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1. 发明授权

US09732427B2 Tunable nanoporous films on polymer substrates, and method for their manufacture 有权
公开(公告)号：US09732427B2
公开(公告)日：2017-08-15
申请号：US13817922
申请日：2011-08-25
申请人： David J. Poxson , Frank W. Mont , E. Fred Schubert , Richard W. Siegel
发明人： David J. Poxson , Frank W. Mont , E. Fred Schubert , Richard W. Siegel
IPC分类号： C23C14/08 , C23C16/48 , C23C14/10 , C23C14/22 , C23C14/32 , C23C14/34 , C23C16/44 , C23C16/50 , B82Y20/00 , B82Y30/00
CPC分类号： C23C16/487 , B82Y20/00 , B82Y30/00 , C23C14/083 , C23C14/10 , C23C14/226 , C23C14/325 , C23C14/34 , C23C16/44 , C23C16/50 , Y02T50/67 , Y10T428/249967 , Y10T428/249969 , Y10T428/24997 , Y10T428/249978
摘要： The invention is directed to a composite polymer/nanoporous film system and methods of fabrication of tunable nanoporous coatings on flexible polymer substrates. The porosity of the nanoporous film can be tuned during fabrication to a desired value by adjusting the deposition conditions. Experiments show that SiO2 coatings with tunable porosity fabricated by oblique-angle electron beam deposition can be deposited on polymer substrates. These conformable coatings have many applications, including in the field of optics where the ability to fabricate tunable refractive index coatings on a variety of materials and shapes is of great importance.

2. 发明授权

US09562225B2 Internalization of proteins into hollowed gold nanostructures 有权
标题翻译：将蛋白质内化为中空金纳米结构
公开(公告)号：US09562225B2
公开(公告)日：2017-02-07
申请号：US14676258
申请日：2015-04-01
申请人： Xi Qian , Jennifer E. Gagner , Jonathan S. Dordick , Richard W. Siegel
发明人： Xi Qian , Jennifer E. Gagner , Jonathan S. Dordick , Richard W. Siegel
IPC分类号： C12N11/14 , C12N9/36 , C23C18/16 , B82Y40/00 , C23C18/54 , A61K47/48
CPC分类号： C12N11/14 , A61K47/48861 , A61K47/48884 , A61K47/6923 , A61K47/6929 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C12N9/2462 , C12Y302/01017 , C12Y304/21001 , C23C18/1635 , C23C18/1657 , C23C18/54
摘要： Provided is a gold nanocage with pores, charged ligand molecules covalently bound to internal surfaces of the gold nanocage, and payload molecules electrostatically adsorbed onto said charged ligand molecules, wherein a pore diameter is between 1.2 and 20 times a gyration radius of the payload molecule. Also provided is a method for making a nanoparticle, including using polyvinylpyrrolidone as a capping agent in a galvanic replacement reaction to convert a silver nanocube into a gold nanocage having pores, replacing the polyvinylpyrrolidone on internal surfaces with charged ligand molecules, and electrostatically adsorbing payload molecules onto the charged ligand molecules, with a pore diameter less than twenty times a gyration radius of the payload molecule. Also provided is a method of delivering a pharmacological agent to a mammalian cell, including contacting the cell with a gold nanocage having pores, ligand molecules bound to internal surfaces, and pharmacological agent adsorbed onto ligand molecules.
摘要翻译：提供了具有孔的金纳米笼，带电的配体分子共价结合到金纳米笼的内表面，以及静电吸附到所述带电配位体分子上的有效载荷分子，其中孔直径为有效载荷分子的回转半径的1.2至20倍。还提供了一种制备纳米颗粒的方法，包括在电替换反应中使用聚乙烯吡咯烷酮作为封端剂将银纳米管转化成具有孔的金纳米笼，用带电的配体分子代替内表面上的聚乙烯吡咯烷酮，以及静电吸附有效载体分子带电的配体分子，其孔径小于有效载荷分子的回转半径的二十倍。还提供了将药理学递送到哺乳动物细胞的方法，包括使细胞与具有孔的金纳米笼，结合到内表面的配体分子和吸附在配体分子上的药理学接触。

