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1. 发明申请

US20120107414A1 PHARMACEUTICAL FORMULATIONS AND METHODS FOR TREATING RESPIRATORY TRACT INFECTIONS 审中-公开
标题翻译：药物制剂和治疗呼吸道感染的方法
公开(公告)号：US20120107414A1
公开(公告)日：2012-05-03
申请号：US13259651
申请日：2010-03-26
申请人： Michael M. Lipp , Robert W. Clarke , David L. Hava , Richard Batycky , John Hanrahan
发明人： Michael M. Lipp , Robert W. Clarke , David L. Hava , Richard Batycky , John Hanrahan
IPC分类号： A61K33/42 , A61K33/10 , A61K33/06 , A61K33/00 , A61K33/04 , A61K33/22 , A61K31/19 , A61K31/734 , A61K31/20 , A61K31/191 , A61K31/194 , A61K31/375 , A61K31/192 , A61P31/00 , A61K33/14
CPC分类号： A61K31/19 , A61K9/0078 , A61K31/194 , A61K31/20 , A61K31/734 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/10 , A61K33/14 , A61K33/42 , A61K45/06 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要： The present invention relates to pharmaceutical formulations for treating a respiratory tract infection or a pulmonary disease in an individual, comprising a calcium salt and a sodium salt, wherein the ratio of Ca+2 to Na+ is from about 4:1 (mole:mole) to about 16:1 (mole:mole). The invention also relates to methods of treating (including prophylactically treating) and reducing the spread of a respiratory tract infection, methods of treating (including prophylactically treating) a pulmonary disease or an acute exacerbation of a pulmonary disease, and methods of reducing the spread of an acute exacerbation of a pulmonary disease, comprising administering a pharmaceutical formulation that comprises a calcium salt and a sodium salt.
摘要翻译：本发明涉及用于治疗个体中的呼吸道感染或肺部疾病的药物制剂，其包含钙盐和钠盐，其中Ca + 2与Na +的比例为约4:1（摩尔：摩尔）至约16：1（摩尔：摩尔）。本发明还涉及治疗（包括预防性治疗）和减少呼吸道感染扩散的方法，治疗（包括预防性治疗）肺部疾病或肺部疾病急性加重的方法，以及减少是肺疾病的急性恶化，包括施用包含钙盐和钠盐的药物制剂。

2. 发明申请

US20120070417A1 ANTI-INFLUENZA FORMULATIONS AND METHODS 审中-公开
标题翻译：抗流感制剂和方法
公开(公告)号：US20120070417A1
公开(公告)日：2012-03-22
申请号：US13259659
申请日：2010-03-26
申请人： Richard Batycky , David L. Hava , Robert W. Clarke , Michal M. Lipp
发明人： Richard Batycky , David L. Hava , Robert W. Clarke , Michal M. Lipp
IPC分类号： A61K33/14 , A61K38/21 , A61K31/19 , A61K31/715 , A61P31/16 , A61K31/7105 , A61K31/351 , A61K31/195 , A61K31/245 , A61K38/47 , A61K31/713
CPC分类号： A61K47/183 , A61K9/0075 , A61K9/0078 , A61K9/1617 , A61K9/1694 , A61K31/125 , A61K31/155 , A61K31/196 , A61K31/454 , A61K33/06 , A61K33/14 , A61K45/06 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions that contain a calcium salt as an active ingredient and also comprise another anti-influenza agent, and to methods for treating or preventing influenza virus infection.
摘要翻译：本发明涉及含有钙盐作为活性成分并且还包含另一种抗流感药物的药物组合物，以及用于治疗或预防流感病毒感染的方法。

3. 发明申请

US20130213398A1 DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES 有权
公开(公告)号：US20130213398A1
公开(公告)日：2013-08-22
申请号：US13817963
申请日：2011-08-26
申请人： Michael M. Lipp , Jean C. Sung , Robert W. Clarke , David L. Hava
发明人： Michael M. Lipp , Jean C. Sung , Robert W. Clarke , David L. Hava
IPC分类号： A61K47/02 , A61M15/00
CPC分类号： A61K47/02 , A61K9/0073 , A61K9/0075 , A61K31/137 , A61K31/198 , A61K33/06 , A61K33/14 , A61K47/12 , A61K47/183 , A61K2300/00 , A61M15/00 , B22F3/1125 , B22F5/10 , C22C21/00
摘要： The present invention is directed toward respirable dry particles for delivery of divalent metal cation salts and/or monovalent cation salts to the respiratory tract and methods for treating a subject having a respiratory disease and/or infection.

