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1. 发明授权

US07831290B2 MRI biopsy device localization fixture 有权
公开(公告)号：US07831290B2
公开(公告)日：2010-11-09
申请号：US11103959
申请日：2005-04-12
申请人： Robert J. Hughes , Timothy G. Dietz , Michael J. Andreyko , Kent Swendseid , Jay Wilkins , William E. Clem
发明人： Robert J. Hughes , Timothy G. Dietz , Michael J. Andreyko , Kent Swendseid , Jay Wilkins , William E. Clem
IPC分类号： A61B5/05 , A61B17/32
CPC分类号： A61B10/02 , A61B5/055 , A61B5/0555 , A61B10/0041 , A61B10/0233 , A61B10/0275 , A61B10/0283 , A61B17/3403 , A61B17/3417 , A61B17/3421 , A61B90/11 , A61B90/17 , A61B2010/0208 , A61B2010/0225 , A61B2017/00477 , A61B2017/00796 , A61B2017/00911 , A61B2017/3411 , A61B2090/034 , A61B2090/036 , A61B2090/374 , A61B2090/3908 , A61B2090/3933 , A61B2090/3954 , A61B2090/3987
摘要： A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument, and, in particular, a sleeve to a biopsy site of suspicious tissues or lesions. A z-stop enhances accurate insertion, prevents over-insertion or inadvertent retraction of the sleeve. The sleeve receives a probe of the MRI-compatible biopsy instrument and may contain various features to enhance its imagability, to enhance vacuum and pressure assist therethrough, etc.

2. 发明授权

US07013888B2 Self contained aerosol dual delivery system (SCADDS) 有权
标题翻译：自给式气溶胶双重输送系统（SCADDS）
公开(公告)号：US07013888B2
公开(公告)日：2006-03-21
申请号：US10442120
申请日：2003-05-21
申请人： Robert J. Hughes , Philip J. Paustian
发明人： Robert J. Hughes , Philip J. Paustian
IPC分类号： A61W11/00
CPC分类号： A61M15/009 , A61M15/0003 , A61M15/0093 , A61M15/06
摘要： Self Contained Aerosol Dual Delivery System (SCADDS) is a pocket-sized inhaler for delivering inhaled therapeutic or recreational aerosols simultaneously and separately via oral and nasal routes. A handle assembly has a removable mouthpiece, cartridge penetration needles, puncture needle protective cover, a shuttle, a cam, valves and conduits from the penetration needles to the individual nozzles for oral and nasal inhalation. A cartridge contains separate reservoirs of solutions for oral and nasal inhalation. The reservoirs, impermeable bags with fluid and dissolved gas in solution, are punctured when the cartridge is attached to the handle assembly. Inhalation slides the shuttle toward the mouthpiece and opens the valves to release solution. The oral aerosol is inhaled into the lungs while the nasal aerosol provides a pleasant aroma. The oral reservoir may be coupled with a second reservoir for finely divided solids or divided by a filter such that finely divided solids can interact with the oral solution to further enhance flavor. Degassed water may be used to enhance organic compound solubility in solutions. Alternative reservoir bag systems are twin spring driven or gas driven cylinders to provide proper pressure to aerosolize nasal and oral fluids. Hydraulic intensification, piezoelectric pumping devices, and electromechanically driven pressure pumps are alternative pressurization systems.
摘要翻译：自给式气溶胶双输送系统（SCADDS）是一种口袋式吸入器，用于通过口腔和鼻道同时和分开地提供吸入治疗或娱乐性气溶胶。手柄组件具有可移除的接口管，药筒贯穿针，穿刺针保护盖，梭子，凸轮，阀和从穿刺针到用于口腔和鼻吸入的各个喷嘴的导管。药筒包含单独的口腔和鼻吸入溶液储存器。当墨盒连接到手柄组件时，储存器，具有流体的不透水袋和溶液中的溶解气体被刺穿。吸入将梭子滑向接口并打开阀门以释放溶液。口腔气溶胶吸入肺部，而鼻腔气溶胶提供令人愉快的香气。口腔储存器可以与用于细碎固体的第二储存器联接或由过滤器分开，使得细碎的固体可以与口腔溶液相互作用以进一步增强风味。脱气水可用于提高溶液中有机化合物的溶解度。替代的储存袋系统是双弹簧驱动或气体驱动的气缸，以提供适当的压力以使鼻腔和口腔液体雾化。液压强化，压电泵送装置和机电驱动的压力泵是替代的加压系统。

