专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120322788A1 Compouds 有权
公开(公告)号：US20120322788A1
公开(公告)日：2012-12-20
申请号：US13437410
申请日：2012-04-02
申请人： Lilian Alcaraz , Andrew Bailey , Richard James Bull , Timothy Johnson , Nicholas David Kindon , Andrew Stuart Lister , Andrew James Robbins , Michael John Stocks , Barry John Teobald
发明人： Lilian Alcaraz , Andrew Bailey , Richard James Bull , Timothy Johnson , Nicholas David Kindon , Andrew Stuart Lister , Andrew James Robbins , Michael John Stocks , Barry John Teobald
IPC分类号： C07D498/10 , A61K31/553 , A61P29/00 , A61K31/5386
CPC分类号： C07D498/10
摘要： The present invention relates to spirocyclic amide derivatives of the formula I, pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing them, and their use in therapy.
摘要翻译：本发明涉及式I的螺环酰胺衍生物，其药学上可接受的盐，其制备方法，含有它们的药物组合物及其在治疗中的用途。

2. 发明申请

US20110319446A1 BICYCLO[2.2.1]HEPT-7-YLAMINE DERIVATIVES AND THEIR USES 审中-公开
标题翻译： BICYCLO [2.2.1] HEPT-7-YLAMINE DERIVATIVES及其用途
公开(公告)号：US20110319446A1
公开(公告)日：2011-12-29
申请号：US13164209
申请日：2011-06-20
申请人： Harry Finch , Nicholas Charles Ray , Richard James Bull , Monique Bodil van Niel , Andrew Stephen Robert Jennings
发明人： Harry Finch , Nicholas Charles Ray , Richard James Bull , Monique Bodil van Niel , Andrew Stephen Robert Jennings
IPC分类号： A61K31/136 , C07D409/06 , C07D215/227 , A61K31/381 , A61K31/4535 , A61K31/4709 , A61P11/00 , A61P1/00 , A61P9/00 , A61P11/08 , A61P11/06 , A61P37/08 , A61P1/06 , A61P1/04 , A61P13/02 , A61P13/06 , A61P13/10 , C07C211/53
CPC分类号： C07C271/38 , C07C219/24 , C07C235/36 , C07C2602/42 , C07D211/14 , C07D311/84 , C07D311/86 , C07D333/16 , C07D409/06 , C07D409/14
摘要： Compounds of formula (I) have muscarinic M3 receptor modulating activity; wherein A is an oxygen atom or group —N(R12)—; (i) R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group —R5, —Z—Y—R5, —Z—NR9R10; —Z—CO—NR9R10; —Z—NR9—CO—R5; or —Z—CO2H; and R3 is a lone pair, or C1-C6-alkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (ii) R1 and R3 together with the nitrogen to which they are attached form a heterocycloalkyl ring, and R2 is a hydrogen atom; or a group —R5, —Z—Y—R5, —Z—NR9R10, —Z—CO—NR9R10, —Z—NR9—CO—R5, or —Z—CO2H, in which cases the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (iii) R1 and R2 together with the nitrogen to which they are attached form a heterocycloalkyl ring, said ring being substituted by a group —Y—R5, —Z—Y—R5, —Z—NR9R10; —Z—CO—NR9R10; —Z—NR9—CO—R5; or —Z—CO2H and R3 is a lone pair, or C1-C6-alkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; R4 is a group of formula (a), (b), (c) or (d); is an C1-C6-alkyl, aryl, aryl-fused-cycloalkyl, aryl-fused-heterocycloalkyl, heteroaryl, aryl(C1-C8-alkyl)-, heteroaryl(C1-C8-alkyl)-, cycloalkyl or heterocycloalkyl group, and the remaining variables are as defined in the specification.
摘要翻译：式（I）化合物具有毒蕈碱M3受体调节活性; 其中A是氧原子或基团-N（R 12） - ; （ⅰ）R 1是C 1 -C 6 - 烷基或氢原子; R2为氢原子或基团-R5，-Z-Y-R5，-Z-NR9R10; -Z-CO-NR9R10; -Z-NR9-CO-R5; 或-Z-CO 2 H; 并且R 3是孤对的，或者是C 1 -C 6烷基，在这种情况下，与其连接的氮原子是季氮并携带正电荷; 或（ii）R 1和R 3与它们所连接的氮一起形成杂环烷基环，并且R 2是氢原子; 或基团-R5，-Z-Y-R5，-Z-NR9R10，-Z-CO-NR9R10，-Z-NR9-CO-R5或-Z-CO2H，其中，附着是季氮并带正电荷; 或（iii）R 1和R 2与它们所连接的氮一起形成杂环烷基环，所述环被基团-Y-R 5，-Z-Y-R 5，-Z-NR 9 R 10取代; -Z-CO-NR9R10; -Z-NR9-CO-R5; 或-Z-CO 2 H，并且R 3是孤对的，或者C 1 -C 6 - 烷基，在这种情况下，与其连接的氮原子是季氮并带正电荷; R4是式（a），（b），（c）或（d）的基团; 是C 1 -C 6烷基，芳基，芳基稠合环烷基，芳基 - 稠合 - 杂环烷基，杂芳基，芳基（C 1 -C 8 - 烷基） - ，杂芳基（C 1 -C 8 - 烷基） - ，环烷基或杂环烷基，剩余的变量如规范中所定义。

