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1. 发明授权

US08426151B2 Systems and methods for the detection of biomarkers 失效
标题翻译：用于检测生物标志物的系统和方法
公开(公告)号：US08426151B2
公开(公告)日：2013-04-23
申请号：US12906227
申请日：2010-10-18
申请人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
发明人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： G01N33/54393 , A61B10/0045 , C12Q1/40 , G01N33/50
摘要： System and methods for the detection of biomarkers. In at least one embodiment of a system for the detection of a diagnostic marker in a body fluid of the present disclosure, the system comprises a diagnostic device comprising a plurality of test wells, wherein each test well is capable of containing at least one detection agent, a detection device capable of interacting with the diagnostic device, wherein the detection device is capable of detecting an interaction between the at least one detection agent and a diagnostic marker in at least one of the plurality of test wells, and a stabilization agent contained within at least one of the plurality of test wells, the stabilization agent capable of completely or substantially preventing the degradation or inactivation of the detection agent or the diagnostic marker.
摘要翻译：用于检测生物标志物的系统和方法。在用于检测本公开的体液中的诊断标记物的系统的至少一个实施方案中，该系统包括包含多个测试孔的诊断装置，其中每个测试孔能够含有至少一种检测剂，能够与所述诊断装置相互作用的检测装置，其中所述检测装置能够检测所述多个检测孔中的至少一个中的所述至少一个检测剂和诊断标记之间的相互作用，以及包含在所述检测装置内的稳定剂多个测试孔中的至少一个，稳定剂能够完全或基本上防止检测剂或诊断标记的降解或失活。

2. 发明申请

US20120164674A1 DEVICES AND WASHES FOR BIOMARKER STABILIZATION 审中-公开
标题翻译：用于生物标记稳定的装置和洗涤物
公开(公告)号：US20120164674A1
公开(公告)日：2012-06-28
申请号：US13283425
申请日：2011-10-27
申请人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
发明人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
IPC分类号： G01N21/59 , C12M1/40
CPC分类号： C12Q1/28
摘要： Herein are disclosed compositions, washes, rinses, devices, systems and methods for biomarker stabilization, in part in bodily fluids, as well as methods and formulations for improving the sampling and testing of fluids for biomarkers. Included in the disclosure are exemplary embodiments of rinses or washes containing a stabilizing agent to prevent the destruction of a diagnostic agent or biomarker and exemplary systems for the detection of diagnostic biomarkers in a bodily fluid
摘要翻译：本文公开了部分用于生物标志物稳定的组合物，洗涤剂，漂洗剂，装置，系统和方法，部分地在体液中，以及用于改进用于生物标志物的流体的取样和测试的方法和制剂。本公开中包括的是具有防止破坏诊断剂或生物标志物的稳定剂的漂洗或洗涤物的示例性实施方案和用于检测体液中诊断生物标志物的示例性系统

3. 发明申请

US20110196085A1 BIOMARKER STABILIZING AGENTS 审中-公开
标题翻译：生物标记稳定剂
公开(公告)号：US20110196085A1
公开(公告)日：2011-08-11
申请号：US12906166
申请日：2010-10-18
申请人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
发明人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
IPC分类号： C08C19/22 , C08C19/00
CPC分类号： G01N33/54393 , A61B10/0045 , C12Q1/40 , G01N33/50
摘要： Biomarker stabilizing agents. In at least one embodiment of a stabilizing bead of the present disclosure, the stabilizing bead comprises a latex particle having a carboxylate group, and a stabilizing agent functionally coupled to the latex particle, wherein the stabilizing agent is capable of completely or substantially preventing the degradation or inactivation of a diagnostic agent in close proximity to the stabilizing agent. Optionally, an embodiment of a stabilizing bead may further comprise at least one of human serum albumin (HSA) and bovine serum albumin (BSA). Moreover, an embodiment of a stabilizing bead of the present disclosure may further comprise a linker group coupled to latex particle.
摘要翻译：生物标志物稳定剂。在本公开的稳定化珠粒的至少一个实施方案中，稳定珠粒包含具有羧酸酯基团的胶乳颗粒和与胶乳颗粒功能性偶联的稳定剂，其中稳定剂能够完全或基本上防止降解或在稳定剂附近灭活诊断剂。任选地，稳定珠粒的实施方案还可以包含人血清白蛋白（HSA）和牛血清白蛋白（BSA）中的至少一种。此外，本公开的稳定化珠粒的实施方案还可以包含与胶乳颗粒偶联的连接基团。

