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1. 发明申请

US20180042358A1 PARASITE COMB 审中-公开
公开(公告)号：US20180042358A1
公开(公告)日：2018-02-15
申请号：US15674955
申请日：2017-08-11
申请人： Robert John Wilson
发明人： Robert John Wilson
IPC分类号： A45D24/10 , A45D24/30
CPC分类号： A45D24/10 , A45D24/30
摘要： A comb to collect and subsequently crush parasite having a body having a handleable portion, a row of closely spaced teeth projecting outwardly from the body, and a crusher engaged to one of the teeth or handle. The teeth are configured to collect the parasites when combed through hair, and the teeth present upper surfaces that form a planar first face. The crusher has at least one planar crushing surface configured to move to abut against the first face of the teeth to cause the parasites to be crushed between the at least one crushing surface and the first face of the teeth.

2. 发明授权

US08383382B2 Variant LovD polypeptides and their uses 有权
公开(公告)号：US08383382B2
公开(公告)日：2013-02-26
申请号：US12890134
申请日：2010-09-24
申请人： Lynne Gilson , Steven James Collier , Joly Sukumaran , Wan Lin Yeo , Oscar Alvizo , Ee Ling Teo , Robert John Wilson , Junye Xu
发明人： Lynne Gilson , Steven James Collier , Joly Sukumaran , Wan Lin Yeo , Oscar Alvizo , Ee Ling Teo , Robert John Wilson , Junye Xu
IPC分类号： C12N9/10 , C12Q1/48 , C12P17/06 , C07H21/06
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.

3. 发明授权

US06519120B1 Ap-pinned spin valves with enhanced GMR and thermal stability 失效
标题翻译： Ap-pined自旋阀具有增强的GMR和热稳定性
公开(公告)号：US06519120B1
公开(公告)日：2003-02-11
申请号：US09632014
申请日：2000-08-02
申请人： Wen Yaung Lee , Tsann Lin , Daniele Mauri , Robert John Wilson
发明人： Wen Yaung Lee , Tsann Lin , Daniele Mauri , Robert John Wilson
IPC分类号： G11B539
CPC分类号： B82Y25/00 , B82Y10/00 , G01R33/093 , G11B5/3903 , G11B2005/3996
摘要： An SV sensor with the preferred structure Substrate/Seed/Free/Spacer/Pinned/AFM/Cap where the seed layer is a non-magnetic Ni—Fe—Cr or Ni—Cr film and the AFM layer is preferably Ni—Mn. The non-magnetic Ni—Fe—Cr seed layer results in improved grain structure in the deposited layers enhancing the GMR coefficients and the thermal stability of the SV sensors. The improved thermal stability enables use of Ni—Mn with its high blocking temperature and strong pinning field as the AFM layer material without SV sensor performance degradation from the high temperature anneal step needed to develop the desired exchange coupling.
摘要翻译：具有优选结构的SV传感器，其中种子层是非磁性Ni-Fe-Cr或Ni-Cr膜，AFM层优选为Ni-Mn，其中底物/种子/自由/间隔物/固定/ AFM /帽。非磁性Ni-Fe-Cr种子层导致沉积层中改善的晶粒结构增强了GMR系数和SV传感器的热稳定性。改进的热稳定性使得具有高阻挡温度和强钉扎场的Ni-Mn作为AFM层材料而不会由于开发所需交换耦合所需的高温退火步骤而降低SV传感器性能。

4. 发明申请

US20110111468A1 VARIANT LOVD POLYPEPTIDES AND THEIR USES 有权
标题翻译：各种LOVD多糖及其用途
公开(公告)号：US20110111468A1
公开(公告)日：2011-05-12
申请号：US12890134
申请日：2010-09-24
申请人： Lynne GILSON , Steven James COLLIER , Joly SUKUMARAN , Wan Lin YEO , Oscar ALVIZO , Ee Ling TEO , Robert John WILSON , Junye XU
发明人： Lynne GILSON , Steven James COLLIER , Joly SUKUMARAN , Wan Lin YEO , Oscar ALVIZO , Ee Ling TEO , Robert John WILSON , Junye XU
IPC分类号： C12P17/06 , C12N9/10 , C07H21/04 , C12N1/21
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound
摘要翻译：本公开提供了可用于合成治疗重要的他汀类化合物的酰基转移酶

5. 发明授权

US5932097A Microfabricated magnetic particles for applications to affinity binding 有权
标题翻译：微晶磁性颗粒用于应用于亲和力结合
公开(公告)号：US5932097A
公开(公告)日：1999-08-03
申请号：US153985
申请日：1998-09-16
申请人： Robert John Wilson
发明人： Robert John Wilson
IPC分类号： B03C1/01 , G01N33/543 , G01N33/553 , H01F1/00 , H01F1/20 , H01F1/44 , H01F10/00 , H01F10/32 , B01P35/06
CPC分类号： B82Y25/00 , B03C1/01 , G01N33/54333 , G01N33/5434 , H01F1/0054 , H01F1/20 , H01F1/44 , H01F10/3268 , Y10S435/815 , Y10S530/811
摘要： Ferromagnetic or antiferromagnetic particles are used for selective separation of affinity bound partners in solution. The magnetic particles have large magnetic moments which can be made such that different strengths of magnetic moments and/or different magnetic field dependencies can be used to allow for separation of several affinity partners simultaneously.
摘要翻译：铁磁或反铁磁颗粒用于选择性分离溶液中亲和键合的配偶体。磁性颗粒具有大的磁矩，可以制成磁矩和/或不同的磁场依赖性的不同强度，以允许同时分离几个亲和配偶体。

