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1. 发明授权

US4796636A Noninvasive reflectance oximeter 失效
标题翻译：无创反射血氧计
公开(公告)号：US4796636A
公开(公告)日：1989-01-10
申请号：US95125
申请日：1987-09-10
申请人： Ronald L. Branstetter , Reuben W. Edgar, Jr.
发明人： Ronald L. Branstetter , Reuben W. Edgar, Jr.
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , G01N21/31 , G01N33/48
CPC分类号： A61B5/14551 , G01N21/3151
摘要： A noninvasive optical oximeter for measuring oxygen saturation of arterial blood. A sample of blood is illuminated with light at two different wavelengths. Light reflected by the blood is sensed by a photodetector and an output signal is created in response thereto. The output signal is processed to form a quotient representing the AC components of the reflected light at each wavelength. The oxygen saturation of the blood is calculated by correlating this quotient with an oxygen saturation reference curve uniquely representative of the blood oxygen saturation characteristics of a particular individual. The reference curve used in the preferred embodiment of the invention is calibrated in a two-step process which minimizes the effects of calibration errors. A first oxygen saturation reference curve is calculated which is based on a linear relationship between the ratio of the AC components of the reflected light. This curve is then used to calibrate a second reference curve based on a linear ratio of the squared values of the AC components of the reflected light. Once the second reference curve has been properly calibrated, it is used for all subsequent measurements of oxygen saturation.
摘要翻译：一种用于测量动脉血氧饱和度的无创光学血氧计。用两种不同波长的光照射血样。由光检测器感测由血液反射的光，响应于此产生输出信号。处理输出信号以形成表示每个波长的反射光的AC分量的商。通过将该商与独特地代表特定个体的血氧饱和度特征的氧饱和度参考曲线相关联来计算血液的氧饱和度。在本发明的优选实施例中使用的参考曲线在两步骤过程中被校准，这使得校准误差的影响最小化。计算第一氧饱和度参考曲线，其基于反射光的AC分量的比率之间的线性关系。然后，该曲线用于基于反射光的AC分量的平方值的线性比率来校准第二参考曲线。一旦第二个参考曲线被正确校准，它就被用于所有后续的氧饱和度测量。

2. 发明授权

US07072702B2 Method, apparatus and system for removing motion artifacts from measurements of bodily parameters 失效
标题翻译：用于从身体参数测量中去除运动伪影的方法，装置和系统
公开(公告)号：US07072702B2
公开(公告)日：2006-07-04
申请号：US10873758
申请日：2004-06-22
申请人： Reuben W. Edgar, Jr. , August J. Allo, Jr. , Paul B. Gunneson , Jesus D. Martin , John R. DelFavero , Michael B. Jaffe
发明人： Reuben W. Edgar, Jr. , August J. Allo, Jr. , Paul B. Gunneson , Jesus D. Martin , John R. DelFavero , Michael B. Jaffe
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/7207 , A61B5/7257 , A61B5/726
摘要： A method for removing motion artifacts from devices for sensing bodily parameters and apparatus and system for effecting same. The method includes analyzing segments of measured data representing bodily parameters and possibly noise from motion artifacts. Each segment of measured data may correspond to a single light signal transmitted and detected after transmission or reflection through bodily tissue. Each data segment is frequency analyzed to determine up to three candidate peaks for further analysis. Each of the up to three candidate frequencies may be filtered and various parameters associated with each of the up to three candidate frequencies are calculated. The best frequency, if one exists, is determined by arbitrating the candidate frequencies using the calculated parameters according to predefined criteria. If a best frequency is found, a pulse rate and SPO2 may be output. If a best frequency is not found, other, conventional techniques for calculating pulse rate and SpO2 may be used. The above method may be applied to red and infrared pulse oximetry signals prior to calculating pulse rate and/or pulsatile blood oxygen concentration. Apparatus and systems disclosed are configured to perform methods disclosed according to the invention.
摘要翻译：一种用于从用于感测身体参数的装置和用于实现其的设备和系统的装置中去除运动假象的方法。该方法包括分析表示身体参数和可能的运动伪影噪声的测量数据的段。测量数据的每一段可对应于通过身体组织透射或反射后传输和检测的单个光信号。对每个数据段进行频率分析，以确定最多三个候选峰进行进一步分析。可以对最多三个候选频率中的每一个进行滤波，并且计算与最多三个候选频率中的每一个相关联的各种参数。通过使用根据预定准则的计算参数来仲裁候选频率来确定最佳频率（如果存在）。如果找到最佳频率，则可以输出脉搏率和SPO 2 。如果没有找到最佳频率，则可以使用用于计算脉率和SpO 2 2的其它常规技术。在计算脉搏率和/或脉动血氧浓度之前，上述方法可以应用于红色和红外脉搏血氧饱和度信号。公开的设备和系统被配置为执行根据本发明公开的方法。