3. 发明申请

US20120301870A1 Enhanced Stability of Proteins Immobilized on Nanoparticles 有权
标题翻译：固定在纳米颗粒上的蛋白质的增强的稳定性
公开(公告)号：US20120301870A1
公开(公告)日：2012-11-29
申请号：US13456571
申请日：2012-04-26
申请人： Jonathan S. Dordick , Ravindra S. Kane , Prashanth Asuri , Sandeep S. Karajanagi , Alexey A. Vertegel , Richard W. Siegel
发明人： Jonathan S. Dordick , Ravindra S. Kane , Prashanth Asuri , Sandeep S. Karajanagi , Alexey A. Vertegel , Richard W. Siegel
IPC分类号： C12N11/00 , C12Q1/25 , C12N11/14 , C12N11/08 , C12N9/96 , C12S9/00 , B82Y15/00
CPC分类号： G01N33/54346 , B82Y15/00 , C12Q1/001 , G01N33/587 , G01N33/588
摘要： This invention is directed to the application of a previously unknown property of nanomaterials—its ability to enhance protein activity and stability at high temperatures, in organic solvents, and in polymer composites. Nanomaterials such as single-walled carbon nanotubes (SWNTs) can significantly enhance enzyme function and stability in strongly denaturing environments. Experimental results and theoretical analysis reveal that the enhancement in stability is a result of the curvature of these nanoscale materials, which suppresses unfavorable protein-protein interactions.
摘要翻译：本发明涉及以前未知的纳米材料性质的应用 - 其在高温下，有机溶剂和聚合物复合材料中增强蛋白质活性和稳定性的能力。纳米材料如单壁碳纳米管（SWNT）可以显着增强强力变性环境中的酶功能和稳定性。实验结果和理论分析表明，稳定性的提高是这些纳米材料的曲率的结果，其抑制不利的蛋白质 - 蛋白质相互作用。

4. 发明授权

US06667360B1 Nanoparticle-filled polymers 有权
标题翻译：纳米颗粒填充聚合物
公开(公告)号：US06667360B1
公开(公告)日：2003-12-23
申请号：US09329697
申请日：1999-06-10
申请人： Chek Beng Ng , Linda S. Schadler , Richard W. Siegel
发明人： Chek Beng Ng , Linda S. Schadler , Richard W. Siegel
IPC分类号： C08K334
CPC分类号： B82Y30/00 , C08K3/01 , C08K2201/011 , Y10S977/773 , Y10S977/779 , Y10S977/788
摘要： Polymer resins incorporating nanoparticles having a particle size in the range of 1-100 nm and a narrow particle size distribution have improved tensile properties and scratch resistance.
摘要翻译：纳米颗粒的聚合物树脂具有1-100nm的粒度和窄的粒度分布，具有改进的拉伸性能和耐擦伤性。

5. 发明授权

US5128081A Method of making nanocrystalline alpha alumina 失效
标题翻译：制备纳米晶α氧化铝的方法
公开(公告)号：US5128081A
公开(公告)日：1992-07-07
申请号：US446585
申请日：1989-12-05
申请人： Richard W. Siegel , Horst Hahn , Jeffrey A. Eastman
发明人： Richard W. Siegel , Horst Hahn , Jeffrey A. Eastman
IPC分类号： B01J3/00 , B22F3/00 , B22F9/12 , C01B13/32 , C01B33/02 , C01F5/04 , C01F7/42 , C01G9/02 , C01G23/047
CPC分类号： B82Y30/00 , B01J3/006 , B22F3/006 , B22F9/12 , C01B13/322 , C01B33/02 , C01F5/04 , C01F7/424 , C01G23/047 , C01G9/02 , C01P2002/72 , C01P2004/62 , C01P2004/64 , C01P2006/21
摘要： Method of making selected phases of nanocrystalline ceramic materials. Various methods of controlling the production of nanocrystalline alpha alumina and titanium oxygen phases are described. Control of the gas atmosphere and use of particular oxidation treatments give rise to the ability to control the particular phases provided in the aluminum/oxygen and titanium/oxygen system.
摘要翻译：制备纳米晶陶瓷材料的选定方法。描述了控制纳米晶α氧化铝和钛氧相的生产的各种方法。气体气氛的控制和特定氧化处理的使用产生了控制铝/氧和钛/氧系统中提供的特定相的能力。

