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1. 发明授权

US08664239B2 Tacrolimus for improved treatment of transplant patients 有权
公开(公告)号：US08664239B2
公开(公告)日：2014-03-04
申请号：US13167420
申请日：2011-06-23
申请人： Robert D. Gordon , Per Holm , Anne-Marie Lademann , Tomas Norling
发明人： Robert D. Gordon , Per Holm , Anne-Marie Lademann , Tomas Norling
IPC分类号： A61K31/44 , A61K31/436
CPC分类号： A61K31/436 , A61K9/0053 , A61K9/1617 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/284 , A61K9/2846 , A61K9/4891 , A61K47/10 , Y10S514/885
摘要： An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

2. 发明授权

US5414805A Visual display transition effects using sorted table of display cells 失效
标题翻译：使用显示单元排序表的视觉显示过渡效果
公开(公告)号：US5414805A
公开(公告)日：1995-05-09
申请号：US972696
申请日：1992-11-06
申请人： Robert D. Gordon , Joseph F. Sinnott, Jr. , Lonnie S. Walling
发明人： Robert D. Gordon , Joseph F. Sinnott, Jr. , Lonnie S. Walling
IPC分类号： G06T13/80 , G06T15/70
CPC分类号： G06T13/80
摘要： A computer system generates transition effects for use on a visual display. The system includes a binary table for describing a transition effect and a method for ordering the rows in the table to produce the transition. The table includes an arbitrary number of rows, each row representing a cell (group of picture elements) on the display. A numerical value, based on any function of cell location, is associated with each cell. The table is then sorted according to the numerical values. Each row in the sorted table drives a step in the transition effect. The cells described by the various rows are changed in sorted order to display the material from the image being transitioned-to. The sequence of processing of the rows causes the desired transition effect. By varying the function used to order the rows, an infinite variety of transition effects can be created.
摘要翻译：计算机系统产生在视觉显示器上使用的过渡效果。该系统包括用于描述转换效果的二进制表和用于排序表中的行以产生转换的方法。该表包括任意数量的行，每行表示显示器上的一个单元格（图像元素组）。基于单元格位置的任何函数的数值与每个单元格相关联。然后根据数值对表进行排序。排序表中的每一行都会驱动转换效果的一个步骤。由各行描述的单元格按照排序顺序进行更改，以显示正在转换的图像中的材质。行的处理顺序会产生所需的过渡效果。通过改变用于排列行的功能，可以创建无限多种过渡效果。

3. 发明授权

US5150312A Animation processor method and apparatus 失效
标题翻译：动画处理器方法和装置
公开(公告)号：US5150312A
公开(公告)日：1992-09-22
申请号：US367284
申请日：1989-06-16
申请人： Bradley J. Beitel , Robert D. Gordon
发明人： Bradley J. Beitel , Robert D. Gordon
IPC分类号： H04N5/265 , G06T13/00 , G09G5/36 , G09G5/377 , G09G5/38 , G09G5/39 , G09G5/399
CPC分类号： G06T13/00
摘要： Method and apparatus for generating relative movement between a first image and a second image while avoiding display screen flicker. The method includes a step of copying to a first buffer a portion of a display memory corresponding to a present portion of the second image wherein a first image will first appear. The method further includes the steps of superimposing within the display memory the first image upon the present portion of the second image and copying to a second buffer the portion of the display memory corresponding to the present portion of the second image, including the first image superimposed thereon, and a portion of the display memory corresponding to a next portion of the second image wherein the first image will next appear. The method further includes the steps of erasing the first image from the second buffer by copying the present portion from the first buffer to the second buffer and superimposing, within the second buffer, the first image upon the next portion of the second image. The method includes a further step of copying the second buffer to the display memory such that the first image disappears from the present portion of the second image while simultaneously appearing within the next portion of the second image, thereby avoiding display screen flicker.

4. 发明授权

US4937760A Method for sharing common values implicitly among communicating generative objects 失效
标题翻译：在通信生成对象中隐含共享公共值的方法
公开(公告)号：US4937760A
公开(公告)日：1990-06-26
申请号：US246472
申请日：1988-09-19
申请人： Bradley J. Beitel , Robert D. Gordon , Ming C. Hao , Steven V. Kauffman , Ronald L. Obermarck , Arthur M. Sherman , Lynne C. Thieme , Gene E. Trivett , Lynn Trivett
发明人： Bradley J. Beitel , Robert D. Gordon , Ming C. Hao , Steven V. Kauffman , Ronald L. Obermarck , Arthur M. Sherman , Lynne C. Thieme , Gene E. Trivett , Lynn Trivett
IPC分类号： G06F9/44 , G06F9/46 , G06N5/04
CPC分类号： G06F9/54 , G06N5/046
摘要： A method for synchronizing common values in a distributed system, at least one node of which is a cyclic, rule-based, object-sensitive production system. Values altered in one part of the system are implicity rather than explicitly communicated and processed to and from the rule-based node. All communications to the rule-based node of common values changed by the nonrule-based nodes are by way of a list independent of and concurrently with any procedural request of the rule-based node, there being no necessary relation between the list contents and the procedural request.