3. 发明授权

US4714080A Method and apparatus for noninvasive monitoring of arterial blood oxygen saturation 失效
标题翻译：用于非侵入性监测动脉血氧饱和度的方法和装置
公开(公告)号：US4714080A
公开(公告)日：1987-12-22
申请号：US915688
申请日：1986-10-06
申请人： Reuben W. Edgar, Jr. , Dennis W. Gilstad , Ronald L. Branstetter
发明人： Reuben W. Edgar, Jr. , Dennis W. Gilstad , Ronald L. Branstetter
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1495 , G01N33/497
CPC分类号： A61B5/14551
摘要： A noninvasive optical oximeter for measuring oxygen saturation of arterial blood. A sample of blood is illuminated with light at two different wavelengths. Light reflected by the blood is sensed by a photodetector and an output signal is created in response thereto. The output signal is processed to form a quotient representing the AC components of the reflected light at each wavelength. The oxygen saturation of the blood is calculated by correlating this quotient with an oxygen saturation reference curve uniquely representative of the blood oxygen saturation characteristics of a particular individual.
摘要翻译：一种用于测量动脉血氧饱和度的无创光学血氧计。用两种不同波长的光照射血样。由光检测器感测由血液反射的光，响应于此产生输出信号。处理输出信号以形成表示每个波长的反射光的AC分量的商。通过将该商与独特地代表特定个体的血氧饱和度特征的氧饱和度参考曲线相关联来计算血液的氧饱和度。

4. 发明授权

US08328776B2 Reduced pressure treatment system having blockage clearing and dual-zone pressure protection capabilities 有权
标题翻译：减压处理系统具有堵塞清除和双区压力保护功能
公开(公告)号：US08328776B2
公开(公告)日：2012-12-11
申请号：US12824582
申请日：2010-06-28
申请人： Randall P. Kelch , Xiaolu Zheng , Reuben W. Edgar, Jr. , Jonathan Paul Jaeb , Thomas Paul Lawhorn , Shannon C Ingram
发明人： Randall P. Kelch , Xiaolu Zheng , Reuben W. Edgar, Jr. , Jonathan Paul Jaeb , Thomas Paul Lawhorn , Shannon C Ingram
IPC分类号： A61M1/00
CPC分类号： A61H9/0057 , A61H2201/5056 , A61M1/0001 , A61M1/0023 , A61M1/0025 , A61M1/0027 , A61M1/0031 , A61M1/0058 , A61M1/0088 , A61M5/1415 , A61M2205/15 , A61M2205/33 , A61M2205/3303 , A61M2205/3327 , A61M2205/3331 , A61M2205/3337 , A61M2205/3344 , A61M2205/3379 , A61M2205/43 , A61M2205/581 , A61N1/0468 , A61N5/0616 , A61N2005/0661 , F16M11/046 , F16M11/048 , F16M13/02 , F16M2200/027 , G01F23/14
摘要： A method of treating a tissue site is provided. The method includes applying a reduced pressure to a tissue site with a reduced pressure source. A source pressure is monitored at the reduced pressure source, and a differential pressure is determined between the source pressure and the desired tissue site pressure. If a blockage is present between the reduced pressure source and the tissue site, the differential pressure is limited to a first maximum differential pressure. If no blockage is present between the reduced pressure source and the tissue site, the differential pressure is limited to a second maximum differential pressure.
摘要翻译：提供了一种治疗组织部位的方法。该方法包括用减压源将减压施加到组织部位。在减压源处监测源压力，并且在源压力和期望的组织部位压力之间确定差压。如果减压源和组织部位之间存在阻塞，则压差被限制在第一最大压差。如果减压源和组织部位之间没有堵塞，则差压被限制到第二最大压差。

