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1. 发明授权

US06168922A Methods and devices for collecting and storing clinical samples for genetic analysis 失效
标题翻译：用于收集和存储用于遗传分析的临床样品的方法和装置
公开(公告)号：US06168922A
公开(公告)日：2001-01-02
申请号：US09255151
申请日：1999-02-22
申请人： Michael A. Harvey , Richard D. Kremer , Robert L. Burghoff , Thomas H. King
发明人： Michael A. Harvey , Richard D. Kremer , Robert L. Burghoff , Thomas H. King
IPC分类号： C12Q168
CPC分类号： C12Q1/6806 , B01J2219/00639 , B01J2219/00722 , C12N15/1003 , C40B40/06 , C12Q2565/625 , C12Q2527/127
摘要： The present invention relates to devices and methods for the collection, storage, and purification of nucleic acids, such as DNA or RNA, from fluid samples for subsequent genetic characterization, primarily by conventional amplification methods. The present invention can be used to collect, store, or purify nucleic acids either from a biological source other than untreated whole blood, the biological source having naturally occurring nucleic acid amplification inhibitors present, (including either a buccal swab, cerebrospinal fluid, feces, lymphatic fluid, a plasma sample, a saliva sample, a serum sample, urine, or a suspension of cells or viruses), or from a treated whole blood source that has naturally occurring nucleic acid amplification inhibitors present, as well as added blood stabilization components that also inhibit nucleic acid amplification. More importantly, these nucleic acids can be released after collection or storage in a manner that enables them to be amplified by conventional techniques such as polymerase chain reaction. In particular, an absorbent material that does not bind nucleic acids irreversibly is impregnated with a chaotropic salt. A biological source sample is contacted with the impregnated absorbent material. Any nucleic acids present in the biological source can be either eluted or resolubilized off the absorbent material.
摘要翻译：本发明涉及用于从流体样品中收集，储存和纯化来自流体样品的核酸的装置和方法，用于随后的遗传表征，主要通过常规的扩增方法。本发明可用于从除未经处理的全血之外的生物来源收集，储存或纯化核酸，所述生物来源具有天然存在的核酸扩增抑制剂（包括颊拭子，脑脊液，粪便，淋巴液，血浆样品，唾液样品，血清样品，尿液或细胞或病毒的悬浮液）或来自具有天然存在的核酸扩增抑制剂的处理的全血源，以及添加的血液稳定化成分这也抑制核酸扩增。更重要的是，这些核酸可以在收集或储存之后以能够通过常规技术如聚合酶链反应扩增的方式被释放。特别地，不结合核酸的吸收材料不可逆地浸渍有离液盐。生物源样品与浸渍的吸收材料接触。存在于生物来源中的任何核酸都可以从吸收材料中洗脱或再溶解。

2. 发明授权

US5939259A Methods and devices for collecting and storing clinical samples for genetic analysis 失效
标题翻译：用于收集和存储用于遗传分析的临床样品的方法和装置
公开(公告)号：US5939259A
公开(公告)日：1999-08-17
申请号：US835614
申请日：1997-04-09
申请人： Michael A. Harvey , Richard D. Kremer , Robert L. Burghoff , Thomas H. King
发明人： Michael A. Harvey , Richard D. Kremer , Robert L. Burghoff , Thomas H. King
IPC分类号： C12N15/10 , C12Q1/68 , C40B40/06 , C07H21/02 , C07K1/00 , C12N1/08
CPC分类号： C12Q1/6806 , C12N15/1003 , B01J2219/00639 , B01J2219/00722 , C40B40/06
摘要： The present invention relates to devices and methods for the collection, storage, and purification of nucleic acids, such as DNA or RNA, from fluid samples for subsequent genetic characterization, primarily by conventional amplification methods. The present invention can be used to collect, store, or purify nucleic acids from a treated whole blood source that has naturally occurring nucleic acid amplification inhibitors present, as well as added blood stabilization components that also inhibit nucleic acid amplification. More importantly, these nucleic acids can be released after collection or storage in a manner that enables them to be amplified by conventional techniques such as polymerase chain reaction. In particular, an absorbent material that does not bind nucleic acids irreversibly is impregnated with a chaotropic salt. A biological source sample is contacted with the impregnated absorbent material. Any nucleic acids present in the biological source can be either eluted or resolubilized off the absorbent material.
摘要翻译：本发明涉及用于从流体样品中收集，储存和纯化来自流体样品的核酸的装置和方法，用于随后的遗传表征，主要通过常规的扩增方法。本发明可用于从存在天然存在的核酸扩增抑制剂的经处理的全血源收集，储存或纯化核酸，以及还抑制核酸扩增的添加的血液稳定化成分。更重要的是，这些核酸可以在收集或储存之后以能够通过常规技术如聚合酶链反应扩增的方式被释放。特别地，不结合核酸的吸收材料不可逆地浸渍有离液盐。生物源样品与浸渍的吸收材料接触。存在于生物来源中的任何核酸都可以从吸收材料中洗脱或再溶解。

3. 发明授权

US5607857A Rhodococcus species for removing sulfur from organic carbonaceous fuel substrates-(LAW295) 失效
标题翻译：用于从有机碳质燃料底物中除去硫的红球菌物种（LAW295）
公开(公告)号：US5607857A
公开(公告)日：1997-03-04
申请号：US489859
申请日：1995-06-13
申请人： Matthew J. Grossman , Mary K. Lee , James D. Senius , Robert L. Burghoff , David L. Elmendorf
发明人： Matthew J. Grossman , Mary K. Lee , James D. Senius , Robert L. Burghoff , David L. Elmendorf
IPC分类号： C10G32/00
CPC分类号： C12R1/01 , C10G32/00
摘要： A process is provided for removing organic sulfur from a sulfur-containing organic carbonaceous fuel substrate such as coal or petroleum products having sulfur-carbon bonds. The process comprises contacting the substrate with a microorganism having all the identifying characteristics of Rhodococcus species ATCC 55309 or ATCC 55310 which cleaves the sulfur-carbon bonds resulting in the removal or the organic sulfur from the substrates.
摘要翻译：提供了从含硫有机碳质燃料基质例如煤或具有硫 - 碳键的石油产品中除去有机硫的方法。该方法包括使底物与具有红球菌ATCC 55309或ATCC 55310的所有鉴定特征的微生物接触，所述鉴定特征切割硫 - 碳键从而导致从底物中除去或有机硫。

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