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1. 发明授权

US06210699B1 Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity 有权
公开(公告)号：US06210699B1
公开(公告)日：2001-04-03
申请号：US09285018
申请日：1999-04-01
申请人： Ramesh N. Acharya , Joseph L. Baker
发明人： Ramesh N. Acharya , Joseph L. Baker
IPC分类号： A61F1302
CPC分类号： A61K9/2086 , A61K9/006
摘要： A device and method for the oral transmucosal delivery of active substances to the oral cavity utilizing an unplasticized polyvinyl pyrrolidone polymer (PVP) as the primary mucoadhesive. The device is applied and adheres to the mucosa of the oral cavity without causing side effects or leaving an unpleasant taste. Preferably the device is a bilayer tablet having a mucoadhesive layer and an overlying active substance containing layer. The mucoadhesive layer may contain PVP as the only adhesive or may be combined with other hydrophilic polymeric substances. The active layer also contains a hydrophilic polymer carrier. The layers in the device dissolve and release the active substance to the oral cavity and is particularly adapted for the delivery of substances active in the oral cavity such as breath fresheners and substances to combat dry mouth. It is also useful for the delivery of ionic drugs such as peptides.

2. 发明授权

US5741805A Controlled release pilocarpine delivery system 失效
公开(公告)号：US5741805A
公开(公告)日：1998-04-21
申请号：US435285
申请日：1995-05-05
申请人： Ramesh N. Acharya
发明人： Ramesh N. Acharya
IPC分类号： A61K9/20 , A61K31/4178 , A61K31/415
CPC分类号： A61K31/4178 , A61K9/2027 , Y10S514/912
摘要： There is disclosed a method for treating a patient suffering from xerostomia, xerophthalmia or excessive intraocular pressure. The method comprises administering to said patient a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount sufficient to maintain a blood serum level of pilocarpine in said patient of from about 5 to about 40 ng/ml, for a period of at least 6 hours. Controlled release unit dosage forms containing pilocarpine are also disclosed.

3. 发明授权

US5731338A Controlled release pilocarpine delivery system 失效
标题翻译：受控释放毛果芸香碱输送系统
公开(公告)号：US5731338A
公开(公告)日：1998-03-24
申请号：US433903
申请日：1995-05-02
申请人： Ramesh N. Acharya
发明人： Ramesh N. Acharya
IPC分类号： A61K9/20 , A61K31/4178 , A61K31/415
CPC分类号： A61K31/4178 , A61K9/2027 , Y10S514/912
摘要： There is disclosed a method for treating a patient suffering from xerostomia, xerophthalmia or excessive intraocular pressure. The method comprises administering to said patient a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount sufficient to maintain a blood serum level of pilocarpine in said patient of from about 5 to about 40 ng/ml, for a period of at least 6 hours. Controlled release unit dosage forms containing pilocarpine are also disclosed.
摘要翻译：公开了一种治疗口干燥症，干眼症或过度眼内压的患者的方法。该方法包括给予所述患者治疗有效量的毛果芸香碱或其药学上可接受的盐，其量足以将所述患者血清中毛果芸香碱的水平维持在约5至约40ng / ml，持续一段时间至少6小时。还公开了含有毛果芸香碱的控制释放单位剂型。

4. 发明授权

US5661171A Controlled release pilocarpine delivery system 失效
标题翻译：受控释放毛果芸香碱输送系统
公开(公告)号：US5661171A
公开(公告)日：1997-08-26
申请号：US433713
申请日：1995-05-02
申请人： Ramesh N. Acharya
发明人： Ramesh N. Acharya
IPC分类号： A61K9/20 , A61K31/4178 , A61K31/415
CPC分类号： A61K31/4178 , A61K9/2027 , Y10S514/912
摘要： There is disclosed a method for treating a patient suffering from xerostomia, xerophthaimia or excessive intraocular pressure. The method comprises administering to said patient a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount sufficient to maintain a blood serum level of pilocarpine in said patient of from about 5 to about 40 ng/ml, for a period of at least 6 hours. Controlled release unit dosage forms containing pilocarpine are also disclosed.
摘要翻译：公开了一种治疗患有口干燥症，干眼症或过度眼内压的患者的方法。该方法包括给予所述患者治疗有效量的毛果芸香碱或其药学上可接受的盐，其量足以将所述患者血清中毛果芸香碱的水平维持在约5至约40ng / ml，持续一段时间至少6小时。还公开了含有毛果芸香碱的控制释放单位剂型。