4. 发明申请

US20130203715A1 USE OF TRP CHANNEL AGONISTS TO TREAT INFECTIONS 审中-公开
标题翻译：使用TRP通道激动剂治疗感染
公开(公告)号：US20130203715A1
公开(公告)日：2013-08-08
申请号：US13810762
申请日：2011-07-20
申请人： David L. Hava , Robert W. Clarke
发明人： David L. Hava , Robert W. Clarke
IPC分类号： A61K31/496 , A61K31/23 , A61K31/495 , A61K31/196 , A61K31/045 , A61K31/05 , A61K31/513 , A61K45/06 , A61K31/357
CPC分类号： A61K31/496 , A61K31/045 , A61K31/05 , A61K31/196 , A61K31/23 , A61K31/235 , A61K31/357 , A61K31/381 , A61K31/495 , A61K31/513 , A61K45/06 , Y02A50/475 , Y02A50/479 , A61K2300/00
摘要： Methods are described for treating or preventing a respiratory infection by administering an effective amount of a TRP channel agonist.
摘要翻译：描述了通过施用有效量的TRP通道激动剂来治疗或预防呼吸道感染的方法。

5. 发明申请

US20130164338A1 TREATMENT OF CYSTIC FIBROSIS USING CALCIUM LACTATE, LEUCINE AND SODIUM CHLORIDE IN A RESPIRAPLE DRY POWDER 审中-公开
标题翻译：使用柠檬酸钙，柠檬酸钠和氯化钠在适应干粉中治疗CYSTIC FISHOSIS
公开(公告)号：US20130164338A1
公开(公告)日：2013-06-27
申请号：US13504279
申请日：2011-08-26
申请人： Michael M. Lipp , Robert W. Clarke , David L. Hava
发明人： Michael M. Lipp , Robert W. Clarke , David L. Hava
IPC分类号： A61K31/225 , A61K31/198 , A61K45/00 , A61K45/06 , A61K31/56 , A61K31/131 , A61K31/439 , A61K33/14 , A61K31/496
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K31/19 , A61K31/198 , A61K31/56 , A61K33/06 , A61K33/14 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： The invention relates to a methods for treating cystic fibrosis, comprising administering an effective amount of a calcium salt formulation to the respiratory tract of an individual with cystic fibrosis. The calcium salt formulation is can be a dry powder formulation.
摘要翻译：本发明涉及一种治疗囊性纤维化的方法，包括向患有囊性纤维化的个体的呼吸道施用有效量的钙盐制剂。钙盐制剂可以是干粉制剂。

6. 发明申请

US20120083531A1 CALCIUM CITRATE AND CALCIUM LACTATE FORMULATIONS FOR ALTERATION OF BIOPHYSICAL PROPERTIES OF MUCOSAL LINING 审中-公开
标题翻译：柠檬酸钙和柠檬酸钙配方用于改变粘膜内衬的生物物理特性
公开(公告)号：US20120083531A1
公开(公告)日：2012-04-05
申请号：US13259666
申请日：2010-03-26
申请人： Robert W. Clarke , Richard Batycky , David L. Hava , Michal M. Lipp
发明人： Robert W. Clarke , Richard Batycky , David L. Hava , Michal M. Lipp
IPC分类号： A61K31/194 , A61P11/00 , A61K31/19 , A61P31/00 , C07C59/08 , C07C59/265
CPC分类号： A61K9/0075 , A61K9/0078 , A61K47/02 , A61K47/12 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to pharmaceutical compositions suitable for inhalation, comprising as an active ingredient calcium lactate or calcium citrate. The invention also relates to methods of treating, preventing, and reducing the spread of an infection of the respiratory tract, comprising administering a pharmaceutical composition that comprises calcium lactate or calcium citrate as an active ingredient.
摘要翻译：本发明涉及适于吸入的药物组合物，其包含乳酸钙或柠檬酸钙作为活性成分。本发明还涉及治疗，预防和减少呼吸道感染扩散的方法，包括给予包含乳酸钙或柠檬酸钙作为活性成分的药物组合物。

7. 发明授权

US4195215A Weldable sealant forms 失效
标题翻译：可焊接密封剂形式
公开(公告)号：US4195215A
公开(公告)日：1980-03-25
申请号：US951047
申请日：1978-10-13
申请人： Robert W. Clarke
发明人： Robert W. Clarke
IPC分类号： B23K11/16 , B23K35/22 , B23P17/00 , B23K11/10
CPC分类号： B23P17/00 , B23K11/163 , B23K35/22
摘要： The specification discloses methods of joining two or more metal members together by combinations of innovative sealants, welding and/or cure heat. More particularly, it relates to methods and materials for improving the sealing, welding, and spacing of metal parts by combining adhesive sealants, fluxes, and metallic beads of discrete shape, size, and composition; and further, by novel organization of such components into weldable seals of simple or complex shape; and further, by magnetically treating such combinations to permit the application of wet or dry forms of the weldable sealant in self-retained-in-place locations while awaiting further assembly operations; and further, to utilize combinations of such components so that they can be handled dry prior to and during joining of the metal parts, with cure initiating as a result of weld heat, completed where necessary in subsequent production stages such as in automotive paint-drying operations.
摘要翻译：本说明书公开了通过创新的密封剂，焊接和/或固化热的组合将两个或更多个金属构件连接在一起的方法。更具体地，本发明涉及通过组合粘合剂密封剂，助熔剂和离散形状，尺寸和组成的金属珠来改善金属部件的密封，焊接和间隔的方法和材料; 此外，通过将这些组件新颖组织成简单或复杂形状的可焊接密封件; 此外，通过磁性处理这样的组合以允许在等待进一步组装操作的同时将可焊接密封剂的湿或干形式应用于自我保留的位置; 并且进一步利用这些组件的组合使得它们可以在金属部件接合之前和期间被处理干燥，并且由于焊接热而导致固化起始，在随后的生产阶段如汽车涂料干燥中必要时完成操作。

