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1. 发明申请

US20140343119A1 4-HYDROXYBUTYRIC ACID ANALOGS 有权
标题翻译： 4-羟基丁酸类似物
公开(公告)号：US20140343119A1
公开(公告)日：2014-11-20
申请号：US14255331
申请日：2014-04-17
申请人： Roger D. Tung , Adam J. Morgan , I. Robert Silverman
发明人： Roger D. Tung , Adam J. Morgan , I. Robert Silverman
IPC分类号： C07C59/125 , A61K45/06 , A61K31/19 , A61K31/225 , C07C69/708 , A61K31/22 , C07C69/675
CPC分类号： C07C59/115 , A61K31/19 , A61K31/22 , A61K31/225 , A61K45/06 , C07B59/001 , C07B2200/05 , C07C59/01 , C07C59/125 , C07C69/67 , C07C69/675 , C07C69/708
摘要： This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
摘要翻译：本发明涉及4-羟基丁酸的新衍生物及其前体药物及其药学上可接受的盐。本发明还提供了包含本发明化合物的药物组合物以及这些组合物在治疗发作性睡病，纤维肌痛，其它障碍或通过改善夜间睡眠或通过施用羟酸钠有益治疗的病症的方法中的用途。

2. 发明授权

US08710072B2 Morphinan compounds 有权
公开(公告)号：US08710072B2
公开(公告)日：2014-04-29
申请号：US13119905
申请日：2009-09-18
申请人： Philip B. Graham , I. Robert Silverman
发明人： Philip B. Graham , I. Robert Silverman
IPC分类号： A61K31/485 , A61P25/04 , A61P25/08 , A61P17/00 , A61P25/14 , A61P29/00 , A61P25/28 , A61P25/00 , A61P27/06 , A61P35/00 , C07D221/28
CPC分类号： A61K31/485 , A61K31/195 , A61K31/4709 , A61K45/06 , C07D221/28
摘要： This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.

3. 发明申请

US20110151431A1 DETECTION OF XENOTROPIC MURINE LEUKEMIA VIRUS 审中-公开
标题翻译：检测XENOTROPIC MURINE LEUKEMIA VIRUS
公开(公告)号：US20110151431A1
公开(公告)日：2011-06-23
申请号：US12818893
申请日：2010-06-18
申请人： Judy A. Mikovits , Vincent Lombardi , Sandra Ruscetti , Francis Ruscetti , Robert Silverman
发明人： Judy A. Mikovits , Vincent Lombardi , Sandra Ruscetti , Francis Ruscetti , Robert Silverman
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , G01N2333/15 , G01N2469/20 , Y02A50/57
摘要： Methods of detecting, diagnosing, monitoring or managing an XMRV-related neuroimmune disease such as chronic fatigue syndrome or XMRV-related lymphoma such as mantle cell lymphoma in a subject are disclosed. These methods comprise determining presence, absence or quantity an XMRV nucleic acid in a sample from a subject.
摘要翻译：公开了检测，诊断，监测或管理XMRV相关神经免疫疾病如慢性疲劳综合征或XMRV相关淋巴瘤（例如套细胞淋巴瘤）的方法。这些方法包括测定来自受试者的样品中XMRV核酸的存在，不存在或数量。

4. 发明申请

US20100137215A1 NOVEL TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES 审中-公开
标题翻译：新四氢-1H-吡咯并[4,3-B]吲哚
公开(公告)号：US20100137215A1
公开(公告)日：2010-06-03
申请号：US12625059
申请日：2009-11-24
申请人： I. Robert Silverman , Craig E. Masse
发明人： I. Robert Silverman , Craig E. Masse
IPC分类号： A61K38/18 , A61K31/55 , A61K31/437 , C07D471/04 , A61P25/28 , A61P25/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/475 , A61K31/55 , A61K45/06
摘要： This invention relates to novel tetrahydro-1H-pyrido[4,3-b]indoles, their derivatives and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by NMDA antagonists, acetylcholinesterase inhibitors, 5-HT6 antagonists, other neuroprotectors, antihistamines and agents that delay age-related pathologies and conditions.
摘要翻译：本发明涉及新的四氢-1H-吡啶并[4,3-b]吲哚及其衍生物及其药学上可接受的盐。本发明还提供了包含本发明化合物和这些组合物在治疗由NMDA拮抗剂，乙酰胆碱酯酶抑制剂，5-HT6拮抗剂，其它神经保护剂，抗组胺剂和延缓衰老的药剂有益治疗的疾病和病症的方法中的用途。相关病理和病情。

