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1. 发明授权

US5006466A Fermentation analogs of virginiamycin M.sub.1 失效
标题翻译：维吉尼亚霉素M1的发酵类似物
公开(公告)号：US5006466A
公开(公告)日：1991-04-09
申请号：US426836
申请日：1989-10-26
申请人： Yiu-kuen T. Lam , Otto D. Hensens , Raymond S. Chang , Cheryl D. Schwartz , Deborah L. Zink
发明人： Yiu-kuen T. Lam , Otto D. Hensens , Raymond S. Chang , Cheryl D. Schwartz , Deborah L. Zink
IPC分类号： A61K38/00 , C07K5/078 , C12P17/18
CPC分类号： C12R1/58 , C07K5/06139 , C12P17/188 , A61K38/00 , Y10S435/886 , Y10S435/902
摘要： Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527, while the analog of Formula II is produced by chemical synthesis.
摘要翻译：维生素B1，具有下式的维他明霉素M1：具有式I-IV的维吉尼好霉素M1类似物：（I）图像（III） -IV是胆囊收缩素（CCK）和胃泌素的拮抗剂。胆囊收缩素拮抗剂可用作止痛剂和用于治疗和预防动物，特别是人类的胃肠道，中枢神经和食欲调节系统的紊乱。胃泌素拮抗剂可用于阻断人类胃泌素受体，并且可用作治疗溃疡，肿瘤或其它胃肠道疾病的药剂。式I-IV的化合物是抗生素，并且可用作包括人在内的动物的抗微生物剂，并且可用作促进动物饲料利用的食品添加剂。弗吉尼亚霉素M1和式I，III和IV的类似物是通过控制好氧发酵链霉菌链霉菌ATCC No.55327产生的，而式II的类似物是通过化学合成制备的。

2. 发明授权

US4942230A Process for preparing synthetic virginiamycin M.sub.1 analogs 失效
标题翻译：合成维拉霉素M1类似物的制备方法
公开(公告)号：US4942230A
公开(公告)日：1990-07-17
申请号：US365324
申请日：1989-06-13
申请人： Yiu-kuen T. Lam , Raymond S. Chang
发明人： Yiu-kuen T. Lam , Raymond S. Chang
IPC分类号： A61K38/00 , C07K5/078 , C12P17/18
CPC分类号： C12R1/58 , C07K5/06139 , C12P17/188 , A61K38/00
摘要： Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, II and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527, while the analog of Formula II is produced by chemical synthesis.
摘要翻译：维生素B1，具有下式的维他明霉素M1：具有式I-IV的维吉尼好霉素M1类似物：（I）图像（III） -IV是胆囊收缩素（CCK）和胃泌素的拮抗剂。胆囊收缩素拮抗剂可用作止痛剂和用于治疗和预防动物，特别是人类的胃肠道，中枢神经和食欲调节系统的紊乱。胃泌素拮抗剂可用于阻断人类胃泌素受体，并且可用作治疗溃疡，肿瘤或其它胃肠道疾病的药剂。式I-IV的化合物也是抗生素，并且可用作包括人在内的动物的抗微生物剂，并且可用作促进动物饲料利用的食品添加剂。弗吉尼亚霉素M1和式I，II和IV的类似物通过对链霉菌链霉菌ATCC No.55327的受控好氧发酵产生，而式II的类似物通过化学合成制备。

3. 发明授权

US5189050A Fermentation analogs of Virginiamycin M.sub.1 to treat panic and anxiety disorder 失效
标题翻译： VIRGINIAMYCIN M1的发酵模拟物治疗神经性和恶性疾病
公开(公告)号：US5189050A
公开(公告)日：1993-02-23
申请号：US709676
申请日：1991-06-03
申请人： Roger M. Freidinger , Mark G. Bock , Yiu-Kuen T. Lam , Raymond S. Chang , Otto D. Hensens , Cheryl D. Schwartz , Deborah L. Zink
发明人： Roger M. Freidinger , Mark G. Bock , Yiu-Kuen T. Lam , Raymond S. Chang , Otto D. Hensens , Cheryl D. Schwartz , Deborah L. Zink
IPC分类号： A61K31/42 , A61K38/00 , A61P25/00 , A61P25/20 , A61P25/30 , A61P27/02 , A61P35/00 , C07D498/18 , C07K5/078 , C12P17/18 , C12R1/58
CPC分类号： C07K5/06182 , A61K38/00
摘要： Pharmaceutical compositions containing Virginiamycin M.sub.1 having the Formula: ##STR1## and Virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.

