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1. 发明申请

US20130030503A1 GASTROINTESTINAL ELECTRICAL THERAPY 有权
标题翻译：胃肠道电疗
公开(公告)号：US20130030503A1
公开(公告)日：2013-01-31
申请号：US13576485
申请日：2011-02-01
申请人： IRIT Yaniv , Walid Haddad , Paul V. Goode , Harold Lebovitz , Ricardo Aviv , Benny Rousso , Shlomo Ben-Haim
发明人： IRIT Yaniv , Walid Haddad , Paul V. Goode , Harold Lebovitz , Ricardo Aviv , Benny Rousso , Shlomo Ben-Haim
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61N1/0509 , A61N1/36007 , A61N1/36053 , A61N1/36085
摘要： Apparatus (18) for treating a human patient, which includes one or more electrode contact surfaces (100), which are configured to be applied to a fundus (22) of the patient. A control unit (90) is configured to drive the one or more electrode contact surfaces (100) to apply an electrical signal to the fundus (22) that chronically improves a blood glucose level of the patient, in order to treat the patient, without calculating an impedance of tissue of the fundus (22) based on a sensed parameter that varies in response to the electrical signal, for detecting eating by the patient or a characteristic of food eaten by the patient. Other embodiments are also described.
摘要翻译：用于治疗人类患者的装置（18），其包括被配置为施加到患者的眼底（22）的一个或多个电极接触表面（100）。控制单元（90）被配置为驱动所述一个或多个电极接触表面（100）以将电信号施加到眼底（22），所述电信号长期改善患者的血糖水平，以便治疗患者，而没有基于响应于电信号变化的感测参数，用于检测患者的进食或患者吃的食物的特征，计算眼底组织的阻抗（22）。还描述了其它实施例。

2. 发明申请

US20090118797A1 MONITORING, ANALYSIS, AND REGULATION OF EATING HABITS 有权
标题翻译：监测，分析和监管工作
公开(公告)号：US20090118797A1
公开(公告)日：2009-05-07
申请号：US11573722
申请日：2005-08-18
申请人： Anat Kliger , Shai Policker , Ricardo Aviv
发明人： Anat Kliger , Shai Policker , Ricardo Aviv
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/08 , A61N1/36007
摘要： Gastric apparatus (18) is provided, including one or more sensors (70, 72, 74), adapted to generate respective sensor signals responsive to activity of a gastrointestinal tract of a subject. A control unit (90) is adapted to receive and analyze the sensor signals and to determine that an eating event has occurred, responsive to at least one of the sensor signals and a threshold. The control unit identifies an aspect of at least one of the sensor signals deriving from rhythmic activity of the gastrointestinal tract that is not indicative of current eating by the subject, and modifies the threshold responsive to the aspect of the signals that derives from activity that is not indicative of current eating. For some applications, the control unit is adapted to modify the threshold if the aspect is indicative of a migrating motor complex (MMC). Other embodiments are also described.
摘要翻译：提供了胃装置（18），其包括一个或多个传感器（70,72,74），适于产生响应受试者的胃肠道活动的相应传感器信号。控制单元（90）适于接收和分析传感器信号并响应于至少一个传感器信号和阈值来确定进食事件已经发生。控制单元识别出来自胃肠道节奏活动的至少一个传感器信号的一个方面，其不指示受试者目前的饮食，并且根据来自活动的信号的方面修改阈值不表示目前的饮食。对于某些应用，如果该方面指示迁移电动机复合体（MMC），则控制单元适于修改阈值。还描述了其它实施例。