5. 发明申请

US20070096456A1 Folders with Entertainment Functionality 审中-公开
标题翻译：具有娱乐功能的文件夹
公开(公告)号：US20070096456A1
公开(公告)日：2007-05-03
申请号：US11534449
申请日：2006-09-22
申请人： Robert Silverman
发明人： Robert Silverman
IPC分类号： B42D3/18
CPC分类号： B42D3/123
摘要： The present invention is directed toward a folder having at least one pocket with entertainment functionality. The outer and inner sides of the front, back and/or divider panels serve as display layers comprising a variety of interactive audio/visual stimuli enabling elements such as picture graphics, illuminated picture sections and/or sound recording or playing systems.
摘要翻译：本发明涉及具有至少一个具有娱乐功能的口袋的文件夹。前，后和/或分隔板的外侧和内侧用作显示层，其包括各种各样的交互式音频/视觉刺激，使得诸如图片图形，照明图像部分和/或声音记录或播放系统的元件。

6. 发明申请

US20060143496A1 System and method for problem resolution in communications networks 失效
标题翻译：通信网络中问题解决的系统和方法
公开(公告)号：US20060143496A1
公开(公告)日：2006-06-29
申请号：US11019454
申请日：2004-12-23
申请人： Robert Silverman
发明人： Robert Silverman
IPC分类号： G06F11/00
CPC分类号： H04L43/08 , G06F11/3495 , H04L41/0663 , H04L41/16 , H04L43/0852 , H04L43/0876 , H04L43/16 , H04Q3/0083
摘要： A system and method is provided for using network asset management data including attributes such as device type, location, and link speed for modeling network performance and identifying performance issues. Functionally complete mathematical characterization of a system may be employed in order to create a system for problem recognition and resolution in which disruptive changes to physical and logical system components are only performed when necessary. Mathematical analysis of pings (or other time stamped traffic) and mathematical analysis of MIB and other asset data may be performed separately and the results compared to “self-check” and form and verify the complete mathematical characterization of a network system. Additionally, the invention may provide projections of performance impacts based upon proposed changes to one or more components in the network. Performance metrics, ping times, MIB data, link speeds, propagation delays, device latency, serialization rates, conversational speeds, conversational utilization and other data are used to model a network for determining or isolating problematic issues and to forecast performance impacts of potential changes to the network.
摘要翻译：提供了一种系统和方法，用于使用网络资产管理数据，包括诸如设备类型，位置和链路速度等属性来建模网络性能并识别性能问题。可以采用系统的功能完整的数学表征，以便创建用于问题识别和解决的系统，其中仅在必要时才进行对物理和逻辑系统组件的破坏性改变。可以分别执行ping（或其他时间戳流量）的数学分析和MIB和其他资产数据的数学分析，并将结果与“自我检查”进行比较，形成和验证网络系统的完整数学表征。另外，本发明可以基于对网络中的一个或多个组件的提出的改变来提供对性能影响的预测。使用性能指标，ping时间，MIB数据，链路速度，传播延迟，设备延迟，序列化速率，会话速度，对话利用率和其他数据来建模网络，以确定或隔离有问题的问题，并预测潜在更改的性能影响网络。

7. 发明申请

US20050269815A1 Elastomeric book cover 有权
标题翻译：弹性书封面
公开(公告)号：US20050269815A1
公开(公告)日：2005-12-08
申请号：US10534448
申请日：2003-11-10
申请人： Robert Silverman
发明人： Robert Silverman
IPC分类号： B42D3/00 , B42D3/04
CPC分类号： B42D3/04
摘要： A book cover (20), which may be formed or molded from an elastomeric polymer material, has pocket portions for receiving the covers (20) of a book (10). The pocket portions may form an elliptically shaped access slot (25) that eases insertion of the covers (20) into the pocket portion. The access slot (25) may be aligned with and parallel to the spine of the book (10) and contain recesses (23) to engage the top and bottom of the spine in a spine locking engagement. The peripheral edges (11) of the book cover, and also the edges (11) of the access slot (25), may be reinforced, such as by thickening the material at these locations, for increased strength. The book cover (20) may have various visual effects or indicia, and may be textured or patterned, which may increase the grip of the hook cover (20).
摘要翻译：可以由弹性聚合物材料形成或模制的书盖（20）具有用于容纳书（10）的盖（20）的口袋部分。口袋部分可以形成椭圆形的进入狭槽（25），其可以使盖子（20）插入口袋部分。进入狭槽25可以与书（10）的脊对准并平行，并且包含凹部（23），以使脊柱的顶部和底部以脊柱锁定接合方式接合。书盖的周边边缘（11）以及进入狭槽（25）的边缘（11）可以被加强，例如通过在这些位置增厚材料以增加强度。书盖（20）可以具有各种视觉效果或标记，并且可以被纹理化或图案化，这可以增加钩盖（20）的抓握力。

