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    • 2. 发明授权
    • Preparation of high purity sodium (S)-2(6-methoxy-2-naphthyl)propionate
    • 制备高纯度(S)-2(6-甲氧基-2-萘基)丙酸钠
    • US5859292A
    • 1999-01-12
    • US988796
    • 1997-12-11
    • Hao V. PhanRobert E. Young
    • Hao V. PhanRobert E. Young
    • C07C51/41C07C63/34
    • C07C51/412
    • Sodium (S)-2-(6-methoxy-2-naphthyl)propionate of at least 99% chiral purity is formed from (S)-2-(6-methoxy-2-naphthyl)propionic acid having a chiral purity of at least about 82%, but below 99%. This is done by distilling a two-phase mixture formed from (i) the (S)-2-(6-methoxy-2-naphthyl)propionic acid, (ii) water, (iii) sodium hydroxide, sodium oxide and/or at least one basic inorganic sodium salt in an amount proportioned to neutralize from about 50 to about 99% of said acid, and optionally but preferably, (iv) an inert organic solvent that has a boiling point of at least 95.degree. C. at 760 mm Hg such that water is removed from said mixture, and a pot residue containing sodium (S)-2-(6-methoxy-2-naphthyl)propionate of at least 99% chiral purity is formed.
    • 具有至少99%手性纯度的(S)-2-(6-甲氧基-2-萘基)丙酸钠由手性纯度为(S)-2-(6-甲氧基-2-萘基)丙酸形成 至少约82%,但低于99%。 这是通过蒸馏由(i)(S)-2-(6-甲氧基-2-萘基)丙酸形成的两相混合物,(ii)水,(iii)氢氧化钠,氧化钠和/或 至少一种碱性无机钠盐,其成分为中和所述酸的约50至约99%,并且任选但优选(iv)在760℃下具有至少95℃的沸点的惰性有机溶剂 mm Hg,使得从所述混合物中除去水,并形成含有至少99%手性纯度的(S)-2-(6-甲氧基-2-萘基)丙酸钠的罐残渣。