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1. 发明授权

US08911749B2 Vaccine delivery via microneedle arrays 有权
标题翻译：通过微针阵列进行疫苗输送
公开(公告)号：US08911749B2
公开(公告)日：2014-12-16
申请号：US12249795
申请日：2008-10-10
申请人： Esi Ghartey-Tagoe , Janet Wendorf , Steve Williams , Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Esi Ghartey-Tagoe , Janet Wendorf , Steve Williams , Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
IPC分类号： A61K39/07 , A61K39/02 , A61K45/00 , A61K9/00 , A61M37/00 , A61B17/20 , A61K39/00
CPC分类号： A61K39/07 , A61B17/205 , A61K9/0021 , A61K39/00 , A61K2039/54 , A61M37/0015 , Y02A50/388 , Y02A50/39 , Y02A50/401 , Y02A50/464 , Y02A50/466 , Y02A50/484
摘要： A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.
摘要翻译：提供了一种微突出物阵列，其包括近似平面的基底和多个微突出物，其中阵列包括疫苗和聚合物材料。阵列可能有多个层。疫苗可以仅放置在一个层中。在本发明的另一个实施方案中，提供了一种预防疾病的方法，其包括向患者的皮肤插入包含一层包含该疾病的疫苗和聚合物的微阵列的微阵列阵列。

2. 发明授权

US08821446B2 Applicators for microneedles 有权
标题翻译：微针贴片机
公开(公告)号：US08821446B2
公开(公告)日：2014-09-02
申请号：US12009954
申请日：2008-01-22
申请人： Joseph C. Trautman , Robert Wade Worsham , Danir F. Bayramov , Danny Lee Bowers , Steven Richard Klemm , Parminder Singh
发明人： Joseph C. Trautman , Robert Wade Worsham , Danir F. Bayramov , Danny Lee Bowers , Steven Richard Klemm , Parminder Singh
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： A microneedle applicator is provided which has two roughly concentric portions which may be, for example, a solid disk and an annulus surrounding it. On the skin-facing side of the inner portion of the applicator a microneedle array is located. The outer portion of the applicator is placed against the skin, contacting it at a zone. The microneedle array is then pressed towards the skin.
摘要翻译：提供了一种微针施加器，其具有两个大致同心的部分，其可以是例如实心盘和围绕它的环。在施用器的内部的面向皮肤的一侧，定位有微针阵列。将施用器的外部部分放置在皮肤上，使其在一个区域接触。然后将微针阵列压向皮肤。

3. 发明申请

US20090155330A1 Vaccine Delivery via Microneedle Arrays 有权
标题翻译：通过微针阵列进行疫苗输送
公开(公告)号：US20090155330A1
公开(公告)日：2009-06-18
申请号：US12249795
申请日：2008-10-10
申请人： Esi Ghartey-Tagoe , Janet Wendorf , Steve Williams , Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Esi Ghartey-Tagoe , Janet Wendorf , Steve Williams , Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
IPC分类号： A61F2/00 , A61K39/102 , A61K39/05 , A61K39/29 , A61K39/145 , A61K39/205 , A61K39/193 , A61K39/20 , A61K39/09 , A61K39/07
CPC分类号： A61K39/07 , A61B17/205 , A61K9/0021 , A61K39/00 , A61K2039/54 , A61M37/0015 , Y02A50/388 , Y02A50/39 , Y02A50/401 , Y02A50/464 , Y02A50/466 , Y02A50/484
摘要： A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.
摘要翻译：提供了一种微突出物阵列，其包括近似平面的基底和多个微突出物，其中所述阵列包括疫苗和聚合物材料。阵列可能有多个层。疫苗可以仅放置在一个层中。在本发明的另一个实施方案中，提供了一种预防疾病的方法，其包括向患者的皮肤插入包含一层包含该疾病的疫苗和聚合物的微阵列的微阵列阵列。

4. 发明授权

US4234880A Adaptive method and a radar receiver for suppression of disturbing portions of the Doppler spectrum 失效
标题翻译：自适应方法和用于抑制多普勒频谱干扰部分的雷达接收机
公开(公告)号：US4234880A
公开(公告)日：1980-11-18
申请号：US963359
申请日：1978-11-24
申请人： Richard Klemm
发明人： Richard Klemm
IPC分类号： G01S13/524 , G01S13/02
CPC分类号： G01S13/5244
摘要： Disturbing components of the Doppler frequency spectrum in a radar receiver, having coherent integration, are suppressed. In this technique, the order of interference suppression and coherent integration is changed such that the echo values are first fed to a circuit to effect a Fourier transformation. Then, the disturbing components in the frequency band are deliberately suppressed, and a sub-optimal detection method suitable for real-time operation is derived from the optimum detection model in that sub-matrices symmetrical with the principle diagonal are formed from the power spectrum matrix, through which approximate decorrelation of the disturbing components is achieved.
摘要翻译：具有相干积分的雷达接收机中的多普勒频谱的干扰分量被抑制。在这种技术中，改变了干扰抑制和相干积分的顺序，使得首先将回波值馈送到电路以进行傅里叶变换。然后，有意抑制频带中的干扰成分，从最优检测模型导出适合于实时操作的次优检测方法，其中由原理对角线对称的子矩阵由功率谱矩阵通过其实现干扰组件的近似去相关。

