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1. 发明申请

US20120148661A1 HIGH BIOAVAILABILITY ORAL PICOPLATIN ANTI-CANCER THERAPY 审中-公开
标题翻译：高生物量口服皮脂素抗癌治疗
公开(公告)号：US20120148661A1
公开(公告)日：2012-06-14
申请号：US13264343
申请日：2010-03-11
申请人： Angelica F. Phillips , Robert H. Earhart, JR. , Michael S. Perry
发明人： Angelica F. Phillips , Robert H. Earhart, JR. , Michael S. Perry
IPC分类号： A61K31/555 , A61K9/14 , A61K9/127 , A61P35/00 , A61N5/00 , A61K9/48 , C07F15/00 , B82Y5/00
CPC分类号： A61K31/44 , A61K9/1623 , A61K9/4858 , A61K31/555 , A61K33/24
摘要： The invention provides a method of treatment of cancer, wherein a individual doses of picoplatin, each of less than about 200 mg picoplatin content, the individual doses having high oral bioavailability, are administered to a patient in need thereof. The oral bioavailability can be greater than about 50%, or greater than about 75%, or greater than about 90%, depending upon the particular dosage form and dosing regimen used. The invention provides a quasi-metronomic dosing schedule including drug dosing intervals and drug intermission intervals, optionally including fasting periods prior to and following administration of each individual dose of picoplatin.
摘要翻译：本发明提供了一种治疗癌症的方法，其中将单独剂量的吡铂，每种小于约200mg皮素含量，具有高口服生物利用度的单个剂量施用于有需要的患者。取决于具体的剂型和使用的给药方案，口服生物利用度可以大于约50％，或大于约75％，或大于约90％。本发明提供了包括药物给药间隔和药物中断间隔的准节律剂剂量方案，任选地包括在给予每个单独剂量的吡铂之前和之后的禁食期。

2. 发明授权

US07870558B2 Handle passing using an inter-process communication 失效
标题翻译：使用进程间通信处理通过
公开(公告)号：US07870558B2
公开(公告)日：2011-01-11
申请号：US11182712
申请日：2005-07-15
申请人： Genevieve Fernandes , Adrian Marinescu , Neill M. Clift , Robert H. Earhart , Adnan Ilik
发明人： Genevieve Fernandes , Adrian Marinescu , Neill M. Clift , Robert H. Earhart , Adnan Ilik
IPC分类号： G06F3/00 , G06F9/44 , G06F9/46 , G06F13/00
CPC分类号： G06F9/54 , G06F9/468
摘要： Sharing access to resources using an inter-process communication (“IPC”) provides a connection in which references to resources are passed from a sender to a receiver in a trusted third party environment. A sender in possession of a reference to a resource, such as a handle to an object, may initiate the connection with the receiver. In turn, the receiver may accept or refuse the connection, and may further specify the types of resources in which the receiver is interested when accepting through the connection. Sharing access to resources in this manner advantageously insures that only a process that already has access to a resource is able to share that access with another process, and further that only processes that wish to do so will accept such access.
摘要翻译：使用进程间通信（“IPC”）共享对资源的访问提供了一种连接，其中资源的引用在受信任的第三方环境中从发送者传递到接收者。拥有对资源（例如对象的句柄）的引用的发送者可以发起与接收者的连接。反过来，接收机可以接受或拒绝连接，并且可以进一步指定接收者在通过连接接受时感兴趣的资源的类型。以这种方式共享对资源的访问有利地确保仅具有对资源的访问的进程能够与另一进程共享该访问，并且进一步地，仅希望这样访问的进程将接受该访问。

3. 发明授权

US07577657B2 System and method for updating objects in a multi-threaded computing environment 有权
标题翻译：用于在多线程计算环境中更新对象的系统和方法
公开(公告)号：US07577657B2
公开(公告)日：2009-08-18
申请号：US11084745
申请日：2005-03-18
申请人： Robert H Earhart
发明人： Robert H Earhart
IPC分类号： G06F17/30
CPC分类号： G06F9/526 , G06F2209/522 , Y10S707/99938
摘要： An interlocked object transfer data structure is provided for enabling requests made by multiple threads to update objects in a multi-threaded computing environment to be executed by a single processing thread. An object in the interlocked object transfer data structure contains a pair of flags, which the processing thread manipulates via interlocked operations to manage updates for the object that are requested by multiple threads.
摘要翻译：提供了一种互锁的对象传送数据结构，用于使由多个线程做出的请求能够更新要由单个处理线程执行的多线程计算环境中的对象。互锁对象传输数据结构中的一个对象包含一对标志，处理线程通过互锁操作来操作，以管理由多个线程请求的对象的更新。

