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1. 发明授权

US5192551A Neutral glycolipid as an adsorbent for enteric viral pathogens 失效
标题翻译：中性甘露醇作为肠道病毒的吸收剂
公开(公告)号：US5192551A
公开(公告)日：1993-03-09
申请号：US346450
申请日：1989-05-02
申请人： Rodney E. Willoughby, Jr. , Robert H. Yolken
发明人： Rodney E. Willoughby, Jr. , Robert H. Yolken
IPC分类号： A61K31/70 , C07H15/10
CPC分类号： C07H15/10 , A61K31/70
摘要： The binding of neutral glycolipid GA1 (asialo-GM1) to a broad spectrum of enteric viruses is taught. The glycolipid can be used to pass through the gastrointestinal tract of adults and children to adsorb viral particles and remove them from the body. The glycolipid may be used alone or bound to a non-absorbable resin or matrix.
摘要翻译：教导了中性糖脂GA1（asialo-GM1）与广谱肠道病毒的结合。该糖脂可用于通过成人和儿童的胃肠道吸附病毒颗粒并将其从体内除去。糖脂可以单独使用或与非吸收性树脂或基质结合。

2. 发明授权

US5505955A Anti-diarrheic product and method of treating rotavirus-associated infection 失效
标题翻译：抗腹泻产品及治疗轮状病毒相关感染的方法
公开(公告)号：US5505955A
公开(公告)日：1996-04-09
申请号：US378865
申请日：1995-01-23
申请人： Jerry A. Peterson , Robert H. Yolken , David S. Newburg
发明人： Jerry A. Peterson , Robert H. Yolken , David S. Newburg
IPC分类号： A23L1/305 , A61K35/20 , A61K35/55 , A61K38/00 , A61K38/17 , C07K14/47 , A61K45/00 , A61K9/68
CPC分类号： C07K14/47 , A23L33/19 , A61K35/20 , A61K35/55 , A61K38/1709 , Y10S514/867 , Y10S514/904 , Y10S514/905 , Y10S514/937 , Y10S514/962
摘要： An anti-diarrheic product comprises a foodstuff and an anti-rotaviral agent such as human defatted fat globule membranes, the human milk macromolecular fraction, the milk mucin complex, the 46 Kd apparent MW glycoprotein, a polypeptide having the rotavirus-binding specificity of the 46 Kd apparent MW HMFG glycoprotein, mixtures thereof, or mixtures thereof, and optionally skim milk, curd, and/or whey. They product of the invention is provided also as an anti-diarrheal kit, with instructions for its use. The product of the invention has therapeutic and prophylactic application for inhibiting the onset of, or countering, rotavirus infection and/or diarrhea, in a subject, such as for example, infants and children (infantile gasteroenteritis), travellers, and immunodeficient persons, including HIV positive and transplant patients.
摘要翻译：抗腹泻产品包括食品和抗旋转病毒剂如人脱脂脂肪球膜，人乳大分子级分，乳粘蛋白复合物，46Kd表观MW糖蛋白，具有轮状病毒结合特异性的多肽 46Kd表观MW HMFG糖蛋白，其混合物，或其混合物，以及任选的脱脂乳，凝乳和/或乳清。本发明的产品也作为抗腹泻试剂盒提供，其使用说明书。本发明的产品具有治疗和预防性应用，用于抑制受试者例如婴儿和儿童（婴儿胃脚炎），旅行者和免疫缺陷患者的轮状病毒感染和/或腹泻的发作或抵抗，包括 HIV阳性和移植患者。

3. 发明授权

US5667797A Anti-viral composition and kit and use for treating rotavirus infection and diarrhea 失效
标题翻译：抗病毒组合物和试剂盒，用于治疗轮状病毒感染和腹泻
公开(公告)号：US5667797A
公开(公告)日：1997-09-16
申请号：US626057
申请日：1996-04-01
申请人： Jerry A. Peterson , David S. Newburg , Robert H. Yolken
发明人： Jerry A. Peterson , David S. Newburg , Robert H. Yolken
IPC分类号： A23L1/305 , A61K35/20 , A61K35/55 , A61K38/00 , A61K38/17 , C07K14/47 , A61K45/00
CPC分类号： C07K14/47 , A23L33/19 , A61K35/20 , A61K35/55 , A61K38/1709 , Y10S514/867 , Y10S514/904 , Y10S514/905 , Y10S514/937 , Y10S514/962
摘要： An anti-diarrheic product comprises a foodstuff and an anti-rotaviral agent such as human defatted fat globule membranes, the human milk macromolecular fraction, skim milk, curd, whey, the milk mucin complex, the 46 Kd app.MW glycoprotein, a polypeptide having an amino acid sequence having the rotavirus binding specificity of the 46 Kd app.MW HMFG glycoprotein or mixtures thereof. An anti-diarrheal kit comprises the anti-rotaviral agent of this invention and instructions for its use, and optionally a foodstuff. A method for inhibiting or countering rotavirus infection in mammalian cells comprises contacting the cells with an anti-rotaviral amount of the agent of this invention. A therapeutic method for inhibiting the onset of or countering rotavirus infection comprises administering to a subject afflicted with or at risk for rotavirus infections such as those occuring, for example, in infants and children (infantile gasteroenteritis) and immunodeficient persons or those who have received a transplant, an anti-rotaviral effective amount of the agent of this invention.
摘要翻译：抗腹泻产品包括食品和抗旋转病毒剂，例如人脱脂脂肪球膜，人乳大分子级分，脱脂乳，凝乳，乳清，乳粘蛋白复合物，46Kd.MW糖蛋白，多肽具有具有46Kd.MW HMFG糖蛋白的轮状病毒结合特异性的氨基酸序列或其混合物。抗腹泻试剂盒包括本发明的抗旋转病毒剂及其使用说明书，以及任选的食品。用于在哺乳动物细胞中抑制或抵抗轮状病毒感染的方法包括使细胞与抗旋转病毒量的本发明的药剂接触。用于抑制轮状病毒感染发作或抵抗轮状病毒感染的治疗方法包括给患有轮状病毒感染或患有例如婴儿和儿童（婴儿胃食管炎）和免疫缺陷患者或患有免疫缺陷的人的轮状病毒感染的患者施用移植，抗旋转病毒有效量的本发明的药剂。