5. 发明授权

US06836502B2 Spectroscopy light source 有权
标题翻译：光谱光源
公开(公告)号：US06836502B2
公开(公告)日：2004-12-28
申请号：US10347146
申请日：2003-01-17
申请人： Larry D. Canady , Christopher B. Catterson , Reuben W. Edgar, Jr. , Ralph Henry Hill, Jr. , Brian Lee Robey
发明人： Larry D. Canady , Christopher B. Catterson , Reuben W. Edgar, Jr. , Ralph Henry Hill, Jr. , Brian Lee Robey
IPC分类号： H01S300
CPC分类号： H01L33/54 , G01J3/10 , H01L33/507
摘要： A light source for a spectroscopy unit that measures tissue includes a block for engaging tissue and a light source. The block is formed of translucent material. The light source is positioned in close proximity to the block either directly or through use of a light fiber. The light source produces light at a single wavelength or small range of wavelengths shorter than the desired range of wavelengths to be produced by the light source for the spectroscopy unit. A luminescent material is placed in the light path between light source and the tissue to produce the desired wavelength of light when pumped by the light source.
摘要翻译：用于测量组织的光谱单元的光源包括用于接合组织和光源的块。该块由半透明材料形成。光源直接或通过使用光纤定位在块附近。光源产生的光在单个波长或小的波长范围内短于由用于光谱单元的光源产生的期望波长范围。发光材料放置在光源和组织之间的光路中，以在由光源泵送时产生所需的波长的光。

6. 发明授权

US06519486B1 Method, apparatus and system for removing motion artifacts from measurements of bodily parameters 失效
标题翻译：用于从身体参数测量中去除运动伪影的方法，装置和系统
公开(公告)号：US06519486B1
公开(公告)日：2003-02-11
申请号：US09546260
申请日：2000-04-10
申请人： Reuben W. Edgar, Jr. , August J. Allo, Jr. , Paul B. Gunneson , Jesus D. Martin , John R. DelFavero , Michael B. Jaffe
发明人： Reuben W. Edgar, Jr. , August J. Allo, Jr. , Paul B. Gunneson , Jesus D. Martin , John R. DelFavero , Michael B. Jaffe
IPC分类号： A61B500
CPC分类号： A61B5/14551 , A61B5/7207 , A61B5/7257 , A61B5/726
摘要： A method for removing motion artifacts from devices for sensing bodily parameters and apparatus and system for effecting same. The method includes analyzing segments of measured data representing bodily parameters and possibly noise from motion artifacts. Each segment of measured data may correspond to a single light signal transmitted and detected after transmission or reflection through bodily tissue. Each data segment is frequency analyzed to determine up to three candidate peaks for further analysis. Each of the up to three candidate frequencies may be filtered and various parameters associated with each of the up to three candidate frequencies are calculated. The best frequency, if one exists, is determined by arbitrating the candidate frequencies using the calculated parameters according to predefined criteria. If a best frequency is found, a pulse rate and SpO2 may be output. If a best frequency is not found, other, conventional techniques for calculating pulse rate and Spo2 may be used. The above method may be applied to red and infrared pulse oximetry signals prior to calculating pulse rate and/or pulsatile blood oxygen concentration. Apparatus and systems disclosed are configured to perform methods disclosed according to the invention.
摘要翻译：一种用于从用于感测身体参数的装置和用于实现其的设备和系统的装置中去除运动假象的方法。该方法包括分析表示身体参数和可能的运动伪影噪声的测量数据的段。测量数据的每一段可对应于通过身体组织透射或反射后传输和检测的单个光信号。对每个数据段进行频率分析，以确定最多三个候选峰进行进一步分析。可以对最多三个候选频率中的每一个进行滤波，并且计算与最多三个候选频率中的每一个相关联的各种参数。通过使用根据预定准则的计算参数来仲裁候选频率来确定最佳频率（如果存在）。如果发现最佳频率，则可以输出脉率和SpO2。如果没有找到最佳频率，则可以使用用于计算脉率和Spo2的其它常规技术。在计算脉搏率和/或脉动血氧浓度之前，上述方法可以应用于红色和红外脉搏血氧饱和度信号。公开的设备和系统被配置为执行根据本发明公开的方法。

