专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100197591A1 4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES 审中-公开
标题翻译： 4-氨基-7,8-二氢吡啶并[4,3-d]嘧啶-5（6H） - 酮衍生物
公开(公告)号：US20100197591A1
公开(公告)日：2010-08-05
申请号：US12697715
申请日：2010-02-01
申请人： Gary E. Aspnes , Robert L. Dow , Michael J. Munchhof
发明人： Gary E. Aspnes , Robert L. Dow , Michael J. Munchhof
IPC分类号： A61K31/519 , C07D471/04 , A61P31/04 , A61P31/10 , A61K31/536 , A61K31/55 , A61K38/16 , A61K31/4985 , A61P3/10
CPC分类号： C07D471/04
摘要： The invention provides compounds of the general Formula (I) where R1, R2, and A are defined herein, as well as the preparation, compositions and uses thereof.
摘要翻译：本发明提供了其中R 1，R 2和A在本文中定义的通式（I）的化合物，以及其制备，组合物和用途。

2. 发明授权

US07247628B2 Cannabinoid receptor ligands and uses thereof 失效
标题翻译：大麻素受体配体及其用途
公开(公告)号：US07247628B2
公开(公告)日：2007-07-24
申请号：US10702149
申请日：2003-11-04
申请人： Robert L. Dow , Marlys Hammond
发明人： Robert L. Dow , Marlys Hammond
IPC分类号： C07D413/04 , C07D231/12 , A61K31/5377 , A61K31/417 , A61K31/415
CPC分类号： C07D231/12 , C07D233/64 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/08
摘要： Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment diseases, conditions and/or disorders herein.
摘要翻译：作为大麻素受体配体的式（I）化合物及其在治疗本文中的疾病，病症和/或病症中的用途。

3. 发明授权

US06699893B2 Glucocorticoid receptor modulators 有权
标题翻译：糖皮质激素受体调节剂
公开(公告)号：US06699893B2
公开(公告)日：2004-03-02
申请号：US10080174
申请日：2002-02-19
申请人： Robert L. Dow , Kevin K. Liu , Bradley P. Morgan , Andrew G. Swick
发明人： Robert L. Dow , Kevin K. Liu , Bradley P. Morgan , Andrew G. Swick
IPC分类号： C07D21302
CPC分类号： C07D455/06 , C07C49/747 , C07C49/755 , C07C69/76 , C07C215/74 , C07C235/66 , C07C251/44 , C07C251/52 , C07C251/60 , C07C255/53 , C07C255/54 , C07C271/44 , C07C271/52 , C07C281/04 , C07C307/02 , C07C309/65 , C07C309/66 , C07C309/73 , C07C311/04 , C07C311/08 , C07C311/51 , C07C317/18 , C07C333/04 , C07C2603/00 , C07C2603/26 , C07D207/09 , C07D211/46 , C07D213/22 , C07D213/30 , C07D213/40 , C07D213/75 , C07D231/40 , C07D231/56 , C07D239/34 , C07D241/18 , C07D241/20 , C07D249/08 , C07D249/14 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/24 , C07D277/28 , C07D277/56 , C07D295/088 , C07D295/13 , C07D295/185 , C07D295/205 , C07D303/14 , C07D317/36 , C07D333/16 , C07D413/04
摘要： The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.
摘要翻译：本发明提供了类固醇受体的选择性调节剂（即激动剂和拮抗剂），特别是糖皮质激素受体的式I的非类固醇化合物。本发明还提供含有这些化合物的药物组合物和使用这些化合物治疗需要糖皮质激素受体激动剂或拮抗剂治疗的动物的方法。糖皮质激素受体调节剂可用于治疗如下所述的疾病，例如肥胖，糖尿病，炎症等。本发明还提供了制备这些化合物的中间体和方法。

4. 发明授权

US06670480B2 Process for preparing substituted pyridines 失效
标题翻译：制备取代吡啶的方法
公开(公告)号：US06670480B2
公开(公告)日：2003-12-30
申请号：US10317720
申请日：2002-12-12
申请人： Robert L. Dow , Steven R. Schneider
发明人： Robert L. Dow , Steven R. Schneider
IPC分类号： C07D21300
CPC分类号： C07F7/1892 , C07F7/1804 , C07F7/188 , Y02P20/55
摘要： A process for preparing a compound of the formula wherein n, R1, R2, R3 and X are as defined above, used as an intermediate in the synthesis of &bgr;-adrenergic receptor agonists.
摘要翻译：制备n，R 1，R 2，R 3和X的化合物的方法如上所定义，用作β-肾上腺素能受体激动剂的合成中的中间体。