5. 发明授权

US5102666A Calcium polycarbophil controlled release composition and method 失效
标题翻译：多卡多钙控释组合物及方法
公开(公告)号：US5102666A
公开(公告)日：1992-04-07
申请号：US580854
申请日：1990-09-11
申请人： Ramesh N. Acharya
发明人： Ramesh N. Acharya
IPC分类号： A61K8/73 , A61K8/81 , A61K9/00 , A61K9/20 , A61Q11/00 , A61Q19/00
CPC分类号： A61K8/733 , A61K8/8147 , A61K9/006 , A61K9/2027 , A61K9/205 , A61Q11/00 , A61Q19/00
摘要： Controlled release compositions comprising calcium polycarbophil and an active agent selected from the group consisting of medicinal agents, breath fresheners, and flavors, and a method of controlled release of such an active agent.
摘要翻译：包含聚卡波非钙和选自医药，呼吸清新剂和调味剂的活性剂的控制释放组合物以及这种活性剂的控制释放方法。

6. 发明授权

US5336486A Appetite control method 失效
标题翻译：食欲控制方法
公开(公告)号：US5336486A
公开(公告)日：1994-08-09
申请号：US676328
申请日：1991-03-28
申请人： Ramesh N. Acharya
发明人： Ramesh N. Acharya
IPC分类号： A61K9/00 , A61K31/78 , A61K31/74 , A61K9/20
CPC分类号： A61K31/78 , A61K9/0056 , Y10S514/909 , Y10S514/911
摘要： A method for suppressing appetite comprising administering by mouth to a subject an amount of polycarbophil that is effective to suppress the appetite of the subject without inducing a laxative effect in said subject.
摘要翻译：一种用于抑制食欲包括通过口施用给受试者聚卡波非的量能有效抑制所述对象的食欲而不诱导轻泻作用的方法，所述受试者。

7. 发明授权

US5686094A Controlled release formulations for the treatment of xerostomia 失效
标题翻译：用于治疗口腔干燥症的控制释放制剂
公开(公告)号：US5686094A
公开(公告)日：1997-11-11
申请号：US678814
申请日：1991-04-01
申请人： Ramesh N. Acharya
发明人： Ramesh N. Acharya
IPC分类号： A61K8/73 , A61K8/81 , A61K9/00 , A61K9/20 , A61Q11/00 , A61Q19/00
CPC分类号： A61K8/733 , A61K8/8147 , A61K9/006 , A61K9/2027 , A61K9/205 , A61Q11/00 , A61Q19/00 , Y10S514/953
摘要： A polymeric delivery system which is formed by a polycarbophil type composition with an active agent, optionally in the presence of water and/or other cosolvent. The resulting product is especially useful as a carrier or coating of active compositions, such as pharmaceuticals and the like. The composition is also useful for the controlled or sustained release of active agents that are drugs, cosmetic agents, household agents, agricultural agents, industrial chemical agents and nutritional agents. A composition and method for the treatment of xerostomia is also disclosed, comprising polycarbophil in the form of an article having a shape suitable for insertion into the mouth.
摘要翻译：聚合物递送系统，其由具有活性剂的聚卡波非型组合物形成，任选在水和/或其它助溶剂存在下形成。所得产物特别可用作活性组合物如药物等的载体或涂层。该组合物还可用于受控或持续释放作为药物，化妆品，家用剂，农药，工业化学试剂和营养剂的活性剂。还公开了一种治疗口腔干燥症的组合物和方法，其包括具有适于插入口腔形状的制品形式的聚卡波非。

8. 发明授权

US5110605A Calcium polycarbophil-alginate controlled release composition and method 失效
标题翻译：聚卡波非 - 海藻酸钙控释组合物和方法
公开(公告)号：US5110605A
公开(公告)日：1992-05-05
申请号：US570340
申请日：1990-08-21
申请人： Ramesh N. Acharya
发明人： Ramesh N. Acharya
IPC分类号： A61K8/73 , A61K8/81 , A61K9/00 , A61K9/20 , A61Q11/00 , A61Q19/00
CPC分类号： A61Q19/00 , A61K8/733 , A61K8/8147 , A61K9/006 , A61K9/2027 , A61K9/205 , A61Q11/00
摘要： A polymeric complex composition comprising a reaction complex formed by the interaction of a polycarbophil component with alginic acid or a salt thereof, said interaction being performed in the presence of a divalent cation and in the presence of an active agent selected from the group consisting of medicinal agents and cosmetic agents. There is also described a method of controlled release treatment comprising the steps of providing such a polymeric complex and an effective amount of an active agent selected from the group consisting of medicinal agents and cosmetic agents contained within said complex, and contacting an area of skin or mucous membrane to be treated with said composition for a sufficient period of time allow a therapeutically effective amount of said active agent to be released from the complex.
摘要翻译：一种聚合复合物组合物，其包含通过聚卡波非成分与藻酸或其盐的相互作用形成的反应络合物，所述相互作用是在二价阳离子存在下进行的，并且在活性剂存在下进行，所述活性剂选自药物药剂和化妆品。还描述了一种控释方法，其包括以下步骤：提供这样的聚合物复合物和有效量的活性剂，所述活性剂选自包含在所述复合物内的药用剂和化妆剂，并且接触皮肤区域或用所述组合物处理足够时间的粘膜允许治疗有效量的所述活性剂从复合物中释放出来。

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