3. 发明授权

US08934975B2 Gastrointestinal electrical therapy 有权
标题翻译：胃肠电疗
公开(公告)号：US08934975B2
公开(公告)日：2015-01-13
申请号：US13576485
申请日：2011-02-01
申请人： Irit Yaniv , Walid Haddad , Paul V. Goode, Jr. , Harold Lebovitz , Ricardo Aviv , Benny Rousso , Shlomo Ben-Haim
发明人： Irit Yaniv , Walid Haddad , Paul V. Goode, Jr. , Harold Lebovitz , Ricardo Aviv , Benny Rousso , Shlomo Ben-Haim
IPC分类号： A61N1/40 , A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61N1/0509 , A61N1/36007 , A61N1/36053 , A61N1/36085
摘要： Apparatus (18) for treating a human patient, which includes one or more electrode contact surfaces (100), which are configured to be applied to a fundus (22) of the patient. A control unit (90) is configured to drive the one or more electrode contact surfaces (100) to apply an electrical signal to the fundus (22) that chronically improves a blood glucose level of the patient, in order to treat the patient, without calculating an impedance of tissue of the fundus (22) based on a sensed parameter that varies in response to the electrical signal, for detecting eating by the patient or a characteristic of food eaten by the patient. Other embodiments are also described.
摘要翻译：用于治疗人类患者的装置（18），其包括被配置为施加到患者的眼底（22）的一个或多个电极接触表面（100）。控制单元（90）被配置为驱动所述一个或多个电极接触表面（100）以将电信号施加到眼底（22），所述电信号长期改善患者的血糖水平，以便治疗患者，而没有基于响应于电信号变化的感测参数，用于检测患者的进食或患者吃的食物的特征，计算眼底组织的阻抗（22）。还描述了其它实施例。

4. 发明授权

US07840269B2 Analysis of eating habits 有权
标题翻译：分析饮食习惯
公开(公告)号：US07840269B2
公开(公告)日：2010-11-23
申请号：US11848555
申请日：2007-08-31
申请人： Shai Policker , Ricardo Aviv , Ophir Biton
发明人： Shai Policker , Ricardo Aviv , Ophir Biton
IPC分类号： A61B5/053
CPC分类号： A61B5/42 , A61B5/04884 , A61B5/053 , A61B5/076 , A61B5/1107 , A61B5/4023 , A61B5/4233 , A61N1/36007 , Y10S128/903 , Y10S128/92
摘要： Diet evaluation gastric apparatus (18) is provided, which detects when a patient (10) swallows, and detects the type and amount of matter ingested. The apparatus includes electrodes (74, 100) adapted to be coupled to the fundus and antrum of the patient and to measure electrical and mechanical activity therein, and a control unit (90) to analyze such electrical and mechanical activity and optionally apply electrical energy to modify the activity of tissue of the patient.
摘要翻译：提供饮食评价胃装置（18），其检测患者（10）何时吞咽，并检测摄入的物质的类型和数量。该装置包括适于耦合到患者的眼底和窦并测量其中的电和机械活动的电极（74,100），以及控制单元（90），用于分析这种电气和机械活动并且可选地将电能施加到修改患者组织的活动。

5. 发明授权

US07502649B2 Gastrointestinal methods and apparatus for use in treating disorders 有权
标题翻译：用于治疗疾病的胃肠道方法和装置
公开(公告)号：US07502649B2
公开(公告)日：2009-03-10
申请号：US10561491
申请日：2004-06-20
申请人： Shlomo Ben-Haim , Shai Policker , Ricardo Aviv , Ofer Glasberg
发明人： Shlomo Ben-Haim , Shai Policker , Ricardo Aviv , Ofer Glasberg
IPC分类号： A61N1/08
CPC分类号： A61K49/00 , A61B5/053 , A61B5/1116 , A61B5/14539 , A61B5/4238 , A61B5/6871 , A61F5/0026 , A61F5/0036 , A61N1/36007
摘要： A method is provided for detecting a change in posture of a subject. An electrical impedance is measured between two or more sites on a stomach (20) of the subject, and an impedance signal is generated responsive thereto. The change in posture is detected by performing a posture analysis of the impedance signal. A method is also provided for treating a subject. The method includes applying an electrical signal to a site of the subject selected from the list consisting of: a colon (402) of the subject, and a distal small intestine (408) of the subject. The signal is configured to stimulate cells of the subject to increase secretion of glucagon-like-peptide-1 (GLP-1) or PYY, or to decrease secretion of ghrelin, in order to treat the subject.
摘要翻译：提供一种用于检测被检体的姿势变化的方法。在受试者的胃（20）上的两个或更多个部位之间测量电阻抗，并且响应于此产生阻抗信号。通过进行阻抗信号的姿势分析来检测姿势的变化。还提供了一种治疗受试者的方法。该方法包括将电信号施加到从包括受试者的结肠（402）和受试者的远端小肠（408）的列表中选择的对象的部位。信号被配置为刺激受试者的细胞以增加胰高血糖素样肽-1（GLP-1）或PYY的分泌，或者降低生长素释放肽的分泌，以便治疗受试者。