5. 发明授权

US06657063B1 Combinations of &bgr;3 agonists and growth hormone secretagogues 失效
标题翻译： β3激动剂和生长激素促分泌素的组合
公开(公告)号：US06657063B1
公开(公告)日：2003-12-02
申请号：US09649622
申请日：2000-08-28
申请人： Robert L. Dow
发明人： Robert L. Dow
IPC分类号： C07D21300
CPC分类号： C07D213/73 , C07D487/04
摘要： This invention is directed to pharmaceutical compositions comprising &bgr;3 adrenergic agonists including (4-(2-(2-(6-aminopyridin-3-yl)-2(R)-hydroxyethylamino)ethoxy)phenyl)acetic acid and growth hormone or growth hormone secretagogues, prodrugs thereof or pharmaceutically acceptable salts of said compounds or said prodrugs. The invention is also directed to methods of using those compositions in the treatment of obesity, diabetes, hypertension and frailty in animals and particularly in humans.
摘要翻译：本发明涉及包含β3肾上腺素能激动剂的药物组合物，其包括（4-（2-（2-（6-氨基吡啶-3-基）-2（R） - 羟乙基氨基）乙氧基）苯基）乙酸和生长激素或生长激素促分泌素，前药或所述化合物或所述前药的药学上可接受的盐。本发明还涉及使用这些组合物治疗肥胖症，糖尿病，高血压和动物，特别是人体虚弱的方法。

6. 发明授权

US06194454B1 Cyano containing oxamic acids and derivatives as thyroid receptor ligands 失效
标题翻译：含有恶唑酸和衍生物的氰基甲酸受体配体
公开(公告)号：US06194454B1
公开(公告)日：2001-02-27
申请号：US09514696
申请日：2000-02-28
申请人： Robert L. Dow
发明人： Robert L. Dow
IPC分类号： A61K31275
CPC分类号： C07C255/60 , A61K31/275 , A61K31/00 , A61K2300/00
摘要： The present invention provides novel compounds of the Formula and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R1-R8 and X are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, hyperlipidemia, thyroid disease, hypothyroidism and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression and osteoporosis are also provided.
摘要翻译：本发明提供了新的式及其前药化合物，其几何和旋光异构体，以及这些化合物，前药和异构体的药学上可接受的盐，其中R 1 -R 8和X如本文所述。含有这些化合物，前体药物，异构体或其药学上可接受的盐的药物组合物，以及用于治疗肥胖，高脂血症，甲状腺疾病，甲状腺机能减退和相关疾病以及疾病如糖尿病，动脉粥样硬化，高血压，冠心病，还提供高胆固醇血症，抑郁症和骨质疏松症。

7. 发明授权

US5279225A Attenuator for protecting an electroexplosive device from inadvertent RF energy or electrostatic energy induced firing 失效
标题翻译：用于保护防爆装置的衰减器免于无意的RF能量或静电能量引发的烧制
公开(公告)号：US5279225A
公开(公告)日：1994-01-18
申请号：US584045
申请日：1990-09-18
申请人： Robert L. Dow , Paul W. Proctor
发明人： Robert L. Dow , Paul W. Proctor
IPC分类号： A61N1/37 , F42B3/188 , F42B3/18
CPC分类号： F42B3/188 , A61N1/37
摘要： A device for preventing an electroexplosive device from inadvertent RF energy or electrostatic energy induced firing, even if that device is exposed to high RF power levels or high RF frequencies or to high electrostatic potentials, includes an impedance element in the firing input line between a source of dc power and a bridgewire which has an impedance that exceeds an impedance between the input leads and ground. When RF energy levels and frequencies exceed certain values, arcing occurs between one input lead and the other or between the input leads and a conductive case to cause energy to flow to the conductive case instead of to the bridgewire. One form of the device includes a Ferrite element in electrical and thermal contact with both of the firing input leads and with the thermally and electrically conductive case. The Ferrite element has a dc resistance in excess of the dc resistance of the bridgewire so short circuiting the firing current does not occur.
摘要翻译：即使该设备暴露于高RF功率电平或高RF频率或高静电电势，用于防止电气爆炸装置无意中的RF能量或静电能量引发的装置包括在源之间的点火输入线路中的阻抗元件的直流电源和桥接器，其阻抗超过输入引线和地之间的阻抗。当射频能量水平和频率超过某些值时，在一个输入引线和另一个输入引线之间或输入引线与导电壳体之间产生电弧，导致能量流向导电外壳而不是桥梁。该装置的一种形式包括与两个触发输入引线以及导电和导电的壳体电气和热接触的铁氧体元件。铁氧体元件的直流电阻超过桥梁的直流电阻，因此不会发生触发电流的短路。

