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1. 发明授权

US08778019B2 Staged deployment devices and method for transcatheter heart valve delivery 有权
标题翻译：分期部署装置和经导管心脏瓣膜输送的方法
公开(公告)号：US08778019B2
公开(公告)日：2014-07-15
申请号：US13234782
申请日：2011-09-16
申请人： Bradley Charles Knippel , Huisun Wang , Ralph Joseph Thomas , Jacob John Daly
发明人： Bradley Charles Knippel , Huisun Wang , Ralph Joseph Thomas , Jacob John Daly
IPC分类号： A61F2/84 , A61F2/24 , A61F2/966
CPC分类号： A61F2/2436 , A61F2/95 , A61F2/962 , A61F2/966 , A61F2002/9517 , A61F2002/9534
摘要： A delivery device for a collapsible heart valve includes an operating handle and a catheter assembly. The operating handle includes a frame defining a movement space therein, a carriage assembly moveable in a longitudinal direction within the movement space, and a coupler having locked and unlocked conditions, the coupler being operatively connected to the carriage assembly for movement therewith. The catheter assembly includes a shaft around which a valve-receiving compartment is defined, the shaft being operatively connected to one of the frame or the carriage assembly, and a distal sheath operatively connected to the carriage assembly for movement therewith between a closed condition adapted to maintain the valve in the compartment and an open condition adapted to fully deploy the valve.
摘要翻译：用于可折叠心脏瓣膜的递送装置包括操作手柄和导管组件。操作手柄包括限定其中的移动空间的框架，可在移动空间内沿纵向方向移动的滑架组件和具有锁定和解锁状态的联接器，联接器可操作地连接到滑架组件以与其一起运动。导管组件包括轴，围绕该轴限定了阀接收室，所述轴可操作地连接到框架或托架组件中的一个，以及可操作地连接到托架组件的远侧护套，用于在托架组件之间运动，该封闭状态适于将阀门保持在隔室中，并且适于完全展开阀门的打开状态。

2. 发明授权

US08893370B2 System for loading a collapsible heart valve 有权
标题翻译：用于装载可折叠心脏瓣膜的系统
公开(公告)号：US08893370B2
公开(公告)日：2014-11-25
申请号：US13535591
申请日：2012-06-28
申请人： Brett Allen Hillukka , Khoi Le , Ralph Joseph Thomas , Valerie J. Glazier
发明人： Brett Allen Hillukka , Khoi Le , Ralph Joseph Thomas , Valerie J. Glazier
IPC分类号： B21D39/00 , A61F2/24 , A61F2/00 , A61F2/95
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/2412 , A61F2/2436 , A61F2002/9522 , A61F2250/0007 , A61F2250/0039 , A61F2250/0064 , Y10T29/49908
摘要： An assembly for collapsing a self-expanding prosthetic heart valve includes a compression member, a support member, a constricting member, and a spacer which may be used for smaller sized heart valves. The compression member has a tapered wall between its first open end and its second open end, the tapered wall defining an open space adapted to receive the heart valve. The support member has a base and a recess adapted to receive an end of the heart valve. The support member and the compression member are movable toward one another to compress the heart valve and push it through a relatively small aperture in the second open end of the compression member. The second end of the constricting member is sized to receive the compressed heart valve from the second open end of the compression member for loading into a delivery device.
摘要翻译：用于塌陷自扩张假体心脏瓣膜的组件包括可用于较小尺寸的心脏瓣膜的压缩构件，支撑构件，收缩构件和间隔件。压缩构件在其第一开口端和其第二开口端之间具有锥形壁，锥形壁限定适于容纳心脏瓣膜的开放空间。支撑构件具有适于容纳心脏瓣膜的端部的基部和凹部。支撑构件和压缩构件可相对于彼此移动以压缩心脏瓣膜并将其推压通过压缩构件的第二开口端中相对较小的孔。收缩构件的第二端的尺寸被设计成从压缩构件的第二开口端接收压缩的心脏瓣膜，用于装载到输送装置中。