7. 发明授权

US4854699A Backscatter oximeter 失效
标题翻译：反向散射仪
公开(公告)号：US4854699A
公开(公告)日：1989-08-08
申请号：US115204
申请日：1987-11-02
申请人： Reuben W. Edgar, Jr.
发明人： Reuben W. Edgar, Jr.
IPC分类号： A61B5/00
CPC分类号： A61B5/14551
摘要： A noninvasive optical oximeter for measuring oxygen saturation of arterial blood. A sample of blood is illuminated with light at four different wavelengths. Light reflected by the blood is sensed by a photodetector and a plurality of output signals are created in response thereto. The reflected light at each of the four wavelengths is detected after contact with the blood and is correlated with the oxygen saturation of the patient's blood using mathematical relationships for arterial and venous oxygen saturation. The present invention provides a noninvasive backscatter oximeter which is capable of providing accurate indications of a patient's blood oxygen saturation without the need for obtaining prior information relating to the oxygen content of the patient's blood.
摘要翻译：一种用于测量动脉血氧饱和度的无创光学血氧计。用四种不同波长的光照射血样。由光检测器感测由血液反射的光，响应于此产生多个输出信号。在与血液接触后检测四个波长中的每一个处的反射光，并且使用关于动脉和静脉血氧饱和度的数学关系与患者血液的氧饱和度相关。本发明提供一种非侵入性背散射血氧计，其能够提供患者血氧饱和度的准确指示，而不需要获得与患者血液的氧含量相关的先前信息。

8. 发明授权

US07991448B2 Method, apparatus, and system for removing motion artifacts from measurements of bodily parameters 失效
标题翻译：用于从身体参数测量中去除运动伪影的方法，装置和系统
公开(公告)号：US07991448B2
公开(公告)日：2011-08-02
申请号：US11408604
申请日：2006-04-21
申请人： Reuben W. Edgar, Jr. , August J. Allo, Jr. , Paul B. Gunneson , Jesus D. Martin , John R. DelFavero , Michael B. Jaffe
发明人： Reuben W. Edgar, Jr. , August J. Allo, Jr. , Paul B. Gunneson , Jesus D. Martin , John R. DelFavero , Michael B. Jaffe
IPC分类号： A61B5/1455 , A61B5/02
CPC分类号： A61B5/14551 , A61B5/7207 , G06K9/0051
摘要： A method for removing motion artifacts from devices for sensing bodily parameters and apparatus and system for effecting same that includes analyzing segments of measured data representing bodily parameters and possibly noise from motion artifacts. Each data segment is frequency analyzed to determine up to three candidate peaks for further analysis. Up to three candidate frequencies may be filtered and various parameters associated with each candidate frequency are calculated. A pulse-estimate input may also be accepted from an external source. The best frequency, if one exists, is determined by arbitrating the candidate frequencies and the pulse-estimate input using the calculated parameters according to predefined criteria. If a best frequency is found, a pulse rate and SpO2 may be output. If a best frequency is not found, other, conventional techniques for calculating pulse rate and SpO2 may be used.
摘要翻译：一种用于从用于感测身体参数的装置和装置和系统中去除运动假象的方法，用于实现该运动伪影，其包括分析代表身体参数和可能的运动伪影噪声的测量数据的段。对每个数据段进行频率分析，以确定最多三个候选峰进行进一步分析。可以过滤多达三个候选频率，并且计算与每个候选频率相关联的各种参数。也可以从外部来源接受脉冲估计输入。如果存在最佳频率，则通过使用根据预定准则的计算参数来仲裁候选频率和脉冲估计输入来确定。如果发现最佳频率，则可以输出脉率和SpO2。如果没有发现最佳频率，则可以使用用于计算脉率和SpO2的其它常规技术。

