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1. 发明授权

US5327225A Surface plasmon resonance sensor 失效
标题翻译：表面等离子体共振传感器
公开(公告)号：US5327225A
公开(公告)日：1994-07-05
申请号：US10267
申请日：1993-01-28
申请人： William J. H. Bender , Raymond E. Dessy
发明人： William J. H. Bender , Raymond E. Dessy
IPC分类号： G01Q90/00 , G01N21/55
CPC分类号： G01N21/553 , Y10S435/808
摘要： An optical fiber surface plasmon resonance (SPR) sensor includes both a metal layer and an overlay or underlay material on its surface. Existing fiber based SPR devices are inherently incapable of monitoring aqueous systems which have a refractive index ranging between 1.33 and 1.35, and existing prism based SPR sensors have proved too cumbersome for online chemical and biochemical analyses. Inclusion of the overlay or underlay material on the SPR sensor allows monitoring media with a refractive index from 1.00 to the 1.39 barrier and above. Hence, the SPR sensor allows monitoring important biochemical and chemical aqueous processes where the media typically have a refractive index between 1.33 and 1.35. In operation, samples are simply applied to the sensing region of the SPR sensor where the metal layer and overlay or underlay materials are coated, introducing a polarized beam of light into the optical fiber, and detecting surface plasmon resonance. The optical fiber can be positioned in a flow cell for on line operations where media are simply moved past the sensing region of the SPR sensor or can be part of a dip stick which is used for batch processes. The SPR sensor has particular utility in monitoring biochemical (antigen-antibody) reactions, detecting corrosion of metal surfaces, and identifying chemical products in an HPLC effluent.
摘要翻译：光纤表面等离子体共振（SPR）传感器包括金属层和其表面上的覆盖层或底层材料。现有的基于光纤的SPR设备本身不能监测折射率介于1.33和1.35之间的水性体系，现有的基于棱镜的SPR传感器对于在线化学和生物化学分析已被证明是太麻烦了。将覆盖层或底层材料纳入SPR传感器允许监测介质的折射率从1.00到1.39屏障及以上。因此，SPR传感器允许监测重要的生物化学和化学水性过程，其中介质通常具有在1.33和1.35之间的折射率。在操作中，将样品简单地施加到SPR传感器的感测区域，其中金属层和覆盖层或底层材料被涂覆，将偏振光束引入光纤中，并且检测表面等离子体共振。光纤可以定位在流动池中，用于在线操作，其中介质简单地移动经过SPR传感器的感测区域，或者可以是用于批处理的浸渍棒的一部分。 SPR传感器在监测生化（抗原 - 抗体）反应，检测金属表面的腐蚀和鉴定HPLC流出物中的化学产品方面具有特殊的用途。

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