，以及培养，增殖和扩增其的方法。本文还提供了区分胎盘干细胞的方法。本文进一步提供了使用胎盘干细胞来配制适于给予受试者的可植入或可注射组合物的方法。本文进一步提供的是用干细胞治疗骨缺损的方法和包含干细胞的组合物。

7. 发明授权

US08460650B2 Treatment of inflammatory diseases using placental stem cells 有权
标题翻译：使用胎盘干细胞治疗炎性疾病
公开(公告)号：US08460650B2
公开(公告)日：2013-06-11
申请号：US12030161
申请日：2008-02-12
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
IPC分类号： A01N65/00
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译：本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。

8. 发明申请

US20130022581A1 PLACENTAL STEM CELL POPULATIONS 有权
公开(公告)号：US20130022581A1
公开(公告)日：2013-01-24
申请号：US13480370
申请日：2012-05-24
申请人： James EDINGER , Qian Ye , Jai-Lun Wang , Robert J. Hariri
发明人： James EDINGER , Qian Ye , Jai-Lun Wang , Robert J. Hariri
IPC分类号： A61K35/50 , A61P7/00 , C12N5/071
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N5/0607 , C12N2500/25 , C12N2500/36 , C12N2500/42 , C12N2501/11 , C12N2501/135 , C12N2501/39 , C12N2533/52 , A61K2300/00
摘要： The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.

9. 发明授权

US08293223B2 Treatment of organ injuries and burns using placental stem cells 有权
标题翻译：使用胎盘干细胞治疗器官损伤和烧伤
公开(公告)号：US08293223B2
公开(公告)日：2012-10-23
申请号：US13251059
申请日：2011-09-30
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： A01N63/00
CPC分类号： C12N5/0605 , A01N1/021 , A61K35/12 , A61K35/50 , A61K48/00 , A61K2035/124 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12M29/10 , C12M47/04 , C12N5/0603 , C12N5/0647 , C12N5/0668 , C12N2509/00 , C12N2510/02 , C12N2533/90
摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
摘要翻译：本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

10. 发明授权

US08202703B2 Placental stem cell populations 有权
标题翻译：胎盘干细胞群体
公开(公告)号：US08202703B2
公开(公告)日：2012-06-19
申请号：US12848007
申请日：2010-07-30
申请人： James Edinger , Qian Ye , Jai-Lun Wang , Robert J. Hariri
发明人： James Edinger , Qian Ye , Jai-Lun Wang , Robert J. Hariri
IPC分类号： C12Q1/02 , C12N5/02
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N5/0607 , C12N2500/25 , C12N2500/36 , C12N2500/42 , C12N2501/11 , C12N2501/135 , C12N2501/39 , C12N2533/52 , A61K2300/00
摘要： The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
摘要翻译：本发明提供胎盘干细胞和胎盘干细胞群体，以及培养，增殖和扩增胎盘干细胞的方法。本发明还提供了分离胎盘干细胞的方法。本发明还提供了在测定和移植中使用胎盘干细胞的方法。

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