6. 发明申请

US20120244582A1 LOV-D ACYLTRANSFERASE MEDIATED ACYLATION 有权
公开(公告)号：US20120244582A1
公开(公告)日：2012-09-27
申请号：US13499364
申请日：2010-09-24
申请人： Steven James Collier , Ee Ling Teo , Joly Sukumaran , Robert John Wilson , Junye Xu
发明人： Steven James Collier , Ee Ling Teo , Joly Sukumaran , Robert John Wilson , Junye Xu
IPC分类号： C12P17/06
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
摘要翻译：提出了使用LovD酰基转移酶，具有酰基的硫酯和（i）硫醇清除剂和/或（ii）沉淀剂对化学底物改进酰化的方法。还提出了使用（i）活性炭作为硫醇清除剂和/或（ii）氢氧化铵作为沉淀剂来生产辛伐他汀的改进方法。

7. 发明授权

US06337215B1 Magnetic particles having two antiparallel ferromagnetic layers and attached affinity recognition molecules 失效
标题翻译：具有两个反平行铁磁层和附着的亲和识别分子的磁性颗粒
公开(公告)号：US06337215B1
公开(公告)日：2002-01-08
申请号：US08982019
申请日：1997-12-01
申请人： Robert John Wilson
发明人： Robert John Wilson
IPC分类号： G01N33353
CPC分类号： B82Y25/00 , B03C1/01 , G01N33/54333 , G01N33/5434 , H01F1/0054 , H01F1/20 , H01F1/44 , H01F10/3268 , Y10S435/815 , Y10S530/811
摘要： Magnetic particles are prepared and used for selective separation of affinity bound partners in solution. The magnetic particles have large magnetic moments which can be made such that different strengths of magnetic moments and/or different magnetic field dependencies can be used to allow for separation of several affinity partners simultaneously. Magnetic particles having different magnetic moments and different attached acceptor molecules move at different rates in a magnetic field. The magnetic particles have a first ferromagnetic layer having a moment oriented in a first direction, a second ferromagnetic layer having a moment oriented in a second direction generally antiparallel to the first direction and a nonmagnetic spacer layer located between and in contact with the first and second ferromagnetic layers. The magnitude of the moment of the first ferromagnetic layer is substantially equal to the magnitude of the moment of the second ferromagnetic layer so that the magnetic particles have substantially zero net magnetic moment in the absence of an applied magnetic field. First and second antiferromagnetic layers may be in contact with and exchange coupled with the first and second ferromagnetic layers, respectively, for pinning the moments in the first and second directions. Affinity recognition molecules may be attached to a coating on the surface of the particles for selectively binding with a target molecule. When the recognition molecule is an antibody, the particles may be used in an immunoassay or to separate cells from a mixture by binding to cell surface antigens.
摘要翻译：制备磁性颗粒并用于溶液中选择性分离亲和键合的配偶体。磁性颗粒具有大的磁矩，可以制成磁矩和/或不同的磁场依赖性的不同强度，以允许同时分离几个亲和配偶体。具有不同磁矩和不同连接的受体分子的磁性颗粒在磁场中以不同的速率移动。磁性颗粒具有第一铁磁层，其具有沿第一方向定向的力矩，第二铁磁层具有通常反向平行于第一方向的第二方向的力矩，以及位于第一和第二方向之间并与之接触的非磁性间隔层铁磁层。第一铁磁层的力矩的大小基本上等于第二铁磁层的力矩的大小，使得磁性颗粒在没有施加的磁场的情况下具有基本上零的净磁矩。第一和第二反铁磁层可以分别与第一和第二铁磁层接触并与其交换，用于固定第一和第二方向上的力矩。亲和识别分子可以连接到颗粒表面上的涂层，以选择性地与靶分子结合。当识别分子是抗体时，该颗粒可以用于免疫测定中，或通过结合细胞表面抗原从混合物中分离细胞。