3. 发明授权

US6047483A Heating system for compressive shrinkage machines 有权
标题翻译：压缩收缩机加热系统
公开(公告)号：US6047483A
公开(公告)日：2000-04-11
申请号：US208231
申请日：1998-12-09
申请人： Earl S. Allison , Gavin B. Rumble , Robert J. Hughes , Barry D. Miller
发明人： Earl S. Allison , Gavin B. Rumble , Robert J. Hughes , Barry D. Miller
IPC分类号： D06C21/00 , D06F58/00
CPC分类号： D06C21/00
摘要： A heating system for a mechanical compressive shrinkage apparatus in which a continuously flowing liquid heat exchange medium is caused to flow in series through each of the components required to be heated. Heat is input to the flowing medium in accordance with the temperature of one of the components to be heated, preferably the first in the series. Uniformity and constancy of both absolute and relative temperatures of the series-connected components is achieved. A mixture of water and propylene glycol alcohol is an advantageous heat exchange medium for the purpose, which allows operation at lower pressure without the maintenance problems of a system using, for example, oil as the exchange medium.
摘要翻译：一种用于机械压缩收缩装置的加热系统，其中连续流动的液体热交换介质通过需要加热的每个部件串联流动。根据要加热的部件之一的温度，优选地将串联的热量输入到流动介质中。实现串联组件的绝对和相对温度的均匀性和恒定性。水和丙二醇醇的混合物是用于该目的的有利的热交换介质，其允许在较低压力下操作而没有使用例如作为交换介质的油的系统的维护问题。

4. 发明授权

US5761909A Breathing gas temperature modification device 失效
标题翻译：呼吸气体温度调节装置
公开(公告)号：US5761909A
公开(公告)日：1998-06-09
申请号：US767507
申请日：1996-12-16
申请人： Robert J. Hughes , Kenneth Price , Dennis McCrory , Billy Courson , Joseph Rudolph
发明人： Robert J. Hughes , Kenneth Price , Dennis McCrory , Billy Courson , Joseph Rudolph
IPC分类号： A62B9/00 , F25B21/02
CPC分类号： F25B21/02 , A62B9/003 , Y10S165/009
摘要： A device is provided for modifying the temperature of a breathing or other as supplied through a conduit. A heat exchanger is mounted in-line with the conduit. A thermoelectric device has first and second thermally conductive plates separated by at least one thermoelectric couple. The first thermally conductive plate is in thermal contact with the heat exchanger. A phase change material is in thermal contact with the second thermally conductive plate. A voltage is applied to the thermoelectric couple(s) to maintain the first and second thermally conductive plates at different temperatures. The phase change material changes from a first phase to a second phase at a phase change temperature that is selected to be between the different temperatures of the first and second thermally conductive plates.
摘要翻译：提供了一种用于改变通过导管供应的呼吸或其它气体的温度的装置。热交换器与管道成一直线安装。热电装置具有由至少一个热电偶隔开的第一和第二导热板。第一导热板与热交换器热接触。相变材料与第二导热板热接触。向热电偶施加电压以将第一和第二导热板保持在不同的温度。相变材料在第一和第二导热板的不同温度之间的相变温度下从第一相变为第二相。