3. 发明授权

US08814931B2 Staged deployment devices and methods for transcatheter heart valve delivery systems 有权
标题翻译：经导管心脏瓣膜输送系统的分期部署装置和方法
公开(公告)号：US08814931B2
公开(公告)日：2014-08-26
申请号：US13212442
申请日：2011-08-18
申请人： Huisun Wang , Ralph Joseph Thomas
发明人： Huisun Wang , Ralph Joseph Thomas
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2436 , A61F2/95 , A61F2/962 , A61F2/966 , A61F2002/9517 , A61F2002/9528 , A61F2002/9534
摘要： A delivery device for a collapsible heart valve includes an operating handle, including a frame defining a movement space therein, a carriage assembly moveable within the movement space, and a first resheathing lock having a locked position and an unlocked position. The delivery device further includes a catheter assembly, including a first shaft around which a valve-receiving compartment is defined, the first shaft being fixedly connected to one of the frame or the carriage assembly, and a distal sheath operatively connected to the carriage assembly. The distal sheath is moveable between a closed condition adapted to maintain the valve in the compartment and an open condition adapted to fully deploy the valve. With the resheathing lock in the locked position, the distal sheath is unable to move to the open condition to fully deploy the valve.
摘要翻译：用于可折叠心脏瓣膜的递送装置包括操作手柄，其包括限定其中的移动空间的框架，可在移动空间内移动的滑架组件和具有锁定位置和解锁位置的第一再适配锁。输送装置还包括导管组件，其包括限定了阀接收室的第一轴，第一轴固定地连接到框架或托架组件中的一个，以及可操作地连接到托架组件的远侧护套。远侧护套可在适于维持隔室中的阀的关闭状态和适于完全展开阀的打开状态之间移动。随着再锁定锁定在锁定位置，远侧护套不能移动到打开状态以完全展开阀门。

4. 发明申请

US20140052238A1 DELIVERY DEVICE HAVING A CURVED SHAFT AND A STRAIGHTENING MEMBER FOR TRANSCATHETER AORTIC VALVE IMPLANTATION 审中-公开
标题翻译：具有弯曲轴的输送装置和用于行驶室动力阀植入物的连接构件
公开(公告)号：US20140052238A1
公开(公告)日：2014-02-20
申请号：US13823415
申请日：2011-09-16
申请人： Huisun Wang , Ralph Joseph Thomas
发明人： Huisun Wang , Ralph Joseph Thomas
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2250/0018 , A61F2250/0019 , A61F2250/0029 , A61M25/0041 , A61M25/01 , A61M2025/0004
摘要： A delivery device (100) includes a support member (128), a distal sheath (130), an outer shaft (120) and a strengthening member (140). The support member is adapted to hold a prosthetic heart valve. The distal sheath is slidable relative to the support member between a first position in which the distal sheath is adapted to maintain the prosthetic heart valve in a collapsed condition, and a second position in which the distal sheath is adapted to expose the prosthetic heart valve. The outer shaft is connected to the distal sheath and has a curved portion (134). The straightening member is slidable on the outer shaft between a proximal position in which the straightening member does not cover the curved portion of the outer shaft, and a distal position in which the straightening member covers and substantially straightens at least a portion of the curved portion of the outer shaft.
摘要翻译：输送装置（100）包括支撑构件（128），远侧护套（130），外轴（120）和加强构件（140）。支撑构件适于保持假体心脏瓣膜。远侧护套可在第一位置和第二位置之间相对于支撑构件滑动，在第一位置，远侧护套适于将假体心脏瓣膜保持在折叠状态，以及第二位置，远端护套适于暴露假体心脏瓣膜。外轴连接到远端护套并且具有弯曲部分（134）。矫直构件可以在外轴上在矫正构件不覆盖外轴的弯曲部分的近端位置和矫直构件覆盖的远侧位置之间滑动，并且基本上拉直弯曲部分的至少一部分的外轴。