3. 发明申请

US20110190309A1 PHARMACEUTICAL PRODUCT COMPRISING A MUSCARINIC RECEPTOR ANTAGONIST AND A Beta2-ADRENOCEPTOR AGONIST 审中-公开
标题翻译：包含MUSCARINIC受体拮抗剂和β2-肾上腺素受体激动剂的药物产品
公开(公告)号：US20110190309A1
公开(公告)日：2011-08-04
申请号：US12992226
申请日：2009-05-12
申请人： Rhonan Ford , Andrew Mather , Antonio Mete , Katherine Wiley , Richard James Bull
发明人： Rhonan Ford , Andrew Mather , Antonio Mete , Katherine Wiley , Richard James Bull
IPC分类号： A61K31/501 , A61K31/497 , A61K31/439 , A61P11/00
CPC分类号： A61K45/06 , A61K31/428 , A61K31/439 , A61K2300/00
摘要： The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a selected muscarinic receptor antagonist, and a second active ingredient which is a β2-adrenoceptor agonist, or use in the treatment of respiratory diseases such as chronic obstructive pulmonary disease and asthma.
摘要翻译：本发明提供药物产品，试剂盒或组合物，其包含作为选择的毒蕈碱受体拮抗剂的第一活性成分和作为二肾上腺素受体激动剂的第二活性成分，或用于治疗呼吸系统疾病如慢性阻塞性肺部疾病和哮喘。

4. 发明授权

US07846955B2 Salt 失效
标题翻译：盐
公开(公告)号：US07846955B2
公开(公告)日：2010-12-07
申请号：US12523172
申请日：2008-02-06
申请人： Barbara Giuseppina Avitabile , David O'Sullivan , Richard James Bull
发明人： Barbara Giuseppina Avitabile , David O'Sullivan , Richard James Bull
IPC分类号： A61K31/421 , C07D263/30
CPC分类号： C07D263/32
摘要： The invention provides [2-(4-chloro-benzyloxy)-ethyl]-[2-((R)-cyclohexyl-hydroxy-phenyl-methyl)-oxazol-5-yl-methyl]-dimethyl-ammonium napadisylate, pharmaceutical compositions containing it, and its use in therapy.
摘要翻译：本发明提供[2-（4-氯 - 苄氧基） - 乙基] - [2 - （（R） - 环己基 - 羟基 - 苯基 - 甲基） - 恶唑-5-基 - 甲基] - 二甲基 - 萘二甲酸铵，药物组合物含有它，以及其在治疗中的用途。

5. 发明申请

US20090298807A1 Compounds 有权
标题翻译：化合物
公开(公告)号：US20090298807A1
公开(公告)日：2009-12-03
申请号：US12365570
申请日：2009-02-04
申请人： Lilian Alcaraz , Andrew Bailey , Richard James Bull , Timothy Johnson , Nicholas David Kindon , Andrew Stuart Lister , Andrew James Robbins , Michael John Stocks , Barry John Teobald
发明人： Lilian Alcaraz , Andrew Bailey , Richard James Bull , Timothy Johnson , Nicholas David Kindon , Andrew Stuart Lister , Andrew James Robbins , Michael John Stocks , Barry John Teobald
IPC分类号： A61K31/5386 , C07D498/10 , A61K31/553 , A61P29/00
CPC分类号： C07D498/10
摘要： The present invention relates to spirocyclic amide derivatives of the formula I, pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing them, and their use in therapy.
摘要翻译：本发明涉及式I的螺环酰胺衍生物，其药学上可接受的盐，其制备方法，含有它们的药物组合物及其在治疗中的用途。

