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1. 发明申请

US20160083747A1 INTRACELLULAR TRANSLATION OF CIRCULAR RNA 有权
标题翻译：圆形RNA的细胞内翻译
公开(公告)号：US20160083747A1
公开(公告)日：2016-03-24
申请号：US14890799
申请日：2014-05-13
申请人： Robert KRUSE
发明人： Robert KRUSE
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , A61K48/00 , C12N15/115 , C12N2310/16 , C12N2800/50 , C12N2830/42 , C12N2840/203 , C12N2840/44 , C12N2999/007 , C12Q1/6865 , C12Q2521/119 , C12Q2531/125
摘要： A circular mRNA molecule possessing features resembling native mammalian mRNA demonstrates improved translation, while retaining the properties of an extremely long half-life inside cells. This circular mRNA is functional inside mammalian cells, being able to compete against native cellular mRNAs for the eukaryotic translation initiation machinery. The invention possesses additional RNA elements compared to a previous invention containing only an IRES element for successful in vitro or in vivo translation.
摘要翻译：具有类似于天然哺乳动物mRNA的特征的环状mRNA分子表现出改善的翻译，同时保留细胞内非常长的半衰期的性质。该循环mRNA在哺乳动物细胞内是功能性的，能够与天然细胞mRNA竞争用于真核翻译起始机制。与仅含有用于成功体外或体内翻译的IRES元件的先前发明相比，本发明具有额外的RNA元件。

2. 发明授权

US08357464B2 Electric vehicle propulsion system and method utilizing solid-state rechargeable electrochemical cells 有权
公开(公告)号：US08357464B2
公开(公告)日：2013-01-22
申请号：US13294980
申请日：2011-11-11
申请人： Ann Marie Sastry , Fabio Albano , Chia-Wei Wang , Robert Kruse , Jeffrey Lebrun
发明人： Ann Marie Sastry , Fabio Albano , Chia-Wei Wang , Robert Kruse , Jeffrey Lebrun
IPC分类号： H01M4/02
CPC分类号： H01M10/0587 , B60L11/18 , H01M2/1077 , H01M4/131 , H01M4/136 , H01M4/40 , H01M4/405 , H01M10/0431 , H01M10/052 , H01M10/0525 , H01M10/054 , H01M10/0562 , H01M10/0565 , H01M10/63 , H01M16/00 , H01M2220/20 , H01M2300/0068 , H01M2300/0071 , H01M2300/0082 , Y02E60/12
摘要： A vehicle propulsion system comprising a plurality of solid state rechargeable battery cells configured to power a drivetrain. In accordance with once aspect of the invention, a transportation system that is powered at least in part by electricity stored in the form of rechargeable electrochemical cells. According to an embodiment of the present invention, these cells are combined in series and in parallel to form a pack that is regulated by charge and discharge control circuits that are programmed with algorithms to monitor state of charge, battery lifetime, and battery health.

3. 发明授权

US08691122B2 Multi-colored shaped body 有权
公开(公告)号：US08691122B2
公开(公告)日：2014-04-08
申请号：US13155124
申请日：2011-06-07
申请人： Volker M. Rheinberger , Marcel Schweiger , Robert Kruse , Harald Kerschbaumer
发明人： Volker M. Rheinberger , Marcel Schweiger , Robert Kruse , Harald Kerschbaumer
IPC分类号： A61C13/00
CPC分类号： A61C13/0022 , A61C5/77 , A61C13/0004 , A61C13/09 , Y10T428/24967 , Y10T428/26
摘要： The present invention relates to a multi-colored shaped body having layers arranged on top of one another for producing dental restorations, a process for its production and its use for the manufacture of dental restorations.

4. 发明申请

US20110236857A1 Multi-Colored Shaped Body 有权
公开(公告)号：US20110236857A1
公开(公告)日：2011-09-29
申请号：US13155124
申请日：2011-06-07
申请人： Volker M. Rheinberger , Marcel Schweiger , Robert Kruse , Harald Kerschbaumer
发明人： Volker M. Rheinberger , Marcel Schweiger , Robert Kruse , Harald Kerschbaumer
IPC分类号： A61C8/00 , B27N7/00
CPC分类号： A61C13/0022 , A61C5/77 , A61C13/0004 , A61C13/09 , Y10T428/24967 , Y10T428/26
摘要： The present invention relates to a multi-colored shaped body having layers arranged on top of one another for producing dental restorations, a process for its production and its use for the manufacture of dental restorations.

5. 发明申请

US20180080041A1 INTRACELLULAR TRANSLATION OF CIRCULAR RNA 审中-公开
公开(公告)号：US20180080041A1
公开(公告)日：2018-03-22
申请号：US15812800
申请日：2017-11-14
申请人： Robert KRUSE
发明人： Robert KRUSE
IPC分类号： C12N15/85 , C12N15/115
CPC分类号： C12N15/85 , A61K48/00 , C12N15/115 , C12N2310/16 , C12N2800/50 , C12N2830/42 , C12N2840/203 , C12N2840/44 , C12N2999/007 , C12Q1/6865 , C12Q2521/119 , C12Q2531/125
摘要： A circular mRNA molecule possessing features resembling native mammalian mRNA demonstrates improved translation, while retaining the properties of an extremely long half-life inside cells. This circular mRNA is functional inside mammalian cells, being able to compete against native cellular mRNAs for the eukaryotic translation initiation machinery. The invention possesses additional RNA elements compared to a previous invention containing only an IRES element for successful in vitro or in vivo translation.

