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1. 发明授权

US06251964B1 Biocompatible compositions 有权
标题翻译：生物相容性组合物
公开(公告)号：US06251964B1
公开(公告)日：2001-06-26
申请号：US09117729
申请日：1998-08-05
申请人： Manuchehr Porssa , Paul Matthew McNeillis , Richard Neil Templar Freeman
发明人： Manuchehr Porssa , Paul Matthew McNeillis , Richard Neil Templar Freeman
IPC分类号： A61K31715
CPC分类号： A61L33/0029 , C08L101/02
摘要： A polymer is formed from monomers including a zwitterionic monomer, a cationic monomer and a hydrophobic termonomer. The polymer may be cross-linkable. The polymer may be coated onto a surface from a liquid coating composition followed by contacting the coated surface with heparin. The double coated substrates have improved heparin activity over extended periods as compared to heparinised surfaces which are commercially available. Other anionically charged mucopolysaccharides may be used. The polymers may also scavenge heparin from treated blood to avoid use of potentially toxic heparin inhibitors. Preferably the terpolymer is formed from 2-methacryloyloxyethyl-2-(trimethylamonium)phosphate inner salt, choline methacrylate and n-dodecyl methacrylate.
摘要翻译：聚合物由包括两性离子单体，阳离子单体和疏水性单体的单体形成。聚合物可以是可交联的。聚合物可以从液体涂料组合物涂覆到表面上，然后将涂覆的表面与肝素接触。与可商购的肝素化表面相比，双重涂覆的基质在延长的时间内具有改善的肝素活性。可以使用其它阴离子充电的粘多糖。聚合物还可以从处理的血液中清除肝素，以避免使用潜在的毒性肝素抑制剂。优选地，三元共聚物由2-甲基丙烯酰氧基乙基-2-（三甲基铵）磷酸盐内酯，甲基丙烯酸胆碱酯和甲基丙烯酸正十二烷基酯形成。

2. 发明授权

US06432314B1 Anion exchange materials and processes 有权
标题翻译：阴离子交换材料和工艺
公开(公告)号：US06432314B1
公开(公告)日：2002-08-13
申请号：US09308496
申请日：1999-07-26
申请人： Joachim Storch , Robert Neil Hanley , Richard Neil Templar Freeman
发明人： Joachim Storch , Robert Neil Hanley , Richard Neil Templar Freeman
IPC分类号： C02F142
CPC分类号： A61L33/0029 , C08L101/02
摘要： Anion exchange material surfaces are provided with zwitterionic and cationic groups, preferably by coating with a polymer formed from monomers including a zwitterionic monomer, a cationic monomer and, optionally, a termonomer providing stable binding at the substrate surface. The ion exchange materials may be used to scavenge heparin from blood by an ion exchange separation process. The zwitterionic group reduces the rate of fouling by biological materials such as proteins.
摘要翻译：阴离子交换材料表面设置有两性离子和阳离子基团，优选通过用包含两性离子单体，阳离子单体和任选地在基材表面稳定结合的单体的单体形成的聚合物涂覆。离子交换材料可用于通过离子交换分离方法从血液中清除肝素。两性离子基团降低生物材料如蛋白质的结垢率。

3. 发明授权

US5645883A Zwitterionic materials 失效
标题翻译：两性离子材料
公开(公告)号：US5645883A
公开(公告)日：1997-07-08
申请号：US464677
申请日：1995-06-07
申请人： Jeremy Colin Russell , Richard Neil Templar Freeman , Stephen Alexander Charles
发明人： Jeremy Colin Russell , Richard Neil Templar Freeman , Stephen Alexander Charles
IPC分类号： A61L27/00 , A61L27/34 , A61L33/00 , A61L33/06 , C07F9/09 , C07F9/10 , C08F20/10 , C08F20/18 , C08F20/26 , C08F20/34 , C08F20/52 , C08F20/56 , C08F26/10 , C08G18/08 , C08G18/30 , C08G63/692 , B05D3/02
CPC分类号： C08G63/6926 , A61L27/34 , A61L33/00 , A61L33/0082 , A61L33/066 , C07F9/091 , C07F9/10 , C08G18/0833
摘要： The present invention provides materials which comprise a surface having pendant zwitterionic groups Z comprising, as anion, a phosphate, sulphonate, carboxylate or phosphate-ester group or a phosphate ester group in which one or more of the ester oxygen atoms is replaced by --S--, --NH-- or by a valence bond and, as cation, an ammonium, phosphonium or sulphonium moiety, provided that where the anion is a phosphate-ester group or derivative thereof or sulphonate and the cation is a trialkyl quaternary ammonium group (the alkyl groups each containing from 1 to 4 carbon atoms) and the group linking the anion and cation moieties is an alkylene group, the alkylene group, contains at least 5, preferably at least 6, and more preferably at least 7, carbon atoms. The materials have improved biocompatibility for instance as evidenced by reduced protein deposition and reduced platelet activation.
摘要翻译： PCT No.PCT / GB94 / 00178 Sec。 371日期：1995年6月7日 102（e）1995年6月7日PCT PCT 1994年1月28日PCT公布。第WO94 / 16749号公报日期1994年8月4日本发明提供了包含具有侧向两性离子基团Z的表面的材料，其包含作为阴离子的磷酸盐，磺酸盐，羧酸盐或磷酸酯基团或磷酸酯基团，其中一个或多个酯氧原子由-S-，-NH-或价键取代，并且作为阳离子，铵，鏻或锍部分，其中阴离子是磷酸酯基团或其衍生物或磺酸盐并且阳离子是三烷基季铵基（各自含有1至4个碳原子的烷基）和连接阴离子和阳离子部分的基团是亚烷基，亚烷基含有至少5个，优选至少6个，更优选至少7个，碳原子。这些材料具有改善的生物相容性，例如通过减少的蛋白质沉积和减少的血小板活化来证明。