5. 发明授权

US5655275A Adjustment and cleaning mechanisms for compressive shrinkage apparatus 失效
标题翻译：压缩收缩装置的调整和清洁机构
公开(公告)号：US5655275A
公开(公告)日：1997-08-12
申请号：US714891
申请日：1996-09-17
申请人： Earl S. Allison , Robert J. Hughes , Barry Defoy Miller
发明人： Earl S. Allison , Robert J. Hughes , Barry Defoy Miller
IPC分类号： D06C21/00
CPC分类号： D06C21/00
摘要： A mechanical compressive shrinkage machine, especially for tubular and open width knitted fabrics, and of the type comprising feeding and retarding rollers cooperating with entry side and exit blades forming a compressive shrinkage zone between the rollers, is provided with novel and improved adjusting mechanisms. For each of the blades, there is a separate adjusting mechanism, each comprising, at each side of the machine, an in-line fluid cylinder, a technician-accessible independent adjustment, and a rotatable eccentric. The rotatable eccentrics on each side are carried by a common shaft, which is accessible externally and provides an operator-controlled adjustment. After initial setup of the machine by a skilled technician, adjustment of the machine by the production operator is effected by rotation of a control shaft, effecting simultaneous movement of the control linkage at opposite sides of the machine. The limits of production operator control, even with full rotation of the control shaft, are such, by design of the eccentric portions of the shaft, as to be within a safe range, to avoid damage or destruction of delicate critical parts of the equipment through careless operator action. The in-line fluid actuators, incorporated into the adjustment linkage, enable rapid, gross movement of the elements for the purpose of reconfiguring the machine in a wide open condition for cleanout. Such reconfiguration is carried out by a predetermined sequence to avoid damage to the components.
摘要翻译：一种机械压缩收缩机，特别是用于管状和开口宽度的针织物，并且包括进料和延迟辊的类型，其与在辊之间形成压缩收缩区的入口侧和出口叶片配合，提供了新的和改进的调节机构。对于每个叶片，存在单独的调节机构，每个机构包括在机器的每一侧的直列流体缸，技术人员可接近的独立调节和可旋转的偏心轮。每侧可旋转的偏心轮由公共轴承载，该轴可从外部进入，并提供操作者控制的调节。在由熟练的技术人员初始设置机器之后，由生产操作者对机器的调节通过控制轴的旋转来实现，从而在机器的相对侧同时移动控制连杆。生产操作员控制的限制，即使是控制轴的完全旋转，也是通过将轴的偏心部分设计为在安全范围之内，以避免损坏或破坏设备的精密关键部件粗心大意的操作员动作。结合到调节联动装置中的在线流体致动器能够快速，大量地移动元件，以在重新配置机器的情况下在大的打开状态下进行清洁。这样的重新配置由预定的顺序执行，以避免损坏组件。

6. 发明授权

US10286163B1 On demand aerosolized delivery inhaler 有权
公开(公告)号：US10286163B1
公开(公告)日：2019-05-14
申请号：US14521504
申请日：2014-10-23
申请人： Philip J. Paustian , Robert J. Hughes
发明人： Philip J. Paustian , Robert J. Hughes
IPC分类号： A61M11/02 , A61M15/00
摘要： A hand-held aerosolized inhaler that delivers an aerosolized solution to the user on demand when he or she inhales is provided. A pressure or flow sensor within the invention detects the change in air flow as the user inhales and triggers spraying the aerosol solution only when the inhaled breath stream will optimally entrain the sprayed aerosol. The pressure or flow sensor sends an electronic signal to turn on or off liquid and air pumps as the user breathes. Liquid, or liquid and air are pumped to the nozzle inside the invention to create an aerosolized mixture.