6. 发明申请

US20110236855A1 Multi-Colored Shaped Body 有权
标题翻译：多色成型体
公开(公告)号：US20110236855A1
公开(公告)日：2011-09-29
申请号：US13155095
申请日：2011-06-07
申请人： Volker M. Rheinberger , Marcel Schweiger , Robert Kruse , Harald Kerschbaumer
发明人： Volker M. Rheinberger , Marcel Schweiger , Robert Kruse , Harald Kerschbaumer
IPC分类号： A61C8/00 , B32B9/04 , B32B5/00 , B32B17/06 , B32B18/00 , A61C5/08 , A61C5/10 , A61C13/003 , A61C13/007
CPC分类号： A61C13/0022 , A61C5/77 , A61C13/0004 , A61C13/09 , Y10T428/24967 , Y10T428/26
摘要： The present invention relates to a multi-colored shaped body having layers arranged on top of one another for producing dental restorations, a process for its production and its use for the manufacture of dental restorations.
摘要翻译：本发明涉及一种多色成形体，其具有彼此顶部布置的用于产生牙科修复体的层，其生产方法及其用于制造牙科修复体的多色形体。

7. 发明授权

US07981531B2 Multi-colored shaped body 有权
标题翻译：多色身材
公开(公告)号：US07981531B2
公开(公告)日：2011-07-19
申请号：US11819412
申请日：2007-06-27
申请人： Volker M. Rheinberger , Marcel Schweiger , Robert Kruse , Harald Kerschbaumer
发明人： Volker M. Rheinberger , Marcel Schweiger , Robert Kruse , Harald Kerschbaumer
IPC分类号： A61C5/00
CPC分类号： A61C13/0022 , A61C5/77 , A61C13/0004 , A61C13/09 , Y10T428/24967 , Y10T428/26
摘要： The present invention relates to a multi-colored shaped body having layers arranged on top of one another for producing dental restorations, a process for its production and its use for the manufacture of dental restorations.
摘要翻译：本发明涉及一种多色成形体，其具有彼此顶部布置的用于产生牙科修复体的层，其生产方法及其用于制造牙科修复体。

8. 发明申请

US20060045610A1 Keyway, and method of holding a key in a keyway 失效
标题翻译：键槽，以及在键槽中固定键的方法
公开(公告)号：US20060045610A1
公开(公告)日：2006-03-02
申请号：US10933154
申请日：2004-09-02
申请人： Robert Kruse , David Revelle
发明人： Robert Kruse , David Revelle
IPC分类号： F16B1/00
CPC分类号： F16D1/0876 , Y10T29/49908 , Y10T29/49925 , Y10T403/4966
摘要： An improved method of holding a key (20) in a keyway (31) includes the steps of: forming an elongated keyway in the member, the member having at least one sharp corner (34) facing into the keyway adjacent either end thereof; forming a key (20) to fit in the keyway, the key being so dimensioned, proportioned and configured that the part of the key immediately adjacent each sharp corner will be recessed with respect to the surface of the member at the corner; placing the key in the keyway; and plastically deforming portions (40) of the member at the sharp corners into the keyway so as to permanently hold the key in the keyway.
摘要翻译：在键槽（31）中保持键（20）的改进方法包括以下步骤：在构件中形成细长的键槽，所述构件具有至少一个尖锐的角部（34），所述尖锐的角部（34）面向邻近其任一端的键槽; 形成键（20）以配合在键槽中，该键的尺寸，比例和构造使得紧邻每个锐角的键的部分将相对于在角部处的构件的表面凹陷; 将键放在键槽中; 并且使所述构件在所述尖角处的所述部分（40）变形成所述键槽，以将所述键永久地保持在所述键槽中。

9. 发明授权

US5202246A Treatment of immobilized matrices for preparation of pharmaceutical and biological products with anti-microbial agents to remove pyrogen-producing organisms and pyrogens 失效
标题翻译：用抗微生物剂处理用于制备药物和生物制品的固定化基质以除去产生热原的生物和热原
公开(公告)号：US5202246A
公开(公告)日：1993-04-13
申请号：US798255
申请日：1991-11-18
申请人： Robert Kruse , Sudhish Chandra , Fred Feldman
发明人： Robert Kruse , Sudhish Chandra , Fred Feldman
IPC分类号： A61L2/00 , A61L2/18 , C07K1/16
CPC分类号： A61L2/18 , A61L2/0088 , C07K1/16
摘要： Disclosed are methods of inactivating pyrogen producing organisms and pyrogenic substances in immobilized solid matrices which are used in the production and/or purification of biomedical and pharmaceutical products and materials by contacting the solid matrices with pyrogen inactivating solutions.
摘要翻译：公开了通过使固体基质与热原灭活溶液接触而使用于生物医药和药物产品和材料的生产和/或纯化中的固定化固体基质中产生热原产生生物和致热物质的方法。

10. 发明授权

US09822378B2 Intracellular translation of circular RNA 有权
公开(公告)号：US09822378B2
公开(公告)日：2017-11-21
申请号：US14890799
申请日：2014-05-13
申请人： Robert Kruse
发明人： Robert Kruse
IPC分类号： C12N15/85 , C12N15/115 , C12Q1/68 , A61K48/00
CPC分类号： C12N15/85 , A61K48/00 , C12N15/115 , C12N2310/16 , C12N2800/50 , C12N2830/42 , C12N2840/203 , C12N2840/44 , C12N2999/007 , C12Q1/6865 , C12Q2521/119 , C12Q2531/125
摘要： A circular mRNA molecule possessing features resembling native mammalian mRNA demonstrates improved translation, while retaining the properties of an extremely long half-life inside cells. This circular mRNA is functional inside mammalian cells, being able to compete against native cellular mRNAs for the eukaryotic translation initiation machinery. The invention possesses additional RNA elements compared to a previous invention containing only an IRES element for successful in vitro or in vivo translation.

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