6. 发明申请

US20130030001A1 QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：喹啉衍生物作为MUSCARINIC M3受体拮抗剂
公开(公告)号：US20130030001A1
公开(公告)日：2013-01-31
申请号：US13564194
申请日：2012-08-01
申请人： Richard James BULL , Elizabeth Anne SKIDMORE , Rhonan Lee FORD , Andrew Nigel MATHER , Antonio METE
发明人： Richard James BULL , Elizabeth Anne SKIDMORE , Rhonan Lee FORD , Andrew Nigel MATHER , Antonio METE
IPC分类号： C07D453/02 , A61P11/00 , A61K31/501 , A61K31/506 , A61K31/444 , A61K31/497
CPC分类号： C07D453/02
摘要： The invention provides named compounds of formula (I), pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions and their use in therapy.
摘要翻译：本发明提供命名的式（I）化合物，含有它们的药物组合物，制备药物组合物的方法及其在治疗中的用途。

7. 发明授权

US08329729B2 Quinuclidine derivatives as muscarinic M3 receptor antagonists 失效
标题翻译：奎宁环衍生物作为毒蕈碱M3受体拮抗剂
公开(公告)号：US08329729B2
公开(公告)日：2012-12-11
申请号：US12992045
申请日：2008-05-13
申请人： Richard James Bull , Rhonan Lee Ford , Antonio Mete
发明人： Richard James Bull , Rhonan Lee Ford , Antonio Mete
IPC分类号： A61K31/44
CPC分类号： C07D453/02
摘要： The invention provides named compounds of formula (I), wherein R4 is a N-substituted quinuclidine (I) pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for the treatment of conditions mediated by M3 muscarinic receptors, such as chronic obstructive pulmonary disease is also disclosed.
摘要翻译：本发明提供了命名的式（I）化合物，其中R 4是含有它们的N-取代的奎宁环（I）药物组合物和制备药物组合物的方法。它们也用于治疗M3毒蕈碱受体介导的病症，如慢性阻塞性肺疾病。

8. 发明申请

US20120277275A1 AZOLE AND THIAZOLE DERIVATIVES AND THEIR USE 审中-公开
标题翻译：偶氮和噻唑衍生物及其用途
公开(公告)号：US20120277275A1
公开(公告)日：2012-11-01
申请号：US13454159
申请日：2012-04-24
申请人： Nicholas Charles Ray , Richard James Bull , Harry Finch , Marco van den Heuvel , Jose Antonio Bravo
发明人： Nicholas Charles Ray , Richard James Bull , Harry Finch , Marco van den Heuvel , Jose Antonio Bravo
IPC分类号： A61K31/421 , A61P37/08 , A61P11/06 , A61P11/02 , C07D263/32 , A61P11/00
CPC分类号： C07D263/32 , C07D277/28 , C07D413/06 , C07D413/12
摘要： Compounds of formula (I) are useful in the treatment of diseases where enhanced M3 receptor activation is implicated, such as respiratory tract diseases:
摘要翻译：式（I）化合物可用于治疗涉及增强的M3受体活化的疾病，例如呼吸道疾病：

9. 发明申请

US20110172237A1 QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS 失效
标题翻译：喹啉衍生物作为MUSCARINIC M3受体拮抗剂
公开(公告)号：US20110172237A1
公开(公告)日：2011-07-14
申请号：US12992045
申请日：2008-05-13
申请人： Richard James Bull , Elizabeth Anne Skidmore , Rhonan Lee Ford , Andrew Nigel Mather , Antonio Mete
发明人： Richard James Bull , Elizabeth Anne Skidmore , Rhonan Lee Ford , Andrew Nigel Mather , Antonio Mete
IPC分类号： A61K31/501 , C07D453/02 , A61K31/439 , C07D401/14 , A61K31/506 , A61K31/497 , A61P11/00
CPC分类号： C07D453/02
摘要： The invention provides named compounds of formula (I), wherein R4 is a N-substituted quinuclidine (I) pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for’ the treatment of conditions mediated by M3 muscarinic receptors, such as chronic obstructive pulmonary disease is also disclosed.
摘要翻译：本发明提供了命名的式（I）化合物，其中R 4是含有它们的N-取代的奎宁环（I）药物组合物和制备药物组合物的方法。它们也用于治疗由M3毒蕈碱受体介导的病症，如慢性阻塞性肺疾病。