5. 发明申请

US20140005768A1 SLEEVE FOR FACILITATING MOVEMENT OF A TRANSFEMORAL CATHETER 审中-公开
标题翻译：用于促进传输导管的运动
公开(公告)号：US20140005768A1
公开(公告)日：2014-01-02
申请号：US13817056
申请日：2011-08-17
申请人： Ralph Joseph Thomas , Huisun Wang , Jacob John Daly , Thomas A. Savard
发明人： Ralph Joseph Thomas , Huisun Wang , Jacob John Daly , Thomas A. Savard
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2436 , A61F2/966 , A61M25/0054 , A61M25/0136 , A61M25/0147 , A61M25/0668 , A61M2025/0175
摘要： A delivery device (10) for an implantable medical device includes an inner shaft (26) extending in a longitudinal direction and defining a compartment (23) adapted to receive the medical device in an assembled condition, an outer shaft (22) surrounding a longitudinal portion of the inner shaft, and a distal sheath (24) operatively attached to the outer shaft (22). The distal sheath (24) is slidable between a first position enclosing the compartment (23) and a second position exposing the compartment (23) for deployment of the medical device. A sleeve 30 surrounds at least a longitudinal portion of the outer shaft (22) and provides a substantially blood tight bearing surface that facilitates sliding movement of the delivery device (10) in an introducer (2).
摘要翻译：用于可植入医疗装置的输送装置（10）包括沿纵向方向延伸并限定适于在组装状态下容纳医疗装置的隔间（23）的内轴（26），围绕纵向所述内轴的一部分以及可操作地附接到所述外轴（22）的远侧护套（24）。远端护套（24）可以在包围隔室（23）的第一位置与暴露隔室（23）的第二位置之间滑动以便展开医疗装置。套管30围绕外轴（22）的至少纵向部分并提供基本上血液密封的支承表面，其有利于输送装置（10）在导引器（2）中的滑动运动。

6. 发明申请

US20120078352A1 STAGED DEPLOYMENT DEVICES AND METHODS FOR TRANSCATHETER HEART VALVE DELIVERY SYSTEMS 有权
标题翻译：分段部署装置和方法用于过渡式心脏瓣膜输送系统
公开(公告)号：US20120078352A1
公开(公告)日：2012-03-29
申请号：US13212442
申请日：2011-08-18
申请人： Huisun Wang , Ralph Joseph Thomas
发明人： Huisun Wang , Ralph Joseph Thomas
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2436 , A61F2/95 , A61F2/962 , A61F2/966 , A61F2002/9517 , A61F2002/9528 , A61F2002/9534
摘要： A delivery device for a collapsible heart valve includes an operating handle, including a frame defining a movement space therein, a carriage assembly moveable within the movement space, and a first resheathing lock having a locked position and an unlocked position. The delivery device further includes a catheter assembly, including a first shaft around which a valve-receiving compartment is defined, the first shaft being fixedly connected to one of the frame or the carriage assembly, and a distal sheath operatively connected to the carriage assembly. The distal sheath is moveable between a closed condition adapted to maintain the valve in the compartment and an open condition adapted to fully deploy the valve. With the resheathing lock in the locked position, the distal sheath is unable to move to the open condition to fully deploy the valve.
摘要翻译：用于可折叠心脏瓣膜的递送装置包括操作手柄，其包括限定其中的移动空间的框架，可在移动空间内移动的滑架组件和具有锁定位置和解锁位置的第一再适配锁。输送装置还包括导管组件，其包括限定了阀接收室的第一轴，第一轴固定地连接到框架或托架组件中的一个，以及可操作地连接到托架组件的远侧护套。远侧护套可在适于维持隔室中的阀的关闭状态和适于完全展开阀的打开状态之间移动。随着再锁定锁定在锁定位置，远侧护套不能移动到打开状态以完全展开阀门。

