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1. 发明授权

US06792355B2 Methods for determining polypeptide structure, function or pharmacophore from comparison of polypeptide sequences 失效
标题翻译：通过比较多肽序列确定多肽结构，功能或药效团的方法
公开(公告)号：US06792355B2
公开(公告)日：2004-09-14
申请号：US10032395
申请日：2001-12-21
申请人： Mark R. Hansen , Richard Kho , Hugo O. Villar
发明人： Mark R. Hansen , Richard Kho , Hugo O. Villar
IPC分类号： G06F1700
CPC分类号： G06F19/22 , G01N33/6803
摘要： The invention provides a method for separating two or more subsets of polypeptides within a set of polypeptides. The method includes the steps of: (a) determining a sequence comparison signature for each amino acid sequence in a set of amino acid sequences, wherein the sequence comparison signature includes pairwise comparison scores for the amino acid sequence compared to each of the other amino acid sequences in the set; (b) constructing a distance arrangement including the sequence comparison signatures related according to the distance between each of the sequence comparison signatures; and (c) identifying a first and second cluster of sequence comparison signatures in the distance arrangement, wherein the first cluster includes sequence comparison signatures for polypeptides having a similar protein fold or biological function, the protein fold or function being different compared to a protein fold or function of polypeptides having sequence comparison signatures in the second cluster.
摘要翻译：本发明提供了一种用于分离一组多肽内的多个亚组的方法。该方法包括以下步骤：（a）确定一组氨基酸序列中每个氨基酸序列的序列比较特征，其中序列比较特征包括与每个其它氨基酸相比的氨基酸序列的成对比较分数集合中的序列; （b）构建包括根据每个序列比较签名之间的距离相关的序列比较签名的距离排列; 并且（c）识别所述距离排列中的第一和第二序列比较特征簇，其中所述第一群集包括具有相似蛋白质折叠或生物学功能的多肽的序列比较特征，所述蛋白质折叠或功能与蛋白质折叠不同或在第二簇中具有序列比较特征的多肽的功能。

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