4. 发明授权

US06841639B1 Polymer solutions 有权
标题翻译：聚合物溶液
公开(公告)号：US06841639B1
公开(公告)日：2005-01-11
申请号：US09979682
申请日：2000-05-30
申请人： Richard Paul Redman , Laurence Gerald Hughes , Richard Neil Templar Freeman , Andrew Lennard Lewis
发明人： Richard Paul Redman , Laurence Gerald Hughes , Richard Neil Templar Freeman , Andrew Lennard Lewis
IPC分类号： C08F2/00 , C08F2/04 , C08F2/08 , C08F220/18 , C08F220/26 , C08F246/00 , C08F230/02
CPC分类号： C08F246/00
摘要： Copolymers of zwitterionic monomer, especially 2-methacryloyloxyethyl-2′-trimethylammoniumethyl phosphate inner salt, and hydrophobic comonomer, especially dodecylmethacrylate, are made in a monomer starved polymerization process in which solutions of monomers are fed to the reaction vessel in which initiator is present over an extended period. The copolymers have improved compositional uniformity and provide better coatings on a range of substrates. The novel copolymers can be distinguished from prior art batch type bulk solution polymerization polymers of the same monomer composition by solubility characteristics especially in alcohol/water mixtures. Particularly preferred coating compositions comprise an alcohol:water mixture containing around 20 to 40% by volume alcohol.
摘要翻译：两性离子单体的共聚物，特别是2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸酯内盐和疏水性共聚单体，特别是十二烷基甲基丙烯酸酯，是在单体缺乏聚合方法中制备的，其中将单体溶液加入到其中存在引发剂的反应容器中一段时间共聚物具有改善的组成均匀性并在一系列基材上提供更好的涂层。新型共聚物可以区别于具有相同单体组成的现有技术的分散型本体溶液聚合物，其溶解性特别是在醇/水混合物中。特别优选的涂料组合物包含含有约20至40体积％的醇的醇：水混合物。

5. 发明授权

US5717047A Materials 失效
标题翻译：材料
公开(公告)号：US5717047A
公开(公告)日：1998-02-10
申请号：US464692
申请日：1995-06-07
申请人： Jeremy Colin Russell , Stephen Alexander Charles , Richard Neil Templar Freeman , Judith Elizabeth Browne
发明人： Jeremy Colin Russell , Stephen Alexander Charles , Richard Neil Templar Freeman , Judith Elizabeth Browne
IPC分类号： A61L27/00 , A61L27/34 , A61L33/00 , A61L33/06 , C07C229/22 , C07C229/24 , C07F9/09 , C07F9/10 , C07F9/24 , C07F9/54 , C07F9/58 , C08F30/02 , C08G18/08 , C08G63/692 , C08F130/02 , C08F128/02 , C08F120/56 , C08F120/18 , C08F116/12 , C08F112/08
CPC分类号： C08G63/6926 , A61L27/34 , A61L33/00 , A61L33/0082 , A61L33/0088 , A61L33/064 , A61L33/066 , C07C229/24 , C07F9/091 , C07F9/10 , C07F9/2458 , C07F9/5407 , C07F9/581 , C07F9/585 , C08G18/0833
摘要： The present invention relates to materials which comprise a surface having pendant groups of formula (I), in which the groups --B-- are the same or different, preferably the same, and each is --CH.sub.2 -- or --C(.dbd.O)--, preferably --CH.sub.2 --, R.sup.1 is hydrogen alkyl of 1 to 12, preferably 1 to 4 carbon atoms, or a group capable of bonding to, or bonded to, a ligand or R.sup.1 is a polymerisable, preferably ethylenically unsaturated, group and Z is a zwitterionic group. Usually both groups B are the same and are joined to identical groups so that the compound of formula (I) is achiral. New compounds are achiral glyceryl phosphatidyl choline analogues. Surfaces having the groups (I) at their surface have improved biocompatibility, and show reduced fibrinogen absorption, reduced platelet activation, reduced microorganism adhesion and are useful in the production of implants or prostheses, for extra-corporeal circuitry for body fluids, for treating membranes of various type, for contact lenses. The compounds may also be used to form liposomes.
摘要翻译： PCT No.PCT / GB94 / 00177 Sec。 371日期：1995年6月7日 102（e）1995年6月7日PCT PCT 1994年1月28日PCT公布。第WO94 / 16748号公报日期1994年8月4日本发明涉及包含具有式（I）侧基的表面的材料，其中基团-B-相同或不同，优选相同，并且各自为-CH 2 - 或-C （= O） - ，优选-CH 2 - ，R 1是1至12个，优选1至4个碳原子的烷基，或能够键合或键合至配体的基团，或R 1是可聚合的，优选烯属不饱和的，基团Z是两性离子基团。通常两个基团B相同并连接到相同的基团，使得式（I）的化合物是非手性的。新化合物是非手性甘油磷脂酰胆碱类似物。在其表面具有基团（I）的表面具有改善的生物相容性，并且显示纤维蛋白原吸收减少，血小板活化降低，微生物附着力降低，并且可用于植入物或假体的生产，用于体液的体外电路，用于治疗膜各种类型的隐形眼镜。该化合物也可用于形成脂质体。

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