6. 发明申请

US20160097081A1 INTERNALIZATION OF PROTEINS INTO HOLLOWED GOLD NANOSTRUCTURES 有权
标题翻译：将蛋白质内部化成中性黄金纳米结构
公开(公告)号：US20160097081A1
公开(公告)日：2016-04-07
申请号：US14676258
申请日：2015-04-01
申请人： Xi QIAN , Jennifer E. GAGNER , Jonathan S. DORDICK , Richard W. SIEGEL
发明人： Xi QIAN , Jennifer E. GAGNER , Jonathan S. DORDICK , Richard W. SIEGEL
IPC分类号： C12Q1/34 , G01N33/50 , C25D1/00 , C12N9/96
CPC分类号： C12N11/14 , A61K47/48861 , A61K47/48884 , A61K47/6923 , A61K47/6929 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C12N9/2462 , C12Y302/01017 , C12Y304/21001 , C23C18/1635 , C23C18/1657 , C23C18/54
摘要： Provided is a gold nanocage with pores, charged ligand molecules covalently bound to internal surfaces of the gold nanocage, and payload molecules electrostatically adsorbed onto said charged ligand molecules, wherein a pore diameter is between 1.2 and 20 times a gyration radius of the payload molecule. Also provided is a method for making a nanoparticle, including using polyvinylpyrrolidone as a capping agent in a galvanic replacement reaction to convert a silver nanocube into a gold nanocage having pores, replacing the polyvinylpyrrolidone on internal surfaces with charged ligand molecules, and electrostatically adsorbing payload molecules onto the charged ligand molecules, with a pore diameter less than twenty times a gyration radius of the payload molecule. Also provided is a method of delivering a pharmacological agent to a mammalian cell, including contacting the cell with a gold nanocage having pores, ligand molecules bound to internal surfaces, and pharmacological agent adsorbed onto ligand molecules.
摘要翻译：提供了具有孔的金纳米笼，带电的配体分子共价结合到金纳米笼的内表面，以及静电吸附到所述带电配位体分子上的有效载荷分子，其中孔直径为有效载荷分子的回转半径的1.2至20倍。还提供了一种制备纳米颗粒的方法，包括在电替换反应中使用聚乙烯吡咯烷酮作为封端剂将银纳米管转化成具有孔的金纳米笼，用带电的配体分子代替内表面上的聚乙烯吡咯烷酮，以及静电吸附有效载体分子带电的配体分子，其孔径小于有效载荷分子的回转半径的二十倍。还提供了将药理学递送到哺乳动物细胞的方法，包括使细胞与具有孔的金纳米笼，结合到内表面的配体分子和吸附在配体分子上的药理学接触。

7. 发明授权

US08974915B2 Block copolymer and nanofiller composites 有权
标题翻译：嵌段共聚物和纳米填料复合材料
公开(公告)号：US08974915B2
公开(公告)日：2015-03-10
申请号：US11080668
申请日：2005-03-16
申请人： Junrong Zheng , Rahmi Ozisik , Richard W. Siegel
发明人： Junrong Zheng , Rahmi Ozisik , Richard W. Siegel
IPC分类号： B32B15/08 , B82Y30/00 , C08K3/22
CPC分类号： B82Y30/00 , C08K3/22 , C08K2003/2296 , C08K2201/011 , Y10T428/12569
摘要： PU/ZnO nanocomposites are provided wherein the addition of less than 1 vol % 33 nm ZnO nanoparticles into a PU matrix effect a decrease in the Young's Modulus and storage modulus of the polymer, while simultaneously effecting an increase glass transition temperature of the polymer. Detailed experiments are described (e.g., FTIR, DMTA, FESEM and AFM) that suggest that the reaction between hydroxyl groups of the ZnO nanoparticles and isocyanate groups of the polyurethane prepolymer disrupts the self-assembly of the phase separation in PU. Phase separation is responsible for the good mechanical properties of PU. Further, detailed experiments suggest that the increase of the glass transition temperature results from the crosslinking effect of the ZnO nanoparticles.
摘要翻译：提供了PU / ZnO纳米复合材料，其中将少于1体积％的33纳米ZnO纳米颗粒加入到PU基质中可以降低聚合物的杨氏模量和储能模量，同时会增加聚合物的玻璃化转变温度。描述了详细的实验（例如，FTIR，DMTA，FESEM和AFM），其表明ZnO纳米颗粒的羟基与聚氨酯预聚物的异氰酸酯基团之间的反应破坏了PU中相分离的自组装。相分离负责PU的良好机械性能。此外，详细的实验表明，玻璃化转变温度的升高是由ZnO纳米颗粒的交联效应引起的。