4. 发明申请

US20080104586A1 Allowing Virtual Machine to Discover Virtual Status Thereof 审中-公开
标题翻译：允许虚拟机发现其虚拟状态
公开(公告)号：US20080104586A1
公开(公告)日：2008-05-01
申请号：US11553843
申请日：2006-10-27
申请人： Andrew John Thorton , Adrian J. Oney , Robert H. Earhart
发明人： Andrew John Thorton , Adrian J. Oney , Robert H. Earhart
IPC分类号： G06F9/455
CPC分类号： G06F9/45533
摘要： A host computing device has a virtual machine (VM) instantiated thereon. The VM has a virtual application instantiated thereon and a virtual processor. The host also has a virtual machine monitor (VMM) instantiated thereon to oversee the VM and to intercept instructions from a virtual entity comprising one of the virtual application and the VM to the virtual processor of such VM. The virtual entity becomes self-aware of the virtual status thereof based on a self-aware flag as obtained from the VMM, and based thereon obtains particular virtual metadata from a Synthetic range of the virtual processor by way of the VMM to operate efficiently. The Synthetic range of the virtual processor is implemented by the VMM and does not correspond to any defined range of the physical processor corresponding to the virtual processor.
摘要翻译：主计算设备具有在其上实例化的虚拟机（VM）。 VM具有在其上实例化的虚拟应用程序和虚拟处理器。主机还具有在其上实例化的虚拟机监视器（VMM），以监督虚拟机并且从包括虚拟应用程序和虚拟机中的虚拟实体的虚拟实体截取到该VM的虚拟处理器的指令。虚拟实体基于从VMM获得的自我感知标志变得自我感知其虚拟状态，并且基于该虚拟实体通过VMM从虚拟处理器的合成范围获得特定的虚拟元数据以有效地操作。虚拟处理器的合成范围由VMM实现，并且不对应于与虚拟处理器对应的物理处理器的任何定义的范围。

5. 发明授权

US5087639A Preventing CNS toxicity of acivicin when used with four large neutral amino acids 失效
标题翻译：使用四种大中性氨基酸时，可预防中枢神经系统毒性
公开(公告)号：US5087639A
公开(公告)日：1992-02-11
申请号：US266437
申请日：1988-11-02
申请人： J. Patrick McGovren , Marta G. Williams , Robert H. Earhart
发明人： J. Patrick McGovren , Marta G. Williams , Robert H. Earhart
IPC分类号： A61K31/195 , A61K31/42
CPC分类号： A61K31/195 , A61K31/42
摘要： A method for the prevention of central nervous system toxicity of acivicin which comprises the concomitant administration of acivicin and an amino acid solution consisting essentially of large neutral amino acids.
摘要翻译：一种用于预防acivicin的中枢神经系统毒性的方法，其包括伴随施用acivicin和基本上由大的中性氨基酸组成的氨基酸溶液。

6. 发明授权

US08874888B1 Managed boot in a cloud system 有权
标题翻译：在云系统中管理引导
公开(公告)号：US08874888B1
公开(公告)日：2014-10-28
申请号：US13344450
申请日：2012-01-05
申请人： Joseph S. Beda, III , Sanjeet Singh Mehat , Robert H. Earhart, III , Andrew Thornton , David T. McWherter , Evan K. Anderson , Frank Berreth
发明人： Joseph S. Beda, III , Sanjeet Singh Mehat , Robert H. Earhart, III , Andrew Thornton , David T. McWherter , Evan K. Anderson , Frank Berreth
IPC分类号： G06F15/177 , G06F9/24 , G06F9/00 , G06F9/455 , G06F9/44 , G06F9/445
CPC分类号： G06F9/4406 , G06F9/4401 , G06F9/4416 , G06F9/44505 , G06F9/455 , G06F9/45533 , G06F9/45558 , G06F2009/45575 , G06F2009/45579 , G06F2009/45595
摘要： Techniques and systems for managed boot are described. A described technique includes creating, at a server system, a boot image based on one or more user-specified parameters associated with virtual machine booting, providing a first virtual drive that includes the boot image, booting a virtual machine using the boot image on the first virtual drive, and providing a second virtual drive to the virtual machine, where the virtual machine mounts the second virtual drive as a root file system.
摘要翻译：描述了用于管理引导的技术和系统。所描述的技术包括在服务器系统处基于与虚拟机启动相关联的一个或多个用户指定的参数来创建引导映像，提供包括引导映像的第一虚拟驱动器，使用引导映像引导虚拟机第一虚拟驱动器，以及向虚拟机提供第二虚拟驱动器，其中虚拟机将第二虚拟驱动器作为根文件系统安装。

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