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1. 发明授权

US08725425B2 Image data efficient genetic sequencing method and system 有权
标题翻译：图像数据有效的遗传测序方法和系统
公开(公告)号：US08725425B2
公开(公告)日：2014-05-13
申请号：US12020739
申请日：2008-01-28
申请人： David L. Heiner , Robert C. Kain
发明人： David L. Heiner , Robert C. Kain
IPC分类号： G06F19/00 , G06F15/00 , C12Q1/68 , C12M1/00
CPC分类号： C12Q1/6874 , C12Q1/686 , C12Q1/6869 , G06F19/20 , G06F19/22 , C12Q2565/501 , C12Q2537/143
摘要： A technique is disclosed for performing sequencing of polymers such as DNA and RNA. A sample containing multiple sites to be sequenced is cyclically subjected to attachment of nucleotides, and imaging. A digital mask corresponding to sites of interest in the sample array is generated and image data for the sites is processed differently from image data not corresponding to sites of interest. The latter may be discarded during the sequencing operation. The use of the mask improves computational efficiency and reduces memory allocated for the image data during sequencing.
摘要翻译：公开了一种用于进行聚合物如DNA和RNA的测序的技术。含有待测序的多个位点的样品循环地进行核苷酸的附着和成像。产生对应于样本阵列中的感兴趣位点的数字掩码，并且处理不同于不对应于感兴趣的位点的图像数据的站点的图像数据。后者可能在排序操作期间丢弃。掩码的使用提高了计算效率，并减少了排序期间为图像数据分配的内存。

2. 发明授权

US08628952B2 Array kits and processing systems 有权
标题翻译：阵列套件和处理系统
公开(公告)号：US08628952B2
公开(公告)日：2014-01-14
申请号：US12405162
申请日：2009-03-16
申请人： John R. Stuelpnagel , Mark S. Chee , Steven R. Auger , Gan G. Wang , Laura S. Casas , Shawn Christopher Baker , Robert C. Kain
发明人： John R. Stuelpnagel , Mark S. Chee , Steven R. Auger , Gan G. Wang , Laura S. Casas , Shawn Christopher Baker , Robert C. Kain
IPC分类号： C12M1/34 , C12M3/00 , G01N15/06 , G01N21/00 , G01N33/543 , C07H21/02 , C07H21/04
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00382 , B01J2219/005 , B01J2219/00511 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , G01N33/54393
摘要： The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods of making and using the composite arrays. The invention further provides a hybridization chamber for use with a composite array.
摘要翻译：本发明涉及包括单独阵列的复合阵列的传感器组合物，以允许同时处理多个样品。本发明还提供了制备和使用复合阵列的方法。本发明还提供了一种与复合阵列一起使用的杂交室。

3. 发明授权

US08315817B2 Independently removable nucleic acid sequencing system and method 有权
标题翻译：独立拆除的核酸测序系统及方法
公开(公告)号：US08315817B2
公开(公告)日：2012-11-20
申请号：US12492073
申请日：2009-06-25
申请人： Robert C. Kain , David L. Heiner , Chanfeng Zhao , Kevin Gunderson
发明人： Robert C. Kain , David L. Heiner , Chanfeng Zhao , Kevin Gunderson
IPC分类号： G06F19/00 , C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6874 , C12Q1/686 , C12Q1/6869 , C12Q2565/501 , C12Q2537/143
摘要： A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.
摘要翻译：公开了以自动或半自动方式测序核酸的技术。多个核酸位点的样品阵列在多个周期内进行处理以向要测序的材料添加核苷酸，检测添加到位点的核苷酸，以及去除阻断剂的添加核苷酸和用于鉴定最后添加的标签核苷酸。对系统的多个参数进行监控，以便在样品排序期间发生问题的诊断和纠正。质量控制程序在排序过程中运行，以确定样品的质量和收集的数据的质量。