7. 发明授权

US10130470B2 Sleeve for facilitating movement of a transfemoral catheter 有权
公开(公告)号：US10130470B2
公开(公告)日：2018-11-20
申请号：US13817056
申请日：2011-08-17
申请人： Ralph Joseph Thomas , Huisun Wang , Jacob John Daly , Thomas A. Savard
发明人： Ralph Joseph Thomas , Huisun Wang , Jacob John Daly , Thomas A. Savard
IPC分类号： A61F2/24 , A61M25/01 , A61M25/06 , A61F2/966 , A61M25/00
摘要： A delivery device (10) for an implantable medical device includes an inner shaft (26) extending in a longitudinal direction and defining a compartment (23) adapted to receive the medical device in an assembled condition, an outer shaft (22) surrounding a longitudinal portion of the inner shaft, and a distal sheath (24) operatively attached to the outer shaft (22). The distal sheath (24) is slidable between a first position enclosing the compartment (23) and a second position exposing the compartment (23) for deployment of the medical device. A sleeve 30 surrounds at least a longitudinal portion of the outer shaft (22) and provides a substantially blood tight bearing surface that facilitates sliding movement of the delivery device (10) in an introducer (2).

8. 外观设计

USD708744S1 Deployment handle 有权
标题翻译：部署手柄
公开(公告)号：USD708744S1
公开(公告)日：2014-07-08
申请号：US29425933
申请日：2012-06-28
申请人： Benjamin E. Morris , Eric E. Bielefeld , Gregory R. Furnish , Ralph Joseph Thomas , Khoi Le , Bradley Charles Knippel , Valerie J. Glazier
设计人： Benjamin E. Morris , Eric E. Bielefeld , Gregory R. Furnish , Ralph Joseph Thomas , Khoi Le , Bradley Charles Knippel , Valerie J. Glazier

9. 发明授权

US10603166B2 Delivery device having a curved shaft and a straightening member for transcatheter aortic valve implantation 有权
公开(公告)号：US10603166B2
公开(公告)日：2020-03-31
申请号：US13823415
申请日：2011-09-16
申请人： Huisun Wang , Ralph Joseph Thomas
发明人： Huisun Wang , Ralph Joseph Thomas
IPC分类号： A61F2/24 , A61F2/966 , A61M25/00 , A61M25/01
摘要： A delivery device may generally include a support member, a distal sheath, an outer shaft and a straightening member. The support member is adapted to hold a prosthetic heart valve. The distal sheath is slidable relative to the support member between a first position in which the distal sheath is adapted to maintain the prosthetic heart valve in a collapsed condition, and a second position in which the distal sheath is adapted to expose the prosthetic heart valve. The outer shaft is connected to the distal sheath and has a curved portion. The straightening member is slidable on the outer shaft between a proximal position in which the straightening member does not cover the curved portion of the outer shaft, and a distal position in which the straightening member covers and substantially straightens at least a portion of the curved portion of the outer shaft.

10. 发明授权

US09700411B2 Delivery system for collapsible heart valve 有权
公开(公告)号：US09700411B2
公开(公告)日：2017-07-11
申请号：US13211486
申请日：2011-08-17
申请人： Daniel J. Klima , Huisun Wang , Ralph Joseph Thomas , Gary W. Geiger
发明人： Daniel J. Klima , Huisun Wang , Ralph Joseph Thomas , Gary W. Geiger
IPC分类号： A61F2/24 , B29C70/68 , A61B17/00 , A61F2/966
CPC分类号： A61F2/2436 , A61B17/00234 , A61B2017/00314 , A61F2/966 , Y10T156/1043
摘要： A delivery system for delivering a collapsible prosthetic heart valve includes a valve support structure for supporting a collapsible prosthetic heart valve, and a distal sheath movable in a longitudinal direction relative to the valve support structure between a first position in which the distal sheath is adapted to surround a collapsible prosthetic heart valve supported on the valve support structure, and a second position in which the distal sheath is adapted to expose the collapsible prosthetic heart valve for deployment. The distal sheath is at least partially formed of an inner polymer layer, an outer polymer layer, and a tubular supporting member sandwiched between the inner polymer layer and the outer polymer layer.

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