4. 发明授权

US4772595A Synthetic virginiamycin M1 analogs 失效
标题翻译：合成维吉尼亚霉素M1类似物
公开(公告)号：US4772595A
公开(公告)日：1988-09-20
申请号：US934232
申请日：1986-11-21
申请人： Yiu-kuen T. Lam , Raymond S. Chang
发明人： Yiu-kuen T. Lam , Raymond S. Chang
IPC分类号： A61K38/00 , C07K5/078 , C12P17/18 , A61K31/33 , C07D498/12
CPC分类号： C12R1/58 , C07K5/06139 , C12P17/188 , A61K38/00
摘要： Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527, while the analog of Formula II is produced by chemical synthesis.
摘要翻译：维生素B1，具有下式的维他明霉素M1：具有式I-IV的维吉尼好霉素M1类似物：（I）图像（III） -IV是胆囊收缩素（CCK）和胃泌素的拮抗剂。胆囊收缩素拮抗剂可用作止痛剂和用于治疗和预防动物，特别是人类的胃肠道，中枢神经和食欲调节系统的紊乱。胃泌素拮抗剂可用于阻断人类胃泌素受体，并且可用作治疗溃疡，肿瘤或其它胃肠道疾病的药剂。式I-IV的化合物也是抗生素，并且可用作包括人在内的动物的抗微生物剂，并且可用作促进动物饲料利用的食品添加剂。弗吉尼亚霉素M1和式I，III和IV的类似物是通过控制好氧发酵链霉菌链霉菌ATCC No.55327产生的，而式II的类似物是通过化学合成制备的。

5. 发明授权

US4762923A Fermentation analogs of virginiamycin M1 失效
标题翻译：维吉尼亚霉素M1的发酵类似物
公开(公告)号：US4762923A
公开(公告)日：1988-08-09
申请号：US934231
申请日：1986-11-21
申请人： Yiu-Kuen T. Lam , Raymond S. Chang , Otto D. Hensens , Cheryl D. Schwartz , Deborah L. Zink
发明人： Yiu-Kuen T. Lam , Raymond S. Chang , Otto D. Hensens , Cheryl D. Schwartz , Deborah L. Zink
IPC分类号： A61K31/41 , A61K38/00 , A61K38/55 , A61P1/00 , A61P25/00 , C07D498/04 , C07K5/078 , C12P17/18 , C12R1/58 , C07D498/16 , A61K31/42 , C12P17/14
CPC分类号： C12R1/58 , C07K5/06139 , C12P17/188 , A61K38/00
摘要： Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III, and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527, while the analog of Formula II is produced by chemical synthesis.
摘要翻译：维生素B1，具有下式的维他明霉素M1：具有式I-IV的维吉尼好霉素M1类似物：（I）图像（III） -IV是胆囊收缩素（CCK）和胃泌素的拮抗剂。胆囊收缩素拮抗剂可用作止痛剂和用于治疗和预防动物，特别是人类的胃肠道，中枢神经和食欲调节系统的紊乱。胃泌素拮抗剂可用于阻断人类胃泌素受体，并且可用作治疗溃疡，肿瘤或其它胃肠道疾病的药剂。式I-IV的化合物也是抗生素，并且可用作包括人在内的动物的抗微生物剂，并且可用作促进动物饲料利用的食品添加剂。维生素霉素M1和式I，III和IV的类似物通过对链霉菌链霉菌ATCC No.55327的受控好氧发酵产生，而式II的类似物通过化学合成产生。

6. 发明授权

US4859690A Therapeutic virginiamycin M.sub.1 analogs 失效
标题翻译：治疗维吉尼亚霉素M1类似物
公开(公告)号：US4859690A
公开(公告)日：1989-08-22
申请号：US934212
申请日：1986-11-21
申请人： Yiu-kuen T. Lam , Raymond S. Chang , Otto D. Hensens , Cheryl D. Schwartz , Deborah L. Zink
发明人： Yiu-kuen T. Lam , Raymond S. Chang , Otto D. Hensens , Cheryl D. Schwartz , Deborah L. Zink
IPC分类号： A61K38/00 , C07K5/078 , C12P17/18
CPC分类号： C12R1/58 , C07K5/06139 , C12P17/188 , A61K38/00
摘要： Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527. The analog of Formula II is produced by chemical synthesis.
摘要翻译：（I）图像（III）（IV）维他命霉素M1和类似物I -IV是胆囊收缩素（CCK）和胃泌素的拮抗剂。胆囊收缩素拮抗剂可用作止痛剂和用于治疗和预防动物，特别是人类的胃肠道，中枢神经和食欲调节系统的紊乱。胃泌素拮抗剂可用于阻断人类胃泌素受体，并且可用作治疗溃疡，肿瘤或其它胃肠道疾病的药剂。式I-IV的化合物也是抗生素，并且可用作包括人在内的动物的抗微生物剂，并且可用作促进动物饲料利用的食品添加剂。维生素霉素M1和式I，III和IV的类似物是通过控制好氧发酵的链霉菌链霉菌ATCC No.55327产生的。式II的类似物是通过化学合成制备的。