6. 发明授权

US07437195B2 Regulation of eating habits 有权
标题翻译：调节饮食习惯
公开(公告)号：US07437195B2
公开(公告)日：2008-10-14
申请号：US10250714
申请日：2002-01-03
申请人： Shai Policker , Ricardo Aviv , Ophir Bitton
发明人： Shai Policker , Ricardo Aviv , Ophir Bitton
IPC分类号： A61N1/00
CPC分类号： A61K49/0004 , A61N1/36007
摘要： A method for treating a subject is provided, including receiving a sensor signal responsive to the subject eating, analyzing the sensor signal, and driving a current into tissue of the subject responsive to analyzing the signal. The current is typically driven into muscle tissue of the subject's stomach (20). Preferably, receiving the sensor signal includes sensing electrical potential change generated responsive to contraction of a muscle such as a stomach muscle of the subject. In a preferred embodiment, the sensor signal is analyzed with respect to the timing of ingestion, and a level of compliance of the subject with a desired ingestion schedule is determined. As appropriate, a parameter of the current driven into the tissue may be configured such that the application of the current to the tissue induces in the subject a sensation of satiation, discomfort, nausea, or vertigo.
摘要翻译：提供了一种用于治疗受试者的方法，包括响应于所述受试者进食，分析所述传感器信号，并且响应于所述信号的分析而将电流驱动到所述对象的组织中。电流通常被驱动到受试者的胃的肌肉组织（20）中。优选地，接收传感器信号包括响应于诸如受试者的胃肌的肌肉收缩而产生的电位变化。在优选实施例中，相对于摄取的时间来分析传感器信号，并且确定受试者与期望摄取时间表的顺应性水平。适当地，驱动到组织中的电流的参数可以被配置为使得电流施加到组织会在受试者中引起饱腹感，不适感，恶心或眩晕感。

7. 发明申请

US20070239216A9 Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue 有权
标题翻译：使用应用于组织的非兴奋性电信号调节细胞内钙浓度
公开(公告)号：US20070239216A9
公开(公告)日：2007-10-11
申请号：US10116201
申请日：2002-04-03
申请人： Itzik Shemer , Bella Felzen , Nissim Darvish , Yuval Mika , Walid Haddad , Ricardo Aviv , Yaakov Haham
发明人： Itzik Shemer , Bella Felzen , Nissim Darvish , Yuval Mika , Walid Haddad , Ricardo Aviv , Yaakov Haham
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3628 , A61N1/368
摘要： According to a method and device for modulating intracellular calcium concentration in biological tissue, a stimulation probe is applied to the tissue, a non-excitatory stimulation pulse is generated, and the pulse is conveyed to the stimulation probe. In one embodiment concerning cardiac tissue, a stimulation probe is applied to a patient's heart, a signal is received from at least one sensor responsive to the patient's cardiac muscle activity, a non-excitatory stimulation pulse responsive to the signal is generated, and the pulse is conveyed to the stimulation probe.
摘要翻译：根据用于调节生物组织中细胞内钙浓度的方法和装置，将刺激探针施加到组织，产生非兴奋性刺激脉冲，并将脉冲输送到刺激探针。在关于心脏组织的一个实施例中，将刺激探针应用于患者的心脏，响应于患者的心肌活动从至少一个传感器接收信号，产生响应于该信号的非兴奋性刺激脉冲，并且脉冲被传送到刺激探针。