8. 发明授权

US07923500B2 Nanocomposites with controlled electrical properties 有权
标题翻译：具有受控电性能的纳米复合材料
公开(公告)号：US07923500B2
公开(公告)日：2011-04-12
申请号：US10568829
申请日：2004-08-20
申请人： Richard W. Siegel , Linda Schadler-Feist , Dongling Ma , Jung-Il Hong , Eva Martensson , Carina Onneby
发明人： Richard W. Siegel , Linda Schadler-Feist , Dongling Ma , Jung-Il Hong , Eva Martensson , Carina Onneby
IPC分类号： C08K3/18
CPC分类号： H01B3/004 , B82Y30/00 , C08K3/22 , C08K2201/011 , H02G15/068 , H02G15/103 , H02G15/105
摘要： A field grading material includes a field grading effective amount of a nanoparticle filler distributed in a polymeric matrix, and the nanoparticle filler is heterogeneously distributed in the polymeric matrix.
摘要翻译：场分级材料包括分散在聚合物基质中的纳米颗粒填料的场分级有效量，并且纳米颗粒填料在聚合物基质中非均匀分布。

9. 发明授权

US06960378B1 Tubular microstructures via controlled nanoparticle assembly 有权
标题翻译：通过受控纳米颗粒装配的管状微结构
公开(公告)号：US06960378B1
公开(公告)日：2005-11-01
申请号：US10608892
申请日：2003-06-27
申请人： Richard W. Siegel , Linda S. Schadler Feist , Dongling Ma
发明人： Richard W. Siegel , Linda S. Schadler Feist , Dongling Ma
IPC分类号： A61M5/00 , F26B5/06
CPC分类号： F26B5/06 , Y10T428/139
摘要： A process for producing microtubes from nanoparticles includes forming a dispersion of the nanoparticles in a liquid phase and freeze-drying the dispersion to produce microtubes. The nanoparticles have surface functionality capable of self-bonding and bonding with the liquid phase during freeze-drying, particularly surface hydroxy functionality.
摘要翻译：从纳米颗粒生产微管的方法包括在液相中形成纳米颗粒的分散体并冷冻干燥分散体以产生微管。纳米颗粒具有能够在冷冻干燥过程中与液相自粘合和结合的表面官能团，特别是表面羟基官能团。

10. 发明授权

US06420293B1 Ceramic matrix nanocomposites containing carbon nanotubes for enhanced mechanical behavior 有权
标题翻译：包含碳纳米管的陶瓷基体纳米复合材料用于增强机械性能
公开(公告)号：US06420293B1
公开(公告)日：2002-07-16
申请号：US09648274
申请日：2000-08-25
申请人： Sekyung Chang , Robert H. Doremus , Richard W. Siegel , Pulickel M. Ajayan
发明人： Sekyung Chang , Robert H. Doremus , Richard W. Siegel , Pulickel M. Ajayan
IPC分类号： C04B3580
CPC分类号： C04B35/80 , B82Y30/00 , F16C2240/64 , Y10S977/734 , Y10S977/742 , Y10S977/776 , Y10S977/778
摘要： A ceramic matrix nanocomposite having enhanced mechanical behavior is made up of a nanotube filler composed of at least one nanotube material, and a ceramic matrix composed of a nanocrystalline ceramic oxide. A method for producing ceramic articles having improved fracture toughness includes combining of a nanotube filler made up of a nanotube material and a ceramic matrix made up of a nanocrystalline ceramic oxide, forming an article therefrom, and sintering the article under elevated pressure at elevated temperature.
摘要翻译：具有增强的机械性能的陶瓷基体纳米复合材料由至少一种纳米管材料构成的纳米管填料和由纳米晶体陶瓷氧化物构成的陶瓷基体构成。具有改善的断裂韧性的陶瓷制品的制造方法包括将由纳米管材料构成的纳米管填料和由纳米晶体氧化陶瓷构成的陶瓷基体组合，从而形成制品，并在升高的温度下在高压下烧结制品。

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