8. 发明申请

US20050225073A1 Stretchable fabric book cover and method 有权
标题翻译：可伸缩面料书套和方法
公开(公告)号：US20050225073A1
公开(公告)日：2005-10-13
申请号：US11157006
申请日：2005-06-20
申请人： Robert Silverman
发明人： Robert Silverman
IPC分类号： B42D3/04 , B42D3/00
CPC分类号： B42D3/04 , Y10T83/0448
摘要： A flexible, preferably elastic empanelled book cover (12) that has pocket portions (25) to receive the covers of a book (10) that is inserted therein. The cover (12) consists of a unitary hexagonal sheet of pliable material such as “SPANDEX”, having extended upper and lower edges, with each edge bisected by a slot (32) of predetermined width that extends orthogonally. Fold lines (34, 36 and 38) form a laterally-extended rectangle, with the side fold lines (38) forming the lateral apices of the hexagon two triangular flap portions (20) of the cover pockets. The in-folded upper and lower flap portions of the hexagon are attached to each other and to the triangular side flap portions, to form the pocket portion (25), with lock stitching (27) at the innermost juncture by the spine opening. A central top and bottom fold-over engages the spine of the book in stabilizing relation. The unitary hexagonal blanks can be economically mass produced from roll material (40).
摘要翻译：一种柔性的，优选弹性的带舌状的书盖（12），其具有用于容纳插入其中的书（10）的盖的口袋部分（25）。盖（12）由诸如“SPANDEX”的柔韧材料的整体六边形片组成，具有延伸的上边缘和下边缘，每个边缘由正交延伸的预定宽度的狭槽（32）平分。折叠线（34,36和38）形成横向延伸的矩形，侧折线（38）形成盖口袋的六角形两个三角形折片部分（20）的侧顶部。六边形折叠的上折叠部分和下折片部分彼此附接到三角形侧翼片部分，以形成袋部分（25），锁定缝合（27）通过脊柱开口处于最内侧。中央的顶部和底部折叠在稳定的关系中接合书的书脊。单一的六边形坯料可以经济地从轧辊材料（40）生产。

9. 发明授权

US06411715B1 Methods and apparatus for verifying the cryptographic security of a selected private and public key pair without knowing the private key 失效
标题翻译：用于在不知道私钥的情况下验证所选择的私钥和公钥对的加密安全性的方法和装置
公开(公告)号：US06411715B1
公开(公告)日：2002-06-25
申请号：US09188963
申请日：1998-11-10
申请人： Moses Liskov , Robert Silverman , Ari Juels
发明人： Moses Liskov , Robert Silverman , Ari Juels
IPC分类号： H04L908
CPC分类号： H04L9/3218 , H04L9/002 , H04L9/302 , H04L2209/04 , H04L2209/805
摘要： Methods and apparatus are disclosed for demonstrating that a public/private key pair is cryptographically strong without revealing information sufficient to compromise the private key. A key pair can be shown to be cryptographically strong by demonstrating that its modulus N is the product of two relatively large prime numbers. In addition, a key pair can be shown to be cryptographically strong by demonstrating that N is cryptographically strong against Pollard factoring attacks, Williams factoring attacks, Bach-Shallit factoring attacks, and weighted difference of squares factoring attacks.
摘要翻译：公开了用于示出公共/私人密钥对在密码学上很强而不显露足以危及私钥的信息的方法和装置。通过证明其模数N是两个相对较大素数的乘积，密钥对可以被证明是加密的。此外，通过证明N对波拉德因子分解攻击，威廉姆斯因子分解攻击，巴赫 - 沙利特因子分解攻击以及平方分解攻击的加权差异具有密码学强度，可以显示密钥对密码。

10. 发明申请

US20130012565A1 4-HYDROXYBUTYRIC ACID ANALOGS 有权
公开(公告)号：US20130012565A1
公开(公告)日：2013-01-10
申请号：US13372989
申请日：2012-02-14
申请人： Roger D. Tung , Adam J. Morgan , I. Robert Silverman
发明人： Roger D. Tung , Adam J. Morgan , I. Robert Silverman
IPC分类号： A61K31/225 , C07C69/34 , C07C69/353 , C07C69/40 , C07C69/675 , A61K31/19 , A61K31/222 , A61P25/00 , A61P29/00 , A61P21/00 , A61P25/18 , A61P25/32 , A61P25/16 , A61P25/30 , A61K31/197 , C07C59/01
CPC分类号： C07C59/115 , A61K31/19 , A61K31/22 , A61K31/225 , A61K45/06 , C07B59/001 , C07B2200/05 , C07C59/01 , C07C59/125 , C07C69/67 , C07C69/675 , C07C69/708
摘要： This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.

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