8. 发明授权

US3691971A Multiple ply moire textile 失效
标题翻译：多款羊绒纺织品
公开(公告)号：US3691971A
公开(公告)日：1972-09-19
申请号：US3691971D
申请日：1971-06-16
申请人： ROBERT W CLARKE
发明人： CLARKE ROBERT W
IPC分类号： A41D31/00 , B32B7/08
CPC分类号： B32B5/26 , A41D31/00 , B32B7/08 , B32B27/12 , B32B2437/00 , Y10T428/24025 , Y10T428/24033
摘要： The specification discloses a moire textile material for use in making garments in which an under sheet has a grid like pattern thereon and an over sheet is effectively translucent and has a grid like pattern characteristic, the sheets being fastened by basting which can be removed after the cutting and sewing of a garment therefrom, the garment being adapted by virtue of the material to generate motion suggestive moire patterns of an accentuated nature responsive to slight motion of the wearer of the garment.
摘要翻译：该说明书公开了一种用于制造服装的莫尔纺织材料，其中底片具有格子状图案，并且上面的片材有效地是半透明的并且具有格栅状图案特征，该片材通过可以在衣服从其切割和缝合，衣服由于材料而适应以产生响应于衣服佩戴者的轻微运动的突出特征的运动暗示性莫尔图案。

9. 发明申请

US20130281361A1 METHODS OF TREATING AND PREVENTING RHINOVIRUS INFECTION 审中-公开
标题翻译：治疗和预防恶病毒感染的方法
公开(公告)号：US20130281361A1
公开(公告)日：2013-10-24
申请号：US13883912
申请日：2011-11-04
申请人： David L. Hava , Robert W. Clarke
发明人： David L. Hava , Robert W. Clarke
IPC分类号： A61K38/17
CPC分类号： A61K38/1729 , A61K38/17
摘要： The present invention relates to methods of treating or preventing non-enveloped viral infection and/or disease caused by non-enveloped virus infection, particularly a viral infection caused by rhino virus. The methods comprise administering to an individual in need thereof an effective amount of a defensin peptide. The defensin peptide may be selected from α-, β-, or θ-defensins.
摘要翻译：本发明涉及治疗或预防由非包膜病毒感染引起的非包膜病毒感染和/或疾病的方法，特别是由犀病毒引起的病毒感染。所述方法包括向有需要的个体施用有效量的防御素肽。防御素肽可以选自α-，β-或θ-防御素。

10. 发明申请

US20110190096A1 Stretching Apparatus 审中-公开
标题翻译：拉伸装置
公开(公告)号：US20110190096A1
公开(公告)日：2011-08-04
申请号：US12997656
申请日：2009-06-12
申请人： Robert W. Clarke
发明人： Robert W. Clarke
IPC分类号： A63B21/00
CPC分类号： A61H1/0274 , A61H1/0237 , A61H1/0292 , A61H2203/0437 , A63B21/00178 , A63B23/0211 , A63B23/0233 , A63B23/03575 , A63B23/04 , A63B23/085 , A63B2023/006 , A63B2208/0238 , A63B2225/09
摘要： The invention relates to a stretching apparatus which is used to stretch the posterior muscles and tendons by means of powered stretching movements. The apparatus comprises a body (102), a seat area (101) a moveable handle grip (111) and foot pedals (105). In use grips (111) are moved forward whilst the user keeps his or her legs straight. That movement stretches some of the posterior muscles (including the back and buttock muscles). Further movement of the foot pedals 105 toward the user stretches his or her upper and lower leg muscles. The stretching movements could be mechanical, e.g. spring or worm screw actuated, or other power could be used. Electronic control (120) of the apparatus is described.
摘要翻译：本发明涉及一种拉伸装置，其用于通过动力拉伸运动来拉伸后肌肉和肌腱。该装置包括主体（102），座位区域（101），可移动手柄把手（111）和脚踏板（105）。使用手柄（111）向前移动，同时使用者将他或她的双腿保持直线。该运动延伸一些后部肌肉（包括背部和臀部肌肉）。脚踏板105向使用者的进一步运动使他或她的上肢和小腿肌肉伸展。拉伸运动可以是机械的。可以使用弹簧或蜗杆螺杆，或者可以使用其他动力。描述该装置的电子控制（120）。

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