9. 发明申请

US20100268179A1 REDUCED PRESSURE TREATMENT SYSTEM HAVING BLOCKAGE CLEARING AND DUAL-ZONE PRESSURE PROTECTION CAPABILITIES 有权
标题翻译：具有堵塞清除和双区压力保护能力的降低压力处理系统
公开(公告)号：US20100268179A1
公开(公告)日：2010-10-21
申请号：US12824582
申请日：2010-06-28
申请人： Randall P. Kelch , Xiaolu Zheng , Reuben W. Edgar, JR. , Jonathan Paul Jaeb , Thomas Paul Lawhorn , Shannon C. Ingram
发明人： Randall P. Kelch , Xiaolu Zheng , Reuben W. Edgar, JR. , Jonathan Paul Jaeb , Thomas Paul Lawhorn , Shannon C. Ingram
IPC分类号： A61M1/00
CPC分类号： A61H9/0057 , A61H2201/5056 , A61M1/0001 , A61M1/0023 , A61M1/0025 , A61M1/0027 , A61M1/0031 , A61M1/0058 , A61M1/0088 , A61M5/1415 , A61M2205/15 , A61M2205/33 , A61M2205/3303 , A61M2205/3327 , A61M2205/3331 , A61M2205/3337 , A61M2205/3344 , A61M2205/3379 , A61M2205/43 , A61M2205/581 , A61N1/0468 , A61N5/0616 , A61N2005/0661 , F16M11/046 , F16M11/048 , F16M13/02 , F16M2200/027 , G01F23/14
摘要： A method of treating a tissue site is provided. The method includes applying a reduced pressure to a tissue site with a reduced pressure source. A source pressure is monitored at the reduced pressure source, and a differential pressure is determined between the source pressure and the desired tissue site pressure. If a blockage is present between the reduced pressure source and the tissue site, the differential pressure is limited to a first maximum differential pressure. If no blockage is present between the reduced pressure source and the tissue site, the differential pressure is limited to a second maximum differential pressure.
摘要翻译：提供了一种治疗组织部位的方法。该方法包括用减压源将减压施加到组织部位。在减压源处监测源压力，并且在源压力和期望的组织部位压力之间确定差压。如果减压源和组织部位之间存在阻塞，则压差被限制在第一最大压差。如果减压源和组织部位之间没有堵塞，则差压被限制到第二最大压差。

10. 发明授权

US07758555B2 Reduced pressure treatment system having blockage clearing and dual-zone pressure protection capabilities 有权
标题翻译：减压处理系统具有堵塞清除和双区压力保护功能
公开(公告)号：US07758555B2
公开(公告)日：2010-07-20
申请号：US11903165
申请日：2007-09-19
申请人： Randall P. Kelch , Xiaolu Zheng , Reuben W. Edgar, Jr. , Jonathan Paul Jaeb , Thomas Paul Lawhorn , Shannon C Ingram
发明人： Randall P. Kelch , Xiaolu Zheng , Reuben W. Edgar, Jr. , Jonathan Paul Jaeb , Thomas Paul Lawhorn , Shannon C Ingram
IPC分类号： A61M1/00 , A01J3/00 , A61M35/00
CPC分类号： A61H9/0057 , A61H2201/5056 , A61M1/0001 , A61M1/0023 , A61M1/0025 , A61M1/0027 , A61M1/0031 , A61M1/0058 , A61M1/0088 , A61M5/1415 , A61M2205/15 , A61M2205/33 , A61M2205/3303 , A61M2205/3327 , A61M2205/3331 , A61M2205/3337 , A61M2205/3344 , A61M2205/3379 , A61M2205/43 , A61M2205/581 , A61N1/0468 , A61N5/0616 , A61N2005/0661 , F16M11/046 , F16M11/048 , F16M13/02 , F16M2200/027 , G01F23/14
摘要： A method of treating a tissue site is provided. The method includes applying a reduced pressure to a tissue site with a reduced pressure source. A source pressure is monitored at the reduced pressure source, and a differential pressure is determined between the source pressure and the desired tissue site pressure. If a blockage is present between the reduced pressure source and the tissue site, the differential pressure is limited to a first maximum differential pressure. If no blockage is present between the reduced pressure source and the tissue site, the differential pressure is limited to a second maximum differential pressure.
摘要翻译：提供了一种治疗组织部位的方法。该方法包括用减压源将减压施加到组织部位。在减压源处监测源压力，并且在源压力和期望的组织部位压力之间确定差压。如果减压源和组织部位之间存在阻塞，则压差被限制在第一最大压差。如果减压源和组织部位之间没有堵塞，则差压被限制到第二最大压差。

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