7. 发明授权

US07913686B2 Self contained aerosol dual delivery system (SCADDS) 有权
标题翻译：自给式气溶胶双重输送系统（SCADDS）
公开(公告)号：US07913686B2
公开(公告)日：2011-03-29
申请号：US11269246
申请日：2005-11-08
申请人： Robert J. Hughes , Philip J. Paustian
发明人： Robert J. Hughes , Philip J. Paustian
IPC分类号： A61M11/00
CPC分类号： A61M15/009 , A61M15/0003 , A61M15/0093 , A61M15/06
摘要： Self Contained Aerosol Dual Delivery System (SCADDS) is a pocket-sized inhaler for delivering inhaled therapeutic or recreational aerosols simultaneously and separately via oral and nasal routes. A handle assembly has a removable mouthpiece, cartridge penetration needles, puncture needle protective cover, a shuttle, a cam, valves and conduits from the penetration needles to the individual nozzles for oral and nasal inhalation. A cartridge contains separate reservoirs of solutions for oral and nasal inhalation. The reservoirs, impermeable bags with fluid and dissolved gas in solution, are punctured when the cartridge is attached to the handle assembly. Inhalation slides the shuttle toward the mouthpiece and opens the valves to release solution. The oral aerosol is inhaled into the lungs while the nasal aerosol provides a pleasant aroma. To enhance oral inhalation solution properties the oral inhalation reservoir may contain finely divided solids in a semi-permeable membranous bag, attached to a second reservoir, or be divided by a filter such that these solids do not occlude nozzles or penetration needles Degassed water may be used to enhance organic compound solubility in solutions. Alternative reservoir bag systems are twin spring driven or gas driven cylinders to provide proper pressure to aerosolize nasal and oral fluids. Hydraulic intensification, piezoelectric pumping devices, and electromechanically driven pressure pumps are alternative pressurization systems.
摘要翻译：自给式气溶胶双输送系统（SCADDS）是一种口袋式吸入器，用于通过口腔和鼻道同时和分开地提供吸入治疗或娱乐性气溶胶。手柄组件具有可移除的接口管，药筒贯穿针，穿刺针保护盖，梭子，凸轮，阀和从穿刺针到用于口腔和鼻吸入的各个喷嘴的导管。药筒包含单独的口腔和鼻吸入溶液储存器。当墨盒连接到手柄组件时，储存器，具有流体的不透水袋和溶液中的溶解气体被刺穿。吸入将梭子滑向接口并打开阀门以释放溶液。口腔气溶胶吸入肺部，而鼻腔气溶胶提供令人愉快的香气。为了增强口腔吸入溶液的性质，口腔吸入容器可以在半透膜的膜袋中包含细分的固体，连接到第二储存器，或者由过滤器分开，使得这些固体不堵塞喷嘴或穿透针。脱气的水可以是用于提高溶液中有机化合物的溶解度。替代的储存袋系统是双弹簧驱动或气体驱动的气缸，以提供适当的压力以使鼻腔和口腔液体雾化。液压强化，压电泵送装置和机电驱动的压力泵是替代的加压系统。

8. 发明申请

US20110015517A1 MRI BIOPSY DEVICE LOCALIZATION FIXTURE 审中-公开
标题翻译： MRI生物装置本地化装置
公开(公告)号：US20110015517A1
公开(公告)日：2011-01-20
申请号：US12889801
申请日：2010-09-24
申请人： Robert J. Hughes , Timothy G. Dietz , Michael J. Andreyko , Kent Swendseid , Jay Wilkins , William E. Clem
发明人： Robert J. Hughes , Timothy G. Dietz , Michael J. Andreyko , Kent Swendseid , Jay Wilkins , William E. Clem
IPC分类号： A61B5/055
CPC分类号： A61B10/02 , A61B5/055 , A61B5/0555 , A61B10/0041 , A61B10/0233 , A61B10/0275 , A61B10/0283 , A61B17/3403 , A61B17/3417 , A61B17/3421 , A61B90/11 , A61B90/17 , A61B2010/0208 , A61B2010/0225 , A61B2017/00477 , A61B2017/00796 , A61B2017/00911 , A61B2017/3411 , A61B2090/034 , A61B2090/036 , A61B2090/374 , A61B2090/3908 , A61B2090/3933 , A61B2090/3954 , A61B2090/3987
摘要： A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument, and, in particular, a sleeve to a biopsy site of suspicious tissues or lesions. A z-stop enhances accurate insertion, prevents over-insertion or inadvertent retraction of the sleeve. The sleeve receives a probe of the MRI-compatible biopsy instrument and may contain various features to enhance its imagability, to enhance vacuum and pressure assist therethrough, etc.
摘要翻译：定位机构或夹具与乳房线圈一起用于乳房压缩，并用于在开放和闭合的磁共振成像（MRI）机器中的易行活检过程中引导核心活检仪器。定位夹具包括用于支撑和定向MRI兼容的活检器具的三维笛卡尔定位引导件，并且特别地，将套筒连接到可疑组织或病变的活检部位。 Z形止动器可提高精确插入，防止套筒过度插入或意外收回。袖子接受MRI兼容的活检仪器的探针，并且可以包含各种特征以增强其成像能力，以增强真空和压力辅助等。