8. 发明授权

US06694192B2 Uterus muscle controller 有权
标题翻译：子宫肌肉控制器
公开(公告)号：US06694192B2
公开(公告)日：2004-02-17
申请号：US09753848
申请日：2001-01-03
申请人： Shai Policker , Ricardo Aviv , Daniel Kamil
发明人： Shai Policker , Ricardo Aviv , Daniel Kamil
IPC分类号： A61N100
CPC分类号： A61N1/36007
摘要： A method and apparatus for controlling uterine contractions in a female comprises providing sensors for sensing uterine contractions; providing an electric signal generator for generating signals to be applied on the uterus; providing a control unit for receiving signal corresponding to uterus contractions from the sensors and actuate said signal generator to generate a non-excitatory electric signal in a predetermined timing and duration with respect to a sensed uterine contraction; providing signal delivery leads for delivering the electric signal from the electric signal generator to predetermined locations on the uterus; sensing a uterine contraction using the sensors; and applying non-excitatory electric field at the predetermined locations on the uterus in predetermined timing and duration with respect to the sensed uterine contraction.
摘要翻译：用于控制女性中的子宫收缩的方法和装置包括提供用于感测子宫收缩的传感器; 提供用于产生施加在子宫上的信号的电信号发生器; 提供用于从所述传感器接收对应于子宫收缩的信号的控制单元，并致动所述信号发生器以相对于感测到的子宫收缩的预定时间和持续时间产生非兴奋性电信号; 提供用于将电信号从电信号发生器传送到子宫上的预定位置的信号传递线; 使用传感器感测子宫收缩; 以及相对于感测到的子宫收缩的预定时间和持续时间，在子宫上的预定位置施加非兴奋性电场。

9. 发明授权

US07330753B2 Analysis of eating habits 有权
标题翻译：分析饮食习惯
公开(公告)号：US07330753B2
公开(公告)日：2008-02-12
申请号：US10475198
申请日：2002-04-16
申请人： Shai Policker , Ricardo Aviv , Ophir Biton
发明人： Shai Policker , Ricardo Aviv , Ophir Biton
IPC分类号： A61B5/053
CPC分类号： A61B5/42 , A61B5/04884 , A61B5/053 , A61B5/076 , A61B5/1107 , A61B5/4023 , A61B5/4233 , A61N1/36007 , Y10S128/903 , Y10S128/92
摘要： Diet evaluation gastric apparatus (18) is provided, which detects when a patient (10) swallows, and detects the type and amount of matter ingested. The apparatus includes electrodes (74, 100) adapted to be coupled to the fundus and antrum of the patient and to measure electrical and mechanical activity therein, and a control unit (90) to analyze such electrical and mechanical activity and optionally apply electrical energy to modify the activity of tissue of the patient.
摘要翻译：提供饮食评价胃装置（18），其检测患者（10）何时吞咽，并检测摄入的物质的类型和数量。该装置包括适于耦合到患者的眼底和窦并测量其中的电和机械活动的电极（74,100），以及控制单元（90），用于分析这种电气和机械活动并且可选地将电能施加到修改患者组织的活动。

10. 发明申请

US20070299320A1 Analysis Of Eating Habits 有权
标题翻译：饮食习惯分析
公开(公告)号：US20070299320A1
公开(公告)日：2007-12-27
申请号：US11848555
申请日：2007-08-31
申请人： Shai Policker , Ricardo Aviv , Ophir Biton
发明人： Shai Policker , Ricardo Aviv , Ophir Biton
IPC分类号： A61B5/00
CPC分类号： A61B5/42 , A61B5/04884 , A61B5/053 , A61B5/076 , A61B5/1107 , A61B5/4023 , A61B5/4233 , A61N1/36007 , Y10S128/903 , Y10S128/92
摘要： Diet evaluation gastric apparatus (18) is provided, which detects when a patient (10) swallows, and detects the type and amount of matter ingested. The apparatus includes electrodes (74, 100) adapted to be coupled to the fundus and antrum of the patient and to measure electrical and mechanical activity therein, and a control unit (90) to analyze such electrical and mechanical activity and optionally apply electrical energy to modify the activity of tissue of the patient.
摘要翻译：提供饮食评价胃装置（18），其检测患者（10）何时吞咽，并检测摄入的物质的类型和数量。该装置包括适于耦合到患者的眼底和窦并测量其中的电和机械活动的电极（74,100），以及控制单元（90），用于分析这种电气和机械活动并且可选地将电能施加到修改患者组织的活动。

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