5. 发明申请

US20110086329A1 DEVICE AND METHOD FOR DELIVERING AN ORAL CARE AGENT 有权
标题翻译：用于输送口服护理剂的装置和方法
公开(公告)号：US20110086329A1
公开(公告)日：2011-04-14
申请号：US12974627
申请日：2010-12-21
申请人： Adrian L. Faasse , Steven Richard Klemm , Glen Edward Groeneweg , Alan Gene Thelen
发明人： Adrian L. Faasse , Steven Richard Klemm , Glen Edward Groeneweg , Alan Gene Thelen
IPC分类号： A61C19/04
CPC分类号： A61C19/063
摘要： An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.
摘要翻译：提供一种口腔护理剂递送装置，其包括永久可变形的背衬层，口腔护理层和非织造粘合材料，其具有基本上投入到口腔护理层中的第一部分和基本上投入在口腔护理层中的第二部分背衬层。该装置的尺寸适于装配在受试者的上部或下部牙弓中的多个牙齿上。口腔护理层包含至少一种口腔护理剂和至少一种亲水性聚合物。当水合时，口腔护理层相对于使用者牙齿的表面具有足够的粘附性，足以在放置在使用者的牙齿上时将该装置保持在使用者的牙齿上。该装置还可以具有在口腔护理层的水合时活化的口腔护理剂，或随着时间释放口腔护理剂的口腔护理层。

6. 外观设计

USD786300S1 Display screen or portion thereof with a graphical user interface 有权
公开(公告)号：USD786300S1
公开(公告)日：2017-05-09
申请号：US29584586
申请日：2016-11-16
申请人： Ghazala Hashmi , Richard Klemm , Michael Seul
设计人： Ghazala Hashmi , Richard Klemm , Michael Seul

7. 发明授权

US09114238B2 Solvent-cast microprotrusion arrays containing active ingredient 有权
标题翻译：含有活性成分的溶剂滴注微阵列
公开(公告)号：US09114238B2
公开(公告)日：2015-08-25
申请号：US12148180
申请日：2008-04-16
申请人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
IPC分类号： A61M5/00 , A61M37/00 , A61K9/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61K38/29 , A61K38/385 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61M2202/0007 , A61M2202/07 , A61M2202/30 , A61M2207/00
摘要： In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
摘要翻译：在本发明的一个方面，通过向模具提供对应于微突起的负极的空腔形成微突起阵列，在模具上方铸造包含生物相容性材料和溶剂的第一溶液，除去溶剂，铸造第二溶液在第一浇铸溶液顶部，从第二溶液中除去溶剂，并将得到的阵列从模具中脱模。第一溶液优选含有活性成分。

8. 发明授权

US08944819B2 Device and method for delivering an oral care agent 有权
标题翻译：用于递送口腔护理剂的装置和方法
公开(公告)号：US08944819B2
公开(公告)日：2015-02-03
申请号：US12974627
申请日：2010-12-21
申请人： Adrian L. Faasse , Steven Richard Klemm , Glen Edward Groeneweg , Alan Gene Thelen
发明人： Adrian L. Faasse , Steven Richard Klemm , Glen Edward Groeneweg , Alan Gene Thelen
IPC分类号： A61Q11/00 , A61C19/06 , A61K6/00 , A61K8/00
CPC分类号： A61C19/063
摘要： An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.
摘要翻译：提供一种口腔护理剂递送装置，其包括永久可变形的背衬层，口腔护理层和非织造粘合材料，其具有基本上投入到口腔护理层中的第一部分和基本上投入在口腔护理层中的第二部分背衬层。该装置的尺寸适于装配在受试者的上部或下部牙弓中的多个牙齿上。口腔护理层包含至少一种口腔护理剂和至少一种亲水性聚合物。当水合时，口腔护理层相对于使用者牙齿的表面具有足够的粘附性，足以在放置在使用者的牙齿上时将该装置保持在使用者的牙齿上。该装置还可以具有在口腔护理层的水合时活化的口腔护理剂，或随着时间释放口腔护理剂的口腔护理层。

9. 发明申请

US20080269685A1 Solvent-cast microneedle arrays containing active 有权
标题翻译：含有活性的溶剂型微针阵列
公开(公告)号：US20080269685A1
公开(公告)日：2008-10-30
申请号：US12148180
申请日：2008-04-16
申请人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
IPC分类号： A61M37/00 , B29C43/14
CPC分类号： A61M37/0015 , A61K9/0021 , A61K38/29 , A61K38/385 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61M2202/0007 , A61M2202/07 , A61M2202/30 , A61M2207/00
摘要： In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
摘要翻译：在本发明的一个方面，通过向模具提供对应于微突起的负极的空腔形成微突起阵列，在模具上方铸造包含生物相容性材料和溶剂的第一溶液，除去溶剂，铸造第二溶液在第一浇铸溶液顶部，从第二溶液中除去溶剂，并将得到的阵列从模具中脱模。第一溶液优选含有活性成分。

10. 发明申请

US20080183144A1 Applicators for microneedles 有权
标题翻译：微针贴片机
公开(公告)号：US20080183144A1
公开(公告)日：2008-07-31
申请号：US12009954
申请日：2008-01-22
申请人： Joseph C. Trautman , Robert Wade Worsham , Danir F. Bayramov , Danny Lee Bowers , Steven Richard Klemm , Parminder Singh
发明人： Joseph C. Trautman , Robert Wade Worsham , Danir F. Bayramov , Danny Lee Bowers , Steven Richard Klemm , Parminder Singh
IPC分类号： A61M5/158
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： A microneedle applicator is provided which has two roughly concentric portions which may be, for example, a solid disk and an annulus surrounding it. On the skin-facing side of the inner portion of the applicator a microneedle array is located. The outer portion of the applicator is placed against the skin, contacting it at a zone. The microneedle array is then pressed towards the skin.
摘要翻译：提供了一种微针施加器，其具有两个大致同心的部分，其可以是例如实心盘和围绕它的环。在施用器的内部的面向皮肤的一侧，定位有微针阵列。将施用器的外部部分放置在皮肤上，使其在一个区域接触。然后将微针阵列压向皮肤。

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