4. 发明授权

US07901897B2 Methods of making arrays 有权
标题翻译：数组方法
公开(公告)号：US07901897B2
公开(公告)日：2011-03-08
申请号：US12405163
申请日：2009-03-16
申请人： John R Stuelpnagel , Mark S Chee , Steven R Auger , Gan G Wang , Laura S Casas , Shawn Christopher Baker , Robert C Kain
发明人： John R Stuelpnagel , Mark S Chee , Steven R Auger , Gan G Wang , Laura S Casas , Shawn Christopher Baker , Robert C Kain
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00382 , B01J2219/005 , B01J2219/00511 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , G01N33/54393
摘要： The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods of making and using the composite arrays. The invention further provides a hybridization chamber for use with a composite array.
摘要翻译：本发明涉及包括单独阵列的复合阵列的传感器组合物，以允许同时处理多个样品。本发明还提供了制备和使用复合阵列的方法。本发明还提供了一种与复合阵列一起使用的杂交室。

5. 发明授权

US07835871B2 Nucleic acid sequencing system and method 有权
标题翻译：核酸测序系统及方法
公开(公告)号：US07835871B2
公开(公告)日：2010-11-16
申请号：US12020721
申请日：2008-01-28
申请人： Robert C. Kain , David L. Heiner , Chanfeng Zhao , Kevin Gunderson
发明人： Robert C. Kain , David L. Heiner , Chanfeng Zhao , Kevin Gunderson
IPC分类号： G06F19/00 , C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/686 , C12Q1/6869 , G06F19/20 , G06F19/22 , C12Q2565/501 , C12Q2537/143
摘要： A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.
摘要翻译：公开了以自动或半自动方式测序核酸的技术。多个核酸位点的样品阵列在多个周期内进行处理以向要测序的材料添加核苷酸，检测添加到位点的核苷酸，以及去除阻断剂的添加核苷酸和用于鉴定最后添加的标签核苷酸。对系统的多个参数进行监控，以便在样品排序期间发生问题的诊断和纠正。质量控制程序在排序过程中运行，以确定样品的质量和收集的数据的质量。

6. 发明申请

US20100138162A1 NUCLEIC ACID SEQUENCING SYSTEM AND METHOD USING A SUBSET OF SITES OF A SUBSTRATE 有权
标题翻译：核酸序列测序系统和使用基片的位点的方法
公开(公告)号：US20100138162A1
公开(公告)日：2010-06-03
申请号：US12492078
申请日：2009-06-25
申请人： Robert C. Kain , David L. Heiner , Chanfeng Zhao , Kevin Gunderson
发明人： Robert C. Kain , David L. Heiner , Chanfeng Zhao , Kevin Gunderson
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： C12Q1/6874 , C12Q1/686 , C12Q1/6869 , G06F19/20 , G06F19/22 , C12Q2565/501 , C12Q2537/143
摘要： A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.
摘要翻译：公开了以自动或半自动方式测序核酸的技术。多个核酸位点的样品阵列在多个周期内进行处理以向要测序的材料添加核苷酸，检测添加到位点的核苷酸，以及去除阻断剂的添加核苷酸和用于鉴定最后添加的标签核苷酸。对系统的多个参数进行监控，以便在样品排序期间发生问题的诊断和纠正。质量控制程序在排序过程中运行，以确定样品的质量和收集的数据的质量。

7. 发明申请

US20090298716A1 COMPOSITE ARRAYS UTILIZING MICROSPHERES WITH A HYBRIDIZATION CHAMBER 审中-公开
标题翻译：使用混合室的复合微阵列
公开(公告)号：US20090298716A1
公开(公告)日：2009-12-03
申请号：US12419218
申请日：2009-04-06
申请人： John R. Stuelpnagel , Mark S. Chee , Steven R. Auger , Gan G. Wang , Laura S. Casas , Shawn Christopher Baker , Robert C. Kain
发明人： John R. Stuelpnagel , Mark S. Chee , Steven R. Auger , Gan G. Wang , Laura S. Casas , Shawn Christopher Baker , Robert C. Kain
IPC分类号： C40B50/14
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00382 , B01J2219/005 , B01J2219/00511 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , G01N33/54393
摘要： The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods of making and using the composite arrays. The invention further provides a hybridization chamber for use with a composite array.
摘要翻译：本发明涉及包括单独阵列的复合阵列的传感器组合物，以允许同时处理多个样品。本发明还提供了制备和使用复合阵列的方法。本发明还提供了一种与复合阵列一起使用的杂交室。