4. 发明授权

US4713328A Microbial Enzyme assays 失效
标题翻译：微生物酶检测
公开(公告)号：US4713328A
公开(公告)日：1987-12-15
申请号：US567152
申请日：1984-01-03
申请人： Robert H. Yolken
发明人： Robert H. Yolken
IPC分类号： C12Q1/04 , C12Q1/34 , C12Q1/02 , C12Q1/06
CPC分类号： C12Q1/04 , C12Q1/34 , G01N2333/986 , G01N2415/00 , Y10S435/803 , Y10S435/81
摘要： A method is disclosed for efficient, rapid diagnosis of bacterial infections by measuring for the presence of beta-lactamase using .sup.14 C-benzylpenicillin as an enzyme substrate and isolating cleaved substrate with an ion exchange column.
摘要翻译：公开了一种通过使用14 C-苄基青霉素作为酶底物测定β-内酰胺酶的存在并用离子交换柱分离裂解的底物来有效，快速诊断细菌感染的方法。

5. 发明授权

US08431611B2 Artemisinin derivatives 有权
标题翻译：青蒿素衍生物
公开(公告)号：US08431611B2
公开(公告)日：2013-04-30
申请号：US12445499
申请日：2007-10-19
申请人： Lorraine V. Brando , Gary H. Posner , John G. D'Angelo , Robert H. Yolken , Christopher P. Hencken , Lauren Woodard
发明人： Lorraine V. Brando , Gary H. Posner , John G. D'Angelo , Robert H. Yolken , Christopher P. Hencken , Lauren Woodard
IPC分类号： A01N43/02 , A61K31/335
CPC分类号： C07D493/18 , Y02A50/488
摘要： This disclosure provides improved derivatives of artemisinin; pharmaceutical compositions containing these compounds; methods for preparing these compounds and compositions; methods of using these compounds and compositions for preventing, controlling or treating infectious diseases including but not limited to parasitic infectious diseases such as T. gondii infection, trypanosome parasite infection, plasmodia parasite infection, and cryptosporidium parasite infection; methods for preventing, controlling or treating toxoplasma infection; and methods for treating psychiatric disorders associated with toxoplasma infection including but not limited to schizophrenia using the disclosed compounds and compositions alone or in combination with one or more antipsychotic drugs.
摘要翻译：本公开提供了改善的青蒿素衍生物; 含有这些化合物的药物组合物; 制备这些化合物和组合物的方法; 使用这些化合物和组合物用于预防，控制或治疗感染性疾病的方法，包括但不限于寄生传染病如弓形虫感染，锥虫寄生虫感染，疟原虫寄生虫感染和隐孢子虫寄生虫感染; 预防，控制或治疗弓形体感染的方法; 以及使用所公开的化合物和单独的组合物或与一种或多种抗精神病药物组合来治疗与弓形体感染相关的精神疾病的方法，包括但不限于精神分裂症。

6. 发明申请

US20100093651A1 Artemisinin Derivatives 有权
标题翻译：青蒿素衍生物
公开(公告)号：US20100093651A1
公开(公告)日：2010-04-15
申请号：US12445499
申请日：2007-10-19
申请人： Lorraine V. Brando , Gary H. Posner , John G. D'Angelo , Robert H. Yolken , Christopher P. Hencken , Lauren Woodard
发明人： Lorraine V. Brando , Gary H. Posner , John G. D'Angelo , Robert H. Yolken , Christopher P. Hencken , Lauren Woodard
IPC分类号： A61K31/366 , C07D407/14 , C07D417/14 , C07D493/18 , A61K31/427 , A61K31/428 , A61K31/4433 , A61K31/7048 , A61K31/585 , A61P31/00 , A61P25/18
CPC分类号： C07D493/18 , Y02A50/488
摘要： This disclosure provides improved derivatives of artemisinin; pharamaceutical compositions containing these compounds; methods for preparing these compounds and compositions; methods of using these compounds and compositions for preventing, controlling or treating infectious diseases including but not limited to parasitic infectious diseases such as T. gondii infection, trypanosome parasite infection, plasmodia parasite infection, and cryptosporidium parasite infection; methods for preventing, controlling or treating toxoplasma infection; and methods for treating psychiatric disorders associated with toxoplasma infection including but not limited to schizophrenia using the disclosed compounds and compositions alone or in combination with one or more antipsychotic drugs.
摘要翻译：本公开提供了改善的青蒿素衍生物; 含有这些化合物的药用组合物; 制备这些化合物和组合物的方法; 使用这些化合物和组合物用于预防，控制或治疗感染性疾病的方法，包括但不限于寄生传染病如弓形虫感染，锥虫寄生虫感染，疟原虫寄生虫感染和隐孢子虫寄生虫感染; 预防，控制或治疗弓形体感染的方法; 以及使用所公开的化合物和单独的组合物或与一种或多种抗精神病药物组合来治疗与弓形体感染相关的精神疾病的方法，包括但不限于精神分裂症。

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