8. 发明授权

US5197468A Device for protecting an electronic prosthesis from adverse effects of RF and/or electrostatic energy 失效
标题翻译：用于保护电子假体免受RF和/或静电能量的不利影响的装置
公开(公告)号：US5197468A
公开(公告)日：1993-03-30
申请号：US888870
申请日：1992-05-27
申请人： Paul W. Proctor , Robert L. Dow
发明人： Paul W. Proctor , Robert L. Dow
IPC分类号： A61N1/37
CPC分类号： A61N1/37 , A61N1/3718
摘要： An implantable prosthesis, such as an artificial cardiac pacer, or the like, is protected from misoperation caused by RF energy and/or electrostatic energy incident thereon by a protective device attached to the lead wire connecting the device to tissue stimulating electrodes or other such electrodes mounted in a patient. The protective device is the device disclosed in U.S. patent application Ser. Nos. 07/794,125, 07/584,045 and 07/866,512. The protective device includes a Ferrite body electrically and thermally connected to the lead wire and to a ground element, such as the housing for the prosthetic device. The Ferrite body, in conjunction with the lead and the ground element, has an impedance that exceeds the impedance established between the lead wire and ground when the device is exposed to RF energy.
摘要翻译：可植入假体（例如人造心脏起搏器等）被保护免于由附接到连接到组织刺激电极或其它这样的电极的引线的保护装置入射在其上的RF能量和/或静电能量引起的误操作安装在病人身上。保护装置是美国专利申请序列号第07 / 794,125号，07 / 584,045号和07 / 866,512号。保护装置包括铁氧体，其电导体和热连接到引线和接地元件，例如用于假体装置的壳体。当器件暴露于RF能量时，铁氧体与引线和接地元件一起具有超过引线与接地之间建立的阻抗的阻抗。

9. 发明授权

US5115633A Compact high-energy auxiliary power method and means 失效
标题翻译：紧凑型高能辅助电源的方法和手段
公开(公告)号：US5115633A
公开(公告)日：1992-05-26
申请号：US702298
申请日：1984-12-06
申请人： David B. Priser , Robert L. Dow
发明人： David B. Priser , Robert L. Dow
IPC分类号： F02B3/06 , F02C6/04 , F02C7/277
CPC分类号： F02C6/04 , F02C7/277 , F02B3/06 , F05D2200/15 , Y02T50/671
摘要： A low-cost, lightweight mobile gas turbine capable of rotating in excess ofne hundred thousand RPM is coupled to a centrifugal air compressor which supplies high volume airflow to a diesel fueled combustion chamber for supplying hot gas to the turbine. Three energy outputs are obtained in the form of pressurized airflow, hot gas flow and large volumes of directed ambient air. The hardware components are essentially state-of-the-art, but their combination for use in multi-purpose military combat operations has not heretofore been known. Such uses include smoke generation, dissemination of infre-red and radar absorbant clouds, decontamination of large masses, hot water supply and air pressure source for mechanics tool operation.
摘要翻译：能够旋转超过十万RPM的低成本，重量轻的移动式燃气轮机与离心式空气压缩机相连，该离心式空气压缩机向柴油燃料燃烧室提供高体积气流，以向涡轮机供应热气。以加压气流，热气流和大量定向环境空气的形式获得三个能量输出。硬件组件基本上是最先进的，但是它们在多用途军事作战中的组合迄今为止还没有被公认。这种用途包括烟雾产生，红外和雷达吸收云的传播，大质量的净化，热水供应和力学工具操作的气压源。

10. 发明授权

US5036768A Attenuator for dissipating electromagnetic and electrostatic energy 失效
标题翻译：用于消散电磁和静电能量的衰减器
公开(公告)号：US5036768A
公开(公告)日：1991-08-06
申请号：US479117
申请日：1990-02-13
申请人： Robert L. Dow , Paul W. Proctor
发明人： Robert L. Dow , Paul W. Proctor
IPC分类号： A61N1/37 , F42B3/188
CPC分类号： F42B3/188 , A61N1/37
摘要： An attenuator for dissipating electromagnetic energy and equalizing electrostatic energy is formed of a lossy ferrite material having an electrical resistance in a range of about 3,000 to 50,000 ohms. A conductor passes through the material and thence to a bridgewire to supply a firing charge to heat the bridgewire. In one embodiment of the invention, the attenuator is mounted within an electrically and thermally conductive housing, which will dissipate heat and equalize electromagnetic energy which may be induced in the conductor. A capacitive effect may be imparted by the orientation of the conductor as it passes through the ferrite. The capacitive effect is produced in winding the conductor parallel to the metal housing, and parallel to any other conductor passing through the ferrite. In the preferred form, the conductors are wound through the ferrite in a spiral pattern parallel to the conductor housing.
摘要翻译：用于耗散电磁能量和均衡静电能量的衰减器由具有大约3,000至50,000欧姆范围内的电阻的有损铁氧体材料形成。导体通过材料，然后穿过桥梁，以提供点火装置来加热桥梁。在本发明的一个实施例中，衰减器安装在导电和导热的外壳内，这将消散热量并均衡可能在导体中感应的电磁能。当导体通过铁氧体时，电容效应可以由导体赋予。电容效应是在将导体平行于金属外壳缠绕导体并平行于穿过铁氧体的任何其他导体产生的。在优选的形式中，导体以平行于导体外壳的螺旋图案绕过铁氧体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式