4. 发明申请

US20110195858A1 SYSTEMS AND METHODS OF ANALYZING BIOMARKER LEVELS 审中-公开
标题翻译：分析生物标志物水平的系统和方法
公开(公告)号：US20110195858A1
公开(公告)日：2011-08-11
申请号：US12906221
申请日：2010-10-18
申请人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
发明人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
IPC分类号： C40B30/04 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/54393 , A61B10/0045 , C12Q1/40 , G01N33/50
摘要： Systems and methods of analyzing biomarker levels. In at least one embodiment of a method of analyzing biomarker levels, the method comprises the steps of combining a body fluid comprising a diagnostic marker with a stabilization agent for an incubation period, introducing the stabilized body fluid into a detection platform, combining a detection agent with the stabilized body fluid, determining an interaction characteristic of the detection agent and the diagnostic marker of the stabilized body fluid using a detection device in communication with a processor, comparing the interaction characteristic with a plurality of indexed interaction records contained on a database in communication with the processor to determine an identity and concentration of the detection marker, generating a report of the identity and concentration of the detection marker in the body fluid, and delivering the report to a recipient.
摘要翻译：分析生物标志物水平的系统和方法。在分析生物标志物水平的方法的至少一个实施方案中，该方法包括以下步骤：将包含诊断标记的体液与稳定剂组合用于潜伏期，将稳定的体液引入检测平台，组合检测剂使用稳定的体液，使用与处理器通信的检测装置来确定所述检测剂和所述稳定体液的诊断标记物的相互作用特性，将所述交互特征与包含在通信数据库中的多个索引交互记录进行比较处理器确定检测标记的身份和浓度，产生体液中检测标记的身份和浓度的报告，以及将报告递送给接收者。

5. 发明申请

US20110195851A1 SYSTEMS AND METHODS FOR DETERMINING THERAPEUTIC POTENTIAL 审中-公开
标题翻译：用于确定治疗潜力的系统和方法
公开(公告)号：US20110195851A1
公开(公告)日：2011-08-11
申请号：US12906164
申请日：2010-10-18
申请人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
发明人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
IPC分类号： C40B30/02 , C40B60/14
CPC分类号： G01N33/54393 , A61B10/0045 , C12Q1/40 , G01N33/50
摘要： Systems and methods for determining therapeutic potential. In at least one embodiment of a system of the present disclosure, the system comprises a detection platform, a computer processor and a database. The processor, in at least one embodiment of a method of the present disclosure, has and executes a software program operational to determine a binding characteristic of the detection agent and a stabilized diagnostic marker in each of the plurality of detection sites on the platform, compare the binding characteristic, and determining the stabilizing agent with the greatest effect on the binding characteristic between the detection agent and the diagnostic marker. Further, at least one embodiment of a system for determining the therapeutic potential of a therapeutic compound of the present disclosure is able to generate a binding record using the compared binding characteristics, and deliver the binding record to a recipient.
摘要翻译：用于确定治疗潜力的系统和方法。在本公开的系统的至少一个实施例中，系统包括检测平台，计算机处理器和数据库。在本公开的方法的至少一个实施例中，处理器具有并执行可操作的软件程序，以确定该平台上的多个检测位置中的每一个中的检测剂和稳定的诊断标记的结合特性，比较结合特性，以及确定对检测剂和诊断标记之间的结合特性影响最大的稳定剂。此外，用于确定本公开的治疗化合物的治疗潜力的系统的至少一个实施方案能够使用比较的结合特征产生结合记录，并将结合记录递送给接受者。

6. 发明申请

US20110195424A1 SYSTEMS AND METHODS FOR DIAGNOSING FUNGAL INFECTIONS 审中-公开
标题翻译：用于诊断真菌感染的系统和方法
公开(公告)号：US20110195424A1
公开(公告)日：2011-08-11
申请号：US12906253
申请日：2010-10-18
申请人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
发明人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/54393 , A61B10/0045 , C12Q1/40 , G01N33/50
摘要： Systems and methods for diagnosing fungal infections. According to at least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for a fungal infection in a body fluid comprising the diagnostic marker and a detection agent capable of detecting the diagnostic marker.
摘要翻译：用于诊断真菌感染的系统和方法根据本公开的稳定化系统的至少一个实施方案，该系统包含用于完全或基本上防止包含诊断标记物和检测试剂的体液中真菌感染的诊断标记物的降解或失活的稳定剂能够检测诊断标记。