8. 发明授权

US6141191A Spin valves with enhanced GMR and thermal stability 失效
标题翻译：具有增强的GMR和热稳定性的旋转阀
公开(公告)号：US6141191A
公开(公告)日：2000-10-31
申请号：US986311
申请日：1997-12-05
申请人： Wen Yaung Lee , Tsann Lin , Daniele Mauri , Robert John Wilson
发明人： Wen Yaung Lee , Tsann Lin , Daniele Mauri , Robert John Wilson
IPC分类号： G01R33/09 , G11B5/39
CPC分类号： B82Y25/00 , B82Y10/00 , G01R33/093 , G11B5/3903 , G11B2005/3996
摘要： An SV sensor with the preferred structure Substrate/Seed/Free/Spacer/Pinned/AFM/Cap where the seed layer is a non-magnetic Ni--Fe--Cr or Ni--Cr film and the AFM layer is preferably Ni--Mn. The non-magnetic Ni--Fe--Cr seed layer results in improved grain structure in the deposited layers enhancing the GMR coefficients and the thermal stability of the SV sensors. The improved thermal stability enables use of Ni--Mn with its high blocking temperature and strong pinning field as the AFM layer material without SV sensor performance degradation from the high temperature anneal step needed to develop the desired exchange coupling.
摘要翻译：具有优选结构的SV传感器，其中种子层是非磁性Ni-Fe-Cr或Ni-Cr膜，AFM层优选为Ni-Mn，其中底物/种子/自由/间隔物/固定/ AFM /帽。非磁性Ni-Fe-Cr种子层导致沉积层中改善的晶粒结构增强了GMR系数和SV传感器的热稳定性。改进的热稳定性使得具有高阻挡温度和强钉扎场的Ni-Mn作为AFM层材料而不会由于开发所需交换耦合所需的高温退火步骤而降低SV传感器性能。

9. 发明申请

US20080206891A1 Synthetic antiferromagnetic nanoparticles 审中-公开
标题翻译：合成反铁磁性纳米粒子
公开(公告)号：US20080206891A1
公开(公告)日：2008-08-28
申请号：US11894046
申请日：2007-08-16
申请人： Shan X. Wang , Robert John Wilson , Wei Hu
发明人： Shan X. Wang , Robert John Wilson , Wei Hu
IPC分类号： G01N33/553
CPC分类号： G01N33/5434 , B03C1/01 , B82Y25/00 , H01F1/0054 , H01F10/3272
摘要： The present invention provides a synthetic antiferromagnetic (SAF) nanoparticle. The SAF nanoparticle includes at least two ferromagnetic layers and at least one non-magnetic spacer layer. The spacer layer is situated in between planar surfaces of the ferromagnetic layers. The saturation field of the SAF nanoparticle is tunable by the geometry and composition of the nanoparticle. Preferably, the saturation field can be tuned to be between about 100 Oe and about 10,000 Oe. Also preferably, the SAF nanoparticle has a magnetic moment of at least 800 emu/cm3. In a preferred embodiment, the SAF nanoparticle has at least one of a biomolecule, a recognition moiety, or a molecular coating attached to its surface. The SAF nanoparticle may also have a dye attached to its surface.
摘要翻译：本发明提供一种合成反铁磁（SAF）纳米颗粒。 SAF纳米颗粒包括至少两个铁磁层和至少一个非磁性间隔层。间隔层位于铁磁层的平坦表面之间。 SAF纳米颗粒的饱和场可以通过纳米颗粒的几何形状和组成来调节。优选地，饱和场可以调节在约100Oe和约10,000Oe之间。还优选地，SAF纳米颗粒具有至少800emu / cm 3的磁矩。在优选的实施方案中，SAF纳米颗粒具有附着于其表面的生物分子，识别部分或分子涂层中的至少一种。 SAF纳米颗粒也可以具有附着在其表面上的染料。

10. 发明授权

US06548186B1 High resistivity films for AP layers in spin valves 失效
标题翻译：自旋阀中AP层的高电阻率膜
公开(公告)号：US06548186B1
公开(公告)日：2003-04-15
申请号：US09574301
申请日：2000-05-19
申请人： Matthew Joseph Carey , Bruce Alvin Gurney , Robert John Wilson
发明人： Matthew Joseph Carey , Bruce Alvin Gurney , Robert John Wilson
IPC分类号： G11B539
CPC分类号： B82Y25/00 , B32B15/01 , B82Y10/00 , G11B5/3903 , H01F10/3268 , Y10T428/1171 , Y10T428/12465 , Y10T428/12861 , Y10T428/12937 , Y10T428/12986
摘要： In a spin valve, at least one AP pinned sublayer and/or one AP free sublayer comprise high resistivity alloys of the type AB, wherein A is selected from the group consisting of CoFe, NiFe, and CoFeNi, and B is selected from the group consisting of B, Ta, Nb, Zr, and/or Hf. The resistivity value of the highly resistive layer is typically between about 30 &mgr;&OHgr;-cm and 100 &mgr;&OHgr;-cm. The highly resistive layers reduce the shunting of the sense current away from the rest of the structure, and prevent electrons from being shunted away from the active region of the spin valve and, thus, reducing &Dgr;R/R. The spin valve of this layered structure can increase the overall sheet resistance and optimize the &Dgr;R/R value of the spin valve.
摘要翻译：在自旋阀中，至少一个AP钉扎子层和/或一个AP自由子层包括AB型的高电阻率合金，其中A选自CoFe，NiFe和CoFeNi，B选自由B，Ta，Nb，Zr和/或Hf组成。高电阻层的电阻率值通常在约30μOMEGA-cm和100μOMEGA-cm之间。高电阻层减少了感测电流与结构的其余部分的分流，并且防止电子被分流离开自旋阀的有源区域，从而减少DELTAR / R。这种分层结构的自旋阀可以增加整体薄层电阻并优化自旋阀的DELTAR / R值。

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