10. 发明申请

US20100144852A1 Bicyclo[2.2.1]hept-7-ylamine Derivatives and Their Uses 失效
标题翻译：双环[2.2.1]庚-7-基胺衍生物及其用途
公开(公告)号：US20100144852A1
公开(公告)日：2010-06-10
申请号：US12063212
申请日：2006-08-08
申请人： Harry Finch , Nicholas Charles Ray , Richard James Bull , Monique Bodil van Niel , Andrew Stephen Robert Jennings
发明人： Harry Finch , Nicholas Charles Ray , Richard James Bull , Monique Bodil van Niel , Andrew Stephen Robert Jennings
IPC分类号： A61K31/381 , C07C269/00 , C07D409/06 , A61K31/24 , A61P11/06 , A61P1/00 , A61P9/10
CPC分类号： C07C271/38 , C07C219/24 , C07C235/36 , C07C2602/42 , C07D211/14 , C07D311/84 , C07D311/86 , C07D333/16 , C07D409/06 , C07D409/14
摘要： Compounds of formula (I) have muscarinic M3 receptor modulating activity; Formula (I) wherein A is an oxygen atom or group —N(R12)—; (i) R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group —R5, —Z—Y—R5—Z—NR9R10; —Z—CO—NR9R10; —Z—NR9—CO—R5; or —Z—CO2H; and R3 is a lone pair, or C1-C6-alkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (ii) R1 and R3 together with the nitrogen to which they are attached form a heterocycloalkyl ring, and R2 is a hydrogen atom; or a group —R5, —Z—Y—R5, —Z—NR9R10, —Z—CO—NR9R10, —Z—NR9—CO—R5, or —Z—CO2H, in which cases the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (iii) R1 and R2 together with the nitrogen to which they are attached form a heterocycloalkyl ring, said ring being substituted by a group —Y—R5, —Z—Y—R5, —Z—NR9R10; —Z—CO—NR9R10; —Z—NR9—CO—R5; or —Z—CO2H and R3 is a lone pair, or C1-C6-alkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; R4 is a group of formula (a), (b), (c) or (d); is an C1-C6-alkyl, aryl, aryl-fused-cycloalkyl, aryl-fused-heterocycloalkyl, heteroaryl, aryl(C1-C8-alkyl)-, heteroaryl(C1-C8-alkyl)-, cycloalkyl or heterocycloalkyl group, and the remaining variables are as defined in the specification.
摘要翻译：式（I）化合物具有毒蕈碱M3受体调节活性; 式（I）其中A是氧原子或基团-N（R12） - ; （ⅰ）R 1是C 1 -C 6 - 烷基或氢原子; 并且R 2是氢原子或基团-R 5，-Z-Y-R 5 -Z-NR 9 R 10; -Z-CO-NR9R10; -Z-NR 9 -CO-R 5; 或-Z-CO 2 H; 并且R 3是孤对的，或者是C 1 -C 6烷基，在这种情况下，与其连接的氮原子是季氮并携带正电荷; 或（ii）R 1和R 3与它们所连接的氮一起形成杂环烷基环，并且R 2是氢原子; 或基团-R5，-Z-Y-R5，-Z-NR9R10，-Z-CO-NR9R10，-Z-NR9-CO-R5或-Z-CO2H，其中，附着是季氮并带正电荷; 或（iii）R 1和R 2与它们所连接的氮一起形成杂环烷基环，所述环被基团-Y-R 5，-Z-Y-R 5，-Z-NR 9 R 10取代; -Z-CO-NR9R10; -Z-NR9-CO-R5; 或-Z-CO 2 H，并且R 3是孤对的，或者C 1 -C 6 - 烷基，在这种情况下，与其连接的氮原子是季氮并带正电荷; R4是式（a），（b），（c）或（d）的基团; 是C 1 -C 6烷基，芳基，芳基稠合环烷基，芳基 - 稠合 - 杂环烷基，杂芳基，芳基（C 1 -C 8 - 烷基） - ，杂芳基（C 1 -C 8 - 烷基） - ，环烷基或杂环烷基，剩余的变量如规范中所定义。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式