5. 发明申请

US20120029009A1 Tacrolimus For Improved Treatment Of Transplant Patients 有权
标题翻译：他克莫司用于改善移植患者的治疗
公开(公告)号：US20120029009A1
公开(公告)日：2012-02-02
申请号：US13167420
申请日：2011-06-23
申请人： Robert D. Gordon , Per Holm , Anne-Marie Lademann , Tomas Norling
发明人： Robert D. Gordon , Per Holm , Anne-Marie Lademann , Tomas Norling
IPC分类号： A61K31/436 , A61P37/06
CPC分类号： A61K31/436 , A61K9/0053 , A61K9/1617 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/284 , A61K9/2846 , A61K9/4891 , A61K47/10 , Y10S514/885
摘要： An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.
摘要翻译：包括作为活性物质他克莫司或其药学活性类似物的延长释放口服剂型，每天一次免疫抑制治疗有需要的患者，优选肾或肝移植患者。剂型长时间释放活性物质。它还提供改善的药物动力学参数，由于延长的和恒定的体内释放，包括显着降低的峰浓度，尽管与常规立即释放剂型和最近的改进释放他克莫司相比，尽管生物利用度增加，最大浓度的显着延长时间和更高的最小浓度剂型

6. 发明授权

US5491778A System and method for providing visual display transition effects 失效
标题翻译：提供视觉显示过渡效果的系统和方法
公开(公告)号：US5491778A
公开(公告)日：1996-02-13
申请号：US324196
申请日：1994-10-17
申请人： Robert D. Gordon , Joseph F. Sinnott, Jr. , Lonnie S. Walling
发明人： Robert D. Gordon , Joseph F. Sinnott, Jr. , Lonnie S. Walling
IPC分类号： G06T13/80 , G06T3/00
CPC分类号： G06T13/80
摘要： A system is provided for generating transition effects for use on a visual display. The system includes a binary table for describing a transition effect and a method for ordering the rows in the table to produce the transition. The table includes an arbitrary number of rows, each row representing a cell (group of picture elements) on the display. A numerical value, based on any function of cell location, is associated with each cell. The table is then sorted according to the numerical values. Each row in the sorted table drives a step in the transition effect. The cells described by the various rows are changed in sorted order to display the material from the image being transitioned-to. The sequence of processing of the rows causes the desired transition effect. By varying the function used to order the rows, an infinite variety of transition effects can be created.
摘要翻译：提供了一种用于产生在视觉显示器上使用的过渡效果的系统。该系统包括用于描述转换效果的二进制表和用于排序表中的行以产生转换的方法。该表包括任意数量的行，每行表示显示器上的一个单元格（图像元素组）。基于单元格位置的任何函数的数值与每个单元格相关联。然后根据数值对表进行排序。排序表中的每一行都会驱动转换效果的一个步骤。由各行描述的单元格按照排序顺序进行更改，以显示正在转换的图像中的材质。行的处理顺序会产生所需的过渡效果。通过改变用于排列行的功能，可以创建无限多种过渡效果。

7. 发明申请

US20110275659A1 Tacrolimus For Improved Treatment Of Transplant Patients 审中-公开
标题翻译：他克莫司用于改善移植患者的治疗
公开(公告)号：US20110275659A1
公开(公告)日：2011-11-10
申请号：US13167381
申请日：2011-06-23
申请人： Robert D. GORDON , Per HOLM , Anne-Marie LADEMANN , Tomas NORLING
发明人： Robert D. GORDON , Per HOLM , Anne-Marie LADEMANN , Tomas NORLING
IPC分类号： A61K31/436 , A61P37/06
CPC分类号： A61K31/436 , A61K9/0053 , A61K9/1617 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/284 , A61K9/2846 , A61K9/4891 , A61K47/10 , Y10S514/885
摘要： An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.
摘要翻译：包括作为活性物质他克莫司或其药学活性类似物的延长释放口服剂型，每天一次免疫抑制治疗有需要的患者，优选肾或肝移植患者。剂型长时间释放活性物质。它还提供改善的药物动力学参数，由于延长的和恒定的体内释放，包括显着降低的峰浓度，尽管与常规立即释放剂型和最近的改进释放他克莫司相比，尽管生物利用度增加，最大浓度的显着延长时间和更高的最小浓度剂型