8. 发明授权

US08914241B2 Nucleic acid sequencing system and method 有权
标题翻译：核酸测序系统及方法
公开(公告)号：US08914241B2
公开(公告)日：2014-12-16
申请号：US12878687
申请日：2010-09-09
申请人： Robert C. Kain , David L. Heiner , Chanfeng Zhao , Kevin Gunderson
发明人： Robert C. Kain , David L. Heiner , Chanfeng Zhao , Kevin Gunderson
IPC分类号： G06F19/20 , C12Q1/68 , C12M1/34 , C12M3/00 , G06F19/22
CPC分类号： C12Q1/6874 , C12Q1/686 , C12Q1/6869 , G06F19/20 , G06F19/22 , C12Q2565/501 , C12Q2537/143
摘要： A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.
摘要翻译：公开了以自动或半自动方式测序核酸的技术。多个核酸位点的样品阵列在多个周期内进行处理以向要测序的材料添加核苷酸，检测添加到位点的核苷酸，以及去除阻断剂的添加核苷酸和用于鉴定最后添加的标签核苷酸。对系统的多个参数进行监控，以便在样品排序期间发生问题的诊断和纠正。质量控制程序在排序过程中运行，以确定样品的质量和收集的数据的质量。

9. 发明申请

US20090221450A1 METHODS OF MAKING ARRAYS 有权
标题翻译：制作阵列的方法
公开(公告)号：US20090221450A1
公开(公告)日：2009-09-03
申请号：US12405163
申请日：2009-03-16
申请人： John R Stuelpnagel , Mark S. Chee , Steven R. Auger , Gan G. Wang , Laura S. Casas , Shawn Christopher Baker , Robert C. Kain
发明人： John R Stuelpnagel , Mark S. Chee , Steven R. Auger , Gan G. Wang , Laura S. Casas , Shawn Christopher Baker , Robert C. Kain
IPC分类号： C40B50/18
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00382 , B01J2219/005 , B01J2219/00511 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , G01N33/54393
摘要： The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods of making and using the composite arrays. The invention further provides a hybridization chamber for use with a composite array.
摘要翻译：本发明涉及包括单独阵列的复合阵列的传感器组合物，以允许同时处理多个样品。本发明还提供了制备和使用复合阵列的方法。本发明还提供了一种与复合阵列一起使用的杂交室。

10. 发明授权

US6008892A Optical substrate for enhanced detectability of fluorescence 失效
标题翻译：用于增强荧光检测性的光学基底
公开(公告)号：US6008892A
公开(公告)日：1999-12-28
申请号：US864363
申请日：1997-05-23
申请人： Robert C. Kain , Eric G. Marason , Richard F. Johnston
发明人： Robert C. Kain , Eric G. Marason , Richard F. Johnston
IPC分类号： G01N21/01 , G01N21/64 , G01N1/00
CPC分类号： G01N21/6456 , G01N21/6452 , G01N21/6428
摘要： A sample substrate for use in a fluorescence imaging system includes a rigid base with a specularly reflective surface, typically metal, on which is deposited a transparent coating layer. The coating layer has a thickness selected so that a particular fluorescence excitation wavelength, corresponding to a specified fluorescent constituent to be sought in sample material, has an optical path from the top of the coating layer to the reflecting surface in the base of substantially an odd multiple of one-quarter wavelength, so that the standing wave of the fluorescence excitation wavelength of light incident on the substrate has an antinode located at or near where sample material would be disposed on top of the coating layer. This maximizes fluorescence excitation of the sample on the reflective substrate. The transparent coating layer may be a dielectric material (e.g. silica) or may be a multilayer structure with a top layer of biologically active material for binding a specified sample constituent.
摘要翻译：用于荧光成像系统的样品衬底包括具有镜面反射表面（通常为金属）的刚性基底，其上沉积有透明涂层。涂层具有选择的厚度，使得对应于在样品材料中寻找的特定荧光成分的特定荧光激发波长具有从涂层的顶部到基底中的反射表面的基本上奇数的光路使得入射到基板上的光的荧光激发波长的驻波具有位于或附近的样品材料将设置在涂层顶部上的波腹。这使得样品在反射基板上的荧光激发最大化。透明涂层可以是介电材料（例如二氧化硅），也可以是具有用于结合特定样品成分的生物活性材料顶层的多层结构。

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