9. 发明授权

US07711407B2 MRI biopsy device localization fixture 有权
标题翻译： MRI活检装置定位夹具
公开(公告)号：US07711407B2
公开(公告)日：2010-05-04
申请号：US11463346
申请日：2006-08-09
申请人： Robert J. Hughes , Timothy G. Dietz , Michael J. Andreyko , Kent Swendseid , Jay Wilkins , William E. Clem
发明人： Robert J. Hughes , Timothy G. Dietz , Michael J. Andreyko , Kent Swendseid , Jay Wilkins , William E. Clem
IPC分类号： A61B5/05
CPC分类号： A61B10/02 , A61B5/055 , A61B5/0555 , A61B10/0041 , A61B10/0233 , A61B10/0275 , A61B10/0283 , A61B17/3403 , A61B17/3417 , A61B17/3421 , A61B90/11 , A61B90/17 , A61B2010/0208 , A61B2010/0225 , A61B2017/00477 , A61B2017/00796 , A61B2017/00911 , A61B2017/3411 , A61B2090/034 , A61B2090/036 , A61B2090/374 , A61B2090/3908 , A61B2090/3933 , A61B2090/3954 , A61B2090/3987
摘要： A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument, and, in particular, a sleeve to a biopsy site of suspicious tissues or lesions. A z-stop enhances accurate insertion, prevents over-insertion or inadvertent retraction of the sleeve. The sleeve receives a probe of the MRI-compatible biopsy instrument and may contain various features to enhance its imagability, to enhance vacuum and pressure assist therethrough, etc.
摘要翻译：定位机构或夹具与乳房线圈一起用于乳房压缩，并用于在开放和闭合的磁共振成像（MRI）机器中的易行活检过程中引导核心活检仪器。定位固定器包括用于支撑和定向MRI兼容的活检器具的三维笛卡尔定位引导件，特别是将套筒连接到可疑组织或病变的活检部位。 Z形止动器可提高精确插入，防止套筒过度插入或意外收回。袖子接受MRI兼容的活检仪器的探针，并且可以包含各种特征以增强其成像能力，以增强真空和压力辅助等。

10. 发明授权

US07708751B2 MRI biopsy device 有权
标题翻译： MRI活检装置
公开(公告)号：US07708751B2
公开(公告)日：2010-05-04
申请号：US11076612
申请日：2005-03-10
申请人： Robert J. Hughes , Timothy G. Dietz , Michael J. Andreyko , William E. Clem , Martin B. Albini
发明人： Robert J. Hughes , Timothy G. Dietz , Michael J. Andreyko , William E. Clem , Martin B. Albini
IPC分类号： A61B17/32
CPC分类号： A61B10/02 , A61B5/055 , A61B5/0555 , A61B10/0041 , A61B10/0233 , A61B10/0275 , A61B10/0283 , A61B17/3403 , A61B17/3417 , A61B17/3421 , A61B90/11 , A61B90/17 , A61B2010/0208 , A61B2010/0225 , A61B2017/00477 , A61B2017/00796 , A61B2017/00911 , A61B2017/3411 , A61B2090/034 , A61B2090/036 , A61B2090/374 , A61B2090/3908 , A61B2090/3933 , A61B2090/3954 , A61B2090/3987
摘要： A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument, and in particular a sleeve, to a biopsy site of suspicious tissues or lesions. A depth stop enhances accurate insertion, prevents over-insertion or inadvertent retraction of the sleeve. The sleeve receives a probe of the MRI-compatible biopsy instrument and may contain various features to enhance its imagability, to enhance vacuum and pressure assist therethrough, etc.
摘要翻译：定位机构或夹具与乳房线圈一起用于乳房压缩，并用于在开放和闭合的磁共振成像（MRI）机器中的易行活检过程中引导核心活检仪器。定位固定装置包括一个三维笛卡尔定位指南，用于支持和定向MRI兼容的活检仪器，特别是套筒，用于可疑组织或病变的活检部位。深度限位器可提高精确插入，防止套筒过度插入或意外收回。袖子接受MRI兼容的活检仪器的探针，并且可以包含各种特征以增强其成像能力，以增强真空和压力辅助等。

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