7. 发明申请

US20110195402A1 SYSTEMS AND METHODS FOR DETECTING DRUG USE 审中-公开
标题翻译：用于检测药物使用的系统和方法
公开(公告)号：US20110195402A1
公开(公告)日：2011-08-11
申请号：US12906255
申请日：2010-10-18
申请人： Richard H. SELINFREUND , Rakesh VIG , Richard P. GILL
发明人： Richard H. SELINFREUND , Rakesh VIG , Richard P. GILL
IPC分类号： C12Q1/68 , C12Q1/34
CPC分类号： G01N33/54393 , A61B10/0045 , C12Q1/40 , G01N33/50
摘要： Systems and methods for detecting drug use. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker indicative of drug use in a body fluid, comprising the diagnostic marker, and a detection agent capable of detecting the diagnostic marker.
摘要翻译：用于检测药物使用的系统和方法。在本公开的系统的至少一个实施方案中，所述系统包含稳定剂，其用于完全或基本上防止指示体液中药物使用的诊断标志物的降解或失活，所述诊断标志物包括诊断标记物和检测剂能够检测诊断标记。

8. 发明申请

US20110195398A1 SYSTEMS AND METHODS FOR DETECTING INSULIN RESISTANCE BIOMARKERS 审中-公开
标题翻译：用于检测胰岛素抵抗生物标志物的系统和方法
公开(公告)号：US20110195398A1
公开(公告)日：2011-08-11
申请号：US12906202
申请日：2010-10-18
申请人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
发明人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
IPC分类号： C12Q1/68 , C12Q1/00 , C12Q1/54
CPC分类号： G01N33/54393 , A61B10/0045 , C12Q1/40 , G01N33/50
摘要： Systems and methods for detecting insulin resistance biomarkers. At least one embodiment of a system of the present disclosure comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for insulin resistance or glucose intolerance in a body fluid comprising the diagnostic marker, and a detection agent capable of detecting the diagnostic marker.
摘要翻译：检测胰岛素抵抗生物标志物的系统和方法。本公开的系统的至少一个实施方案包含稳定剂，其用于完全或基本上防止包含诊断标记的体液中的胰岛素抵抗或葡萄糖不耐受的诊断标记物的降解或失活，以及能够检测的检测剂诊断标记。

9. 发明申请

US20110195395A1 RINSE COMPOSITION FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS 审中-公开
标题翻译：用于稳定诊断性生物标志物的组合物
公开(公告)号：US20110195395A1
公开(公告)日：2011-08-11
申请号：US12906196
申请日：2010-10-18
申请人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
发明人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/54393 , A61B10/0045 , C12Q1/40 , G01N33/50
摘要： Rinse composition for the stabilization of diagnostic biomarkers. In at least one embodiment of a rinse useful to stabilize a diagnostic marker, the rinse comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker in saliva, and a liquid.
摘要翻译：用于稳定诊断性生物标志物的漂洗组合物。在用于稳定诊断标记物的漂洗液的至少一个实施方案中，漂洗剂包含用于完全或基本上防止唾液中的诊断标记物和液体降解或失活的稳定剂。

10. 发明申请

US20110192239A1 DEVICES FOR COLLECTION AND STABILIZATION OF BIOMARKERS IN LIQUID SAMPLES 审中-公开
标题翻译：生物标志物在液体样品中收集和稳定的装置
公开(公告)号：US20110192239A1
公开(公告)日：2011-08-11
申请号：US12906173
申请日：2010-10-18
申请人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
发明人： Richard H. Selinfreund , Rakesh Vig , Richard P. Gill
IPC分类号： G01N1/10
CPC分类号： G01N33/54393 , A61B10/0045 , C12Q1/40 , G01N33/50
摘要： Device for collection and stabilization of biomarkers in liquid samples. In at least one embodiment of a fluid collection device, the device comprises a housing having a top end, a bottom end, and a tubular compartment therethrough, a swab connected to bottom end of the housing and in fluid communication with the tubular compartment, the swab designed to collect a body fluid, and a stabilizing agent contained within the fluid collection device, the stabilizing agent capable of completely or substantially preventing the degradation or inactivation of a diagnostic agent in a bodily fluid upon receipt of the bodily fluid into the fluid collection device. Optionally, the stabilizing agent may be coupled to the swab, and/or contained within the tubular compartment of the housing.
摘要翻译：用于收集和稳定液体样品中生物标志物的装置。在流体收集装置的至少一个实施例中，该装置包括具有顶端，底端和穿过其中的管状隔室的壳体，连接到壳体的底端并与管状隔室流体连通的拭子，设计用于收集体液的拭子和包含在流体收集装置内的稳定剂，所述稳定剂能够在将体液接收到流体收集器中时完全或基本上防止体液中的诊断剂的降解或失活设备。任选地，稳定剂可以联接到拭子和/或包含在壳体的管状隔室内。

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