8. 发明授权

US06783953B1 Vascular endothelial growth factor-X 有权
标题翻译：血管内皮生长因子-X
公开(公告)号：US06783953B1
公开(公告)日：2004-08-31
申请号：US09468647
申请日：1999-12-21
申请人： Robert D. Gordon , Jörg J. Sprengel , Jeffrey R. Yon , Josiena J. H. Dijkmans , Anna Gosiewska , Sridevi N. Dhanaraj , Jean Xu
发明人： Robert D. Gordon , Jörg J. Sprengel , Jeffrey R. Yon , Josiena J. H. Dijkmans , Anna Gosiewska , Sridevi N. Dhanaraj , Jean Xu
IPC分类号： C12P2106
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： There is provided a novel vascular endothelial growth factor, herein designated VEGF-X, in addition to the nucleic acid molecule encoding it, a host cell transformed with said vector and compounds which inhibit or enhance angiogenesis. Also provided is the sequence of a CUB domain present in the sequence of VEGF-X which domain itself prevents angiogenesis and which is used to treat diseases associated with inappropriate vascularisation or angiogenesis.
摘要翻译：除了编码它的核酸分子，用所述载体转化的宿主细胞和抑制或增强血管发生的化合物之外，还提供了新颖的血管内皮生长因子，其被称为VEGF-X。还提供了存在于VEGF-X序列中的CUB结构域本身防止血管生成并用于治疗与不适当血管形成或血管发生相关的疾病的序列。

9. 发明授权

US08685998B2 Tacrolimus for improved treatment of transplant patients 有权
标题翻译：他克莫司用于改善移植患者的治疗
公开(公告)号：US08685998B2
公开(公告)日：2014-04-01
申请号：US12499034
申请日：2009-07-07
申请人： Robert D. Gordon , Per Holm , Anne-Marie Lademann , Tomas Norling
发明人： Robert D. Gordon , Per Holm , Anne-Marie Lademann , Tomas Norling
IPC分类号： A61K31/44 , A61K31/436
CPC分类号： A61K31/436 , A61K9/0053 , A61K9/1617 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/284 , A61K9/2846 , A61K9/4891 , A61K47/10 , Y10S514/885
摘要： An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.
摘要翻译：包括作为活性物质他克莫司或其药学活性类似物的延长释放口服剂型，每天一次免疫抑制治疗有需要的患者，优选肾或肝移植患者。剂型长时间释放活性物质。它还提供改善的药物动力学参数，由于延长的和恒定的体内释放，包括显着降低的峰浓度，尽管与常规立即释放剂型和最近的改进释放他克莫司相比，尽管生物利用度增加，最大浓度的显着延长时间和更高的最小浓度剂型

10. 发明授权

US08135603B1 Method for formulating a plan to secure access to limited deliverable resources 有权
标题翻译：制定计划以确保获得有限可交付资源的方法
公开(公告)号：US08135603B1
公开(公告)日：2012-03-13
申请号：US12077901
申请日：2008-03-20
申请人： Robert D. Gordon
发明人： Robert D. Gordon
IPC分类号： G06Q10/00
CPC分类号： G06Q10/06315 , G06Q10/0631 , G06Q10/0637
摘要： The method of applying constraints across a generally extensible and configurable resource delivery system as a basis for identifying or calculating the relative impacts of each constraint on resource delivery to various points and, through the use of constraint release mechanisms, developing prescriptive courses of action to optimize and increase the certainty of delivery of the resource, or in the reverse sense, restrict delivery of the resource. In an embodiment of the present invention, a method for characterizing the availability and potential use of water resources alongside associated impacts in order to identify and time the various policy decisions and investments needed to ensure access to water supplies over time given multiple stakeholders and uncertain, variable supplies and demands where such embodiment provides additional methods generally applicable across the full scope of embodiments of the invention.
摘要翻译：在通常可扩展和可配置的资源传递系统中应用约束的方法作为识别或计算每个约束对资源传递到各个点的相对影响的基础，并且通过使用约束释放机制来制定规定的行动方案以优化并且增加资源的确定性，或者相反地，限制资源的传递。在本发明的一个实施例中，一种用于表征水资源的可用性和潜在用途以及相关影响的方法，以便识别和时间确保多个利益相关者和不确定因素确保获得供水所需的各种政策决策和投资，可变供应和需求，其中这样的实施例提供了在本发明的整个实施例的整个范围内通常可应用的附加方法。

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