7. 发明授权

US4695544A Process for the preparation of cholecystokinin antagonists 失效
标题翻译：缩胆囊素拮抗剂的制备方法
公开(公告)号：US4695544A
公开(公告)日：1987-09-22
申请号：US712046
申请日：1985-03-15
申请人： Richard L. Monaghan , Michael A. Goetz , Raymond S. Chang
发明人： Richard L. Monaghan , Michael A. Goetz , Raymond S. Chang
IPC分类号： C07D487/04 , C07D487/22 , C07D519/00 , C12P17/18 , C12N1/14 , C12R1/66
CPC分类号： C07D487/04 , C12P17/182 , C12R1/66 , Y10S435/913
摘要： A process for preparing the compound having Formula I and several minor related compounds. ##STR1## The compound of Formula I and the several minor related compounds are antagonists of cholecystokinin (CCK). CCK antagonists are useful in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems of animals, especially humans.
摘要翻译：一种制备具有式I化合物和几种次要相关化合物的方法。 I型化合物和几种次要相关化合物是缩胆囊素（CCK）的拮抗剂。 CCK拮抗剂可用于治疗和预防动物，特别是人的胃肠道，中枢神经和食欲调节系统的紊乱。

8. 发明授权

US5137900A Therapeutic virginiamycin M.sub.1 analogs 失效
标题翻译：治疗维吉尼亚霉素M1类似物
公开(公告)号：US5137900A
公开(公告)日：1992-08-11
申请号：US644755
申请日：1991-01-23
申请人： Yiu-kuen T. Lam , Raymond S. Chang , Otto D. Hensens , Cheryl D. Schwartz , Deborah L. Zink
发明人： Yiu-kuen T. Lam , Raymond S. Chang , Otto D. Hensens , Cheryl D. Schwartz , Deborah L. Zink
IPC分类号： A61K31/42 , A61K38/00 , C07K5/078
CPC分类号： C07K5/06182 , A61K31/42 , A61K38/00
摘要： Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527. The analog of Formula II is produced by chemical synthesis.
摘要翻译：维生素B1，具有下式的维他明霉素M1：具有式I-IV的维吉尼好霉素M1类似物：（I）图像（III） -IV是胆囊收缩素（CCK）和胃泌素的拮抗剂。胆囊收缩素拮抗剂可用作止痛剂和用于治疗和预防动物，特别是人类的胃肠道，中枢神经和食欲调节系统的紊乱。胃泌素拮抗剂可用于阻断人类胃泌素受体，并且可用作治疗溃疡，肿瘤或其它胃肠道疾病的药剂。式I-IV的化合物也是抗生素，并且可用作包括人在内的动物的抗微生物剂，并且可用作促进动物饲料利用的食品添加剂。维生素霉素M1和式I，III和IV的类似物是通过控制好氧发酵的链霉菌链霉菌ATCC No.55327产生的。式II的类似物是通过化学合成制备的。

9. 发明授权

US4894370A Compositions having fermentation analogs of virginiamycin M.sub.1 as active ingredient 失效
标题翻译：具有维吉尼亚霉素M1的发酵类似物作为有效成分的组合物
公开(公告)号：US4894370A
公开(公告)日：1990-01-16
申请号：US173342
申请日：1988-03-25
申请人： Yiu-kuen T. Lam , Raymond S. Chang , Otto D. Hensens , Cheryl D. Schwartz , Deborah L. Zink
发明人： Yiu-kuen T. Lam , Raymond S. Chang , Otto D. Hensens , Cheryl D. Schwartz , Deborah L. Zink
IPC分类号： A61K38/00 , C07K5/078 , C12P17/18
CPC分类号： C12R1/58 , C07K5/06139 , C12P17/188 , A61K38/00
摘要： Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527, while the analog of Formula II is produced by chemical synthesis.
摘要翻译：维生素B1，具有下式的维他明霉素M1：具有式I-IV的维吉尼好霉素M1类似物：（I）图像（III） -IV是胆囊收缩素（CCK）和胃泌素的拮抗剂。胆囊收缩素拮抗剂可用作止痛剂和用于治疗和预防动物，特别是人类的胃肠道，中枢神经和食欲调节系统的紊乱。胃泌素拮抗剂可用于阻断人类胃泌素受体，并且可用作治疗溃疡，肿瘤或其它胃肠道疾病的药剂。式I-IV的化合物也是抗生素，并且可用作包括人在内的动物的抗微生物剂，并且可用作促进动物饲料利用的食品添加剂。弗吉尼亚霉素M1和式I，III和IV的类似物是通过控制好氧发酵链霉菌链霉菌ATCC No.55327产生的，而式II的类似物是通过化学合成制备的。

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